Full Text Journal Articles by
Author Rasha Nassra

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Cationic nanocarrier of rhein based on hydrophobic ion pairing approach as intra-articular targeted regenerative therapy for osteoarthritis.

Heba Mk Ebada, Maha Ma Nasra, Rasha A Nassra, Amany A Solaiman, Ossama Y Abdallah,

Cartilage deterioration is the hallmark of osteoarthritis (OA). Rapid clearance of intra-articularly injected drugs and inherent cartilage barrier properties represent enormous challenges facing the effective local OA therapy. Rhein (RH), a dihydroxy-anthraquinone acid molecule, possess a potential chondroprotective effect. However, RH suffers from poor oral bioavailability besides its gastrointestinal side ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2022, 211:112285]

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Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones.

Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib, Mohamed G Temraz, Ahmed S F Belal, Ahmed F El-Yazbi,

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC<sub>50</sub> values of 0.09-0.14 µM) with significant 15-LOX inhibitory activities (IC<sub>50</sub>s ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):669-684]

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