Full Text Journal Articles by
Author Rajni Sharma

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Feeling offended by clients: The experiences of doctoral student therapists.

Lydia HaRim Ahn, Stephanie E Yee, Katherine Morales Dixon, Colleen A Kase, Rajni Sharma, Clara E Hill,

Ten doctoral student therapists (8 White, 5 female) in 1 counseling psychology doctoral program located in the Mid-Atlantic United States were interviewed for approximately 1 hour each about their experiences of feeling offended by a client during an individual psychotherapy session. Interview data were analyzed with consensual qualitative research (CQR). ... Read more >>

J Couns Psychol (Journal of counseling psychology)
[2020, :]

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Intestinal mucormycosis complicated by iliac artery aneurysm and ureteric rupture in a child with new-onset type 1 diabetes mellitus.

Ganesh Jevalikar, Rajni Sharma, Veena Raghunathan, Meera Luthra, Maninder S Dhaliwal, Vandana Jain, Ambrish Mithal,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, :]

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Medical nutrition therapy of pediatric type 1 diabetes mellitus in India: Unique aspects and challenges.

Sheryl Salis, Mini Joseph, Anuja Agarwala, Rajni Sharma, Nitin Kapoor, Aspi J Irani,

Medical nutrition therapy (MNT) is a vital aspect of management of type 1 diabetes mellitus (T1DM) and should be tailored to ethnic and family traditions and the socioeconomic and educational status of the patient. In this article, we discuss the unique aspects of MNT in children and adolescents with T1DM ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, :]

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Accessing Counseling Services Where the Rainbow Doesn't Shine: A Heterosexism Audit Study.

Richard Q Shin, Lance C Smith, Collin N Vernay, Jamie C Welch, Rajni Sharma, Maeve Eberhardt,

Through a field experiment set among licensed therapists (N = 425), we found nuanced evidence of heterosexist discrimination at the entry point of mental health services for a fictitious White, presumably gay man seeking counseling. We called therapists in LGB-affirming and LGB-hostile states and left voicemails requesting services. To manipulate perceived ... Read more >>

J Homosex (Journal of homosexuality)
[2020, :1-20]

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A novel spectrophotometric method for simultaneous estimation of dibenzothiophene and 2-hydroxybiphenyl in their mixed spectrum and its application in screening of specific biodesulfurizing microbes.

Rajni Sharma, Jagdish Singh, Neelam Verma,

The desulfurization of fuel is currently enforced to meet environmental legislation and prevent pollution. The use of specific biodesulfurizing microbes with a unique 4S pathway allows the desulfurization without compromising the quality of fuel. These specific microbes can be screened by the detection of 2-hydroxybiphenol (2-HBP) in desulfurizing mixture of ... Read more >>

3 Biotech (3 Biotech)
[2020, 10(4):153]

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Vital Need for Sex Education in Indian Youth and Adolescents.

Rajni Sharma,

Indian J Pediatr (Indian journal of pediatrics)
[2020, 87(4):255]

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Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.

Rajni Sharma, Manju Kumari, Prem Prakash, Sushil Gupta, Swasti Tiwari,

Impaired insulin-induced suppression of renal gluconeogenesis could be a risk for hyperglycemia. Diabetes is associated with elevated renal gluconeogenesis; however, its regulation in early insulin resistance is unclear in humans. A noninvasive marker of renal gluconeogenesis would be helpful. Here, we show that human urine exosomes (uE) contain three gluconeogenic ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2020, 318(3):F720-F731]

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Management of Infants with Congenital Adrenal Hyperplasia.

Aashima Dabas, Pallavi Vats, Rajni Sharma, Preeti Singh, Anju Seth, Vandana Jain, Prerna Batra, Neerja Gupta, Ravindra Kumar, Madhulika Kabra, Seema Kapoor, Sangeeta Yadav,

Treatment of congenital adrenal hyperplasia (CAH) requires lifelong replacement of glucocorticoids with regular follow up to manage associated morbidities. The current review focuses on follow-up and management of infants diagnosed with classical CAH pertinent to Indian context. Early initiation of oral hydrocortisone in divided doses is recommended after diagnosis in ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(2):159-164]

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Immune checkpoint status and tumor microenvironment in vulvar squamous cell carcinoma.

Margaret Cocks, Alcides Chaux, Erik G Jenson, James A Miller, Maria Del Carmen Rodriguez Pena, Aline C Tregnago, Diana Taheri, Marie-Lisa Eich, Rajni Sharma, Russell Vang, George J Netto,

Vulvar squamous cell carcinoma accounts for 5% of cancers of the female genital tract. Current guidelines recommend wide local excision with negative surgical margins as the standard treatment. However, the extent of the tumor-free resection margin after wide local excision is still controversial in many cases. Drugs targeting immune checkpoints ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2020, 477(1):93-102]

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Newborn Screening and Diagnosis of Infants with Congenital Adrenal Hyperplasia.

Pallavi Vats, Aashima Dabas, Vandana Jain, Anju Seth, Sangeeta Yadav, Madhulika Kabra, Neerja Gupta, Preeti Singh, Rajni Sharma, Ravindra Kumar, Sunil K Polipalli, Prerna Batra, B K Thelma, Seema Kapoor,

Congenital adrenal hyperplasia (CAH) is an autosomal recessive endocrine disorder which can manifest after birth with ambiguous genitalia and salt-wasting crisis. However, genital ambiguity is not seen in male babies and may be mild in female babies, leading to a missed diagnosis of classical CAH at birth. In this review, ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(1):49-55]

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Use of Smartphone Applications in Children with Type 1 Diabetes Mellitus.

Rajni Sharma,

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(12):1087-1088]

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Immunogenicity and Protective Efficacy of Seasonal Human Live Attenuated Cold-Adapted Influenza Virus Vaccine in Pigs.

Barbara Holzer, Sophie B Morgan, Veronica Martini, Rajni Sharma, Becky Clark, Christopher Chiu, Francisco J Salguero, Elma Tchilian,

Influenza A virus infection is a global health threat to livestock and humans, causing substantial mortality and morbidity. As both pigs and humans are readily infected with influenza viruses of similar subtype, the pig is a robust and appropriate model for investigating swine and human disease. We evaluated the efficacy ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:2625]

Cited: 1 time

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Tumour immune microenvironment in primary and metastatic papillary renal cell carcinoma.

Marie-Lisa Eich, Alcides Chaux, Maria Angélica Mendoza Rodriguez, Gunes Guner, Diana Taheri, Maria Del Carmen Rodriguez Pena, Rajni Sharma, Mohamad E Allaf, George J Netto,

AIMS:Among renal cell carcinoma (RCC) the tumour immune microenvironment has been best characterised in clear cell RCC. In this study we investigated the expression of several immune markers, including PD-L1, FoxP3 and CD8 in primary and metastatic papillary RCC. METHODS AND RESULTS:Three tissue microarrays were constructed from 78 cases with ... Read more >>

Histopathology (Histopathology)
[2020, 76(3):423-432]

Cited: 1 time

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Diffuse normolipemic plane xanthoma with underlying photosensitive dermatoses.

Mudita Gupta, Rajni Sharma, Anchana Gulati, Archit Gupta,

Diffuse plane xanthomatosis is a normolipemic non-Langerhan cell histiocytosis. Clinically, patient presents as asymptomatic yellowish plaques involving eyelids, neck, upper trunk and flexures. Usually, there is an associated haematological or lymphoproliferative malignancy which may precede or follow dermatological manifestations by many years. Rarely inflammatory dermatosis like atopic eczema, photosensitive dermatosis, ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(11):]

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To study the profile of Candida isolates and antifungal susceptibility pattern of neonatal sepsis in a tertiary care hospital of North India.

Mamta Lamba, Deepak Sharma, Rajni Sharma, Aruna Vyas, Ved Mamoria,

Aims and objective: To study the profile of Candida infection and antifungal susceptibility (AFS) pattern in neonatal sepsis. Materials and methods: In this prospective observational study, 850 blood samples were collected and processed from neonates who were suspected clinically to have sepsis. The blood culture that showed growth of Candida ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-5]

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Life-threatening Hypercalcemia as the First Manifestation of Acute Lymphoblastic Leukemia.

Kakali Roy, Rajni Sharma, Manisha Jana, Vandana Jain,

Hypercalcemia of malignancy, usually reported in adults in advanced stages, is rare in children. A 4-year-old boy presented with intermittent episodes of severe hypercalcemia, which improved with intravenous hydration therapy, furosemide and bisphosphonates as the initial manifestation of occult acute lymphoblastic leukemia. Pediatricians should rule out hematological malignancy in patients ... Read more >>

Indian Pediatr (Indian pediatrics)
[2019, 56(11):972-974]

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X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls.

Priyanka Madaan, Sandeep Negi, Rajni Sharma, Anupriya Kaur, Jitendra Kumar Sahu,

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(11):1072-1073]

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Immunohistochemical assessment of basal and luminal markers in non-muscle invasive urothelial carcinoma of bladder.

Maria Del Carmen Rodriguez Pena, Alcides Chaux, Marie-Lisa Eich, Aline C Tregnago, Diana Taheri, Walaa Borhan, Rajni Sharma, M Katayoon Rezaei, George J Netto,

The Cancer Genome Atlas project introduced genomic taxonomy of basal and luminal molecular subtypes in muscle invasive bladder cancer. Fewer studies have addressed the molecular classification in non-muscle invasive bladder cancer (NMIBC). Our aim is to assess the applicability of the proposed phenotypic classification for NMIBC. Three TMAs were constructed ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2019, 475(3):349-356]

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A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses.

Alexandra S Zimmer, Erin Nichols, Ashley Cimino-Mathews, Cody Peer, Liang Cao, Min-Jung Lee, Elise C Kohn, Christina M Annunziata, Stanley Lipkowitz, Jane B Trepel, Rajni Sharma, Lekha Mikkilineni, Margaret Gatti-Mays, William D Figg, Nicole D Houston, Jung-Min Lee,

<h4>Background</h4>Strategies to improve activity of immune checkpoint inhibitors are needed. We hypothesized enhanced DNA damage by olaparib, a PARP inhibitor, and reduced VEGF signaling by cediranib, a VEGFR1-3 inhibitor, would complement anti-tumor activity of durvalumab, a PD-L1 inhibitor, and the 3-drug combination would be tolerable.<h4>Methods</h4>This phase 1 study tested the ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2019, 7(1):197]

Cited: 9 times

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Continuous Metabolic Syndrome Score in Children: How Useful is it?

Rajni Sharma,

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(10):881-882]

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A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers.

Razelle Kurzrock, Douglas W Ball, Marianna L Zahurak, Barry D Nelkin, Vivek Subbiah, Shabina Ahmed, Ashley O'Connor, Enusha Karunsena, Rose M Parkinson, Justin A Bishop, Yoonji Ha, Rajni Sharma, Christopher D Gocke, Ralph Zinner, Michelle A Rudek, Steven I Sherman, Nilofer S Azad,

<h4>Purpose</h4>Differentiated thyroid cancer (DTC) responds to VEGF receptor inhibitors. VEGF signals through RAS/RAF/MEK signaling. We evaluated the safety and efficacy of the VEGF receptor inhibitor pazopanib and MEK inhibitor trametinib in advanced solid tumors and DTC.<h4>Patients and methods</h4>Patients with advanced solid tumors were enrolled in a phase I, multicenter trial ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(18):5475-5484]

Cited: 3 times

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Congenital Hyperinsulinemic Hypoglycemia and Hyperammonemia due to Pathogenic Variants in GLUD1.

Kakali Roy, Amit Kumar Satapathy, Jayne A L Houhton, Sarah E Flanagan, Venkatesan Radha, Viswanathan Mohan, Rajni Sharma, Vandana Jain,

Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder, characterized by dysregulated insulin secretion. Pathogenic variants in at least twelve different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A, UCP2, TRMT10A HK1, and PGM1) are known to cause CHI. Pathogenic variants in the GLUD1 gene, which encodes the ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(11):1051-1053]

Cited: 0 times

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Tumor immune microenvironment in non-muscle-invasive urothelial carcinoma of the bladder.

Marie-Lisa Eich, Alcides Chaux, Gunes Guner, Diana Taheri, Maria Angélica Mendoza Rodriguez, Maria Del Carmen Rodriguez Peña, Alexander S Baras, Noah M Hahn, Charles Drake, Rajni Sharma, Trinity J Bivalacqua, Katayoon Rezaei, George J Netto,

Immunotherapy has gained significance in a variety of tumor types including advanced urothelial carcinoma. Noninvasive urothelial lesions have been treated with intravesical Bacillus-Calmette-Guerin (BCG) for decades. Given treatment failure in a subset of these tumors, ongoing clinical trials investigating the role of checkpoint inhibitors are actively pursued in this group ... Read more >>

Hum Pathol (Human pathology)
[2019, 89:24-32]

Cited: 2 times

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Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.

Noelle R Jurcak, Agnieszka A Rucki, Stephen Muth, Elizabeth Thompson, Rajni Sharma, Ding Ding, Qingfeng Zhu, James R Eshleman, Robert A Anders, Elizabeth M Jaffee, Kenji Fujiwara, Lei Zheng,

<h4>Background & aims</h4>Little is known about mechanisms of perineural invasion (PNI) by pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the receptor PLXND1 to promote PDA invasion and metastasis. We investigated whether axon guidance molecules promote ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 157(3):838-850.e6]

Cited: 2 times

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Myocardin ablation in a cardiac-renal rat model.

Anupam Mittal, Santanu Rana, Rajni Sharma, Akhilesh Kumar, Rishikesh Prasad, Satish K Raut, Sagartirtha Sarkar, Uma Nahar Saikia, Ajay Bahl, Perundurai S Dhandapany, Madhu Khullar,

Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction. Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased in DCM porcine and patient cardiac ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):5872]

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