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Author Rebeccah J Katzenberger

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Effects of blunt force injuries in third-instar Drosophila larvae persist through metamorphosis and reduce adult lifespan.

Jorgo Lika, Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarman,

Blunt force injuries are a significant cause of disability and death worldwide. Here, we describe a <i>Drosophila melanogaster</i> model of blunt force injury that can be used to investigate cellular and molecular mechanisms that underlie the short-term and long-term effects of injuries sustained at a juvenile stage of development. Injuries ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Survival Following Traumatic Brain Injury in Drosophila Is Increased by Heterozygosity for a Mutation of the NF-κB Innate Immune Response Transcription Factor Relish.

Laura C Swanson, Edna A Trujillo, Gene H Thiede, Rebeccah J Katzenberger, Evgenia Shishkova, Joshua J Coon, Barry Ganetzky, David A Wassarman,

Traumatic brain injury (TBI) pathologies are caused by primary and secondary injuries. Primary injuries result from physical damage to the brain, and secondary injuries arise from cellular responses to primary injuries. A characteristic cellular response is sustained activation of inflammatory pathways commonly mediated by nuclear factor-κB (NF-κB) transcription factors. Using ... Read more >>

Genetics (Genetics)
[2020, 216(4):1117-1136]

Cited: 2 times

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Anesthetics Influence Mortality in a Drosophila Model of Blunt Trauma With Traumatic Brain Injury.

Julie A Fischer, Zachariah P G Olufs, Rebeccah J Katzenberger, David A Wassarman, Misha Perouansky,

BACKGROUND:Exposure to anesthetics is common in the majority of early survivors of life-threatening injuries. Whether and to what degree general anesthetics influence outcomes from major trauma is unknown. Potential confounding effects of general anesthetics on outcome measures are usually disregarded. We hypothesized that exposure to isoflurane or sevoflurane modulates the ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2018, 126(6):1979-1986]

Cited: 10 times

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Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila.

Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarman,

Outcomes of traumatic brain injury (TBI) vary because of differences in primary and secondary injuries. Primary injuries occur at the time of a traumatic event, whereas secondary injuries occur later as a result of cellular and molecular events activated in the brain and other tissues by primary injuries. We used ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2016, 6(12):4151-4166]

Cited: 20 times

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A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila.

Rebeccah J Katzenberger, Carin A Loewen, R Tayler Bockstruck, Mikal A Woods, Barry Ganetzky, David A Wassarman,

Traumatic brain injury (TBI) affects millions of people each year, causing impairment of physical, cognitive, and behavioral functions and death. Studies using Drosophila have contributed important breakthroughs in understanding neurological processes. Thus, with the goal of understanding the cellular and molecular basis of TBI pathologies in humans, we developed the ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2015, (100):e52905]

Cited: 16 times

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The gut reaction to traumatic brain injury.

Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarman,

Traumatic brain injury (TBI) is a complex disorder that affects millions of people worldwide. The complexity of TBI partly stems from the fact that injuries to the brain instigate non-neurological injuries to other organs such as the intestine. Additionally, genetic variation is thought to play a large role in determining ... Read more >>

Fly (Austin) (Fly)
[2015, 9(2):68-74]

Cited: 25 times

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The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia.

Andrew J Petersen, Rebeccah J Katzenberger, David A Wassarman,

Neurodegeneration is a hallmark of the human disease ataxia-telangiectasia (A-T) that is caused by mutation of the A-T mutated (ATM) gene. We have analyzed Drosophila melanogaster ATM mutants to determine the molecular mechanisms underlying neurodegeneration in A-T. Previously, we found that ATM mutants upregulate the expression of innate immune response ... Read more >>

Genetics (Genetics)
[2013, 194(1):133-142]

Cited: 49 times

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The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes.

Rebeccah J Katzenberger, Elizabeth A Rach, Ashley K Anderson, Uwe Ohler, David A Wassarman,

To investigate the importance of core promoter elements for tissue-specific transcription of RNA polymerase II genes, we examined testis-specific transcription in Drosophila melanogaster. Bioinformatic analyses of core promoter sequences from 190 genes that are specifically expressed in testes identified a 10 bp A/T-rich motif that is identical to the translational ... Read more >>

PLoS One (PloS one)
[2012, 7(9):e45009]

Cited: 4 times

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The effect of ATM knockdown on ionizing radiation-induced neuronal cell cycle reentry in Drosophila.

Stacey A Rimkus, Andrew J Petersen, Rebeccah J Katzenberger, David A Wassarman,

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2010, 9(13):2686-2687]

Cited: 0 times

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Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.

Stacey A Rimkus, Rebeccah J Katzenberger, Anthony T Trinh, Gerald E Dodson, Randal S Tibbetts, David A Wassarman,

Mutations in ATM (Ataxia telangiectasia mutated) result in Ataxia telangiectasia (A-T), a disorder characterized by progressive neurodegeneration. Despite advances in understanding how ATM signals cell cycle arrest, DNA repair, and apoptosis in response to DNA damage, it remains unclear why loss of ATM causes degeneration of post-mitotic neurons and why ... Read more >>

Genes Dev (Genes & development)
[2008, 22(9):1205-1220]

Cited: 26 times

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Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.

Jared R Mays, José A Restituyo, Rebeccah J Katzenberger, David A Wassarman, Scott R Rajski,

FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition. ... Read more >>

Tetrahedron Lett (Tetrahedron letters)
[2007, 48(26):4579-4583]

Cited: 2 times

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The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism.

Lori A Pile, Paul T Spellman, Rebeccah J Katzenberger, David A Wassarman,

Deacetylation of histones by the SIN3 complex is a major mechanism utilized in eukaryotic organisms to repress transcription. Presumably, developmental and cellular phenotypes resulting from mutations in SIN3 are a consequence of altered transcription of SIN3 target genes. Therefore, to understand the molecular mechanisms underlying SIN3 mutant phenotypes in Drosophila, ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2003, 278(39):37840-37848]

Cited: 55 times

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TAF1 activates transcription by phosphorylation of serine 33 in histone H2B.

Tobias Maile, Simona Kwoczynski, Rebeccah J Katzenberger, David A Wassarman, Frank Sauer,

Dynamic changes in chromatin structure, induced by posttranslational modification of histones, play a fundamental role in regulating eukaryotic transcription. Here we report that histone H2B is phosphorylated at evolutionarily conserved Ser33 (H2B-S33) by the carboxyl-terminal kinase domain (CTK) of the Drosophila TFIID subunit TAF1. Phosphorylation of H2B-S33 at the promoter ... Read more >>

Science (Science (New York, N.Y.))
[2004, 304(5673):1010-1014]

Cited: 35 times

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