Full Text Journal Articles by
Author Rebecca S Moreci

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Epidermal structure and differentiation.

Rebecca S Moreci, Terry Lechler,

In this Primer, Moreci and Lechler follow the lifetime of an epidermal cell from its birth to its ultimate death, and detail how this journey is necessary for epidermal function. ... Read more >>

Curr. Biol. (Current biology : CB)
[2020, 30(4):R144-R149]

Cited: 0 times

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Steroidogenic Factor 1 (Nr5a1) is Required for Sertoli Cell Survival Post Sex Determination.

Prashanth Anamthathmakula, Chandra Suma Johnson Miryala, Rebecca S Moreci, Chandrashekara Kyathanahalli, Sonia S Hassan, Jennifer C Condon, Pancharatnam Jeyasuria,

The elevated level of Steroidogenic Factor 1 (Nr5a1, Sf-1) expression in the male gonadal development pathway, post sex determination, implies a vital role in testis gonadal differentiation. In this study we generated Sertoli cell-specific Nr5a1 KO mice (SC-SF-1-/-) at E14.5, which coincides with testis development post sex determination, using the ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):4452]

Cited: 1 time

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Ashley V Menk, Nicole E Scharping, Rebecca S Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A Young, Stacy Gelhaus Wendell, Greg M Delgoffe,

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear. We show T cell activation rapidly induces glycolysis independent of transcription, ... Read more >>

Cell Rep (Cell Reports)
[2018, 22(6):1509-1521]

Cited: 26 times

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Nicole E Scharping, Ashley V Menk, Rebecca S Moreci, Ryan D Whetstone, Rebekah E Dadey, Simon C Watkins, Robert L Ferris, Greg M Delgoffe,

Immunity (Immunity)
[2016, 45(3):701-703]

Cited: 30 times

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Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1.

Karthika Natarajan, Yi Xie, Takeo Nakanishi, Rebecca S Moreci, Pancharatnam Jeyasuria, Arif Hussain, Douglas D Ross,

Gene expression in different tissues is often controlled by alternative promoters that result in the synthesis of mRNA with unique - usually untranslated - first exons. Bcrp1 (Abcg2), the murine orthologue of the ABC transporter Breast Cancer Resistance Protein (BCRP, ABCG2), has at least four alternative promoters that are designated ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (111):]

Cited: 0 times

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Nicole E Scharping, Ashley V Menk, Rebecca S Moreci, Ryan D Whetstone, Rebekah E Dadey, Simon C Watkins, Robert L Ferris, Greg M Delgoffe,

Although tumor-specific T cells recognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironment. Here we showed that T cells demonstrated persistent loss of mitochondrial function and mass when infiltrating murine and human tumors, an effect specific to the tumor microenvironment and not merely caused by activation. Tumor-infiltrating T cells showed ... Read more >>

Immunity (Immunity)
[2016, 45(2):374-388]

Cited: 79 times

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Metabolic insufficiency underlies intratumoral cytotoxic T cell dysfunction.

Tushar Gupta, Nicole E Scharping, Rebecca S Moreci, Greg M Delgoffe,

J Immunother Cancer (Journal for immunotherapy of cancer)
[2015, 3(Suppl 2):P399-P399]

Cited: 0 times

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Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent.

Chandrashekara Kyathanahalli, Kenna Organ, Rebecca S Moreci, Prashanth Anamthathmakula, Sonia S Hassan, Steve N Caritis, Pancharatnam Jeyasuria, Jennifer C Condon,

We previously identified myometrial caspase-3 (CASP3) as a potential regulator of uterine quiescence. We also determined that during pregnancy, the functional activation of uterine CASP3 is likely governed by an integrated endoplasmic reticulum stress response (ERSR) and is consequently limited by an increased unfolded protein response (UPR). The present study ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2015, 112(45):14090-14095]

Cited: 14 times

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Restoration of spermatogenesis and male fertility using an androgen receptor transgene.

William H Walker, Evan Easton, Rebecca S Moreci, Corey Toocheck, Prashanth Anamthathmakula, Pancharatnam Jeyasuria,

Androgens signal through the androgen receptor (AR) to regulate male secondary sexual characteristics, reproductive tract development, prostate function, sperm production, bone and muscle mass as well as body hair growth among other functions. We developed a transgenic mouse model in which endogenous AR expression was replaced by a functionally modified ... Read more >>

PLoS ONE (PloS one)
[2015, 10(3):e0120783]

Cited: 3 times

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Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1.

Yi Xie, Karthika Natarajan, Kenneth S Bauer, Takeo Nakanishi, William T Beck, Rebecca S Moreci, Pancharatnam Jeyasuria, Arif Hussain, Douglas D Ross,

Alternative promoter usage is typically associated with mRNAs with differing first exons that contain or consist entirely of a 5' untranslated region. The murine Bcrp1 (Abcg2) transporter has three alternative promoters associated with mRNAs containing alternative untranslated first exons designated as E1A, E1B, and E1C. The E1B promoter regulates Bcrp1 ... Read more >>

Biochim. Biophys. Acta (Biochimica et biophysica acta)
[2013, 1829(12):1288-1299]

Cited: 2 times

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