Full Text Journal Articles by
Author Rajit K Basu

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Kidney support therapy in the pediatric patient: Unique considerations for a unique population.

David Askenazi, Rajit K Basu,

The use of kidney support therapy (KST) for use in managing patients with acute kidney injury (AKI) has expanded greatly in the last several decades. The growing use of KST modalities in children, and now in neonates, has been associated with opportunities for education, clinical research, clinical practice improvements, and ... Read more >>

Semin Dial (Seminars in dialysis)
[2021, :]

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Severe acute respiratory syndrome coronavirus 2 infection and critically ill children.

Rahul Damania, Whitney Moore, Heather C Viamonte, Pradip Kamat, Rajit K Basu,

<h4>Purpose of review</h4>Amidst an ongoing pandemic, the delineation of the pediatric consequence of infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus is emerging. This review summarizes available pediatric data and covers the aspects of epidemiology, critical illness with acute infection [coronavirus disease 2019 (COVID-19)], the discovered ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):286-291]

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Non-resuscitation fluid in excess of hydration requirements is associated with higher mortality in critically ill children.

Matthew F Barhight, Delphine Nelson, Grace Chong, Rajit K Basu, L Nelson Sanchez-Pinto,

<h4>Background</h4>Large volumes of non-resuscitation fluids are often administered to critically ill children. We hypothesize that excess maintenance fluid is a significant contributor to non-resuscitation fluid and that non-resuscitation fluid administered beyond hydration requirements is associated with worse clinical outcomes in critically ill children.<h4>Methods</h4>We evaluated all patients admitted to two large ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Consensus acute kidney injury criteria integration identifies children at risk for long-term kidney dysfunction after multiple organ dysfunction syndrome.

Stephen M Gorga, Erin F Carlton, Joseph G Kohne, Ryan P Barbaro, Rajit K Basu,

<h4>Background</h4>The consensus definition of acute kidney injury (AKI) has evolved since developing the original multiple organ dysfunction syndrome (MODS) definitions. Whether or not risk for adverse short- and long-term outcomes can be identified using the refined AKI criteria in the setting of MODS has not been studied. We hypothesize that ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(6):1637-1646]

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Predicting presumed serious infection among hospitalized children on central venous lines with machine learning.

Azade Tabaie, Evan W Orenstein, Shamim Nemati, Rajit K Basu, Swaminathan Kandaswamy, Gari D Clifford, Rishikesan Kamaleswaran,

<h4>Background</h4>Presumed serious infection (PSI) is defined as a blood culture drawn and new antibiotic course of at least 4 days among pediatric patients with Central Venous Lines (CVLs). Early PSI prediction and use of medical interventions can prevent adverse outcomes and improve the quality of care.<h4>Methods</h4>Clinical features including demographics, laboratory ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2021, 132:104289]

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Clinical phenotypes of acute kidney injury are associated with unique outcomes in critically ill septic children.

Rajit K Basu, Richard Hackbarth, Scott Gillespie, Ayse Akcan-Arikan, Patrick Brophy, Sean Bagshaw, Rashid Alobaidi, Stuart L Goldstein,

<h4>Background</h4>Assessment of acute kidney injury (AKI) in septic patients remains imprecise. In adults, the classification of septic patients by clinical AKI phenotypes (severity and timing) demonstrates unique associations with patient outcome vs. broadly defined AKI.<h4>Methods</h4>In a multinational prospective observational study, AKI diagnosis in critically ill septic children was stratified by ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately.

Heidi J Murphy, Jason Gien, Rashmi Sahay, Eileen King, David T Selewski, Brian C Bridges, David S Cooper, Geoffrey M Fleming, Matthew L Paden, Michael Zappitelli, Katja M Gist, Rajit K Basu, Jennifer G Jetton, David Askenazi,

<h4>Introduction</h4>We aimed to characterize acute kidney injury (AKI), fluid overload (FO), and renal replacement therapy (RRT) utilization by diagnostic categories and examine associations between these complications and mortality by category.<h4>Methods</h4>To test our hypotheses, we conducted a retrospective multicenter, cohort study including 446 neonates (categories: 209 with cardiac disease, 114 with ... Read more >>

Blood Purif (Blood purification)
[2021, :1-10]

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Quality improvement goals for pediatric acute kidney injury: pediatric applications of the 22nd Acute Disease Quality Initiative (ADQI) conference.

David T Selewski, David J Askenazi, Kianoush Kashani, Rajit K Basu, Katja M Gist, Matthew W Harer, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Claudio Ronco, Stuart L Goldstein, Theresa Ann Mottes,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(4):733-746]

Cited: 1 time

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Survey of Current Practices of Outpatient Hemodialysis for AKI Patients.

Victor Ortiz-Soriano, Catherine R Butler, Marla Levy, Sarah C Huen, Jorge L Castaneda, Ankit Sakhuja, Rajit K Basu, Kathleen D Liu, Jorge Cerda, Javier A Neyra,

Kidney Int Rep (Kidney international reports)
[2021, 6(4):1156-1160]

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Use of the Selective Cytopheretic Device in Critically Ill Children.

Stuart L Goldstein, David J Askenazi, Rajit K Basu, David T Selewski, Matthew L Paden, Kelli A Krallman, Cassie L Kirby, Theresa A Mottes, Tara Terrell, H David Humes,

<h4>Introduction</h4>Critically ill children with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT) are at increased risk of death. The selective cytopheretic device (SCD) promotes an immunomodulatory effect when circuit ionized calcium (iCa<sup>2+</sup>) is maintained at <0.40 mmol/l with regional citrate anticoagulation (RCA). In a randomized trial of adult patients ... Read more >>

Kidney Int Rep (Kidney international reports)
[2021, 6(3):775-784]

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Timing of Fluid Overload and Association With Patient Outcome.

Lisa Lima, Shina Menon, Stuart L Goldstein, Rajit K Basu,

<h4>Objectives</h4>To determine if the timing of excess fluid accumulation (fluid overload) is associated with adverse patient outcomes.<h4>Design</h4>Secondary analysis of a prospectively collected dataset.<h4>Setting</h4>PICU of a tertiary care hospital.<h4>Patients</h4>Children 3 months to 25 years old admitted to the PICU with expected length of stay greater than or equal to 48 hours.<h4>Interventions</h4>Patients ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):114-124]

Cited: 0 times

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A Universal, Trauma-Informed Approach to Pediatric Hospital Medicine.

A Monica Agoston, Rajit K Basu, Sarah Nelson,

Hosp Pediatr (Hospital pediatrics)
[2020, 10(11):1017-1019]

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Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis.

Erica C Bjornstad, Kelli A Krallman, David Askenazi, Michael Zappitelli, Stuart L Goldstein, Rajit K Basu, ,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(3):446-448]

Cited: 2 times

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Improving the quality of neonatal acute kidney injury care: neonatal-specific response to the 22nd Acute Disease Quality Initiative (ADQI) conference.

Matthew W Harer, David T Selewski, Kianoush Kashani, Rajit K Basu, Katja M Gist, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Stuart L Goldstein, Theresa Ann Mottes, David J Askenazi,

With the adoption of standardized neonatal acute kidney injury (AKI) definitions over the past decade and the concomitant surge in research studies, the epidemiology of and risk factors for neonatal AKI have become much better understood. Thus, there is now a need to focus on strategies designed to improve AKI ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, 41(2):185-195]

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Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C).

Christina A Rostad, Ann Chahroudi, Grace Mantus, Stacey A Lapp, Mehgan Teherani, Lisa Macoy, Keiko M Tarquinio, Rajit K Basu, Carol Kao, W Matthew Linam, Matthew G Zimmerman, Pei-Yong Shi, Vineet D Menachery, Matthew E Oster, Srilatha Edupuganti, Evan J Anderson, Mehul S Suthar, Jens Wrammert, Preeti Jaggi,

<h4>Objectives</h4>We aimed to measure severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological responses in children hospitalized with multisystem inflammatory syndrome in children (MIS-C) compared with those with coronavirus disease 2019 (COVID-19), those with Kawasaki disease (KD), and hospitalized pediatric controls.<h4>Methods</h4>From March 17, 2020, to May 26, 2020, we prospectively identified ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(6):]

Cited: 9 times

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Severe Kidney Injury and Sepsis: A Long Road to an Incomplete Recovery.

Zaccaria Ricci, Rajit K Basu,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):849-850]

Cited: 0 times

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The impact of biomarkers of acute kidney injury on individual patient care.

Jay L Koyner, Alexander Zarbock, Rajit K Basu, Claudio Ronco,

Acute kidney injury (AKI) remains a common clinical syndrome associated with increased morbidity and mortality. In the last several years there have been several advances in the identification of patients at increased risk for AKI through the use of traditional and newer functional and damage biomarkers of AKI. This article ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(8):1295-1305]

Cited: 5 times

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Fluid Accumulation in Critically Ill Children.

Rashid Alobaidi, Rajit K Basu, Allan DeCaen, Ari R Joffe, Laurance Lequier, Neesh Pannu, Sean M Bagshaw,

OBJECTIVES:To describe the characteristics of fluid accumulation in critically ill children and evaluate the association between the degree, timing, duration, and rate of fluid accumulation and patient outcomes. DESIGN:Retrospective cohort study. SETTING:PICUs in Alberta, Canada. PATIENTS:All children admitted to PICU in Alberta, Canada, between January 1, 2015, and December 31, ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(7):1034-1041]

Cited: 0 times

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Weight as a Risk Factor for Mortality in Critically Ill Patients.

Itay Ayalon, Jessica G Woo, Rajit K Basu, Ahmad Kaddourah, Stuart L Goldstein, Jennifer M Kaplan, ,

OBJECTIVES:To explore the hypothesis that obesity is associated with increased mortality and worse outcomes in children who are critically ill. METHODS:Secondary analysis of the Assessment of Worldwide Acute Kidney Injury, Renal Angina, and Epidemiology study, a prospective, multinational observational study. Patients between 3 months and 25 years across Asia, Australia, ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(2):]

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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady,

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, 16(8):471-482]

Cited: 2 times

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Assessment of the Independent and Synergistic Effects of Fluid Overload and Acute Kidney Injury on Outcomes of Critically Ill Children.

Katja M Gist, David T Selewski, John Brinton, Shina Menon, Stuart L Goldstein, Rajit K Basu,

<h4>Objectives</h4>Evaluate the independent and synergistic associations of fluid overload and acute kidney injury with outcome in critically ill pediatric patients.<h4>Design</h4>Secondary analysis of the Acute Kidney Injury in Children Expected by Renal Angina and Urinary Biomarkers (NCT01735162) prospective observational study.<h4>Setting</h4>Single-center quaternary level PICU.<h4>Patients</h4>One-hundred forty-nine children 3 months to 25 years old ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(2):170-177]

Cited: 1 time

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Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy: a multicenter retrospective cohort study.

Stephen M Gorga, Rashmi D Sahay, David J Askenazi, Brian C Bridges, David S Cooper, Matthew L Paden, Michael Zappitelli, Katja M Gist, Jason Gien, Rajit K Basu, Jennifer G Jetton, Heidi J Murphy, Eileen King, Geoffrey M Fleming, David T Selewski,

<h4>Objective</h4>The aim of this study was to characterize continuous renal replacement therapy (CRRT) utilization on extracorporeal membrane oxygenation (ECMO) and to determine the association of both fluid overload (FO) at CRRT initiation and fluid removal during CRRT with mortality in a large multicenter cohort.<h4>Methods</h4>Retrospective chart review of all children < 18 years ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(5):871-882]

Cited: 2 times

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Early prediction of pediatric acute kidney injury from the emergency department: A pilot study.

Holly R Hanson, Michael A Carlisle, Rachel S Bensman, Terri Byczkowski, Holly Depinet, Tara C Terrell, Hilary Pitner, Ryan Knox, Stuart L Goldstein, Rajit K Basu,

<h4>Background</h4>Identifying acute kidney injury (AKI) early can inform medical decisions key to mitigation of injury. An AKI risk stratification tool, the renal angina index (RAI), has proven better than creatinine changes alone at predicting AKI in critically ill children.<h4>Objective</h4>To derive and test performance of an "acute" RAI (aRAI) in the ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2021, 40:138-144]

Cited: 1 time

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Combining biomarkers for acute kidney injury, moving forward with integration.

Rajit K Basu,

J Crit Care (Journal of critical care)
[2019, 54:282]

Cited: 0 times

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