Full Text Journal Articles by
Author Ralf Langhoff

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Antithrombotic Treatment for Peripheral Arterial Occlusive Disease.

David Hardung, Andrea Behne, Mehmet Boral, Carsten Giesche, Ralf Langhoff,

<h4>Background</h4>Patients with peripheral arterial occlusive disease (PAOD) are at elevated risk for cardiovascular events and vascular events affecting the limbs. The goals of antithrombotic treatment are to keep vessels open after revascularization, to prevent cardiovascular events, and to lessen the frequency of peripheral ischemia and of amputation.<h4>Methods</h4>This review is based ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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The Real-World CONSEQUENT ALL COMERS Study: Predictors for Target Lesion Revascularization and Mortality in an Unselected Patient Population.

Ralf Langhoff, Jawed Arjumand, Matthias Waliszewski, Peter Reimer, Dirk Härtel, Christian Hohl, Werner Raut, Sebastian Romani, Jesús Alós, Esaú Martínez, Albrecht Schmidt, Shaiful Azmi Yahya, Hadi Riazi, Grigorios Korosoglou,

We evaluated the safety and efficacy of a resveratrol-paclitaxel-coated peripheral balloon catheter in an all-comer patient cohort undergoing endovascular treatment of above-the-knee and below-the-knee peripheral artery disease. CONSEQUENT ALL COMERS (Clinical Post-Market Clinical Follow-up [PMCF] on Peripheral Arteries treated with SeQuent Please OTW [Over-the Wire]) is a prospective, single-arm, multicenter ... Read more >>

Angiology (Angiology)
[2021, :3319721997314]

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Provisional focal stenting of complex femoropopliteal lesions using the Multi-LOC multiple stent delivery system - 12-month results from the LOCOMOTIVE EXTENDED study.

Klaus Amendt, Thomas Zeller, Robert Proczka, Ulrich Beschorner, Nicola Troisi, Matthias Waliszewski, Ralf Langhoff, Hans Krankenberg, Andreas Hansch, Tomislav Krcmar, Vinko Vidjak, Claus Nolte-Ernsting, Alexander Hansen, Martin Sigl,

<i>Background</i>: This study aimed to evaluate a Multiple Stent Delivery System for provisional focal stenting of the femoropopliteal artery. <i>Patient and methods</i>: The LOCOMOTIVE EXTENDED study (Multi-<u>LOC</u> for fl<u>O</u>w li<u>M</u>iting <u>O</u>utcomes after plain old balloon angioplasty and/or drug-coated balloon <u>T</u>reatment in the infrainguinal position with the object<u>IVE</u> to implant multiple ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(3):209-216]

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Impact of chemotherapeutic effects on the pathophysiology of the arterial wall - insights from peripheral arterial disease.

Christoph Lange, Njeri Ngare, Philipp Hillmeister, Peter Bramlage, Ralf Langhoff, Ivo Buschmann,

Systemic antineoplastic treatment agents represent one of the fastest developing medical fields. Oncological treatment is becoming increasingly individualized and new targets with corresponding agents, are constantly being developed. In tandem with this progress, new combinations and algorithms have evolved and patient's outcome have improved. Expanding tumors rely on a growing ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, :1-5]

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Demographic and procedural characteristics in the RECording COurses of vasculaR Diseases (RECCORD) registry - the first 1000 patients.

Nasser Malyar, Jürgen Stausberg, Ralf Langhoff, Federico Tatò, Christoph Kalka, Wulf D Ito, Jens Böhme, Jawed Arjumand, Jens Stegemann, Holger Lawall, Sebastian Schellong, Michael Lichtenberg, Ulrich Hoffmann,

<i>Background:</i> The RECcording COurses of vasculaR Diseases (RECCORD) registry established by the German Society of Angiology - Society for Vascular Medicine aimed to address the lack in contemporary real-world data regarding current practice of medical and interventional care in vascular patients. We herein report the demographic and procedural characteristics of ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, 49(5):382-388]

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COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions.

Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schröder, Wulf Euringer, Matthias Ulrich, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Dierk Scheinert,

<h4>Aims</h4>Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities of 3.5 vs. 2.0 μg/mm2.<h4>Methods and results</h4>Within a prospective, multicentre, non-inferiority, clinical trial 414 patients with symptomatic femoropopliteal ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(27):2541-2552]

Cited: 1 time

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[Dual Pathway Inhibition in Atherosclerosis - Which Patients Benefit?]

David Hardung, Andrea Behne, Ralf Langhoff,

Dual antithrombotic therapy (DAT) with low-dose rivaroxaban in combination with acetylsalicylic acid (ASA) is available to patients with stable atherosclerotic disease as a new therapeutic option.The results of the COMPASS trial demonstrate a significant relative risk reduction of cardiovascular outcomes by 24 % with low-dose DAT in patients with stable peripheral ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2019, 144(20):1384-1389]

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First-in-Human Experience With Sirolimus-Eluting Self-Expanding Stent for Femoropopliteal Lesions.

Sabine Steiner, Antoine Sauguet, Ralf Langhoff, Andrea Kahlberg, Marcus Thieme, Thomas Zeller, Philippe Garot, Philippe Commeau, Alberto Cremonesi, Enrico Maria Marone, Dierk Scheinert,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(17):2216-2218]

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Evaluation of a new dual-layer micromesh stent system for the carotid artery: 12-month results from the CLEAR-ROAD study.

Marc Bosiers, Koen Deloose, Giovanni Torsello, Dierk Scheinert, Lieven Maene, Patrick Peeters, Stefan Müller-Hülsbeck, Horst Sievert, Ralf Langhoff, Joren Callaert, Carlo Setacci, Jeroen Wauters,

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2018, 14(10):1144-1146]

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Focal Stenting of Complex Femoropopliteal Lesions with the Multi-LOC Multiple Stent Delivery System: 12-Month Results of the Multicenter LOCOMOTIVE Study.

Martin Sigl, Ulrich Beschorner, Thomas Zeller, Matthias Waliszewski, Ralf Langhoff, Jörg Tautenhahn, Klaus Amendt,

<h4>Introduction</h4>The purpose of this observational study is to report the 12-month clinical outcomes with the novel Multiple Stent Delivery System (MSDS) to treat complex femoropopliteal lesions. Previously, we reported the 6-month clinical outcomes of the all-comers LOCOMOTIVE study, which demonstrated the safety and efficacy of the MSDS with a favorable ... Read more >>

Cardiovasc Intervent Radiol (Cardiovascular and interventional radiology)
[2019, 42(2):169-175]

Cited: 1 time

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[Update ESC-Guideline 2017: Focus on PAD].

Roberto Sansone, Lucas Busch, Ralf Langhoff,

The updated ESC guidelines on PAD were developed, for the first time, as a collaboration between cardiologists and vascular surgeons and unveiled at the European Society of Cardiology (ESC) 2017 congress. Although awareness has improved, PAD is still associated with significant morbidity, mortality, and quality of life impairment. Primarily, the guidelines emphasize ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2018, 143(20):1455-1459]

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Carotid stenosis - basing treatment on individual patients' needs. Optimal medical therapy alone or accompanied by stenting or endarterectomy.

Ralf Langhoff,

Though carotid artery stenosis is a known origin of stroke, risk assessment and treatment modality are not yet satisfactorily established. Guideline updates according to latest evidence are expected shortly. Current clinical weakness concerns in particular the identification of "at-risk" patients. Beside the symptomatic status and the degree of stenosis, further ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2018, 47(1):7-16]

Cited: 4 times

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Directional Atherectomy Followed by a Paclitaxel-Coated Balloon to Inhibit Restenosis and Maintain Vessel Patency: Twelve-Month Results of the DEFINITIVE AR Study.

Thomas Zeller, Ralf Langhoff, Krishna J Rocha-Singh, Michael R Jaff, Erwin Blessing, Beatrice Amann-Vesti, Marek Krzanowski, Patrick Peeters, Dierk Scheinert, Giovanni Torsello, Sebastian Sixt, Gunnar Tepe, ,

<h4>Background</h4>Studies assessing drug-coated balloons (DCB) for the treatment of femoropopliteal artery disease are encouraging. However, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone. Vessel preparation with directional atherectomy (DA) potentially improves outcomes of DCB.<h4>Methods and results</h4>DEFINITIVE AR study (Directional Atherectomy Followed by a Paclitaxel-Coated Balloon ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2017, 10(9):]

Cited: 23 times

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First clinical experience with the Multi-LOC multiple stent delivery system for focal stenting in long femoro-popliteal lesions.

Klaus Amendt, Ulrich Beschorner, Matthias Waliszewski, Martin Sigl, Ralf Langhoff, Jörg Thalwitzer, Ulf Redlich, Britta Vogel, Dirk Härtel, Thomas Zeller,

Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2017, 46(6):452-461]

Cited: 1 time

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Rationale and design of the RECording COurses of vasculaR Diseases registry (RECCORD registry).

Nasser M Malyar, Jürgen Stausberg, Wulf D Ito, Heinz Kölble, Ralf Langhoff, Holger Lawall, Michael Lichtenberg, Jens Stegemann, Marcus Treitl, Norbert Weiss, Ulrich Hoffmann,

<h4>Background</h4>The prevalence of peripheral artery disease (PAD) is increasing worldwide. Revascularization procedures constitute a cornerstone of the therapy in PAD, not only in critical limb ischaemia but increasingly also in patients with intermittent claudication. The German Society of Angiology - Society for Vascular Medicine is establishing a nationwide, prospective, multicentre ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2017, 46(4):262-267]

Cited: 1 time

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Credentialing in interventional therapy in Europe - comparison of curricula including endovascular therapy of arterial diseases.

Karl-Ludwig Schulte, Pia M Jungmann, Vladimir Makaloski, Lino Goncalves, Markus Steinbauer, Susanne Vonberg, Beatrix B Doerr, Ralf Langhoff, Frederic Baumann,

The prevalence of peripheral artery disease (PAD) is continuously increasing. In addition, the treatment of PAD has changed substantially over the last decades. Novel treatment modalities and diagnostic tools were developed and endovascular therapy was established as a first-line therapy. In consequence, vascular medicine has become an interdisciplinary field, involving ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2017, 46(3):169-176]

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[Carotid Artery Stenting].

Ralf Langhoff, Franziska Büttner,

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2017, 142(3):152-156]

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Promising role of drug-coated balloons in the tibial vessels?

Ralf Langhoff, Andrea Behne, Eva Buschmann,

In order to assess the role of drug-coated balloons (DCB) in below-the-knee (BTK) artery interventions, we analyzed randomized trials which compare coated to non-coated balloons and additionally a direct comparison of drug-eluting stents (DES) with DCB. As angioplasty with non-coated balloons is per guideline-recommendation still standard of care for below-the-knee ... Read more >>

J Cardiovasc Surg (Torino) (The Journal of cardiovascular surgery)
[2016, 57(5):667-676]

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The CLEAR-ROAD study: evaluation of a new dual layer micromesh stent system for the carotid artery.

Marc Bosiers, Koen Deloose, Giovanni Torsello, Dierk Scheinert, Lieven Maene, Patrick Peeters, Stefan Müller-Hülsbeck, Horst Sievert, Ralf Langhoff, Michel Bosiers, Carlo Setacci,

<h4>Aims</h4>The aim of this study was to evaluate the 30-day clinical outcome of treatment using the Roadsaver carotid stent in non-consecutive subjects at high risk for carotid endarterectomy requiring revascularisation.<h4>Methods and results</h4>The CLEAR-ROAD study is a prospective, multinational, single-arm, physician-initiated study planned to include 100 patients in nine centres in ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2016, 12(5):e671-6]

Cited: 17 times

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Promising role of drug-coated balloons in the tibial vessels?

Ralf Langhoff, Andrea Behne, Eva E Buschmann,

To judge on the role of drug-coated balloons (DCB) in below-the-knee (BTK) artery interventions, we analyzed randomized trials which compare coated to non-coated balloons and additionally a direct comparison of drug-eluting stents (DES) with DCB. As angioplasty with non-coated balloons is per guideline-recommendation still standard of care for below- the-knee ... Read more >>

J Cardiovasc Surg (Torino) (The Journal of cardiovascular surgery)
[2016, :]

Cited: 0 times

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Primary Self-EXPANDing Nitinol Stenting vs Balloon Angioplasty With Optional Bailout Stenting for the Treatment of Infrapopliteal Artery Disease in Patients With Severe Intermittent Claudication or Critical Limb Ischemia (EXPAND Study).

Karl-Ludwig Schulte, Ernst Pilger, Sebastian Schellong, Kong Ten Tan, Frederic Baumann, Ralf Langhoff, Giovanni Torsello, Thomas Zeller, Klaus Amendt, Marianne Brodmann, ,

<h4>Purpose</h4>To compare primary placement of a self-expanding nitinol stent to percutaneous transluminal angioplasty (PTA) with bailout stenting in infrapopliteal arteries of patients with severe intermittent claudication or critical limb ischemia (CLI).<h4>Methods</h4>In the EXPAND trial (ClinicalTrials.gov; identifier NCT00906022), 92 patients (mean age 72.9±9.5 years; 62 men) undergoing treatment for infrapopliteal stenosis ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2015, 22(5):690-697]

Cited: 15 times

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Carotid stenting with distal protection in high-surgical-risk patients: one-year results of the ASTI trial.

Marc Bosiers, Dierk Scheinert, Klaus Mathias, Ralf Langhoff, Harald Mudra, Juan Diaz-Cartelle,

This prospective, multicenter, nonrandomized study evaluated the periprocedural and 1-year outcomes in high-surgical-risk patients with carotid artery stenosis treated with the Adapt Carotid Stent plus FilterWire EZ distal protection catheter (Boston Scientific Corporation, Natick, MA).The study enrolled 100 patients (32 symptomatic, 63 asymptomatic, 5 unknown) at high risk for carotid ... Read more >>

Cardiovasc Intervent Radiol (Cardiovascular and interventional radiology)
[2015, 38(2):295-303]

Cited: 0 times

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Outcome of carotid angioplasty with a novel open-cell carotid stent system.

Ralf Langhoff, Harald Mudra, Matthias Waliszewski, Bernhard Reimers, Jérôme Berge, Carlo Setacci, Bernard Beyssen,

<h4>Background</h4>The choice of carotid stent systems depends primarily on the anatomy of the carotid artery, the lesion morphology, and the patient's risk factors. Design improvements in devices, in terms of crossing profile and the ability to precisely position the stent, may greatly contribute to the procedural success without compromising acute ... Read more >>

Vasc Endovascular Surg (Vascular and endovascular surgery)
[2014, 48(4):317-324]

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The diagnosis, treatment and follow-up of extracranial carotid stenosis.

Hans-Henning Eckstein, Andreas Kühnl, Arnd Dörfler, Ina B Kopp, Holger Lawall, Peter A Ringleb, ,

<h4>Background</h4>Extracranial atherosclerotic lesions of the carotid bifurcation cause 10% to 20% of all cases of cerebral ischemia. Until now, there have been no comprehensive evidence- and consensus-based recommendations for the management of patients with extracranial carotid stenosis in Germany and Austria.<h4>Methods</h4>The literature was systematically searched for pertinent publications (1990-2011). On ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2013, 110(27-28):468-476]

Cited: 33 times

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MISAGO 2: one-year outcomes after implantation of the Misago self-expanding nitinol stent in the superficial femoral and popliteal arteries of 744 patients.

Karl-Ludwig Schulte, Ivan Kralj, Hans Martin Gissler, Luis Alberto Bagnaschino, Ivo Buschmann, Jean-Marc Pernès, Patrick Haage, Peter Goverde, Jean-Paul Beregi, Martin Válka, Jaroslav Boudny, Thomas Geibel, Marek Velkoborsky, Markus Zähringer, Christian Paetzel, Fabrizio Fanelli, Stefan Müller-Hülsbeck, Thomas Zeller, Ralf Langhoff,

<h4>Purpose</h4>To evaluate the safety and efficacy of the Misago self-expanding rapid-exchange nitinol stent system for the treatment of femoropopliteal occlusive disease in a prospective multicenter observational trial (ClinicalTrials.gov; identifier NCT01118117).<h4>Methods</h4>Between April and October 2008, the registry enrolled 744 patients (496 men; 69 ± 10 years) who had symptomatic ≥ 70% ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2012, 19(6):774-784]

Cited: 24 times

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