Full Text Journal Articles by
Author Rasha M Allam

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Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors.

Heba T Abdel-Mohsen, Ahmed M El Kerdawy, Mohamed A Omar, Andrea Petreni, Rasha M Allam, Hoda I El Diwani, Claudiu T Supuran,

A dual-tail approach was applied to the design of a novel series of 2-thiopyrimidine-benzenesulfonamides as carbonic anhydrase (CA) inhibitors. The design strategy is based on the hybridization between a benzenesulfonamide moiety as Zn<sup>2+</sup> binding group and 2,4-disubstituted thiopyridimidine as a tail. Among the synthesized compounds, 14h displayed the highest potency ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2022, 228:114004]

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Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction.

Tarek S Ibrahim, Amr H Moustafa, Ahmad J Almalki, Rasha M Allam, Abdulhamid Althagafi, Shadab Md, Mamdouh F A Mohamed,

Two series of chalcone/aryl carboximidamide hybrids <b>4a-f</b> and <b>6a-f</b> were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their <i>in vivo</i> anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Compounds <b>4c</b>, <b>4d</b>, <b>6c</b> and <b>6d</b> were proved to be the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1067-1078]

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Panax Ginseng alleviates thioacetamide-induced liver injury in ovariectomized rats: Crosstalk between inflammation and oxidative stress.

Rasha E Mostafa, Nermeen M Shaffie, Rasha M Allam,

Liver diseases impose a substantial health problem. Female hormones play a crucial role in the protection against chronic inflammatory diseases. Fifty female rats were allocated into five groups (n = 10). Group I comprised sham-operated rats. The remaining groups underwent ovariectomy at the beginning of the experiment. Group II served ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0260507]

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Formulation and characterization of propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride for wound healing: In-vitro and in-vivo wound healing assessment.

Menna M Abdellatif, Yara E Elakkad, Ahmed A Elwakeel, Rasha M Allam, Mohamed R Mousa,

This study aimed to develop propolis and tea tree oil nanoemulsion loaded with clindamycin hydrochloride to heal wound effectively. Nanoemulsion formulae were prepared and characterized by droplet size analysis, zeta potential, viscosity, <i>ex-vivo</i> permeation, and skin deposition. The optimal formula was evaluated in terms of morphology, cytotoxicity, and <i>in-vitro</i> wound ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2021, 29(11):1238-1249]

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Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study.

Tarek S Ibrahim, Ahmad J Almalki, Amr H Moustafa, Rasha M Allam, Gamal El-Din A Abuo-Rahma, Hussein I El Subbagh, Mamdouh F A Mohamed,

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs. Thus, in the present investigation, a novel series of 1,2,4-oxadiazole-chalcone/oxime (6a-f) and (7a-f) were synthesized and characterized by IR, NMR (<sup>1</sup>H and ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 111:104885]

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Conventional peritoneal cytology lacks the prognostic significance of detecting local or peritoneal recurrence in colorectal cancer: An Egyptian experience.

Mohamed Shalaby, Tarek S El Baradie, Mohamed Salama, Hebat A M Shaaban, Rasha M Allam, Ehab O A Hafiz, Mohamed Aly Abdelhamed, Amr Attia,

<h4>Background and aim</h4>Colorectal cancer (CRC) accounts for over 8% of all deaths each year, with 1.2 million new cases diagnosed annually worldwide. It represents the seventh most common cancer in Egypt. Early detection of peritoneal metastasis is a major challenge in such cases. It helps with the decision of the ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(2):264-272]

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Duplication 1q is highly correlated with poor prognosis in high hyperdiploid pediatric B-acute lymphoblastic leukemia.

Mona S El Ashry, Ghada M Elsayed, Youssef Madney, Omar Arafah, Rasha M Allam, Eman O Rasekh,

<h4>Background</h4>The role of structural abnormalities in high hyperdiploidy (HeH) has been debatable, with few studies that addressed recurrent translocations with concurrent HeH (t-HeH). We aimed at the characterization of HeH cases in pediatric B-acute lymphoblastic leukemia (B-ALL) patients with special emphasis on the structural abnormalities including t-HeH.<h4>Patients and methods</h4>Our study ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2021, 43(2):235-243]

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Pitfalls in scientific research: critical appraisal of articles published in one of the international journals in Egypt.

Sarah S Nasr, Ghada M Sherif, Amal S Ibrahim, Rasha M Allam,

<h4>Background</h4>To identify and report flaws of Internet-published articles in the Journal of the Egyptian National Cancer Institute (JENCI), Cairo University, through a retrospective documentary study on articles published during the period from 2011 to 2016. All sections were reviewed against a collective checklist. Articles were grouped by publication year into ... Read more >>

J Egypt Natl Canc Inst (Journal of the Egyptian National Cancer Institute)
[2020, 32(1):39]

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Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9.

Abeer A A Salama, Rasha M Allam,

Colorectal cancer is one of the primary causes of cancer-related mortality worldwide. The tumor microenvironment contains growth factors; inflammatory chemokines, matrix metalloproteinases, and pro-oxidants leading to cancer development and progression. Phytochemicals have been used as the main source of anti-cancer agents. Accordingly, the effect of two natural flavonoids (Chrysin and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2021, 892:173763]

Cited: 8 times

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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.

Mamdouh F A Mohamed, Adel A Marzouk, Ayman Nafady, Dalia A El-Gamal, Rasha M Allam, Gamal El-Din A Abuo-Rahma, Hussein I El Subbagh, Amr H Moustafa,

The development of NSAIDs/iNOS inhibitor hybrids is a new strategy for the treatment of inflammatory diseases by suppression of the overproduction of PGE<sub>2</sub> and NO. A novel series of aryl carboximidamides 4a-g and their cyclized 3-aryl-1,2,4-oxadiazoles 5a-g counterparts derived from indomethacin 1 were synthesized. Most of the target compounds displayed ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 105:104439]

Cited: 2 times

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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.

Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal, Ahmed F El-Yazbi, Ali H Eid, Rana Alaaeddine, Rehab R Hegazy, Rasha M Allam, Maged W Helmy, Bahaa Elgendy, Andrea Angeli, Soad A El-Hawash, Claudiu T Supuran,

Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes. Results revealed that compounds ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112439]

Cited: 3 times

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Protective effect of some natural products against chemotherapy-induced toxicity in rats.

Heba M I Abdallah, Rehab F Abdel-Rahman, Sally A El Awdan, Rasha M Allam, Aliaa E M K El-Mosallamy, Manal S Selim, Sahar S Mohamed, Mahmoud S Arbid, Abdel Razik H Farrag,

<h4>Aim</h4>There is a great interest in combining anticancer drugs with natural products aiming at maximizing their efficacy while minimizing systemic toxicity. Hence, the present study was constructed aiming to investigate the protective potential of three natural products, 1,8-cineole an essential oil from <i>Artemisia herba alba</i>, exopolysaccharide (EPS) from locally identified ... Read more >>

Heliyon (Heliyon)
[2019, 5(5):e01590]

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Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.

Rasha M Allam, Ahmed M Al-Abd, Alaa Khedr, Ola A Sharaf, Salwa M Nofal, Amani E Khalifa, Hisham A Mosli, Ashraf B Abdel-Naim,

Sphingolipids are critical regulators of tumor microenvironments and play an important role in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be involved in prostate cancer. Fingolimod (FTY720) is a sphingokinase-1 (SphK1) inhibitor with anticancer properties against various tumor cell types. Herein, we investigated the interference of FTY720 with ... Read more >>

Toxicol Lett (Toxicology letters)
[2018, 291:77-85]

Cited: 12 times

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Assessment of Statistical Methodologies and Pitfalls of Dissertations Carried Out at National Cancer Institute, Cairo University

Rasha M Allam, Maissa K Noaman, Manar M Moneer, Inas A Elattar,

Purpose: To identify statistical errors and pitfalls in dissertations performed as part of the requirements for the Medical Doctorate (MD) degree at the National Cancer Institute (NCI), Cairo University (CU) to improve the quality of medical research. Methods: A critical assessment of 62 MD dissertations conducted in 3 departments at NCI, CU, ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2017, 18(1):231-237]

Cited: 2 times

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Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats.

Rasha M Allam, Dina A Selim, Asser I Ghoneim, Mohamed M Radwan, Salwa M Nofal, Amani E Khalifa, Ola A Sharaf, Soad M Toaima, Aya M Asaad, Nadia A El-Sebakhy,

The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 activation and DNA ... Read more >>

Chin J Nat Med (Chinese journal of natural medicines)
[2013, 11(4):354-361]

Cited: 3 times

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