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Author Rakesh Kumar Vasishta

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Outcome of C3 glomerulopathy patients: largest single-centre experience from South Asia.

Ashwani Kumar, Ritambhra Nada, Raja Ramachandran, Amit Rawat, Karalanglin Tiewsoh, Reena Das, Charan Singh Rayat, Krishan Lal Gupta, Rakesh Kumar Vasishta,

BACKGROUND:C3 glomerulopathy (C3G) is related to dysfunction of alternative complement pathway (ACP) because of its hyperactivation. Triggering factors and genetic profile are likely to be different in developing countries as compared to the Western world. Data regarding C3G from South Asian is scanty. STUDY DESIGN:In the present study, 115 patients ... Read more >>

J. Nephrol. (Journal of nephrology)
[2020, 33(3):539-550]

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Rosette-forming and papillary glioneuronal tumors - A clinicopathological and molecular analysis.

Vikram Singh, Kirti Gupta, Pravin Salunke, Sandeep Kumar, Bishan Dass Radotra, Rakesh Kumar Vasishta,

INTRODUCTION:Rosette-forming glioneuronal tumors (RGNT) and papillary glioneuronal tumors (PGNT) account for < 1% of brain tumors. Genetic data regarding RGNT and PGNT is still evolving. We aimed to perform a detailed clinicopathological analysis on rosette-forming and papillary glioneuronal tumors and to evaluate these for common, known genetic mutations. MATERIALS AND ... Read more >>

Clin. Neuropathol. (Clinical neuropathology)
[2019, 38(4):180-188]

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Phenotype-Genotype Correlation of North Indian Progressive Familial Intrahepatic Cholestasis type2 Children Shows p.Val444Ala and p.Asn591Ser Variants and Retained BSEP Expression.

Suvradeep Mitra, Ashim Das, Baburam Thapa, Rakesh Kumar Vasishta,

Backgrounds and Aims: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a defect or deficiency of bile salt export protein (BSEP) due to mutation in the ABCB11 gene. We intend to evaluate the phenotype-genotype correlation in 10 diagnosed cases of PFIC2 in a single tertiary care center in ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2020, 39(2):107-123]

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Therapeutic Challenges in the Management of Bleeding Duodenal Gastrointestinal Stromal Tumor: a Case Report and Review of Literature.

Gautham Krishnamurthy, Harjeet Singh, Vishal Sharma, Ajay Savlania, Rakesh Kumar Vasishta,

INTRODUCTION:Duodenum is an uncommon site for the gastrointestinal stromal tumors (GISTs). Though the principles of management are the same of that elsewhere in the gastrointestinal tract, the anatomical complexity poses challenges in deciding the most appropriate treatment. A bleeding GIST further compounds the difficulty in managing such patients. CASE REPORT:A ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(1):170-174]

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Adult Pilomyxoid Astrocytoma with Hemorrhage in an Atypical Location.

Madhivanan Karthigeyan, Prankul Singhal, Pravin Salunke, Rakesh Kumar Vasishta,

Pilomyxoid astrocytomas (PMAs) are generally seen in young children and tend to occur in the hypothalamic-chiasmatic region. Their presence in other parts of the brain in the nonpediatric age group is uncommon. In addition, hemorrhage in such low-grade tumors is an occasional event. We describe a case of PMA that ... Read more >>

Asian J Neurosurg (Asian journal of neurosurgery)
[2019, 14(1):300-303]

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The enigma of a pulmonary papillary lesion.

Rajesh Kumar, Nalini Gupta, Navneet Singh, Rakesh Kumar Vasishta, Arvind Rajwanshi,

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2018, 29(6):585-586]

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Surgery for Abdominal Tuberculosis in the Present Era: Experience from a Tertiary-Care Center.

Harjeet Singh, Gautham Krishnamurthy, Jayapal Rajendran, Vishal Sharma, Harshal Mandavdhare, Hemanth Kumar, Thakur Deen Yadav, Rakesh Kumar Vasishta, Rajinder Singh,

BACKGROUND:The role of surgery in abdominal tuberculosis is being redefined, as many patients will be candidates for endoscopic dilatation rather than open surgery. METHODS:A retrospective analysis was done of the surgical procedures performed in patients with abdominal tuberculosis in a large tertiary-care center in North India. Details such as clinical ... Read more >>

Surg Infect (Larchmt) (Surgical infections)
[2018, 19(6):640-645]

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Medulloblastoma with myogenic and/or melanotic differentiation does not align immunohistochemically with the genetically defined molecular subgroups.

Kirti Gupta, Swathi Jogunoori, Ayusman Satapathy, Pravin Salunke, Narendra Kumar, Bishan Dass Radotra, Rakesh Kumar Vasishta,

The World Health Organization classification of central nervous system neoplasms (2016 update) recognizes 4 histological variants and genetically defined molecular subgroups within medulloblastoma (MB). MB with myogenic differentiation is one of the rare variants, which is usually recognized as a pattern alongside the known histological variants. Because of its rarity, ... Read more >>

Hum. Pathol. (Human pathology)
[2018, 75:26-33]

Cited: 1 time

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IDH1, ATRX, and BRAFV600E mutation in astrocytic tumors and their significance in patient outcome in north Indian population.

Debajyoti Chatterjee, Bishan Dass Radotra, Narendra Kumar, Rakesh Kumar Vasishta, Sunil Kumar Gupta,

Background:According to the current World Health Organization (WHO) classification of central nervous system (CNS) tumors (2016), histological diagnosis of gliomas should be supplemented by molecular information. This study was carried out to determine the frequency of isocitrate dehydrogenase 1 (IDH1), ATRX, and BRAF V600E mutations in different grade astrocytomas and ... Read more >>

Surg Neurol Int (Surgical neurology international)
[2018, 9:29]

Cited: 1 time

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Erdheim-Chester disease with unusual clinicopathological features complicated by DRESS syndrome, disseminated Cytomegalovirus infection and hemophagocytic lymphohistiocytosis.

Balan Louis Gaspar, Rakesh Kumar Vasishta, Reena Das, Ashish Bhalla,

APMIS (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica)
[2017, 125(7):669-676]

Cited: 0 times

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Gallbladder tuberculosis camouflaging as gallbladder cancer - case series and review focussing on treatment.

Gautham Krishnamurthy, Harjeet Singh, Jayapal Rajendran, Vishal Sharma, Thakur Deen Yadav, Balan Louis Gaspar, Rakesh Kumar Vasishta, Rajinder Singh,

Gallbladder tuberculosis, in an endemic region, is a common infectious etiology affecting a rare organ. The high prevalence of carcinoma gallbladder in the endemic regions of tuberculosis, like India, poses diagnostic dilemma.We are reporting three cases of gallbladder tuberculosis mimicking carcinoma gallbladder of which the first two cases were operated ... Read more >>

Ther Adv Infect Dis (Therapeutic advances in infectious disease)
[2016, 3(6):152-157]

Cited: 2 times

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Localised SAA amyloidosis with intra-axonal intra-myelin amyloid deposits.

Balan Louis Gaspar, Chandni Garg, Rakesh Kumar Vasishta, Ritambhra Nada, Manoj Kumar Goyal,

Pathology (Pathology)
[2017, 49(1):103-105]

Cited: 1 time

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Endomysial germinal centres in Hashimoto's thyroiditis with myopathic symptoms.

Balan Louis Gaspar, Rajveer Singh, Manoj Kumar Goyal, Bishan Das Radotra, Rakesh Kumar Vasishta,

Pathology (Pathology)
[2017, 49(1):97-100]

Cited: 0 times

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Primary giant cell tumor of the female breast: a diagnostic red herring with therapeutic implications.

Balan Louis Gaspar, Saniya Sharma, Rajinder Singh, Rakesh Kumar Vasishta,

Primary giant cell tumor of the female breast is extremely rare. Major diagnostic difficulty is encountered not only by the surgeon but also by the radiologist and pathologist. Pathologically, it is similar to the bone and soft tissue counterparts. However, this is not always true. We describe a patient presenting ... Read more >>

APMIS (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica)
[2017, 125(1):32-37]

Cited: 1 time

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Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features.

Balan Louis Gaspar, Mukin Kumar, Rahul Gupta, Rashi Garg, Rajinder Singh, Rakesh Kumar Vasishta,

Lipid-rich carcinoma of the breast is a rare form of invasive breast carcinoma of special type. Most cases are grade 3, hormone receptor negative, and associated with aggressive clinical behavior. We report an unusual case of lipid-rich carcinoma with morphological and immunophenotypical features different from those of cases reported so ... Read more >>

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2016, 24(6):538-542]

Cited: 0 times

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Vascular complications of tuberculous meningitis: An autopsy study.

Debajyoti Chatterjee, Bishan Dass Radotra, Rakesh Kumar Vasishta, Kusum Sharma,

AIMS:Vascular complications have the most serious consequences in patients with tuberculous meningitis (TBM). Although stroke is seen in approximately 20% of patients with TBM, the underlying vascular damage and infarction are much more extensive. This study has been undertaken to study the pathology at different levels of cerebral vessels and ... Read more >>

Neurol India (Neurology India)
[2015, 63(6):926-932]

Cited: 4 times

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Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii.

Namrata Anand, Rakesh Sehgal, Rupinder Kaur Kanwar, Mohan Lal Dubey, Rakesh Kumar Vasishta, Jagat Rakesh Kanwar,

Toxoplasma gondii is a deadly intracellular parasite known to reside in every nucleated cell and known to cause severe complications in immunocompromised host. Standard drugs are cost effective and cause side effects, therefore, there is a necessity for a new drug molecule with immunomodulatory potential. Lactoferrin (Lf) is a natural ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2015, 10:6355-6369]

Cited: 3 times

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Gangliocytic Paraganglioma With Atypical Immunohistochemical Features Presenting as Extrahepatic Biliary Obstruction.

Saniya Sharma, Balan Louis Gaspar, Pradeep Kumar, Thakur Deen Yadav, Rakesh Kumar Vasishta,

Gangliocytic paraganglioma is a rare benign tumor of upper gastrointestinal tract that most commonly involves the second part of duodenum. The tumor is detected incidentally on imaging in most of the cases. However, presentation with extrahepatic biliary obstruction is extremely rare. We recently encountered a 50-year-old male patient who was ... Read more >>

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2015, 23(7):561-566]

Cited: 1 time

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Unusual Clinical Presentation and Role of Decompressive Craniectomy in Herpes Simplex Encephalitis.

Pratibha Singhi, Arushi Gahlot Saini, Jitendra Kumar Sahu, Nuthan Kumar, Sameer Vyas, Rakesh Kumar Vasishta, Ashish Aggarwal,

Decompressive craniectomy in pediatric central nervous infections with refractory intracranial hypertension is less commonly practiced. We describe improved outcome of decompressive craniectomy in a 7-year-old boy with severe herpes simplex encephalitis and medically refractory intracranial hypertension, along with a brief review of the literature. Timely recognition of refractory intracranial hypertension ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2015, 30(9):1204-1207]

Cited: 5 times

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Mesenchymal chondrosarcoma of kidney.

Ruchita Tyagi, Nandita Kakkar, Rakesh Kumar Vasishta, Mayank Mohan Aggarwal,

Mesenchymal chondrosarcoma of the kidney is a very rare entity with no definite treatment protocol. Herein, we describe one such case with discussion of its diagnosis and management. The patient had a well circumscribed mass in right kidney extending into the inferior vena cava and metastasis to both the lungs. ... Read more >>

Indian J Urol (Indian journal of urology : IJU : journal of the Urological Society of India)
[2014, 30(2):225-227]

Cited: 3 times

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Benign granular cell tumor of the lung in a child--a case report.

Rama Kumari Badyal, Rakesh Kumar Vasishta, Nandita Kakkar, Anand Kumar Mishra,

Amongst the lung tumors, granular cell tumor (GCT), also known as granular cell myoblastoma, or Abrikossoff is one of the rarest tumors. Herein, we present a case of a 6-year-old male child who presented with a history of cough, fever and recurrent pneumonia due to a 8 × 5 × ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2014, 33(3):191-195]

Cited: 3 times

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Secretory meningioma: a diagnostic pitfall.

Ruchita Tyagi, Rakesh Kumar Vasishta, Nandita Kakkar, Bishan Dass Radotra, K K Mukherjee,

CONTEXT: Secretory meningioma is a rare subtype of meningiomas, displaying epithelial and secretory differentiation of meningothelial cells. It has unique radiological, morphological, and immunohistochemical features, but runs a benign course. Radiological picture because of the variable degrees of peritumoral edema can be confused with aggressive neoplasms. Morphologically, it is difficult ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2014, 57(2):183-186]

Cited: 0 times

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Biochemical, histological, and memory impairment effects of chronic copper toxicity: a model for non-Wilsonian brain copper toxicosis in Wistar rat.

Amit Pal, Rama Kumari Badyal, Rakesh Kumar Vasishta, Savita Verma Attri, Babu Ram Thapa, Rajendra Prasad,

Animal models of copper toxicosis rarely exhibit neurological impairments and increased brain copper accumulation impeding the development of novel therapeutic approaches to treat neurodegenerative diseases having high brain Cu content. The aim of this study was to investigate the effects of intraperitoneally injected copper lactate (0.15 mg Cu/100 g body weight) daily ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2013, 153(1-3):257-268]

Cited: 19 times

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Hepatic and hippocampus iron status is not altered in response to increased serum ceruloplasmin and serum "free" copper in Wistar rat model for non-Wilsonian brain copper toxicosis.

Amit Pal, Rakesh kumar Vasishta, Rajendra Prasad,

Copper and iron dyshomeostasis has been implicated directly or indirectly in the pathogenesis of neurodegenerative diseases. Previously, we have shown the first in vivo evidence of significant increase in the hippocampus copper and zinc content with spatial memory impairments, astrocytes swelling (Alzheimer type-II cells) coupled with increase in the number ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2013, 154(3):403-411]

Cited: 11 times

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Large demyelinating lesions: a neurosurgical perspective.

Pravin Salunke, Ashish Aggarwal, Kirti Gupta, Pallavi Agrawal, Chirag Kamal Ahuja, Rakesh Kumar Vasishta,

UNLABELLED: OBJECT/ BACKGROUND: Large demyelinating lesions (LDLs) may present with unusual features like seizures and significant mass effect and often masquerade a tumour. Even radiological features are confusing. With clinical signs of increased intra-cranial pressure (ICP), decompressive surgery becomes life-saving. However, resection of the involved nervous tissue is unnecessary and ... Read more >>

Br J Neurosurg (British journal of neurosurgery)
[2012, 26(4):490-498]

Cited: 2 times

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