Full Text Journal Articles by
Author Rajiv Sinha

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Are we ignoring coexisting rhabdomyolysis as an important aggravating factor for acute kidney injury among childhood diabetic ketoacidosis?

Prabhas P Giri, Shakil Akhtar, Somrita Laha, Rajiv Sinha,

Objectives Although Acute Kidney Injury (AKI) has been described among childhood diabetes ketocidosis (cDKA) there is scarcity of literature on the role of concomitant rhabdomyolysis. Method A retrospective chart review was undertaken (2014-2018) to identify cDKA who developed AKI and had evidence of rhabdomyolysis defined by serum creatine phosphokinase (CPK) > 5 ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, :]

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Steroid Resistant Nephrotic Syndrome with Clumsy Gait Associated With INF2 Mutation.

Rajiv Sinha, Ranit Maiti, Debaditya Das, Kausik Mandal,

Indian Pediatr (Indian pediatrics)
[2020, 57(8):764]

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Modelling water levels of northwestern India in response to improved irrigation use efficiency.

Shashank Shekhar, Suman Kumar, A L Densmore, W M van Dijk, Rajiv Sinha, Manoranjan Kumar, Suneel Kumar Joshi, Shive Prakash Rai, Dewashish Kumar,

The groundwater crisis in northwestern India is the result of over-exploitation of groundwater resources for irrigation. The Government of India has targeted a 20 percent improvement in irrigation groundwater use efficiency. In this perspective, and using a regional-scale calibrated and validated three-dimensional groundwater flow model, this article provides the first ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13452]

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Nutrient and microbial water quality of the upper Ganga River, India: identification of pollution sources.

Michael J Bowes, Daniel S Read, Himanshu Joshi, Rajiv Sinha, Aqib Ansari, Moushumi Hazra, Monica Simon, Rajesh Vishwakarma, Linda K Armstrong, David J E Nicholls, Heather D Wickham, Jade Ward, Laurence R Carvalho, H Gwyn Rees,

The Ganga River is facing mounting environmental pressures due to rapidly increasing human population, urbanisation, industrialisation and agricultural intensification, resulting in worsening water quality, ecological status and impacts on human health. A combined inorganic chemical, algal and bacterial survey (using flow cytometry and 16S rRNA gene sequencing) along the upper ... Read more >>

Environ Monit Assess (Environmental monitoring and assessment)
[2020, 192(8):533]

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An Overview of Rickets in Children.

Rahul Chanchlani, Paul Nemer, Rajiv Sinha, Lena Nemer, Vinod Krishnappa, Etienne Sochett, Fayez Safadi, Rupesh Raina,

Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phosphate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 5(7):980-990]

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Impact of rituximab on anthropometric indices among childhood steroid-dependent nephrotic syndromes.

Rajiv Sinha, Sushmita Banerjee, Anwesha Mukherjee, Shakil Akhtar, Subal Pradhan,

BACKGROUND:There is scarcity of data on impact of rituximab on anthropometrical parameters (weight, height and body mass index i.e. BMI SD score (SDS)) among children with steroid-dependent nephrotic syndromes (SDNS). METHODS:Multicentre retrospective review. RESULTS:102 children with SDNS (male: 63%; n=64), median age 7 (IQR: 4.3-9.6) years, received a total of ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Pediatric Continuous Renal Replacement Therapy (PCRRT) expert committee recommendation on prescribing prolonged intermittent renal replacement therapy (PIRRT) in critically ill children.

Sidharth Kumar Sethi, Aliza Mittal, Nikhil Nair, Arvind Bagga, Arpana Iyenger, Uma Ali, Rajiv Sinha, Indira Agarwal, Marcelo de Sousa Tavares, Asiri Abeyagunawardena, Mohammed Hanif, Devender Shreshtha, Khemchand Moorani, Sadaf Asim, Vijay Kher, Khalid Alhasan, Chebl Mourani, Mohammed Al Riyami, Timothy E Bunchman, Mignon McCulloch, Rupesh Raina,

INTRODUCTION:Recently, prolonged intermittent renal replacement therapies (PIRRT) have emerged as cost-effective alternatives to conventional CRRT and their use in the pediatric population has started to become more prominent. However, there is a lack of consensus guidelines on the use of PIRRT in pediatric patients in an intensive care setting. METHODS:A ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2020, 24(2):237-251]

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Congenital Nephrotic Syndrome in India in the Current Era: A Multicenter Case Series.

Rajiv Sinha, Anil Vasudevan, Indira Agarwal, Sidharth Kumar Sethi, Abhijeet Saha, Subal Pradhan, Sudha Ekambaram, Nilam Thaker, Manoj Matnani, Sushmita Banerjee, Jyoti Sharma, Jyoti Singhal, Shazia Ashraf, Kausik Mandal,

BACKGROUND:There is a paucity of information on epidemiology, diagnosis, and treatment outcomes of congenital nephrotic syndrome (CNS) in developing countries. METHODS:Retrospective (2012-2017) review of case records undertaken across 12 Indian pediatric nephrology centers. RESULTS:Sixty-five children (58% male, median birth weight 2.4 kg [interquartile range (IQR) 2.1-2.86]) were identified with CNS. ... Read more >>

Nephron (Nephron)
[2020, 144(1):21-29]

Cited: 1 time

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Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls.

Sushmita Banerjee, Surupa Basu, Shakil Akhtar, Rajiv Sinha, Ananda Sen, Jayati Sengupta,

INTRODUCTION:Body stores of vitamin D are measured as "total" serum 25-hydroxy vitamin D (25(OH)D). Its largest component is protein bound and lost in urine in nephrotic syndrome (NS). Our study investigates whether "free" 25(OH)D levels are a better guide to bone health and need for vitamin D supplementation in patients ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):447-454]

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Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database.

Mamta Puraswani, Priyanka Khandelwal, Himanshi Saini, Savita Saini, Bahadur Singh Gurjar, Aditi Sinha, Rajashri Pramod Shende, Tushar Kanti Maiti, Abhishek Kumar Singh, Uma Kanga, Uma Ali, Indira Agarwal, Kanav Anand, Narayan Prasad, Padmaraj Rajendran, Rajiv Sinha, Anil Vasudevan, Anita Saxena, Sanjay Agarwal, Pankaj Hari, Arvind Sahu, Satyajit Rath, Arvind Bagga,

Background: Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1282]

Cited: 1 time

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Treatment and long-term outcome in primary distal renal tubular acidosis.

Sergio Camilo Lopez-Garcia, Francesco Emma, Stephen B Walsh, Marc Fila, Nakysa Hooman, Marcin Zaniew, Aurélia Bertholet-Thomas, Giacomo Colussi, Kathrin Burgmaier, Elena Levtchenko, Jyoti Sharma, Jyoti Singhal, Neveen A Soliman, Gema Ariceta, Biswanath Basu, Luisa Murer, Velibor Tasic, Alexey Tsygin, Stéphane Decramer, Helena Gil-Peña, Linda Koster-Kamphuis, Claudio La Scola, Jutta Gellermann, Martin Konrad, Marc Lilien, Telma Francisco, Despoina Tramma, Peter Trnka, Selçuk Yüksel, Maria Rosa Caruso, Milan Chromek, Zelal Ekinci, Giovanni Gambaro, Jameela A Kari, Jens König, Francesca Taroni, Julia Thumfart, Francesco Trepiccione, Louise Winding, Elke Wühl, Ayşe Ağbaş, Anna Belkevich, Rosa Vargas-Poussou, Anne Blanchard, Giovanni Conti, Olivia Boyer, Ismail Dursun, Ayşe Seda Pınarbaşı, Engin Melek, Marius Miglinas, Robert Novo, Andrew Mallett, Danko Milosevic, Maria Szczepanska, Sarah Wente, Hae Il Cheong, Rajiv Sinha, Zoran Gucev, Stephanie Dufek, Daniela Iancu, , Robert Kleta, Franz Schaefer, Detlef Bockenhauer,

BACKGROUND:Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. METHODS:We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. RESULTS:Adequate data were collected on 340 ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(6):981-991]

Cited: 3 times

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Cyclosporine in Resistant Systemic Arthritis - A Cheaper Alternative to Biologics.

Priyankar Pal, Prabhas Prasun Giri, Rajiv Sinha,

OBJECTIVES:To assess the efficacy of cyclosporine (CsA) in patients of oral steroid unresponsive or steroid dependent systemic juvenile idiopathic arthritis (sJIA); to evaluate the optimum dosage and blood level of CsA to achieve and maintain remission and to observe for side-effects on prolonged usage. METHODS:This prospective observational study was conducted ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2019, 86(7):590-594]

Cited: 1 time

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American Academy of Pediatrics Clinical Practice Guidelines for Screening and Management of High Blood Pressure in Children and Adolescents: What is New?

Rajiv Sinha, Abhijeet Saha, Joshua Samuels,

Childhood hypertension has become a significant health concern. There have been a slew of important new findings in this field over the last decade. This has led to an update by the American Academy of Pediatrics of the original recommendation of United States Fourth Working Group on blood pressure. We ... Read more >>

Indian Pediatr (Indian pediatrics)
[2019, 56(4):317-321]

Cited: 1 time

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Renal Tubular Acidosis Presenting as Nephrogenic Diabetes Insipidus.

Debaditya Das, Rajiv Sinha, Subrata Dey,

BACKGROUND:Nephrogenic diabetes insipidus (DI) can be primary or secondary to various causes. CASE CHARACTERISTICS:One child with Fanconi syndrome with proximal renal tubular acidosis (RTA) due to nephropathic cystinosis, and other with Distal RTA with hearing loss. OBSERVATION:Both cases showed features of nephrogenic DI, which resolved after treating the primary pathology. ... Read more >>

Indian Pediatr (Indian pediatrics)
[2019, 56(4):325-327]

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Towards the assessment of sediment connectivity in a large Himalayan river basin.

Kanchan Mishra, Rajiv Sinha, Vikrant Jain, Santosh Nepal, Kabir Uddin,

Sediment connectivity, defined as the degree of linkage between the sediment sources to downstream areas, is one of the most important properties that control landscape evolution in river basins. The degree of linkages amongst different parts of a catchment depends mainly on the hinterland characteristics (e.g. catchment morphology, slope, shape, ... Read more >>

Sci Total Environ (The Science of the total environment)
[2019, 661:251-265]

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Neonatal Acute Kidney Injury: A Survey of Perceptions and Management Strategies Amongst Pediatricians and Neonatologists.

Sidharth Kumar Sethi, Gopal Agrawal, Sanjay Wazir, Smriti Rohatgi, Arpana Iyengar, Ronith Chakraborty, Rahul Jain, Nikhil Nair, Rajiv Sinha, Raktima Chakrabarti, Deepak Kumar, Rupesh Raina,

Background: Neonatal Acute Kidney Injury (AKI) occurs in 40-70% of critically ill newborn infants and is independently associated with increased morbidity and mortality. Understanding the practice patterns of physicians (neonatologists and pediatricians), caring for neonates in India is important to optimize care and outcomes in neonatal AKI. Aim: The aim ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:553]

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Evaluating dynamic hydrological connectivity of a floodplain wetland in North Bihar, India using geostatistical methods.

Manudeo Singh, Rajiv Sinha,

Spatio-temporal connectivity patterns of a wetland as a function of the land use/land cover (LULC) of its catchment have been analysed in a GIS environment. An innovative method has been implemented for mapping 'dynamic hydrological connectivity' for a water-stressed wetland of Kosi-Ganga interfluve area in the middle Ganga Plains, India ... Read more >>

Sci Total Environ (The Science of the total environment)
[2019, 651(Pt 2):2473-2488]

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Modelling impacts of climate change and socio-economic change on the Ganga, Brahmaputra, Meghna, Hooghly and Mahanadi river systems in India and Bangladesh.

Paul G Whitehead, Li Jin, Ian Macadam, Tamara Janes, Sananda Sarkar, Harvey J E Rodda, Rajiv Sinha, Robert J Nicholls,

The Ganga-Brahmaputra-Meghna (GBM) River System, the associated Hooghly River and the Mahanadi River System represent the largest river basins in the world serving a population of over 780 million. The rivers are of vital concern to India and Bangladesh as they provide fresh water for people, agriculture, industry, conservation and ... Read more >>

Sci Total Environ (The Science of the total environment)
[2018, 636:1362-1372]

Cited: 2 times

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Corrigendum to "Modelling Impacts of Climate Change and Socio-Economic Change on the Ganga, Brahmaputra, Meghna, Hooghly and Mahanadi River Systems in India and Bangladesh" [Stoten 636 (2018) 1362-1372].

Paul Whitehead, Li Jin, Ian Macadam, Tamara Janes, Sananda Sarkar, Harvey J E Rodda, Rajiv Sinha, Robert J Nicholls,

Sci Total Environ (The Science of the total environment)
[2018, 644:1651-1652]

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Water quality assessment and catchment-scale nutrient flux modeling in the Ramganga River Basin in north India: An application of INCA model.

Devanshi Pathak, Paul G Whitehead, Martyn N Futter, Rajiv Sinha,

The present study analyzes the water quality characteristics of the Ramganga (a major tributary of the Ganga river) using long-term (1991-2009) monthly data and applies the Integrated Catchment Model of Nitrogen (INCA-N) and Phosphorus (INCA-P) to the catchment. The models were calibrated and validated using discharge (1993-2011), phosphate (1993-2010) and ... Read more >>

Sci Total Environ (The Science of the total environment)
[2018, 631-632:201-215]

Cited: 2 times

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Recurrent UTI - Make the Child Smile!

Rajiv Sinha, Nayan Banerji, Subhasis Saha,

Indian Pediatr (Indian pediatrics)
[2018, 55(2):169]

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Counter-intuitive influence of Himalayan river morphodynamics on Indus Civilisation urban settlements.

Ajit Singh, Kristina J Thomsen, Rajiv Sinha, Jan-Pieter Buylaert, Andrew Carter, Darren F Mark, Philippa J Mason, Alexander L Densmore, Andrew S Murray, Mayank Jain, Debajyoti Paul, Sanjeev Gupta,

Urbanism in the Bronze-age Indus Civilisation (~4.6-3.9 thousand years before the present, ka) has been linked to water resources provided by large Himalayan river systems, although the largest concentrations of urban-scale Indus settlements are located far from extant Himalayan rivers. Here we analyse the sedimentary architecture, chronology and provenance of ... Read more >>

Nat Commun (Nature communications)
[2017, 8(1):1617]

Cited: 5 times

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Feasibility of sustained low efficiency dialysis in critically sick pediatric patients: A multicentric retrospective study.

Sidharth K Sethi, Rajiv Sinha, Pranaw Jha, Nikita Wadhwani, Veena Raghunathan, Maninder Dhaliwal, Shyam B Bansal, Vijay Kher, Valentine Lobo, Jyoti Sharma, Rupesh Raina,

INTRODUCTION:Sustained low-efficiency dialysis (SLED) has emerged as a cost effective alternative to Continuous Renal Replacement Therapy in the management of hemodynamically unstable adult patients with acute kidney injury. The objective of the study was to document the SLED practices in these centers, and to look at the feasibility, and tolerability ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2018, 22(2):228-234]

Cited: 1 time

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Antibiotics for performing voiding cystourethrogram: a randomised control trial.

Rajiv Sinha, Subhasis Saha, Biplab Maji, Yincent Tse,

OBJECTIVE:To assess whether antibiotic reduces voiding cystourethrogram (VCUG)-associated urinary tract infection (UTI). DESIGN:Open-labelled randomised controlled trial. SETTING:Tertiary paediatric nephrology centre. PATIENTS:120 children (age 2 months-5 years) undergoing VCUG. INTERVENTIONS:Children were randomised into group A (antibiotic, n=72) or group B (no antibiotic, n=48) in 3:2 ratio. Group A received oral antibiotic (cephalexin ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2018, 103(3):230-234]

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Yield of Imaging Performed as per Indian Society of Pediatric Nephrology Guidelines in Children with Urinary Tract Infection.

Rajiv Sinha, Devdeep Mukherjee, Jayati Sengupta, Subhasis Saha, Sushmita Banerjee,

OBJECTIVE:To assess yield of imaging performed as per Indian Society of Pediatric Nephrology (ISPN) urinary tract infection (UTI) guideline. METHODS:Ultrasonography (USG), voiding cystourethrography (VCUG) and dimercaptosuccinic-acid (DMSA) scintigraphy were performed in 183 children (age 0-5y) with first episode (age 0-1y) of UTI or recurrent (age <5y) UTI, as per ISPN ... Read more >>

Indian Pediatr (Indian pediatrics)
[2017, 54(9):749-751]

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