Full Text Journal Articles by
Author Randall Burt

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Colorectal cancer in the setting of pregnancy and familial risk.

N Jewel Samadder, Ken Robert Smith, Jathine Wong, Randall W Burt, Karen Curtin,

BACKGROUND AND AIMS:Women are at risk of colorectal cancer (CRC) during pregnancy but this fact is underappreciated. We performed a population-based study to evaluate the rate, predictors, and familial risk for pregnancy associated CRC in Utah. METHODS:All newly diagnosed cases of CRC between 1973 and 2014 were obtained from the ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2020, 35(8):1559-1566]

Cited: 0 times

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Use of Family History and Genetic Testing to Determine Risk of Colorectal Cancer.

Fay Kastrinos, N Jewel Samadder, Randall W Burt,

Approximately 35% of patients with colorectal cancer (CRC) have a family history of the disease attributed to genetic factors, common exposures, or both. Some families with a history of CRC carry genetic variants that cause CRC with high or moderate penetrance, but these account for only 5% to 10% of ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(2):389-403]

Cited: 2 times

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Familial pancreatic cancer risk: a population-based study in Utah.

Divyanshoo R Kohli, Ken Robert Smith, Jathine Wong, Zhe Yu, Kenneth Boucher, Douglas O Faigel, Rahul Pannala, Randall W Burt, Karen Curtin, N Jewel Samadder,

INTRODUCTION:Pancreas adenocarcinoma (PC) has an undefined hereditary component. We quantified the familial risk of PC among relatives of patients diagnosed with PC and stratified it based on anatomic location of PC and age and sex of the proband. METHODS:This is a retrospective, population-based, case-control study of PC diagnosed in Utah ... Read more >>

J. Gastroenterol. (Journal of gastroenterology)
[2019, 54(12):1106-1112]

Cited: 1 time

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Clinical and Molecular Features of Post-Colonoscopy Colorectal Cancers.

N Jewel Samadder, Deb Neklason, Angela Snow, Wade Samowitz, Melissa H Cessna, Kerry Rowe, Iqbal Sandhu, Kenneth Boucher, Lisa Pappas, Ken Robert Smith, Jathine Wong, Karen Curtin, Dawn Provenzale, Randall W Burt,

BACKGROUND & AIMS:Post-colonoscopy colorectal cancers (PCCRCs) may arise from missed lesions or due to molecular features of tumors that allow them to grow rapidly. We aimed to compare clinical, pathology, and molecular features of PCCRCs (those detected within 6-60 months of colonoscopy) and detected CRCs (those detected within 6 months ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(13):2731-2739.e2]

Cited: 0 times

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Small RNA sequencing of sessile serrated polyps identifies microRNA profile associated with colon cancer.

Priyanka Kanth, Mark W Hazel, Kenneth M Boucher, Zhihong Yang, Li Wang, Mary P Bronner, Katherine E Boylan, Randall W Burt, Michelle Westover, Deborah W Neklason, Don A Delker,

Sessile serrated adenoma/polyps (SSA/Ps) of the colon account for 20-30% of all colon cancers. Small non-coding RNAs, including microRNAs (miRNAs), may function as oncogenes or tumor suppressor genes involved in cancer development. Small RNA sequencing (RNA-seq) was used to characterize miRNA profiles in SSA/Ps, hyperplastic polyps (HPs), adenomatous polyps and ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2019, 58(1):23-33]

Cited: 3 times

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Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases.

N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Jonathan A Leighton, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Randall W Burt, Karen Curtin, Ken R Smith,

BACKGROUND & AIMS:Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(9):1807-1813.e1]

Cited: 2 times

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Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients.

Danielle C Sample, N Jewel Samadder, Lisa M Pappas, Kenneth M Boucher, Wade S Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R Byrne, Randall W Burt, Deborah W Neklason,

BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the duodenal and gastric polyp phenotype in a ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2018, 18(1):115]

Cited: 0 times

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Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial.

N Jewel Samadder, Scott K Kuwada, Kenneth M Boucher, Kathryn Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V Tavtigian, Michelle Westover, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Randall W Burt, Deborah W Neklason,

Importance:Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for colorectal polyps and cancer. A combination of sulindac and erlotinib led to a 71% reduction in duodenal polyp burden in a phase 2 trial. Objective:To evaluate effect of sulindac and erlotinib on colorectal adenoma regression in patients with ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, 4(5):671-677]

Cited: 6 times

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones,

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0192499]

Cited: 3 times

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Cancer Risk in Families Fulfilling the Amsterdam Criteria for Lynch Syndrome.

N Jewel Samadder, Ken Robert Smith, Jathine Wong, Alun Thomas, Heidi Hanson, Kenneth Boucher, Cathryn Kopituch, Lisa A Cannon-Albright, Randall W Burt, Karen Curtin,

Importance:The data describing cancer risks associated with Lynch syndrome are variable. Objectives:To quantify the prevalence of families that fulfill the Amsterdam I or II criteria for Lynch syndrome in the Utah population and investigate the risk of colonic and extracolonic cancers in family members and their relatives. Design, Setting, and ... Read more >>

JAMA Oncol (JAMA oncology)
[2017, 3(12):1697-1701]

Cited: 6 times

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Developmental Delay and Colon Polyposis.

N Jewel Samadder, Randall W Burt, Reha M Toydemir,

Gastroenterology (Gastroenterology)
[2017, 153(4):908-909]

Cited: 0 times

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Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.

Priyanka Kanth, Jade Grimmett, Marjan Champine, Randall Burt, N Jewel Samadder,

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate ... Read more >>

Am. J. Gastroenterol. (The American journal of gastroenterology)
[2017, 112(10):1509-1525]

Cited: 13 times

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Gastrointestinal Polyposis in Cowden Syndrome.

Ruthy Shaco-Levy, Kory W Jasperson, Katie Martin, N J Samadder, Randall W Burt, Jian Ying, Mary P Bronner,

To further characterize the gastrointestinal manifestations of Cowden syndrome in clinically well-annotated patients to improve the diagnosis of this syndrome.The gastrointestinal manifestations of Cowden Syndrome, an important heritable and multiorgan cancer syndrome, are not well defined. Proper diagnosis is essential for effective cancer surveillance and prevention in these patients.Cowden patients ... Read more >>

J. Clin. Gastroenterol. (Journal of clinical gastroenterology)
[2017, 51(7):e60-e67]

Cited: 5 times

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Long-Term Colorectal Cancer Incidence After Negative Colonoscopy in the State of Utah: The Effect of Family History.

N Jewel Samadder, Lisa Pappas, Kenneth M Boucherr, Ken R Smith, Heidi Hanson, Alison Fraser, Yuan Wan, Randall W Burt, Karen Curtin,

Colonoscopy is widely recommended for colorectal cancer (CRC) screening, but evidence to guide the optimal frequency of repeat screening examination is limited. We examined the duration and magnitude of the risk of developing CRC, following a negative colonoscopy in those at average risk and those with a first-degree family history ... Read more >>

Am. J. Gastroenterol. (The American journal of gastroenterology)
[2017, 112(9):1439-1447]

Cited: 4 times

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Reducing the polyp burden in serrated polyposis by serial colonoscopy: the impact of nationally coordinated community surveillance.

Susan Parry, Randall W Burt, Aung Ko Win, Ye Kyaw Aung, Sonja Woodall, Julie Arnold, Mark Clendenning, Daniel D Buchanan, Timothy J Price, Christophe Rosty, Joanne P Young,

Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC) and an evolving management approach. The aims of this study were to assess the polyp burden reduction over time, and the incidence of CRC in serrated polyposis patients undergoing community surveillance.This is an observational study based ... Read more >>

N. Z. Med. J. (The New Zealand medical journal)
[2017, 130(1451):57-67]

Cited: 3 times

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A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.

Yong-Sik Bong, Shahin Assefnia, Therese Tuohy, Deborah W Neklason, Randall W Burt, Jaeil Ahn, Paul J Bueno De Mesquita, Stephen W Byers,

Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and skin diseases as well as in immunity. Activated VDR can indirectly alter β-catenin nuclear localization and ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(49):80508-80520]

Cited: 3 times

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Colorectal Cancer in Inflammatory Bowel Diseases: A Population-Based Study in Utah.

N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith,

The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort.All newly diagnosed cases of CRC between 1996 and ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2017, 62(8):2126-2132]

Cited: 12 times

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Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah.

N Jewel Samadder, Ken Robert Smith, Jathine Wong, Heidi Hanson, Kenneth Boucher, Randall W Burt, Michael Charlton, Kathryn R Byrne, Juan F Gallegos-Orozco, Cathryn Koptiuch, Karen Curtin,

Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2016, 61(12):3627-3632]

Cited: 2 times

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Sulindac and Erlotinib for Familial Adenomatous Polyposis--Reply.

N Jewel Samadder, Deborah W Neklason, Randall W Burt,

JAMA (JAMA)
[2016, 316(5):545]

Cited: 0 times

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Understanding the contribution of family history to colorectal cancer risk and its clinical implications: A state-of-the-science review.

Jan T Lowery, Dennis J Ahnen, Paul C Schroy, Heather Hampel, Nancy Baxter, C Richard Boland, Randall W Burt, Lynn Butterly, Megan Doerr, Mary Doroshenk, W Gregory Feero, Nora Henrikson, Uri Ladabaum, David Lieberman, Elizabeth G McFarland, Susan K Peterson, Martha Raymond, N Jewel Samadder, Sapna Syngal, Thomas K Weber, Ann G Zauber, Robert Smith,

Persons with a family history (FH) of colorectal cancer (CRC) or adenomas that are not due to known hereditary syndromes have an increased risk for CRC. An understanding of these risks, screening recommendations, and screening behaviors can inform strategies for reducing the CRC burden in these families. A comprehensive review ... Read more >>

Cancer (Cancer)
[2016, 122(17):2633-2645]

Cited: 35 times

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Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.

Priyanka Kanth, Mary P Bronner, Kenneth M Boucher, Randall W Burt, Deborah W Neklason, Curt H Hagedorn, Don A Delker,

Sessile serrated colon adenoma/polyps (SSA/P) are found during routine screening colonoscopy and may account for 20% to 30% of colon cancers. However, differentiating SSA/Ps from hyperplastic polyps (HP) with little risk of cancer is challenging and complementary molecular markers are needed. In addition, the molecular mechanisms of colon cancer development ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2016, 9(6):456-465]

Cited: 15 times

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Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial.

N Jewel Samadder, Deborah W Neklason, Kenneth M Boucher, Kathryn R Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V Tavtigian, Michelle W Done, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Rian Davis, Matthew K Topham, Patrick Lynch, Elena Strait, Wendy McKinnon, Randall W Burt, Scott K Kuwada,

Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal polyps and cancer. Surgical and endoscopic management of duodenal neoplasia is difficult and chemoprevention has not been successful.To evaluate the effect of a combination of sulindac and erlotinib on duodenal adenoma regression in patients with FAP.Double-blind, randomized, ... Read more >>

JAMA (JAMA)
[2016, 315(12):1266-1275]

Cited: 38 times

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Familial Risk in Patients With Carcinoma of Unknown Primary.

N Jewel Samadder, Ken Robert Smith, Heidi Hanson, Richard Pimentel, Jathine Wong, Kenneth Boucher, Wallace Akerley, Glynn Gilcrease, Cornelia M Ulrich, Randall W Burt, Karen Curtin,

Carcinoma of unknown primary (CUP) accounts for 3% to 5% of all cancers and is associated with poor prognosis. Familial clustering of different cancer sites with CUP is unknown and may provide information regarding etiology, as well as elevated cancer risks in relatives.To quantify the risk of cancer by site ... Read more >>

JAMA Oncol (JAMA oncology)
[2016, 2(3):340-346]

Cited: 4 times

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A proposed staging system and stage-specific interventions for familial adenomatous polyposis.

Patrick M Lynch, Jeffrey S Morris, Sijin Wen, Shailesh M Advani, William Ross, George J Chang, Miguel Rodriguez-Bigas, Gottumukkala S Raju, Luigi Ricciardiello, Takeo Iwama, Benedito M Rossi, Maria Pellise, Elena Stoffel, Paul E Wise, Lucio Bertario, Brian Saunders, Randall Burt, Andrea Belluzzi, Dennis Ahnen, Nagahide Matsubara, Steffen Bülow, Niels Jespersen, Susan K Clark, Steven H Erdman, Arnold J Markowitz, Inge Bernstein, Niels De Haas, Sapna Syngal, Gabriela Moeslein,

BACKGROUND AND AIMS:It is not possible to accurately count adenomas in many patients with familial adenomatous polyposis (FAP). Nevertheless, polyp counts are critical in evaluating each patient's response to interventions. However, the U.S. Food and Drug Administration no longer recognizes the decrease in polyp burden as a sufficient chemoprevention trial ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2016, 84(1):115-125.e4]

Cited: 3 times

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Screening and Survival in Familial Adenomatous Polyposis.

Randall W Burt,

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2016, 50(1):3-4]

Cited: 1 time

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