Full Text Journal Articles by
Author Rafeeq Alam Khan

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Analgesic, anti-inflammatory and toxic effects of ethanol extracts of Cucumis melo and Citrullus lanatus seeds.

Shahana Wahid, Rafeeq Alam Khan, Zeeshan Feroz, Rahila Ikram,

Plants are vital in drug discovery, since many safe and bioactive molecules have been discovered from plants in past, hence this study was designed to evaluate analgesic, anti-inflammatory and toxic effects of Cucumis melo and Citrullus lanatus. Seeds of these plants were selected due to their traditional value for medicinal ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(3):1049-1055]

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Evaluation of wound healing effects of Syzygium cumini and laser treatment in diabetic rats.

Syed Asif Jahanzeb Kazmi, Azra Riaz, Naheed Akhter, Rafeeq Alam Khan,

This study was aimed to investigate the antioxidant effects of Syzygium cumini (S. cumini) seeds extract along with wound healing score in correlation to glutathione and blood glucose levels in diabetic rats. Sprague-Dawley rats were divided into 8 groups (n=6) and diabetes was induced by a single intraperitoneal injection of ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2(Supplementary)):779-786]

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WB-PBPK approach in predicting zidovudine pharmacokinetics in preterm neonates.

Liuya Wei, Najia Mansoor, Rafeeq Alam Khan, Martin Czejka, Tasneem Ahmad, Mansoor Ahmed, Mohsin Ali, Dong-Hua Yang,

Antiretroviral therapy has been the mainstay of treatment for neonates born to HIV infected mothers. Neonates born prematurely to HIV positive mothers are underdeveloped not only in anatomical terms but also in their physiological systems. Zidovudine, the first antiretroviral drug in clinical therapy for the treatment of HIV has been ... Read more >>

Biopharm Drug Dispos (Biopharmaceutics & drug disposition)
[2019, 40(9):341-349]

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Assessment of anti-coagulant activity of Nelumbo nucifera fruit.

Muhammad Ali Rajput, Rafeeq Alam Khan, Shahid Zafar, Azra Riaz, Rahila Ikram,

The herbal agents rich in flavonoids are progressively becoming popular these days as they are considered to have anti-oxidant effects and also lack bothersome effects. That's why existing research was encircled around the anti-coagulant effect of Nelumbo nucifera fruit (NNF) as it is also a rich source of flavonoids and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(6):2561-2564]

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In vivo study to compare the effects of Choline with Fluoxetine and Clozapine for the modulation of cognitive behavior (Learning Memory and Exploratory Behavior).

Mohammad Iqbal Ahsan, Rafeeq Alam Khan, Syed Mohammad Masood, Aeliya Jaffery, Farhat Ali Jaffery,

Cognitive behavior is associated with physiological processes that affect the working performance of an individual. Cognitive control is used to override self-serving impulses and behave in socially desirable manner. The objective of the study is to compare the effects of Choline with Fluoxetine and Clozapine for the modulation of cognitive ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(3 (Supplementary)):1193-1199]

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Prediction of Clearance and Dose of Midazolam in Preterm and Term Neonates: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling.

Najia Mansoor, Tasneem Ahmad, Rafeeq Alam Khan, Syed Mohammad Sharib, Iftekhar Mahmood,

Children are not small adults because besides size there are subtle physiological and biochemical differences between children and adults. Like adults, children also require medicine for the management or cure for the underlying diseases. To select a right dose in children, pharmacokinetic (PK) information is warranted. However, in many instances, ... Read more >>

Am J Ther (American journal of therapeutics)
[2019, 26(1):e32-e37]

Cited: 2 times

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Effect of Nelumbo nucifera fruit on scopolamine induced memory deficits and motor coordination.

Rafeeq Alam Khan, Muhammad Ali Rajput, Tahira Assad,

From prehistoric time till today herbal medications are supposed to have neuroprotective effects both by inhibiting acetyl cholinesterase enzyme or antioxidant ability and are also affordable. Thus extensive studies are necessary to investigate the pharmacological effects of herbal plants. The goal of the present study was to ascertain the outcome ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2019, 34(1):87-92]

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Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats.

Durr-E-Shahwar Siddiqui, Syeda Afroz, Rafeeq Alam Khan,

Psoriasis has become a topic of global concern because of consistency in its prevalence according to Global Report on Psoriasis 2016, however, till date, no therapy has provided complete cure of this disease and no useful measure was discovered to prevent it or eliminate the risk of its relapse. Hence, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(1):35-42]

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In vivo evaluation of antihyperlipidemic, antihyperglycemic and hepatoprotective effects of Vernonia anthelmintica seeds in diet model.

Subia Jamil, Rafeeq Alam Khan, Shadab Ahmed,

Anti-hyperglycemic, anti-hyperlipidemic and hepatoprotective effects of Vernonia anthelmintica seeds were evaluated in diet rat model. The study included forty eight Sprague Dawley rats of either sex with eight animals in each group. Except for control the disease control, standard and treatment groups were treated with high-fat high-sugar diet for 8 ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3):813-820]

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Effect of Punica granatum, Citrus limon and their combinations on the plasma Gonadotropins in female rabbits.

Azra Riaz, Rafeeq Alam Khan, Neelam Mallick,

Fruits produce revitalizing effects, hence the impact of Punica granatum, Citrus limon and their combinations have been investigated on the plasma levels of gonadotropin, testosterone and sexual development capacity in female rabbits. Ninety female rabbits were randomly assigned into nine groups, each comprising of ten animals. One group was given ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3):785-793]

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Antihyperlipidemic and anti-hyperglycemic effects of Cymbopogon jwarancusa in high-fat high-sugar diet model.

Sarah Jameel Khan, Syeda Afroz, Rafeeq Alam Khan,

Hyperlipidemia is the root cause for development of atherosclerosis, coronary heart disease, diabetes mellitus, obesity, hypertension and cerebral palsy. Cymbopogon jwarancusa is an aromatic grass (Rusha grass, khavi grass) belonging to family Poaceaea. C. jwarancusa essential oil is famous for its use in perfumery, soaps cosmetics, detergents, medicine and pharmaceuticals. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4):1341-1345]

Cited: 1 time

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Effect of Trigonella foenum-graecum Linn. seeds methanol extract on learning and memory.

Tahira Assad, Rafeeq Alam Khan, Muhammad Ali Rajput,

Prevention and delay in the onset of memory disorders will have a great impact on society by reducing the disease burden and finances. Drugs available for the treatment of learning and memory disorders are few. There is need to develop a better drug, several studies have shown the therapeutic effectiveness ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2018, 33(4):1275-1280]

Cited: 1 time

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Report - Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats.

Shadab Ahmed, Rafeeq Alam Khan, Subia Jamil, Syeda Afroz,

Change in dietary pattern, sedentary life style and increasing stresses are contributing factors for high prevalence of diabetes mellitus. Diabetic complications often lead to cardiovascular diseases, hypertension and hyperlipidemia that are the leading cause death and disability all over the world. Apart from pharmacotherapy, use of antihyperglycemic medicinal food is ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(5):1797-1802]

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Bile acids and bile alcohols from Muraenesox bagio, Pomadasys argenteus and Lobeo rohita.

Munawwer Rasheed, Mansoor Ahmed, Amir Hassan, Urooj Nazim, Rafeeq Alam Khan, Mustafa Kamal, Mohammad Abdur Rashid,

Gallbladders bile of three well known commercial fish of South Asia region named Muraenesox bagio (locally called bam), Pomadasys argenteus (dother) and Lobeo rohita (rohu) were analysed on GC-MS, after derivatising the bile alcohols and bile acids as trimethylsilyl ether and trimethylsilyl-methyl ester, respectively. Cholic acid (1) and chenodeoxycholic acid ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(5):1759-1765]

Cited: 0 times

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Anti-epileptic activity of Nelumbo nucifera fruit.

Muhammad Ali Rajput, Rafeeq Alam Khan, Tahira Assad,

Epilepsy is the most commonly encountered neurological disorder affecting around 70 million people worldwide, out of which approximately 80% belongs to developing countries. Several shortcomings appeared with the use of conventional antiepileptic agents like, inadequate seizure control, side effects and cost which limit their use. Thus extensive studies are necessary ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2017, 32(6):1883-1887]

Cited: 1 time

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Physiologically based pharmacokinetic modeling for predicting irinotecan exposure in human body.

Yingfang Fan, Najia Mansoor, Tasneem Ahmad, Rafeeq Alam Khan, Martin Czejka, Syed Sharib, Dong-Hua Yang, Mansoor Ahmed,

Colorectal cancer is the third leading cause of cancer-related deaths in the United States. Treatment of colorectal cancer remains a challenge to clinicians as well as drug developers. Irinotecan, a Camptothecin derivative, is successfully used for the treatment of this rapidly progressing malignancy and finds its place in the first ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(29):48178-48185]

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Evaluation of anti-inflammatory and anti-oxidant potential of seed extracts of Vernonia anthelmintica.

Subia Jamil, Rafeeq Alam Khan, Shadab Ahmed, Sakina Fatima,

Seeds of Vernonia anthelmintica in the form of Ethanol seed extract of Vernonia anthelmintica (EEVA), Hexane extract of Vernonia anthelmintica (HEVA) and water decoction of Vernonia anthelmintica (WDVA) were evaluated for their in-vivo anti-Inflammatory potential in carrageenan induced rat paw model. The results were compared to anti-inflammatory activity of standard ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(3):755-760]

Cited: 2 times

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Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice.

Itefaq Hussain Qureshi, Azra Riaz, Rafeeq Alam Khan, Afaq Ahmed Siddiqui,

Status epilepticus is a life threatening neurological medical emergency. It may cause serious damage to the brain and even death in many cases if not treated properly. There is limited choice of drugs for the short term and long term management of status epilepticus and the dugs recommended for status ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2017, 32(4):1051-1060]

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Phytochemistry, Brine shrimp lethality and mice acute oral toxicity studies on seed extracts of Vernonia anthelmintica.

Subia Jamil, Rafeeq Alam Khan, Syeda Afroz, Shadab Ahmed,

Despite the widespread use of Vernonia anthelmintica seeds in traditional medicine, the need to establish the safety of the Vernonia anthelmintica is required to ascertain the safe use of this herbal medicine. The aim of the present study is to establish the acute toxicity profile of different extracts of Vernonia ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(6):2053-2057]

Cited: 2 times

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Phytochemical screening, acute toxicity, anxiolytic and antidepressant activities of the Nelumbo nucifera fruit.

Muhammad Ali Rajput, Rafeeq Alam Khan,

Recently use of herbal therapies and diet rich in flavonoids and vitamin C have increased significantly to treat minor to modest anxiety disorders and various forms of depression. But further research and studies are necessary to evaluate the pharmacological & toxicological effects of plants. Hence present study was designed to ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2017, 32(3):743-749]

Cited: 6 times

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Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats.

Azra Riaz, Rafeeq Alam Khan, Syeda Afroz, Neelam Mallick,

Pomegranate (Punica granatum L., Punicaceae) contains varieties of antioxidants and phytochemicals; there are evidences that phytochemicals and antioxidants play a vital role in reducing inflammation. Hence this investigation was planned to assess the outcome of Punica granatum on trinitrobenzene sulfonic acid provoked colitis in rats at 2, 5 and 8ml/kg ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(1):155-162]

Cited: 0 times

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Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination.

Tahira Assad, Rafeeq Alam Khan,

Currently available anxiolytics cause numerous adverse effects and show craving and tolerance during long term treatment. Currently traditional medicines have been re-evaluated widely through work on various plant species. Numerous plants in traditional system show pharmacological activity with unlimited prospective for therapeutic use. Hence we planned to evaluate the effect ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2017, 32(2):343-349]

Cited: 2 times

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Anti hyperlipidemic and hepatoprotective effects of native date fruit variety "Aseel" (Phoenix dactylifera).

Shadab Ahmed, Rafeeq Alam Khan, Subia Jamil,

Diet rich in saturated fats and sugars have been associated with obesity, insulin resistance, hyperlipidemia and fatty liver disease. Especially high serum lipid levels are directly connected to the progression of cardiovascular disorders, which are the leading cause of death all over the world. Date palm fruit (Phoenix dactylifera) is ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(6):1945-1950]

Cited: 2 times

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Anti-inflammatory effects of Citrus sinensis L., Citrus paradisi L. and their combinations.

Rafeeq Alam Khan, Neelam Mallick, Zeeshan Feroz,

Citrus bioflavonoids embrace a wide group of phenolic compounds effecting the production and scavenging of reactive oxygen species and the processes relating free radical-mediated injury. Keeping in view of the antioxidant and anti-inflammatory properties of Citrus sinensis and Citrus paradisi, present study was undertaken to explore the effects of C. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(3):843-852]

Cited: 3 times

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Behavioral effects of Citrus limon and Punica granatum combinations in rats.

Azra Riaz, Rafeeq Alam Khan,

Dietary supplements are becoming more influential as viable treatment for common chronic diseases and to promote normal development and functions of all system including brain. Disorders like anxiety and depression may be managed through healthier variations is dietary pattern, since there are indications that diet rich in antioxidants and vitamins ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2017, 32(1):123-131]

Cited: 0 times

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