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Author Rakesh Kochhar

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The relationship between pre-existing diabetes mellitus and the severity of acute pancreatitis: Report from a large international registry.

Pedram Paragomi, Georgios I Papachristou, Kwonho Jeong, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K Goenka, Aiste Gulla, Jose A Gonzalez, Vikesh K Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T Barbu, Haq Nawaz, Silvia C Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J Easler, Konstantinos Triantafyllou, Mario Peláez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A Cote, Bechien U Wu, Peter J Lee, Phil A Hart, Darwin L Conwell, Frederico G S Toledo, Dhiraj Yadav,

<h4>Background/objectives</h4>The relationship between pre-existing diabetes mellitus (DM) and acute pancreatitis (AP) severity has not been established. We assessed the impact of pre-existing DM on AP severity in an international, prospectively ascertained registry.<h4>Methods</h4>APPRENTICE registry prospectively enrolled 1543 AP patients from 22 centers across 4 continents (8 US, 6 Europe, 5 Latin ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, :]

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The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study.

Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K Goenka, Aiste Gulla, Jose A Gonzalez, Vikesh K Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T Barbu, Haq Nawaz, Silvia C Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J Easler, Konstantinos Triantafyllou, Mario Peláez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A Cote, Peter J Lee, Somashekar Krishna, Luis F Lara, Samuel Han, Bechien U Wu, Georgios I Papachristou,

<h4>Background & aims</h4>The aims of this study were to: (1) assess the performance of the Pancreatitis Activity Scoring System (PASS) in a large intercontinental cohort of patients with acute pancreatitis (AP); and (2) investigate whether a modified PASS (mPASS) yields a similar predictive accuracy and produces distinct early trajectories between ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Oral Fluconazole Therapy in Patients With Active Ulcerative Colitis Who Have Detectable Candida in the Stool: A Double-Blind Randomized Placebo-controlled Trial.

Anuraag Jena, Usha Dutta, Jimil Shah, Vishal Sharma, Kaushal K Prasad, Rudramurthy M Shivaprakash, Harshal S Mandavdhare, Jayanta Samanta, Pankaj Sharma, Priyanka Popli, Arun K Sharma, Saroj K Sinha, Arunaloke Chakrabarti, Rakesh Kochhar,

<h4>Background</h4>There is an emerging role of fungal dysbiosis in the pathogenesis of inflammatory bowel disease. Prevalence of Candida in patients with active ulcerative colitis (UC) and the effect of fluconazole therapy in reducing disease activity of UC are not known.<h4>Patients and methods</h4>All consecutive consenting patients with active UC defined as ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, :]

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Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis.

Anupam K Singh, Jayanta Samanta, Jayendra Shukla, Chhagan Lal Birda, Jahnvi Dhar, Pankaj Gupta, Praveen Kumar-M, Vikas Gupta, Thakur Deen Yadav, Saroj K Sinha, Rakesh Kochhar,

<h4>Objectives</h4>Organ failure (OF) and infected necrosis (IN) are the most important predictors of mortality in necrotizing acute pancreatitis (AP). We studied the relationship between timing (onset and duration) and patterns of OF with mortality and the impact of IN on mortality.<h4>Methods</h4>Consecutive patients with necrotizing AP between January 2017 and February ... Read more >>

Pancreas (Pancreas)
[2021, 50(7):1030-1036]

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Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis.

Venkata S Akshintala, Christina J Sperna Weiland, Furqan A Bhullar, Ayesha Kamal, Kavin Kanthasamy, Albert Kuo, Cristian Tomasetti, Merve Gurakar, Joost P H Drenth, Dhiraj Yadav, B Joseph Elmunzer, D Nageshwar Reddy, Mahesh K Goenka, Rakesh Kochhar, Anthony N Kalloo, Mouen A Khashab, Erwin J M van Geenen, Vikesh K Singh,

<h4>Background</h4>Non-steroidal anti-inflammatory drugs (NSAIDs), intravenous fluid, pancreatic stents, or combinations of these have been evaluated in randomised controlled trials (RCTs) for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, but the comparative efficacy of these treatments remains unclear. Our aim was to do an exploratory network meta-analysis of previous RCTs ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(9):733-742]

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Primary EUS-guided therapy of a giant visceral artery pseudoaneurysm: Expanding horizons (with video).

Jimil Shah, Jayanta Samanta, Gaurav Muktesh, Naveen Kumar, Pankaj Gupta, K Hemanth Kumar, Rakesh Kochhar,

Endosc Ultrasound (Endoscopic ultrasound)
[2021, 10(4):307-308]

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Best practices of handling, processing, and interpretation of small intestinal biopsies for the diagnosis and management of celiac disease: A joint consensus of Indian association of pathologists and microbiologists and Indian society of gastroenterology.

Prasenjit Das, Kim Vaiphei, Anjali D Amarapurkar, Puja Sakhuja, Ritambhra Nada, Roopa Rachel Paulose, Rachana Chaturvedi, Anuradha Sekaran, Usha Kini, Archana Rastogi, Niraj Kumari, Anna Pulimood, Mala Banerjee, Prateek Kinra, Lavleen Singh, AmarenderSingh Puri, Ganesh Pai, Rakesh Kochhar, Gopal Krishna Dhali, B S Ramakrishna, Ajit Sood, Uday Chand Ghoshal, Vineet Ahuja, Siddhartha DattaGupta, Govind K Makharia, Vatsala Misra,

The Indian Association of Pathologists and Microbiologists (IAPM) and Indian Society of Gastroenterology (ISG) decided to make a joint consensus recommendation for handling, processing, and interpretation of SI biopsies for the diagnosis and management of celiac disease (CD) recognizing the inhomogeneous practice of biopsy sampling, orientation, processing, and interpretation. A ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2021, 64(Supplement):S8-S31]

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Sham Feeding Induced Gastric Acid Secretion in Patients with Caustic Induced Esophageal Stricture.

Jimil Shah, Nikhil Bush, T Mahesh, C K Nain, Rakesh Kochhar,

Caustic ingestion can lead to structural changes in the upper gastro-intestinal tract. However, there is limited data on the effect of caustic ingestion on gastric secretion. This study was planned to determine changes in gastric acid output after sham feeding in patients with caustic induced esophageal stricture and to compare ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

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Use of thiopurines in inflammatory bowel disease: an update.

Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N Bernstein, Devendra Desai, C Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce Wy Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood,

Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight. 5-Aminosalicylates, corticosteroids, immunosuppressive agents and biologics are the backbone of treatment of IBD. With the ... Read more >>

Intest Res (Intestinal research)
[2021, :]

Cited: 1 time

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Acute-on-Chronic Pancreatitis: Analysis of Clinical Profile and Outcome.

Dibyajyoti Sharma, Bipadabhanjan Mallick, Jayanta Samanta, Vikas Gupta, Saroj K Sinha, Rakesh Kochhar,

<h4>Objective</h4>Overall, a handful of studies are available on the outcomes of acute-on-chronic pancreatitis (ACP). We aimed to provide a more complete and updated picture of ACP.<h4>Methods</h4>We evaluated consecutive patients of acute exacerbation of chronic pancreatitis (CP) in a tertiary care center located in north India and studied their epidemiological profiles, ... Read more >>

Cureus (Cureus)
[2021, 13(4):e14242]

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Should patients with unresectable gallbladder cancer with hilar involvement undergo unilateral or bilateral percutaneous biliary drainage in the setting of cholangitis?

Pankaj Gupta, Varun Bansal, Naveen Kalra, Jayanta Samanta, Harshal Mandavdhare, Vishal Sharma, Usha Dutta, Rakesh Kochhar, Manavjit Singh Sandhu,

<h4>Aim of the study</h4>This study aimed to evaluate the outcomes of patients with unresectable gallbladder cancer (GBC) with hilar involvement and cholangitis undergoing percutaneous transhepatic biliary drainage (PTBD).<h4>Material and methods</h4>This retrospective study comprised consecutive patients with unresectable GBC with cholangitis who underwent PTBD. The procedures were categorized as unilateral or ... Read more >>

Clin Exp Hepatol (Clinical and experimental hepatology)
[2021, 7(1):7-12]

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Multidimensional dynamic healthcare personnel (HCP)-centric model from a low-income and middle-income country to support and protect COVID-19 warriors: a large prospective cohort study.

Usha Dutta, Anurag Sachan, Madhumita Premkumar, Tulika Gupta, Swapnajeet Sahoo, Sandeep Grover, Sugandhi Sharma, P V M Lakshmi, Shweta Talati, Manisha Biswal, Vikas Suri, Mini P Singh, Babita Ghai, Rajesh Chhabra, Bhavneet Bharti, Jayanta Samanta, Pankaj Arora, Ritin Mohindra, Sunita Malhotra, Gurmeet Singh, Rashmi Ranjan Guru, Navin Pandey, Vipin Koushal, Ashok Kumar, Ranjitpal Singh Bhogal, Arun K Aggarwal, Kapil Goel, Pankaj Malhotra, Narayana Yaddanapudi, Pranay Mahajan, J S Thakur, Rakesh Sehgal, Arnab Ghosh, Inderpaul Singh Sehgal, Ritesh Agarwal, Muralidharan Jayashree, Ashish Bhalla, Sanjay Jain, Rakesh Kochhar, Arunaloke Chakrabarti, Goverdhan Dutt Puri, Jagat Ram,

<h4>Objectives</h4>Healthcare personnel (HCP) are at an increased risk of acquiring COVID-19 infection especially in resource-restricted healthcare settings, and return to homes unfit for self-isolation, making them apprehensive about COVID-19 duty and transmission risk to their families. We aimed at implementing a novel multidimensional HCP-centric evidence-based, dynamic policy with the objectives ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e043837]

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Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected.

Jorge D Machicado, Amir Gougol, Xiaoqing Tan, Xiaotian Gao, Pedram Paragomi, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K Goenka, Aiste Gulla, Jose A Gonzalez, Vikesh K Singh, Miguel Ferreira, Tyler Stevens, Sorin T Barbu, Haq Nawaz, Silvia C Gutierrez, Narcis O Zarnescu, Gabriele Capurso, Jeffrey J Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A Cote, Bechien U Wu, Darwin L Conwell, Phil A Hart, Gong Tang, Georgios I Papachristou,

<h4>Background</h4>Persistent organ failure (POF) is the strongest determinant of mortality in acute pancreatitis (AP). There is a paucity of data regarding the impact of different POF attributes on mortality and the role of different characteristics of systemic inflammatory response syndrome (SIRS) in the risk of developing POF.<h4>Objective</h4>We aimed to assess ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2021, 9(2):139-149]

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Per Oral Endoscopic Myotomy for the Management of Large Esophageal Diverticula (D-POEM): Safe and Effective Modality for Complete Septotomy.

Jayanta Samanta, Harshal S Mandavdhare, Naveen Kumar, Praveen Kumar-M, Anudeep Jafra, Rajeev Chauhan, Pankaj Gupta, K Hemanth Kumar, Harjeet Singh, Usha Dutta, Rakesh Kochhar,

With the advent of the technique of sub-mucosal tunnelling, peroral endoscopic myotomy (POEM) has been used for the treatment of esophageal diverticulum, which otherwise is a recurring problem with conventional flexible endoscopic treatment due to incompleteness of septotomy. This study reports our experience of the use of diverticular POEM (D-POEM) ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

Cited: 2 times

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Incidence and risk factors of oral feeding intolerance in acute pancreatitis: Results from an international, multicenter, prospective cohort study.

Ioannis Pothoulakis, Haq Nawaz, Pedram Paragomi, Kwonho Jeong, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh Kumar Goenka, Aiste Gulla, Vikesh K Singh, Jose A Gonzalez, Miguel Ferreira, Sorin T Barbu, Tyler Stevens, Silvia C Gutierrez, Narcis O Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Bechien U Wu, Gregory A Cote, Kaleab Abebe, Gong Tang, Ali Lahooti, Anna E Phillips, Georgios I Papachristou,

<h4>Background</h4>Inability to advance to an oral diet, or oral feeding intolerance, is a common complication in patients with acute pancreatitis associated with worse clinical outcomes. The factors related to oral feeding intolerance are not well studied.<h4>Objective</h4>We aimed to determine the incidence and risk factors of oral feeding intolerance in acute ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2021, 9(1):54-62]

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Retrograde Myotomy as an Alternative to Antegrade Myotomy in Peroral Endoscopic Myotomy (POEM) for Achalasia Cardia - Is It Better?

Harshal S Mandavdhare, Jayanta Samanta, Anudeep Jafra, Rajeev Chauhan, Harjeet Singh, Naveen Kumar, Kimavat Hemanth Kumar, Pankaj Gupta, Usha Dutta, Rakesh Kochhar,

<h4>Background</h4>Antegrade approach myotomy is usually performed in peroral endoscopic myotomy (POEM) for achalasia cardia. This study assessed the feasibility of retrograde approach as an alternative.<h4>Methods</h4>This is a retrospective review of a prospectively maintained database of patients undergoing POEM, comparing the 2 techniques of antegrade myotomy (AM) and retrograde myotomy (RM). ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, 31(4):444-447]

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ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature.

Kaniyappan Nambiyar, Kirti Gupta, Uma Debi, Saroj Kant Sinha, Rakesh Kochhar,

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with ... Read more >>

Autops Case Rep (Autopsy & case reports)
[2021, 11:e2020231]

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Gastric secretion in patients with caustic ingestion: A prospective study.

Jimil Shah, Nikhil Bush, K Rajan, C K Nain, Kartar Singh, Rakesh Kochhar,

<h4>Background</h4>Caustic ingestion can lead to structural changes in the upper gastrointestinal tract. However, there are limited data on the effect of caustic ingestion on gastric secretion. This study was planned to determine the changes in gastric acid output in patients with caustic ingestion.<h4>Methods</h4>It was a prospective study done at a ... Read more >>

Indian J Gastroenterol (Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology)
[2021, 40(1):50-55]

Cited: 1 time

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Quality of life in patients of corrosive esophageal stricture treated with endoscopic dilatation.

Naveen Anand, Akhilesh Sharma, Jimil Shah, Rakesh Kochhar, Shubh Mohan Singh,

<h4>Background and aim</h4>Caustic ingestion is associated with long-term sequelae in the form of esophageal and/or gastric cicatrization requiring endoscopic or surgical intervention. Quality of life (QoL) and disability in patients with caustic-induced sequelae is less explored.<h4>Methods</h4>In this prospective study, we included consecutive patients with symptomatic caustic-induced esophageal stricture undergoing endoscopic ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(2):301-306]

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Computed Tomography Findings in Intraabdominal Hypertension in Patients with Acute Pancreatitis.

Pankaj Gupta, Rohan Kamat, Jayanta Samanta, Harshal Mandavdhare, Vishal Sharma, Saroj Kant Sinha, Usha Dutta, Rakesh Kochhar,

<b>Purpose</b>  Intraabdominal hypertension (IAH) in acute pancreatitis (AP) may reduce tissue perfusion and impair organ function and has been shown to portend poor prognosis. We investigated the computed tomography (CT) findings in patients with AP with IAH. <b>Methods</b>  This retrospective study comprised of consecutive patients with AP from June 2016 ... Read more >>

Indian J Radiol Imaging (The Indian journal of radiology & imaging)
[2021, 31(1):150-156]

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Splenic abscess in a tertiary care centre in India: clinical characteristics and prognostic factors.

Anupam K Singh, Saurabh Karmani, Jayanta Samanta, Pankaj Gupta, Vikas Gupta, Thakur D Yadav, Savita Kumari, Usha Dutta, Saroj K Sinha, Rakesh Kochhar,

<h4>Background</h4>Splenic abscess has been an uncommon entity which is now being encountered more frequently due to increased prevalence of immunodeficiency disorders and chronic illnesses. This study was aimed to audit our experience with splenic abscesses at a tertiary care centre in India highlighting usefulness of an algorithmic approach.<h4>Methods</h4>Retrospective analysis of ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91(9):1819-1825]

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Can serum resistin predict severity of acute pancreatitis?

Anupam Kumar Singh, Saurabh Dawra, Satyavati Rana, Pankaj Gupta, Jayanta Samanta, Saroj K Sinha, Vikas Gupta, Thakur Deen Yadav, Rakesh Kochhar,

<h4>Objective</h4>Acute pancreatitis (AP) is a common disorder with high mortality in severe cases. Several markers have been studied to predict development of severe AP (SAP) including serum resistin with conflicting results. This study aimed at assessing the role of baseline serum resistin levels in predicting SAP.<h4>Methods</h4>This prospective study collected data ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2021, 26(1):31-37]

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Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis.

Sathya Sagar, Raghuraman Soundarajan, Pankaj Gupta, M Praveen Kumar, Jayanta Samanta, Vishal Sharma, Rakesh Kochhar,

<h4>Background</h4>There is a significant variability in the reported outcomes following endovascular embolization of arterial pseudoaneurysms in pancreatitis. The objective of this systematic review and meta-analysis is to evaluate the efficacy of endovascular embolization of pancreatitis-related pseudoaneurysms.<h4>Methods</h4>Searches of MEDLINE, EMBASE, and SCOPUS databases were performed through July 1, 2019 in accordance ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, 21(1):46-58]

Cited: 2 times

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Outcome of percutaneous drainage in patients with pancreatic necrosis having organ failure.

Anupam K Singh, Jayanta Samanta, Ajay Gulati, Vikas Gautam, Anmol Bhatia, Pankaj Gupta, Vikas Gupta, Thakur D Yadav, Saroj K Sinha, Rakesh Kochhar,

<h4>Background</h4>Percutaneous catheter drainage (PCD) is an effective way of drainage in acute pancreatitis (AP) and its role in persistent organ failure (OF) has not been studied. This study assessed the outcome of severe AP managed with PCD.<h4>Methods</h4>We retrospectively analysed outcome of AP patients undergoing PCD for persistent OF with respect ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2021, 23(7):1030-1038]

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Larger bore percutaneous catheter in necrotic pancreatic fluid collection is associated with better outcomes.

Pankaj Gupta, Akash Bansal, Jayanta Samanta, Harshal Mandavdhare, Vishal Sharma, Vikas Gupta, Thakur Deen Yadav, Usha Dutta, Rakesh Kochhar, Manavjit Singh Sandhu,

<h4>Objective</h4>To evaluate the impact of initial catheter size on the clinical outcomes in acute pancreatitis (AP).<h4>Methods</h4>This retrospective study comprised consecutive patients with AP who underwent percutaneous catheter drainage (PCD) between January 2018 and May 2019. Three hundred fifteen consecutive patients underwent PCD during the study period. Based on the initial ... Read more >>

Eur Radiol (European radiology)
[2021, 31(5):3439-3446]

Cited: 1 time

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