Full Text Journal Articles by
Author Rainer Blaesius

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High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue.

Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W Shannon Dillmore, Rainer Blaesius,

Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigations are still limited by the precision of analysis methods and access to relevant tissue ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238594]

Cited: 0 times

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Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

[This corrects the article DOI: 10.18632/oncotarget.26911.]. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(49):5119]

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Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not well defined. We compare 12 human clinical BE and adjacent normal squamous epithelium biopsies using single cell immunophenotyping by ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(38):3592-3604]

Cited: 3 times

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Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue.

Eileen Snowden, Warren Porter, Friedrich Hahn, Mitchell Ferguson, Frances Tong, Joel S Parker, Aaron Middlebrook, Smita Ghanekar, W Shannon Dillmore, Rainer Blaesius,

Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the number of cells which can be assessed or are very resource ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2017, 15(4):429-438]

Cited: 4 times

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Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening.

Kirsten Crapnell, Rainer Blaesius, Abel Hastings, Donald P Lennon, Arnold I Caplan, Scott P Bruder,

The presence of serum in cell culture medium presents an obstacle to safe and efficient production of hMSCs for therapeutic purposes. Availability of defined medium will be crucial to elucidating the mechanism of action of hMSCs in many indications as well as a prerequisite to consistently produce cells with predictable ... Read more >>

Exp Cell Res (Experimental cell research)
[2013, 319(10):1409-1418]

Cited: 17 times

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State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.

Christopher A Johnston, Francis S Willard, J Kevin Ramer, Rainer Blaesius, C Natalia Roques, David P Siderovski,

Heterotrimeric G-proteins, comprising Galpha, Gbeta, and Ggamma subunits, are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive state in which GDP-bound Galpha is complexed with the Gbetagamma dimer, and an active state in which ... Read more >>

Comb Chem High Throughput Screen (Combinatorial chemistry & high throughput screening)
[2008, 11(5):370-381]

Cited: 5 times

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A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity.

Christopher A Johnston, J Kevin Ramer, Rainer Blaesius, Zoey Fredericks, Val J Watts, David P Siderovski,

Signaling via G-protein coupled receptors is initiated by receptor-catalyzed nucleotide exchange on Galpha subunits normally bound to GDP and Gbetagamma. Activated Galpha . GTP then regulates effectors such as adenylyl cyclase. Except for Gbetagamma, no known regulators bind the adenylyl cyclase-stimulatory subunit Galphas in its GDP-bound state. We recently described ... Read more >>

FEBS Lett (FEBS letters)
[2005, 579(25):5746-5750]

Cited: 9 times

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Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.

Christopher A Johnston, Ekaterina S Lobanova, Alexander S Shavkunov, Justin Low, J Kevin Ramer, Rainer Blaesius, Zoey Fredericks, Francis S Willard, Brian Kuhlman, Vadim Y Arshavsky, David P Siderovski,

G-proteins cycle between an inactive GDP-bound state and an active GTP-bound state, serving as molecular switches that coordinate cellular signaling. We recently used phage display to identify a series of peptides that bind G alpha subunits in a nucleotide-dependent manner [Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, ... Read more >>

Biochemistry (Biochemistry)
[2006, 45(38):11390-11400]

Cited: 22 times

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Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.

Christopher A Johnston, Francis S Willard, Mark R Jezyk, Zoey Fredericks, Erik T Bodor, Miller B Jones, Rainer Blaesius, Val J Watts, T Kendall Harden, John Sondek, J Kevin Ramer, David P Siderovski,

Heterotrimeric G proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP bound state and an active, GTP bound state. Under basal conditions, G proteins exist in the inactive, GDP bound state; thus, ... Read more >>

Structure (Structure (London, England : 1993))
[2005, 13(7):1069-1080]

Cited: 42 times

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Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins.

Erik T Bodor, Gary L Waldo, Rainer Blaesius, T Kendall Harden,

P2Y receptors are G protein coupled receptors that respond to extracellular nucleotides to promote a multitude of signaling events. Our laboratory has purified several P2Y receptors with the goal of providing molecular insight into their: (1) ligand binding properties, (2) G protein signaling selectivities, and (3) regulation by RGS proteins ... Read more >>

Purinergic Signal (Purinergic signalling)
[2004, 1(1):43-49]

Cited: 3 times

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