Full Text Journal Articles by
Author Rajit K Basu

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Renal angina index predicts fluid overload in critically ill children: an observational cohort study.

Stephen M Gorga, Erin F Carlton, Joseph G Kohne, Ryan P Barbaro, Rajit K Basu,

<h4>Background</h4>Fluid overload and acute kidney injury are common and associated with poor outcomes among critically ill children. The prodrome of renal angina stratifies patients by risk for severe acute kidney injury, but the predictive discrimination for fluid overload is unknown.<h4>Methods</h4>Post-hoc analysis of patients admitted to a tertiary care pediatric intensive ... Read more >>

BMC Nephrol (BMC nephrology)
[2021, 22(1):336]

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Deep Learning Model to Predict Serious Infection Among Children With Central Venous Lines.

Azade Tabaie, Evan W Orenstein, Shamim Nemati, Rajit K Basu, Gari D Clifford, Rishikesan Kamaleswaran,

<b>Objective:</b> Predict the onset of presumed serious infection, defined as a positive blood culture drawn and new antibiotic course of at least 4 days (PSI<sup>*</sup>), among pediatric patients with Central Venous Lines (CVLs). <b>Design:</b> Retrospective cohort study. <b>Setting:</b> Single academic children's hospital. <b>Patients:</b> All hospital encounters from January 2013 to ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:726870]

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Cumulative Application of Creatinine and Urine Output Staging Optimizes the Kidney Disease: Improving Global Outcomes Definition and Identifies Increased Mortality Risk in Hospitalized Patients With Acute Kidney Injury.

Scott M Sutherland, Ahmad Kaddourah, Scott E Gillespie, Danielle E Soranno, Robert P Woroniecki, Rajit K Basu, Michael Zappitelli, ,

<h4>Objectives</h4>Acute kidney injury is diagnosed according to creatinine and urine output criteria. Traditionally, both are applied, and a severity stage (1-3) is conferred based upon the more severe of the two; information from the other criteria is discarded. Physiologically, however, rising creatinine and oliguria represent two distinct types of renal ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1912-1922]

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Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study.

Katja M Gist, Andrew Misfeldt, Rashmi D Sahay, Stephen M Gorga, David J Askenazi, Brian C Bridges, Matthew L Paden, Michael Zappitelli, Jason Gien, Rajit K Basu, Jennifer G Jetton, Heidi J Murphy, Eileen King, Geoffrey M Fleming, David T Selewski, David S Cooper,

Acute kidney injury (AKI) and fluid overload (FO) are common complications of extracorporeal membrane oxygenation (ECMO). The purpose of this study was to characterize AKI and FO in children receiving extracorporeal cardiopulmonary resuscitation (eCPR). We performed a multicenter retrospective study of children who received eCPR. AKI was assessed during ECMO ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Prevention of Acute Kidney Injury after Cardiac Surgery: When Fixing Broken Hearts, Is Breaking Kidneys Avoidable?

Rajit K Basu, Katja M Gist,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(10):1459-1461]

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Controversies in paediatric acute kidney injury and continuous renal replacement therapy: can paediatric care lead the way to precision acute kidney injury medicine?

Natalja L Stanski, Dana Fuhrman, Rajit K Basu,

<h4>Purpose of review</h4>Paediatric patients represent a unique challenge for providers managing acute kidney injury (AKI). Critical care for these children requires a precise approach to assessment, diagnostics and management.<h4>Recent findings</h4>Primarily based on observational data, large epidemiologic datasets have demonstrated a strong association between AKI prevalence (one in four critically ill ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2021, :]

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Acute kidney injury in critically Ill children and young adults with suspected SARS-CoV2 infection.

Rajit K Basu, Erica C Bjornstad, Katja M Gist, Michelle Starr, Paras Khandhar, Rahul Chanchlani, Kelli A Krallman, Michael Zappitelli, David Askenazi, Stuart L Goldstein, ,

<h4>Background</h4>We aimed to study the association of suspected versus confirmed infection with the novel SARS-CoV2 virus with the prevalence of acute kidney injury (AKI) in critically ill children.<h4>Methods</h4>Sequential point-prevalence study of children and young adults aged 7 days to 25 years admitted to intensive care units under investigation for SARS-CoV2 ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Transient and persistent acute kidney injury phenotypes following the Norwood operation: a retrospective study.

Katja M Gist, Santiago Borasino, Megan SooHoo, Danielle E Soranno, Emily Mack, Kristal M Hock, A K M Fazlur Rahman, John T Brinton, Rajit K Basu, Jeffrey A Alten,

<h4>Background</h4>Acute kidney injury is a common complication following the Norwood operation. Most neonatal studies report acute kidney injury peaking within the first 48 hours after cardiac surgery. The aim of this study was to evaluate if persistent acute kidney injury (>48 postoperative hours) after the Norwood operation was associated with ... Read more >>

Cardiol Young (Cardiology in the young)
[2021, :1-8]

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Kidney support therapy in the pediatric patient: Unique considerations for a unique population.

David Askenazi, Rajit K Basu,

The use of kidney support therapy (KST) for use in managing patients with acute kidney injury (AKI) has expanded greatly in the last several decades. The growing use of KST modalities in children, and now in neonates, has been associated with opportunities for education, clinical research, clinical practice improvements, and ... Read more >>

Semin Dial (Seminars in dialysis)
[2021, :]

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Severe acute respiratory syndrome coronavirus 2 infection and critically ill children.

Rahul Damania, Whitney Moore, Heather C Viamonte, Pradip Kamat, Rajit K Basu,

<h4>Purpose of review</h4>Amidst an ongoing pandemic, the delineation of the pediatric consequence of infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus is emerging. This review summarizes available pediatric data and covers the aspects of epidemiology, critical illness with acute infection [coronavirus disease 2019 (COVID-19)], the discovered ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):286-291]

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Altered amino acid profile in patients with SARS-CoV-2 infection.

Chris A Rees, Christina A Rostad, Grace Mantus, Evan J Anderson, Ann Chahroudi, Preeti Jaggi, Jens Wrammert, Juan B Ochoa, Augusto Ochoa, Rajit K Basu, Stacy Heilman, Frank Harris, Stacey A Lapp, Laila Hussaini, Miriam B Vos, Lou Ann Brown, Claudia R Morris,

Low plasma arginine bioavailability has been implicated in endothelial dysfunction and immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to cellular damage if low. Our objective was to determine arginine bioavailability in adults and children with COVID-19 vs. healthy controls. We hypothesized that arginine bioavailability ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(25):]

Cited: 4 times

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Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group.

Stephen M Gorga, Lisa Lima, David J Askenazi, Brian C Bridges, David S Cooper, Matthew L Paden, Michael Zappitelli, Katja M Gist, Jason Gien, Jennifer G Jetton, Heidi J Murphy, Geoffrey M Fleming, David T Selewski, Rajit K Basu,

Fluid overload (FO) and acute kidney injury (AKI) occur commonly in children supported with extracorporeal membrane oxygenation (ECMO). Continuous renal replacement therapy (CRRT) may be used to manage AKI and FO in children on ECMO. In 2012, our group surveyed ECMO centers to begin to understand the practice patterns around ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Recalibration of the Renal Angina Index for Pediatric Septic Shock.

Natalja L Stanski, Hector R Wong, Rajit K Basu, Natalie Z Cvijanovich, Julie C Fitzgerald, Scott L Weiss, Michael T Bigham, Parag N Jain, Adam Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L Allen, Neal J Thomas, Jocelyn R Grunwell, Michael Quasney, Bereketeab Haileselassie, Lakhmir S Chawla, Stuart L Goldstein,

<h4>Introduction</h4>Sepsis-associated acute kidney injury (AKI) is a common diagnosis in children that is associated with poor outcomes. The lack of therapeutic options once present makes early identification of at-risk patients essential. The renal angina index (RAI) has been previously validated to predict severe AKI in heterogeneous populations of critically ill ... Read more >>

Kidney Int Rep (Kidney international reports)
[2021, 6(7):1858-1867]

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Non-resuscitation fluid in excess of hydration requirements is associated with higher mortality in critically ill children.

Matthew F Barhight, Delphine Nelson, Grace Chong, Rajit K Basu, L Nelson Sanchez-Pinto,

<h4>Background</h4>Large volumes of non-resuscitation fluids are often administered to critically ill children. We hypothesize that excess maintenance fluid is a significant contributor to non-resuscitation fluid and that non-resuscitation fluid administered beyond hydration requirements is associated with worse clinical outcomes in critically ill children.<h4>Methods</h4>We evaluated all patients admitted to two large ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Consensus acute kidney injury criteria integration identifies children at risk for long-term kidney dysfunction after multiple organ dysfunction syndrome.

Stephen M Gorga, Erin F Carlton, Joseph G Kohne, Ryan P Barbaro, Rajit K Basu,

<h4>Background</h4>The consensus definition of acute kidney injury (AKI) has evolved since developing the original multiple organ dysfunction syndrome (MODS) definitions. Whether or not risk for adverse short- and long-term outcomes can be identified using the refined AKI criteria in the setting of MODS has not been studied. We hypothesize that ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(6):1637-1646]

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Predicting presumed serious infection among hospitalized children on central venous lines with machine learning.

Azade Tabaie, Evan W Orenstein, Shamim Nemati, Rajit K Basu, Swaminathan Kandaswamy, Gari D Clifford, Rishikesan Kamaleswaran,

<h4>Background</h4>Presumed serious infection (PSI) is defined as a blood culture drawn and new antibiotic course of at least 4 days among pediatric patients with Central Venous Lines (CVLs). Early PSI prediction and use of medical interventions can prevent adverse outcomes and improve the quality of care.<h4>Methods</h4>Clinical features including demographics, laboratory ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2021, 132:104289]

Cited: 1 time

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Clinical phenotypes of acute kidney injury are associated with unique outcomes in critically ill septic children.

Rajit K Basu, Richard Hackbarth, Scott Gillespie, Ayse Akcan-Arikan, Patrick Brophy, Sean Bagshaw, Rashid Alobaidi, Stuart L Goldstein,

<h4>Background</h4>Assessment of acute kidney injury (AKI) in septic patients remains imprecise. In adults, the classification of septic patients by clinical AKI phenotypes (severity and timing) demonstrates unique associations with patient outcome vs. broadly defined AKI.<h4>Methods</h4>In a multinational prospective observational study, AKI diagnosis in critically ill septic children was stratified by ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

Cited: 1 time

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Survey of Current Practices of Outpatient Hemodialysis for AKI Patients.

Victor Ortiz-Soriano, Catherine R Butler, Marla Levy, Sarah C Huen, Jorge L Castaneda, Ankit Sakhuja, Rajit K Basu, Kathleen D Liu, Jorge Cerda, Javier A Neyra,

Kidney Int Rep (Kidney international reports)
[2021, 6(4):1156-1160]

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Quality improvement goals for pediatric acute kidney injury: pediatric applications of the 22nd Acute Disease Quality Initiative (ADQI) conference.

David T Selewski, David J Askenazi, Kianoush Kashani, Rajit K Basu, Katja M Gist, Matthew W Harer, Jennifer G Jetton, Scott M Sutherland, Michael Zappitelli, Claudio Ronco, Stuart L Goldstein, Theresa Ann Mottes,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(4):733-746]

Cited: 2 times

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Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately.

Heidi J Murphy, Jason Gien, Rashmi Sahay, Eileen King, David T Selewski, Brian C Bridges, David S Cooper, Geoffrey M Fleming, Matthew L Paden, Michael Zappitelli, Katja M Gist, Rajit K Basu, Jennifer G Jetton, David Askenazi,

<h4>Introduction</h4>We aimed to characterize acute kidney injury (AKI), fluid overload (FO), and renal replacement therapy (RRT) utilization by diagnostic categories and examine associations between these complications and mortality by category.<h4>Methods</h4>To test our hypotheses, we conducted a retrospective multicenter, cohort study including 446 neonates (categories: 209 with cardiac disease, 114 with ... Read more >>

Blood Purif (Blood purification)
[2021, 50(6):808-817]

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Timing of Fluid Overload and Association With Patient Outcome.

Lisa Lima, Shina Menon, Stuart L Goldstein, Rajit K Basu,

<h4>Objectives</h4>To determine if the timing of excess fluid accumulation (fluid overload) is associated with adverse patient outcomes.<h4>Design</h4>Secondary analysis of a prospectively collected dataset.<h4>Setting</h4>PICU of a tertiary care hospital.<h4>Patients</h4>Children 3 months to 25 years old admitted to the PICU with expected length of stay greater than or equal to 48 hours.<h4>Interventions</h4>Patients ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(1):114-124]

Cited: 2 times

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A Universal, Trauma-Informed Approach to Pediatric Hospital Medicine.

A Monica Agoston, Rajit K Basu, Sarah Nelson,

Hosp Pediatr (Hospital pediatrics)
[2020, 10(11):1017-1019]

Cited: 0 times

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Use of the Selective Cytopheretic Device in Critically Ill Children.

Stuart L Goldstein, David J Askenazi, Rajit K Basu, David T Selewski, Matthew L Paden, Kelli A Krallman, Cassie L Kirby, Theresa A Mottes, Tara Terrell, H David Humes,

<h4>Introduction</h4>Critically ill children with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT) are at increased risk of death. The selective cytopheretic device (SCD) promotes an immunomodulatory effect when circuit ionized calcium (iCa<sup>2+</sup>) is maintained at <0.40 mmol/l with regional citrate anticoagulation (RCA). In a randomized trial of adult patients ... Read more >>

Kidney Int Rep (Kidney international reports)
[2021, 6(3):775-784]

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Early Sequential Risk Stratification Assessment to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury: Taking Focus 2 Process Article.

Jean-Philippe Roy, Kelli A Krallman, Rajit K Basu, Ranjit S Chima, Lin Fei, Sarah Wilder, Alexandra Schmerge, Bradley Gerhardt, Kaylee Fox, Cassie Kirby, Stuart L Goldstein,

<h4>Background</h4>Acute Kidney Injury (AKI) is common in critically ill children and is associated with increased morbidity and mortality. Recognition and management of AKI is often delayed, predisposing patients to risk of clinically significant fluid accumulation (Fluid Overload (FO)). Early recognition and intervention in high risk patients could decrease fluid associated ... Read more >>

J Clin Trials (Journal of clinical trials)
[2020, 10(6):]

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Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis.

Erica C Bjornstad, Kelli A Krallman, David Askenazi, Michael Zappitelli, Stuart L Goldstein, Rajit K Basu, ,

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(3):446-448]

Cited: 10 times

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