Full Text Journal Articles by
Author Rebecca C Taylor

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A stress-free stress response.

Nadia Cummins, Rebecca C Taylor,

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1038-1039]

Cited: 0 times

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Molty-Level Regulation: Lysosomes Participate in Developmental ECM Remodeling in C. elegans.

Soudabeh Imanikia, Rebecca C Taylor,

Dynamic regulation of lysosomes allows them to play key roles in cell and tissue homeostasis. In this issue of Developmental Cell, Miao et al. find that a novel transcriptional pathway triggered by loss of cell adhesion activates lysosomes in C. elegans epidermis during developmental remodeling of the cuticle. ... Read more >>

Dev. Cell (Developmental cell)
[2020, 52(1):1-2]

Cited: 0 times

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XBP-1 Remodels Lipid Metabolism to Extend Longevity.

Soudabeh Imanikia, Ming Sheng, Cecilia Castro, Julian L Griffin, Rebecca C Taylor,

The endoplasmic reticulum unfolded protein response (UPRER) is a cellular stress response that maintains homeostasis within the secretory pathway, regulates glucose and lipid metabolism, and influences longevity. To ask whether this role in lifespan determination depends upon metabolic intermediaries, we metabotyped C. elegans expressing the active form of the UPRER transcription ... Read more >>

Cell Rep (Cell reports)
[2019, 28(3):581-589.e4]

Cited: 1 time

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Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans.

Soudabeh Imanikia, Neşem P Özbey, Christel Krueger, M Olivia Casanueva, Rebecca C Taylor,

The unfolded protein response of the endoplasmic reticulum (UPRER) is a crucial mediator of secretory pathway homeostasis. Expression of the spliced and active form of the UPRER transcription factor XBP-1, XBP-1s, in the nervous system triggers activation of the UPRER in the intestine of Caenorhabditis elegans (C. elegans) through release of ... Read more >>

Curr. Biol. (Current biology : CB)
[2019, 29(14):2322-2338.e7]

Cited: 3 times

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Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation.

Jonathan A G Cox, Rebecca C Taylor, Alistair K Brown, Samuel Attoe, Gurdyal S Besra, Klaus Fütterer,

The intracellular pathogen Mycobacterium tuberculosis is the causative agent of tuberculosis, which is a leading cause of mortality worldwide. The survival of M. tuberculosis in host macrophages through long-lasting periods of persistence depends, in part, on breaking down host cell lipids as a carbon source. The critical role of fatty-acid catabolism ... Read more >>

Acta Crystallogr D Struct Biol (Acta crystallographica. Section D, Structural biology)
[2019, 75(Pt 1):101-108]

Cited: 0 times

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An elegant UPR discovery.

Rebecca C Taylor,

Nat. Rev. Mol. Cell Biol. (Nature reviews. Molecular cell biology)
[2018, 19(9):545]

Cited: 0 times

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Cell Non-autonomous UPRER Signaling.

Soudabeh Imanikia, Ming Sheng, Rebecca C Taylor,

The UPRER is an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPRER to coordinate physiological processes between cells and tissues. Recent ... Read more >>

Curr. Top. Microbiol. Immunol. (Current topics in microbiology and immunology)
[2018, 414:27-43]

Cited: 3 times

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Aging and the UPR(ER).

Rebecca C Taylor,

The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response ... Read more >>

Brain Res. (Brain research)
[2016, 1648(Pt B):588-593]

Cited: 22 times

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XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity.

Rebecca C Taylor, Andrew Dillin,

The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR(ER)) in aging of C. elegans and found that age-onset loss of ER proteostasis could be reversed by expression ... Read more >>

Cell (Cell)
[2013, 153(7):1435-1447]

Cited: 206 times

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Analysis of aging in Caenorhabditis elegans.

Deepti S Wilkinson, Rebecca C Taylor, Andrew Dillin,

This chapter is dedicated to the study of aging in Caenorhabditis elegans (C. elegans). The assays are divided into two sections. In the first section, we describe detailed protocols for performing life span analysis in solid and liquid medium. In the second section, we describe various assays for measuring age-related ... Read more >>

Methods Cell Biol. (Methods in cell biology)
[2012, 107:353-381]

Cited: 23 times

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Aging as an event of proteostasis collapse.

Rebecca C Taylor, Andrew Dillin,

Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer's and Huntington's. Metabolic signaling pathways that regulate the aging process, mediated by insulin/IGF-1 signaling, dietary restriction, and reduced ... Read more >>

Cold Spring Harb Perspect Biol (Cold Spring Harbor perspectives in biology)
[2011, 3(5):]

Cited: 146 times

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Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis.

Rebecca C Taylor, Alistair K Brown, Albel Singh, Apoorva Bhatt, Gurdyal S Besra,

The lipid-rich cell wall of mycobacteria is essential not only for virulence but also for survival. Whilst anabolic pathways for mycobacterial lipid biosynthesis have been well studied, there has been little research looking into lipid catabolism. The genome of Mycobacterium tuberculosis encodes multiple enzymes with putative roles in the beta-oxidation ... Read more >>

Microbiology (Reading) (Microbiology (Reading, England))
[2010, 156(Pt 7):1975-1982]

Cited: 9 times

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Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

Alexander U Lüthi, Sean P Cullen, Edel A McNeela, Patrick J Duriez, Inna S Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C Taylor, Kristof Kersse, Peter Vandenabeele, Ed C Lavelle, Seamus J Martin,

Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to the proinflammatory cytokines IL-1 beta and IL-18, but this remains unproven. Here we showed ... Read more >>

Immunity (Immunity)
[2009, 31(1):84-98]

Cited: 343 times

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Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.

Alistair K Brown, Rebecca C Taylor, Apoorva Bhatt, Klaus Fütterer, Gurdyal S Besra,

BACKGROUND:There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains. Herein, we have examined the susceptibility of mycobacteria to the natural product platensimycin. METHODS AND FINDINGS:We have ... Read more >>

PLoS ONE (PloS one)
[2009, 4(7):e6306]

Cited: 24 times

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Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.

Qosay Al-Balas, Nahoum G Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K Brown, Rebecca C Taylor, Gurdyal S Besra, Timothy D McHugh, Stephen H Gillespie, Blair F Johnston, Simon P Mackay, Geoffrey D Coxon,

BACKGROUND:Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug resistance and co-infection with HIV/AIDS. Tuberculosis control requires new drugs that act at novel drug ... Read more >>

PLoS One (PloS one)
[2009, 4(5):e5617]

Cited: 15 times

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Diagnosis of pleuritic chest pain query PE: beware of dissecting thoracic aneurysm of aorta.

Rebecca C Taylor, Tarunya S Vedutla, Phyo K Myint, Sanjeevikumar Meenakshisundaram,

Int. J. Cardiol. (International journal of cardiology)
[2010, 140(3):e56-8]

Cited: 0 times

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The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.

Romain Veyron-Churlet, Virginie Molle, Rebecca C Taylor, Alistair K Brown, Gurdyal S Besra, Isabelle Zanella-Cléon, Klaus Fütterer, Laurent Kremer,

Mycolic acids are hallmark features of the Mycobacterium tuberculosis cell wall. They are synthesized by the condensation of two fatty acids, a C56-64-meromycolyl chain and a C24-26-fatty acyl chain. Meromycolates are produced via the combination of type I and type II fatty acid synthases (FAS-I and FAS-II). The beta-ketoacyl-acyl carrier ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2009, 284(10):6414-6424]

Cited: 44 times

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Apoptosis: controlled demolition at the cellular level.

Rebecca C Taylor, Sean P Cullen, Seamus J Martin,

Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture that contribute not only to cell death, but also prepare cells for removal by phagocytes and prevent unwanted immune responses. Much of what happens during the demolition phase of apoptosis is orchestrated by members of the caspase ... Read more >>

Nat. Rev. Mol. Cell Biol. (Nature reviews. Molecular cell biology)
[2008, 9(3):231-241]

Cited: 1089 times

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Tumor-infiltrating lymphocytes predict sentinel lymph node positivity in patients with cutaneous melanoma.

Rebecca C Taylor, Ami Patel, Katherine S Panageas, Klaus J Busam, Mary S Brady,

PURPOSE: Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response to tumor, but the influence of TILs on outcome remains controversial. Studies evaluating the prognostic significance of TILs were published before routine examination of draining lymph nodes by sentinel lymph node (SLN) biopsy, the most important predictor ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2007, 25(7):869-875]

Cited: 122 times

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Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.

Rebecca C Taylor, Gabriela Brumatti, Shu Ito, Michael O Hengartner, W Brent Derry, Seamus J Martin,

Genetic studies have established that the cysteine protease CED-3 plays a central role in coordinating programmed cell death in Caenorhabditis elegans. However, it remains unclear how CED-3 activation results in cell death because few substrates for this protease have been described. We have used a global proteomics approach to seek ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2007, 282(20):15011-15021]

Cited: 21 times

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Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics.

Petrina Delivani, Colin Adrain, Rebecca C Taylor, Patrick J Duriez, Seamus J Martin,

Bcl-2 family proteins play central roles in apoptosis by regulating the release of mitochondrial intermembrane space proteins such as cytochrome c. Death-promoting Bcl-2 family members, such as Bax, can promote cytochrome c release and fragmentation of the mitochondrial network, whereas apoptosis-inhibitory members, such as Bcl-2 and Bcl-xL, can antagonize these ... Read more >>

Mol. Cell (Molecular cell)
[2006, 21(6):761-773]

Cited: 138 times

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Toll-like receptor 2 ligands inhibit TH2 responses to mite allergen.

Rebecca C Taylor, Peter Richmond, John W Upham,

BACKGROUND: There is intense interest in the interaction between microbial compounds and allergy. Although Toll-like receptor (TLR)-2 ligands derived from Gram-positive bacteria alter allergic sensitization in animal models, it is not clear what effect TLR2 ligands have on allergen-specific T-cell memory in human beings. OBJECTIVE: To determine whether in vitro ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2006, 117(5):1148-1154]

Cited: 47 times

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Early results using a dynamic method for delayed primary closure of fasciotomy wounds.

Rebecca C Taylor, Bert J Reitsma, Sue Sarazin, Michael G Bell,

J. Am. Coll. Surg. (Journal of the American College of Surgeons)
[2003, 197(5):872-878]

Cited: 21 times

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Prophylactic beta-blockade to prevent myocardial infarction perioperatively in high-risk patients who undergo general surgical procedures.

Rebecca C Taylor, Giuseppe Pagliarello,

INTRODUCTION: The benefit of administering beta-adrenergic blocking agents perioperatively to surgical patients at high risk for myocardial ischemia has been demonstrated in several well-designed randomized controlled trials. These benefits have included a reduction in the incidence of myocardial complications and an improvement in overall survival for patients with evidence of ... Read more >>

Can J Surg (Canadian journal of surgery. Journal canadien de chirurgie)
[2003, 46(3):216-222]

Cited: 11 times

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