Full Text Journal Articles by
Author Rainer M Bohle

Advertisement

Find full text journal articles






Noninferiority of Monoparametric MRI Versus Multiparametric MRI for the Detection of Prostate Cancer: Diagnostic Accuracy of ADC Ratios Based on Advanced "Zoomed" Diffusion-Weighted Imaging.

Paul Raczeck, Felix Frenzel, Tobias Woerner, Stefan Graeber, Rainer M Bohle, Gesa Ziegler, Arno Buecker, Guenther K Schneider,

<h4>Objectives</h4>The aim of this study was to compare the diagnostic accuracy of apparent diffusion coefficient (ADC) ratios as a monoparametric magnetic resonance imaging (MRI) protocol for the detection of prostate cancer (PCa) with the established multiparametric (mp) MRI at 3.0 T.<h4>Materials and methods</h4>According to power analysis, 52 male patients were ... Read more >>

Invest Radiol (Investigative radiology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas.

Sylvia Hartmann, Sonja Scharf, Yvonne Steiner, Andreas G Loth, Emmanuel Donnadieu, Nadine Flinner, Viola Poeschel, Stephanie Angel, Moritz Bewarder, Julia Bein, Uta Brunnberg, Alessandro Bozzato, Bernhard Schick, Stephan Stilgenbauer, Rainer M Bohle, Lorenz Thurner, Martin-Leo Hansmann,

Profound knowledge exists about the clinical, morphologic, genomic, and transcriptomic characteristics of most lymphoma entities. However, information is currently lacking on the dynamic behavior of malignant lymphomas. This pilot study aimed to gain insight into the motility of malignant lymphomas and bystander cells in 20 human lymph nodes. Generally, B ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(20):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Simultaneous Bilateral Primary Occlusion of the Ophthalmic Artery due to Florid Giant Cell Arteritis.

Tim Berger, Kassandra Xanthopoulou, Elena Zemova, Rainer M Bohle, Berthold Seitz, Alaadin Abdin,

<h4>Purpose</h4>To report a case of simultaneous bilateral ophthalmic artery occlusion in diagnosed giant cell arteritis (GCA).<h4>Observations</h4>A 77-year-old male patient presented to the emergency department with simultaneous vision loss in both eyes for 3 hours. Headache at both temples and jaw claudication had been present for 3 weeks. Laboratory values demonstrated ... Read more >>

Klin Monbl Augenheilkd (Klinische Monatsblatter fur Augenheilkunde)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Severe aortic wall degeneration after aortic wrapping.

Tristan Ehrlich, Jan M Federspiel, Rainer M Bohle, Hans-Joachim Schäfers,

We report a case in whom aortic wrapping had been performed for aortic dilatation. Ten years later, further progression of aortic root diameter was documented (root size of 66 mm). We performed complete replacement of the proximal aorta. Macroscopically and microscopically, there was extreme degeneration and thinning of the aorta under ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2021, 60(2):425-427]

Cited: 0 times

View full text PDF listing >>



miRNA Expression Characterizes Histological Subtypes and Metastasis in Penile Squamous Cell Carcinoma.

Hiresh Ayoubian, Joana Heinzelmann, Sebastian Hölters, Oybek Khalmurzaev, Alexey Pryalukhin, Philine Loertzer, Julia Heinzelbecker, Stefan Lohse, Carol Geppert, Hagen Loertzer, Heiko Wunderlich, Rainer M Bohle, Michael Stöckle, Vsevolod Borisovich Matveev, Arndt Hartmann, Kerstin Junker,

Although microRNAs are described as promising biomarkers in many tumor types, little is known about their role in PSCC. Thus, we attempted to identify miRNAs involved in tumor development and metastasis in distinct histological subtypes considering the impact of HPV infection. In a first step, microarray analyses were performed on ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

Cited: 1 time

View full text PDF listing >>



Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD.

Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph Beisswenger,

Chronic obstructive lung disease (COPD) and lung cancer are both caused by smoking and often occur as comorbidity. The programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) axis is an important canonic immunoregulatory pathway, and antibodies that specifically block PD-1 or PD-L1 have demonstrated efficacy as therapeutic agents ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2021, 320(5):L958-L968]

Cited: 1 time

View full text PDF listing >>



Robotic Salvage Lymph Node Dissection in Recurrent Prostate Cancer: Lessons Learned from 68 Cases and Implications for Future Clinical Management.

Johannes Linxweiler, Jan Sprenk, Katerina Cascetta, Alexej Pryalukhin, Sebastian Hölters, Philip Zeuschner, Alessandro Nini, Zaid Al-Kailani, Samer Ezziddin, Rainer M Bohle, Peter Fries, Carsten H Ohlmann, Julia Heinzelbecker, Stefan Siemer, Michael Stöckle, Kerstin Junker, Matthias Saar,

<h4>Purpose</h4>Salvage lymph node dissection is a rescue treatment for patients with nodal recurrence after radical prostatectomy. Very limited data are available on robotic salvage lymph node dissection. Our purpose was to investigate perioperative and oncological outcomes of robotic salvage lymph node dissection in a large monocentric series.<h4>Materials and methods</h4>Perioperative data, ... Read more >>

J Urol (The Journal of urology)
[2021, 206(1):88-96]

Cited: 0 times

View full text PDF listing >>



Pulmonary vasculitis due to infection with Mycobacterium goodii: A case report.

Elena Pfeuffer-Jovic, Jan Heyckendorf, Udo Reischl, Rainer M Bohle, Thorsten Bley, Andreas Buck, Heinrike Wilkens, Hans-Joachim Schäfers, Heinz-Jakob Langen, Matthias Held,

A 57-year-old Caucasian woman suffered from dyspnea on exertion. One year following a supposed pulmonary embolism event, a chronic thromboembolic vasculopathy was diagnosed and a pulmonary thromboendarterectomy was performed. However, a granulomatous pulmonary arterial vasculitis was identified upon examination. DNA of Mycobacterium goodii was detected as the most likely causative ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 104:178-180]

Cited: 0 times

View full text PDF listing >>



A 71-Year-Old Man With Chest Pain and a Solitary Pulmonary Mass.

Cihan Papan, Frank Langer, Jörg T Bittenbring, Hans-Joachim Schäfers, Rainer M Bohle, Peter Fries, Sören L Becker,

<h4>Case presentation</h4>A 71-year-old man was admitted to our hospital because of diffuse chest pain and a mass on routine chest radiography. He did not report cough, dyspnea, fever, night sweats, or weight loss. His medical history was remarkable for chronic lymphocytic leukemia diagnosed 13 years before presentation, and secondary myelodysplastic ... Read more >>

Chest (Chest)
[2020, 158(3):e123-e126]

Cited: 0 times

View full text PDF listing >>



The metastatic potential of seminomatous germ cell tumours is associated with a specific microRNA pattern.

Simone Ernst, Joana Heinzelmann, Rainer M Bohle, Georg Weber, Michael Stöckle, Kerstin Junker, Julia Heinzelbecker,

<h4>Background</h4>Seminomatous germ cell tumours (SGCT) are the most frequent malignancy in young men. Reliable prognostic biomarkers for the prediction of metastasis at diagnosis and the risk of relapse in clinical stage I (CSI) are lacking. Adjuvant therapies carry a risk of overtreatment, whereas salvage therapies have a risk of high ... Read more >>

Andrology (Andrology)
[2020, 8(6):1687-1698]

Cited: 1 time

View full text PDF listing >>



Changing Trends in Penetrating Keratoplasty Indications between 2011 and 2018 - Histopathology of 2123 Corneal Buttons in a Single Center in Germany.

Milán Tamás Pluzsik, Berthold Seitz, Fidelis A Flockerzi, Achim Langenbucher, Gábor Tóth, Rainer M Bohle, Nóra Szentmáry,

<b>Purpose</b>: To analyse the changing trends in penetrating keratoplasty indications between January 2011 and December 2018, at the Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany. <b>Patients and Methods</b>: This is a retrospective review of 2123 corneal buttons of 1776 patients (1993 eyes, 56.0% males, age at the time ... Read more >>

Curr Eye Res (Current eye research)
[2020, 45(10):1199-1204]

Cited: 1 time

View full text PDF listing >>



Crosstalk of estrogen receptors and Wnt/β-catenin signaling in endometrial cancer.

Mariz Kasoha, Chrisoula Dernektsi, Anita Seibold, Rainer M Bohle, Zoltan Takacs, Iordache Ioan-Iulian, Erich-Franz Solomayer, Ingolf Juhasz-Böss,

<h4>Purpose</h4>To investigate the interaction between Wnt/β-catenin and estrogen signaling pathways in endometrial cancer (EC).<h4>Methods</h4>119 women were involved in this study, including 65 women with histologically confirmed EC and 54 healthy women as a control group. Serum protein levels of Dkk1 were measured using ELISA. Protein expression levels of Dkk1, β-catenin, ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(2):315-327]

Cited: 2 times

View full text PDF listing >>



Preoperative morphological diagnosis of axillary lymph nodes in a breast center consultation service: evaluation of fine-needle aspiration and core biopsy techniques.

Georg-Peter Breitbach, Julia Helen Uhlmann, Rainer M Bohle, Ingolf Juhasz-Böss, Barbara Linxweiler, Ferenc Zoltan Takacs, Erich-Franz Solomayer, Stephanie Juhasz-Böss,

PURPOSE:Preoperative routine examination of axillary lymph nodes (ALN) in breast cancer patients is carried out physically and by ultrasound imaging; unsuspicious nodes will lead to a sentinel node (SN) procedure, suspicious ones require axillary dissection (AD). Pre-operative biopsy techniques like fine needle aspiration (FNA) or core biopsy (CB) may reduce ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2019, 300(6):1659-1670]

Cited: 0 times

View full text PDF listing >>



4-miRNA Score Predicts the Individual Metastatic Risk of Renal Cell Carcinoma Patients.

Joana Heinzelmann, Madeleine Arndt, Ramona Pleyers, Tobias Fehlmann, Sebastian Hoelters, Philip Zeuschner, Alexander Vogt, Alexey Pryalukhin, Elke Schaeffeler, Rainer M Bohle, Mieczyslaw Gajda, Martin Janssen, Michael Stoeckle, Kerstin Junker,

BACKGROUND:In order to improve individual prognostication as well as stratification for adjuvant therapy in patients with clinically localized clear cell renal cell carcinoma (ccRCC), reliable prognostic biomarkers are urgently needed. In this study, microRNAs (miRNAs) have emerged as promising candidates. We investigated whether a combination of differently expressed miRNAs in ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2019, 26(11):3765-3773]

Cited: 4 times

View full text PDF listing >>



Correction: RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation.

Susanne V Schmidt, Stefanie Seibert, Barbara Walch-Rückheim, Benjamin Vicinus, Eva-Maria Kamionka, Jennifer Pahne-Zeppenfeld, Erich-Franz Solomayer, Yoo-Jin Kim, Rainer M Bohle, Sigrun Smola,

[This corrects the article DOI: 10.18632/oncotarget.3249.]. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(43):4503-4504]

Cited: 3 times

View full text PDF listing >>



Spontaneous regression of a plasmablastic lymphoma with MYC rearrangement.

Krista Yordanova, Stephan Stilgenbauer, Rainer M Bohle, Vadim Lesan, Lorenz Thurner, Dominic Kaddu-Mulindwa, Jörg T Bittenbring, Matthias Scharberger, Gunter Aßmann, Moritz Bewarder,

Br J Haematol (British journal of haematology)
[2019, 186(6):e203-e207]

Cited: 3 times

View full text PDF listing >>



Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma.

Sebastian Hölters, Oybek Khalmurzaev, Alexey Pryalukhin, Philine Loertzer, Martin Janssen, Julia Heinzelbecker, Stefan Ueberdiek, Thorsten Pfuhl, Sigrun Smola, Abbas Agaimy, Carol Geppert, Hagen Loertzer, Xaver Krah, Heiko Wunderlich, Stefan Wagenpfeil, Rainer M Bohle, Michael Stöckle, Vsevolod Matveev, Arndt Hartmann, Kerstin Junker,

The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2019, 475(2):211-221]

Cited: 3 times

View full text PDF listing >>



Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study.

Ferenc Zoltan Takacs, Julia Caroline Radosa, Florian Bochen, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Rainer M Bohle, Georg-Peter Breitbach, Bernard Schick, Maximilian Linxweiler,

<h4>Purpose</h4>The aim of this study was to analyze the diagnostic performance of a newly established immunocytochemical dual-staining protocol for the simultaneous expression of SEC62 and Ki67 in vulvar liquid-based cytology specimens for the identification of vulvar intraepithelial neoplasia (VIN) and vulvar cancer. In addition, we investigated the p16/Ki67 dual stain, ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2019, 299(3):825-833]

Cited: 2 times

View full text PDF listing >>



Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer.

Ferenc Zoltan Takacs, Julia Caroline Radosa, Maximilian Linxweiler, Mariz Kasoha, Rainer M Bohle, Florian Bochen, Clara Unger, Erich-Franz Solomayer, Bernard Schick, Ingolf Juhasz-Böss,

<h4>Purpose</h4>In previous studies, we have shown that SEC62 has an essential function in cell migration, epithelial-to-mesenchymal transition, and endoplasmic reticulum stress tolerance of cancer cells. SEC62 expression correlated with distant and lymph node metastasis and poor outcome in different cancer entities. In this initial study, we investigated SEC62 expression and ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2019, 299(5):1405-1413]

Cited: 5 times

View full text PDF listing >>



Uterine Leiomyosarcoma.

Ingolf Juhasz-Böss, Lena Gabriel, Rainer M Bohle, Lars C Horn, Erich-Franz Solomayer, Georg-Peter Breitbach,

Uterine leiomyosarcoma (uLMS) is a rare entity among malignant gynecologic tumors with a very unfavorable prognosis and the highest prevalence in the pre- and peri-menopause. Only early-stage tumors have an acceptable prognosis, provided the patient has been treated without injuring the uterus. uLMS is often diagnosed accidentally and the correct ... Read more >>

Oncol Res Treat (Oncology research and treatment)
[2018, 41(11):680-686]

Cited: 6 times

View full text PDF listing >>



Dickkopf-1 (Dkk1) protein expression in breast cancer with special reference to bone metastases.

Mariz Kasoha, Rainer M Bohle, Anita Seibold, Christoph Gerlinger, Ingolf Juhasz-Böss, Erich-Franz Solomayer,

Dysregulation of the Wnt inhibitor dickkopf-1 protein (Dkk1) has been reported in a variety of cancers. In addition, it has been linked to the progression of malignant bone disease by impairing osteoblast activity. This study investigated serum- and tissue levels of Dkk1 in breast cancer patients with- or without bone ... Read more >>

Clin Exp Metastasis (Clinical & experimental metastasis)
[2018, 35(8):763-775]

Cited: 12 times

View full text PDF listing >>



Flavonifractor (Eubacterium) plautii bloodstream infection following acute cholecystitis.

Fabian K Berger, Nadine Schwab, Matthias Glanemann, Rainer M Bohle, Barbara Gärtner, Heinrich V Groesdonk,

<i>Flavonifractor plautii</i> (formerly <i>Eubacterium plautii</i>) is an anaerobic gram positive rod shaped bacterium belonging to the family of <i>Clostridiales,</i> and a common member of the human gut microbiome. However, it is very rarely isolated from clinical human specimens, so data about its clinical significance are scarce. Here we report of ... Read more >>

IDCases (IDCases)
[2018, 14:e00461]

Cited: 13 times

View full text PDF listing >>



Patient-derived, three-dimensional spheroid cultures provide a versatile translational model for the study of organ-confined prostate cancer.

Johannes Linxweiler, Markus Hammer, Stefanie Muhs, Moritz Kohn, Alexej Pryalukhin, Christian Veith, Rainer M Bohle, Michael Stöckle, Kerstin Junker, Matthias Saar,

<h4>Purpose</h4>To generate and characterize 3D spheroid suspension cultures from radical prostatectomy (RP) specimens as a versatile model system for organ-confined prostate cancer (PCa).<h4>Methods</h4>Cancerous tissue samples from RP specimens were excised by a uropathologist. Preparation of 3D spheroids was done by mechanical disintegration and limited enzymatic digestion followed by serial filtration ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2019, 145(3):551-559]

Cited: 7 times

View full text PDF listing >>



Robust method for isolation of tumor infiltrating lymphocytes with a high vital cell yield from small samples of renal cell carcinomas by a new collagenase-free mechanical procedure.

Fiona Crossey, Stefanie Marx, Sebastian Hölters, Kai Schmitt, Rainer M Bohle, Tina Schmidt, Michael Stöckle, Urban Sester, Martina Sester, Martin W W Janssen,

<h4>Background</h4>Tumor-infiltrating lymphocytes (TIL) play an important role in the pathogenesis of renal cell carcinoma. Characterization of TIL requires efficient isolation procedures, especially in early stage disease when the tumor is of small in size. Conventional methods for isolating TIL are based on enzymatic tissue digestion, most frequently with collagenase. Collagenase ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(9):402.e1-402.e10]

Cited: 0 times

View full text PDF listing >>



A novel mouse model of human prostate cancer to study intraprostatic tumor growth and the development of lymph node metastases.

Johannes Linxweiler, Christina Körbel, Andreas Müller, Markus Hammer, Christian Veith, Rainer M Bohle, Michael Stöckle, Kerstin Junker, Michael D Menger, Matthias Saar,

BACKGROUND:In this study, we aimed to establish a versatile in vivo model of prostate cancer, which adequately mimics intraprostatic tumor growth, and the natural routes of metastatic spread. In addition, we analyzed the capability of high-resolution ultrasonography (hrUS), in vivo micro-CT (μCT), and 9.4T MRI to monitor tumor growth and ... Read more >>

Prostate (The Prostate)
[2018, 78(9):664-675]

Cited: 4 times

View full text PDF listing >>



Advertisement


Disclaimer

1.2157 s