Full Text Journal Articles by
Author Raymond Chung

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Fatty Liver Disease in a Prospective North American Cohort of Adults with HIV and Hepatitis B Coinfection.

Mandana Khalili, Wendy C King, David E Kleiner, Mamta K Jain, Raymond T Chung, Mark Sulkowski, Mauricio Lisker-Melman, David K Wong, Marc Ghany, Arun Sanyal, Richard K Sterling, ,

BACKGROUND:Hepatitis B (HBV) and fatty liver disease (FLD) are common etiologies of liver disease in HIV. Correlates of FLD and its relationship with alanine aminotransferase (ALT) overtime were examined in HIV-HBV coinfection. METHODS:From 04/28/14-11/07/18, 114 HIV-HBV adults underwent a liver biopsy and were followed for a median of 3 years ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Burdensome Transitions of Care for Patients with End-Stage Liver Disease and Their Caregivers.

Nneka N Ufere, John Donlan, Teresa Indriolo, James Richter, Ryan Thompson, Vicki Jackson, Angelo Volandes, Raymond T Chung, Lara Traeger, Areej El-Jawahri,

BACKGROUND:Patients with end-stage liver disease (ESLD) experience frequent readmissions; however, studies focused on patients' and caregivers' perceptions of their transitional care experiences to identify root causes of burdensome transitions of care are lacking. AIM:To explore the transitional care experiences of patients with ESLD and their caregivers in order to identify ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2020, :]

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Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD.

Lindsay T Fourman, James M Billingsley, George Agyapong, Shannan J Ho Sui, Meghan N Feldpausch, Julia Purdy, Isabel Zheng, Chelsea S Pan, Kathleen E Corey, Martin Torriani, David E Kleiner, Colleen M Hadigan, Takara L Stanley, Raymond T Chung, Steven K Grinspoon,

Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity among people living with HIV that has a more aggressive course than NAFLD among the general population. In a recent randomized placebo-controlled trial, we demonstrated that the growth hormone-releasing hormone analog tesamorelin reduced liver fat and prevented fibrosis progression in HIV-associated ... Read more >>

JCI Insight (JCI insight)
[2020, 5(16):]

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In reply to Drs. Lv, Yang, and Deng.

Patricia P Bloom, Raymond T Chung,

We respectfully disagree with your interpretation of the lag in serum alanine aminotransferase (ALT) elevations behind aspartate aminotransferase (AST) elevations in patients with COVID-19. Specifically, you suggest that this lag reflects a dissociation between ALT and AST elevations and therefore implies a non-hepatic source of AST elevation. ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Sarah Alsamman, Stephanie A Christenson, Amy Yu, Nadia M E Ayad, Meghan S Mooring, Joe M Segal, Jimmy Kuang-Hsien Hu, Johanna R Schaub, Steve S Ho, Vikram Rao, Megan M Marlow, Scott M Turner, Mai Sedki, Lorena Pantano, Sarani Ghoshal, Diego Dos Santos Ferreira, Hsiao-Yen Ma, Caroline C Duwaerts, Regina Espanol-Suner, Lan Wei, Benjamin Newcomb, Izolda Mileva, Daniel Canals, Yusuf A Hannun, Raymond T Chung, Aras N Mattis, Bryan C Fuchs, Andrew M Tager, Dean Yimlamai, Valerie M Weaver, Alan C Mullen, Dean Sheppard, Jennifer Y Chen,

Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants (TCAs) reduce hepatic fibrosis by inhibiting aCDase and increasing the bioactive sphingolipid ceramide. We now demonstrate that targeting ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(557):]

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Multicenter Study to Transplant Hepatitis C-Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection.

Meghan E Sise, David S Goldberg, Jens J Kort, Douglas E Schaubel, Rita R Alloway, Christine M Durand, Robert J Fontana, Robert S Brown, John J Friedewald, Stacey Prenner, J Richard Landis, Melissa Fernando, Caitlin C Phillips, E Steve Woodle, Adele Rike-Shields, Kenneth E Sherman, Nahel Elias, Winfred W Williams, Jenna L Gustafson, Niraj M Desai, Brittany Barnaba, Silas P Norman, Mona Doshi, Samuel T Sultan, Meredith J Aull, Josh Levitsky, Dianne S Belshe, Raymond T Chung, Peter P Reese,

BACKGROUND:Single-center trials and retrospective case series have reported promising outcomes using kidneys from donors with hepatitis C virus (HCV) infection. However, multicenter trials are needed to determine if those findings are generalizable. METHODS:We conducted a prospective trial at seven centers to transplant 30 kidneys from deceased donors with HCV viremia ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2020, :]

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Cognitive and psychological interventions for the reduction of post-concussion symptoms in patients with mild traumatic brain injury: a systematic review.

Sock Hong Teo, Kenneth N K Fong, Zhenzhen Chen, Raymond C K Chung,

OBJECTIVE:To evaluate the effects of cognitive and psychological interventions for the reduction of post-concussion symptoms (PCS) in patients with mild traumatic brain injury (MTBI). DATA SOURCES:The databases of CINAHL, Medline, PubMed, PsycINFO, Web of Science, and Cochrane Database of Systematic Reviews. REVIEW METHODS:Meta-analysis was conducted for randomized-controlled trials that have ... Read more >>

Brain Inj (Brain injury)
[2020, 34(10):1305-1321]

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Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation.

Elizabeth C Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K Fix, Karen Hoyt, Kimberly A Page, Rohit Loomba, Ming Li, Gregory T Everson, Michael W Fried, Guadalupe Garcia-Tsao, Norah Terrault, Anna S Lok, Raymond T Chung, K Rajender Reddy,

The SARS-CoV-2 pandemic has drastically altered all facets of clinical care and research. Clinical research in hepatology has had a rich tradition in several domains, including the discovery and therapeutic development for diseases such as hepatitis B and C, and studying the natural history of many forms of chronic liver ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

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Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.

Yingying Yu, Li Jiang, Hao Wang, Zhe Shen, Qi Cheng, Pan Zhang, Jiaming Wang, Qian Wu, Xuexian Fang, Lingyan Duan, Shufen Wang, Kai Wang, Peng An, Tuo Shao, Raymond T Chung, Shusen Zheng, Junxia Min, Fudi Wang,

Although the serum-abundant metal-binding protein transferrin (encoded by the Trf gene) is synthesized primarily in the liver, its function in the liver is largely unknown. Here, we generated hepatocyte-specific Trf knockout mice (Trf-LKO), which are viable and fertile but have impaired erythropoiesis and altered iron metabolism. Moreover, feeding Trf-LKO mice ... Read more >>

Blood (Blood)
[2020, 136(6):726-739]

Cited: 1 time

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Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement.

Oren K Fix, Bilal Hameed, Robert J Fontana, Ryan M Kwok, Brendan M McGuire, David C Mulligan, Daniel S Pratt, Mark W Russo, Michael L Schilsky, Elizabeth C Verna, Rohit Loomba, David E Cohen, Jorge A Bezerra, K Rajender Reddy, Raymond T Chung,

BACKGROUND AND AIMS:Coronavirus disease 2019 (COVID-19), the illness caused by the SARS-CoV-2 virus, is rapidly spreading throughout the world. Hospitals and healthcare providers are preparing for the anticipated surge in critically ill patients, but few are wholly equipped to manage this new disease. The goals of this document are to ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, 72(1):287-304]

Cited: 27 times

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γ-Glutamyltransferase Elevations Are Frequent in Patients With COVID-19: A Clinical Epidemiologic Study.

Tuo Shao, Yu Tong, Shushu Lu, Andre J Jeyarajan, Feifei Su, Jianyi Dai, Jichan Shi, Jianping Huang, Chenchan Hu, Lianpeng Wu, Xianning Dai, Zhimeng Cheng, Jiuliang Yan, Peng Huang, Yanzhang Tian, Shasha Li, Raymond T Chung, Dong Chen,

A newly identified coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the infectious coronavirus disease 2019 (COVID-19), emerged in December 2019 in Wuhan, Hubei Province, China, and now poses a major threat to global public health. Previous studies have observed highly variable alanine aminotransferase (ALT) and aspartate aminotransferase ... Read more >>

Hepatol Commun (Hepatology communications)
[2020, :]

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Shortening treatment with direct-acting antivirals in HCV-positive organ transplantation.

Jacinta A Holmes, Raymond T Chung,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2020, 5(7):626-627]

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Modeling the Hepatology Workforce in the United States: A Predicted Critical Shortage.

Mark W Russo, Oren K Fix, Ayman A Koteish, Katie Duggan, Marcia Ditmyer, Michael Fuchs, Raymond T Chung, Gautham Reddy,

BACKGROUND & AIMS:Liver disease is prevalent in the United States, and as the population ages, an increasing number of patients are anticipated to present for care. The state of the current hepatology workforce and future demand for hepatology providers is not known. The aim of this study was to model ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

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Acute Kidney Injury Following Paracentesis Among Inpatients With Cirrhosis.

Harish Seethapathy, Shreyak Sharma, Sophia Zhao, Raymond T Chung, Michael J Connor, David E Leaf, Andrew S Allegretti,

Kidney Int Rep (Kidney international reports)
[2020, 5(8):1305-1308]

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Maternal knowledge of the risk of vertical transmission and offspring acquisition of hepatitis B.

Mauricio Lisker-Melman, Mandana Khalili, Steven H Belle, Norah A Terrault, Hsing-Hua S Lin, Coleman I Smith, Raymond T Chung, Naoky Tsai, Natalie H Bzowej, Tram T Tran, Sarah Jane Schwarzenberg, ,

INTRODUCTION AND OBJECTIVES:Universal vaccination at birth and in infancy is key to the elimination of chronic hepatitis B infection. We aimed to assess hepatitis B immune-prophylaxis and perinatal transmission knowledge, in a large and ethnically diverse cohort of previously pregnant North American women, chronically infected with hepatitis B. MATERIALS AND ... Read more >>

Ann Hepatol (Annals of hepatology)
[2020, 19(4):388-395]

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Interrelationship Between Coronavirus Infection and Liver Disease.

Esperance A K Schaefer, Ashwini Arvind, Patricia P Bloom, Raymond T Chung,

Clin Liver Dis (Hoboken) (Clinical liver disease)
[2020, 15(5):175-180]

Cited: 2 times

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Liver Biochemistries in Hospitalized Patients With COVID-19.

Patricia P Bloom, Eric A Meyerowitz, Zoe Reinus, Michael Daidone, Jenna Gustafson, Arthur Y Kim, Esperance Schaefer, Raymond T Chung,

Coronavirus disease 2019 (COVID-19) leads to elevated liver biochemistries in approximately half of patients on presentation. To date, data are limited regarding the trend of liver biochemistries over the course of illness. We aimed to evaluate the trend, etiology, and outcomes associated with liver biochemistries in COVID-19. A total of ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

Cited: 4 times

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Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.

Jay Luther, Sanjoy Khan, Manish K Gala, Dmitriy Kedrin, Gautham Sridharan, Russell P Goodman, John J Garber, Ricard Masia, Erik Diagacomo, Daniel Adams, Kevin R King, Samuel Piaker, Hans-Christian Reinecker, Martin L Yarmush, Josepmaria Argemi, Ramon Bataller, Jules L Dienstag, Raymond T Chung, Suraj J Patel,

Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced hepatocyte apoptosis, which fuels a robust secondary inflammatory response that drives ALD. The dominant molecular mechanism by which alcohol activates IRF3 and the pathways that amplify inflammatory signals in ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(21):11667-11673]

Cited: 0 times

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Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice.

Jasmohan S Bajaj, Patricia Pringle Bloom, Raymond T Chung, Tarek I Hassanein, Marielys Padilla-Martinez, Zeid Kayali, Don C Rockey, Roula Sasso, Alagar R Muthukumar, William M Lee, William S Denney, Edith A Gavis, Cami Anderson, Larry Blankstein, Aoife M Brennan, Marja K Puurunen, Eric Lawitz,

INTRODUCTION:Ammonia levels are used to assess hepatic encephalopathy, but their levels are highly variable in clinical practice. METHODS:We studied factors associated with variation in ammonia values in cirrhotic patients without previous hepatic encephalopathy and healthy volunteers (HVs). RESULTS:Ammonia increased by 12% and 18% at 1 and 2 hour, respectively, after ... Read more >>

Am. J. Gastroenterol. (The American journal of gastroenterology)
[2020, 115(5):783-785]

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Clinical Predictors of Liver Fibrosis Presence and Progression in HIV-Associated NAFLD.

Lindsay T Fourman, Takara L Stanley, Isabel Zheng, Chelsea S Pan, Meghan N Feldpausch, Julia Purdy, Julia Aepfelbacher, Colleen Buckless, Andrew Tsao, Kathleen E Corey, Raymond T Chung, Martin Torriani, David E Kleiner, Colleen M Hadigan, Steven K Grinspoon,

Nonalcoholic fatty disease (NAFLD) affects over one-third of people living with HIV. Nonetheless, the natural history of HIV-associated NAFLD is poorly understood, including which patients are most likely to have a progressive disease course. We leveraged a randomized trial of the growth hormone-releasing hormone analogue tesamorelin to treat NAFLD in ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

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Barriers, beliefs, and practices regarding hygiene and vaccination among the homeless during a hepatitis A outbreak in Detroit, MI.

Connor R Buechler, Anita Ukani, Radwa Elsharawi, Jessica Gable, Anneliese Petersen, Michael Franklin, Raymond Chung, Jedidiah Bell, Amanda Manly, Nousha Hefzi, Dean Carpenter, Richard Bryce,

Appropriate hygiene practices and vaccine acceptance are key factors impacting the health of homeless individuals. A recent outbreak of hepatitis A in Michigan, especially impacting Detroit, prompted us to investigate the practices and attitudes of Detroit's homeless population toward hygiene measures and vaccinations, as well as barriers to such resources. ... Read more >>

Heliyon (Heliyon)
[2020, 6(3):e03474]

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Balloon-occluded retrograde transvenous obliteration of colonic varices: a case report.

Chantal Liu, Sivasubramanian Srinivasan, Suresh B Babu, Raymond Chung,

BACKGROUND:Ectopic varices are uncommon and typically due to underlying liver cirrhosis. They can be located in the duodenum, small intestines, colon or rectum, and may result in massive haemorrhage. While established guidelines exist for the management of oesophageal and gastric variceal bleeding, this is currently lacking for colonic varices. Beta-blockers, ... Read more >>

CVIR Endovasc (CVIR endovascular)
[2020, 3(1):17]

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[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis.

Tuo Shao, Zhen Chen, Vasily Belov, Xiaohong Wang, Steve H Rwema, Viksit Kumar, Hualong Fu, Xiaoyun Deng, Jian Rong, Qingzhen Yu, Lixin Lang, Wenyu Lin, Lee Josephson, Anthony E Samir, Xiaoyuan Chen, Raymond T Chung, Steven H Liang,

BACKGROUND & AIMS:The vitronectin receptor integrin αvβ3 drives fibrogenic activation of hepatic stellate cells (HSCs). Molecular imaging targeting the integrin αvβ3 could provide a non-invasive method for evaluating the expression and the function of the integrin αvβ3 on activated HSCs (aHSCs) in the injured liver. In this study, we sought ... Read more >>

J. Hepatol. (Journal of hepatology)
[2020, 73(1):161-169]

Cited: 1 time

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Liquid Biopsy in Hepatocellular Carcinoma

Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting,

Solid tumors release a variety of cellular components into the bloodstream that can be sampled by liquid biopsy. These blood-borne biomarkers include circulating tumor cells, exosomes, cell-free DNA, and cell-free noncoding RNA. As hepatocellular carcinoma (HCC) grows in worldwide prevalence and mortality, the application of emerging liquid biopsy technologies to ... Read more >>

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Tract sealing with normal saline after percutaneous transthoracic lung biopsies.

Suresh B Babu, Sivasubramanian Srinivasan, Raymond Chung, Ashish Chawla, Hsien Khai Tan, Rahul Lohan,

INTRODUCTION:In the present study, we aimed to assess whether normal saline injection for sealing the biopsy track is useful in reducing the incidence of pneumothorax after computed tomography (CT)-guided percutaneous transthoracic lung biopsy (PTLB). METHODS:We retrospectively compared the incidence of pneumothorax in 100 consecutive biopsies (n = 100, group A) that had ... Read more >>

J Med Imaging Radiat Oncol (Journal of medical imaging and radiation oncology)
[2020, 64(2):211-214]

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