Full Text Journal Articles by
Author Radhika Srinivasan

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Fine-needle aspiration cytology of Bacille Calmette-Guerin adenitis: A perplexing distinct clinical entity.

Aleena Jain, Shruti Gupta, Parikshaa Gupta, Manish Rohilla, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey,

BACKGROUND:Bacille Calmette-Guerin (BCG) adenitis is a common complication of post-BCG vaccination. Awareness of this lesser known entity in fine-needle aspiration (FNA) is important to prevent misdiagnosis. AIM:This study described the clinical presentation, cytomorphological features and disease pattern in patients with BCG adenitis. MATERIALS AND METHODS:We analyzed a series of 15 ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Cost effectiveness of strategies for cervical cancer prevention in India.

Akashdeep Singh Chauhan, Shankar Prinja, Radhika Srinivasan, Bhavana Rai, J S Malliga, Gaurav Jyani, Nidhi Gupta, Sushmita Ghoshal,

The establishment of link between high-risk human papillomavirus (HPV) infection and occurrence of cervical cancer has resulted in development of various HPV related control strategies for the prevention of cervical cancer. The objective of the present study was to assess the cost effectiveness of various screening strategies for cervical cancer ... Read more >>

PLoS ONE (PloS one)
[2020, 15(9):e0238291]

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Ameloblastoma diagnosis by fine-needle aspiration cytology supplemented by cell block samples.

Ariba Zaidi, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey, Kirti Gupta,

Ameloblastomas are rarely encountered in clinical practice, accounting for only 1% of tumors and cysts of the jaw although they are one of the most common odontogenic neoplasms. The cytological features are described in a few case reports only. The aim of this study was to describe the morphological features ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Cerebrospinal fluid cytology in a young adult with seizures.

Aleena Jain, Parikshaa Gupta, Gaurav Prakash, Savita Kumari, Radhika Srinivasan,

Involvement of the central nervous system (CNS) by anaplastic large cell lymphoma (ALCL) is rare with majority of the reported cases being primary CNS ALCLs. There are very occasional reports of CNS involvement in systemic ALCL. Establishing a diagnosis of CNS infiltration by ALCL, although difficult, carries immense prognostic significance ... Read more >>

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, :]

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Small Cell Carcinoma of Ovary, Hypercalcemic Type: Cytologic, Histopathologic, and Immunohistochemical Landscapes of a Rare Case.

Divya Aggarwal, Parikshaa Gupta, Prashant Chhabra, Nitin James Peters, Deepak Bansal, Radhika Srinivasan, Nandita Kakkar,

BACKGROUND:Small cell carcinoma of ovary, hypercalcemia type (SCCOHT), also known as the malignant rhabdoid tumor of the ovary, is a rare and highly aggressive malignancy affecting younger women. The pathogenesis involves mutations in SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin group A4 (SMARCA4)/Brahma-related gene 1 (BRG1) and/or SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin ... Read more >>

J Pediatr Adolesc Gynecol (Journal of pediatric and adolescent gynecology)
[2020, :]

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Health-related quality of life among cervical cancer patients in India.

Gaurav Jyani, Akashdeep Singh Chauhan, Bhavana Rai, Sushmita Ghoshal, Radhika Srinivasan, Shankar Prinja,

INTRODUCTION:Estimation of health-related quality of life of cervical cancer patients in India is important in assessing the well-being of patients, monitor treatment outcomes, and conduct health technology assessments. However, health-related quality of life estimates for different stages of cervical cancer are not available for the Indian population. This study aims ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Small Cell Carcinoma of the Ovary: Clinicopathologic and Immunohistochemical Analysis of 7 New Cases of a Rare Malignancy.

Parikshaa Gupta, Gargi Kapatia, Nalini Gupta, Pranab Dey, Manish Rohilla, Ankita Gupta, Bhavana Rai, Vanita Suri, Arvind Rajwanshi, Radhika Srinivasan,

BACKGROUND:Small cell carcinoma of ovary (SCCO) is extremely rare. Two types of SCCO are recognized, the pulmonary type (SCCOPT) and the hypercalcemic type (SCCOHT). Establishing an accurate diagnosis is challenging, owing to its rarity and paucity of data describing the distinctive histopathologic and immunohistochemical (IHC) features. METHODS:This was a retrospective ... Read more >>

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2020, :1066896920947788]

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Role of bronchoalveolar lavage in diagnosing pulmonary infections and malignancies: Experience from a tertiary care center.

Ariba Zaidi, Harpreet Kaur, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Pranab Dey, Manish Rohilla, Arvind Rajwanshi, Amanjit Bal, Ritesh Agarwal,

BACKGROUND:Bronchoalveolar lavage (BAL), is a safe, minimally invasive procedure to sample the terminal airways and the lung parenchyma. Although frequently used, there is lack of contemporary literature regarding the diagnostic utility of BAL for various pulmonary diseases. This study was conducted to evaluate the utility of BAL in diagnosis of ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, :]

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Clinical and Morphological Spectrum of Histoplasmosis on Cytology Along with the Review of Literature.

Gargi Kapatia, Ashmita Saha, Manish Rohilla, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey,

OBJECTIVE:The aim of the study was to study the clinical and morphological spectrum of histoplasmosis diagnosed by fine needle aspiration cytology (FNAC). STUDY DESIGN:A total of 17 patients diagnosed with histoplasmosis on FNAC were studied over a period of 5 years. The cytology smears were studied and analysed for the ... Read more >>

Acta Cytol. (Acta cytologica)
[2020, :1-7]

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Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer.

Praveen Singh, Munmun Kumari, Amanjit Bal, Radhika Srinivasan, Sujata Ghosh,

The diagnostic and therapeutic potential of Maackia amurensis agglutinin (MAA) have been reported in various malignancies. Earlier, we have found that MAA specifically interacted with human non-small cell lung-cancer (NSCLC) cells and induced apoptosis in these cells. The present study was designed to identify M. amurensis leukoagglutinin (MAL-I, one of ... Read more >>

Biol. Chem. (Biological chemistry)
[2020, 401(8):969-983]

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Insulin growth factor-1 pathway in cervical carcinoma cancer stem cells.

Shifa Javed, Shalmoli Bhattacharyya, Rashmi Bagga, Radhika Srinivasan,

Cancer stem cells (CSC) drive tumour progression and are implicated in relapse and resistance to conventional cancer therapies. Identification of differentially expressed genes by gene expression (GEP) profiling may help identify the differentially activated signalling pathways in cancer stem cells as opposed to bulk tumour cells which will provide new ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, 473(1-2):51-62]

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Fine needle aspiration cytology with the aid of immunocytochemistry on cell-block confirms the diagnosis of solid pseudopapillary neoplasm of the pancreas.

Priya Singh, Pankaj Kumar, Manish Rohilla, Parikshaa Gupta, Nalini Gupta, Pranab Dey, Radhika Srinivasan, Arvind Rajwanshi, Ritambhara Nada,

INTRODUCTION:To determine the diagnostic efficacy of fine needle aspiration cytology (FNAC) in cases of pancreatic solid pseudopapillary neoplasm (PSPN) with emphasis on the cytomorphological features and to evaluate the contribution of immunocytochemistry on FNAC cell-block (CB) in cases of PSPN. METHODS:It is a retrospective study in which ultrasound-guided FNAC of ... Read more >>

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, :]

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Morphologic and Immunocytochemical Features of High-Grade Serous Carcinoma of Ovary in Ascitic Fluid Effusion and Fine-Needle Aspiration Cytology.

Akriti Bansal, Radhika Srinivasan, Manish Rohilla, Archana Sundaram, Bhavana Rai, Arvind Rajwanshi, Vanita Suri, Subhash C Saha, Nalini Gupta, Parikshaa Gupta, Pranab Dey,

OBJECTIVES:High-grade serous carcinoma (HGSC) is the most common ovarian malignancy. The role of cytopathology in obtaining tissue diagnosis before institution of neoadjuvant chemotherapy (NACT) was evaluated. METHODS:All histopathology-proven HGSC specimens between 2015 and 2018 with prior cytopathologic diagnosis by ascitic fluid evaluation or fine-needle aspiration (FNA) of ovarian mass were ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2020, 154(1):103-114]

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Indian Academy of Cytologists National Guidelines for Cytopathology Laboratories for Handling Suspected and Positive COVID-19 (SARS-CoV-2) Patient Samples.

Radhika Srinivasan, Parikshaa Gupta, Bharat Rekhi, Prabal Deb, Vijay S Nijhawan, Dev Prasoon, Venkat Iyer, Sandeep Mathur, Nalini Gupta, Meherbano Kamal, Madhu Mati Goel, Indranil Chakrabarti, Madhusmita Jena, Ram Nawal Rao, Arvind Rajwanshi, Siddaraju Raju, Surendra Verma, Rgw Pinto,

COVID-19, caused by the SARS-CoV-2 virus, has been declared a pandemic by the World Health Organization. This scenario has impacted the way we practice cytopathology. Cytology laboratories receive fresh and potentially infectious biological samples including those from the respiratory tract, from COVID-19 positive or suspected patients. Hence, the Indian Academy ... Read more >>

J Cytol (Journal of cytology)
[2020, 37(2):67-71]

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Triplet pregnancy with complete mole.

Sujata Siwatch, Minakshi Rohilla, Vanita Jain, Radhika Srinivasan, Shalini Gainder, G R V Prasad,

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, :1-3]

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Autologous stem cell transplant for high-risk neuroblastoma: Achieving cure with low-cost adaptations.

Richa Jain, Rekha Hans, Sidharth Totadri, Amita Trehan, Ratti Ram Sharma, Prema Menon, Rakesh Kapoor, Akshay Kumar Saxena, Bhagwant Rai Mittal, Prateek Bhatia, Nandita Kakkar, Radhika Srinivasan, Arvind Rajwanshi, Neelam Varma, Ram Samujh, Neelam Marwaha, Deepak Bansal,

BACKGROUND:The majority of patients in low- and middle-income countries (LMIC) are unable to receive optimal therapy, including autologous stem cell transplant (ASCT) for high-risk neuroblastoma. Management is intensive and multidisciplinary; survival is often poor. We report a single-center outcome of high-risk neuroblastoma, with adaptations optimized for LMIC. PROCEDURE:The study was ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(6):e28273]

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Secretory carcinoma: Fine needle aspiration cytology of a rare parotid gland tumour.

Gargi Kapatia, Lijanthung S Kithan, Manish Rohilla, Nalini Gupta, Radhika Srinivasan, Pranab Dey, Arvind Rajwanshi,

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, 31(3):243-245]

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The clinical and cytomorphological spectrum of hydatid disease.

Gargi Kapatia, Jesty P Tom, Manish Rohilla, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey,

INTRODUCTION:Hydatid disease (HD) is caused by the tapeworm of the genus Echinococcus. Fine-needle aspiration cytology (FNAC) is an expedient diagnostic technique that may be used for its rapid diagnosis. AIM:To study the clinical and cytomorphological spectrum of HD diagnosed by cytology. MATERIAL AND METHODS:A total of 24 patients diagnosed with ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, 48(6):547-553]

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Corrigendum to "Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data" [Gynecol. Oncol. 154 (2019) 441-448].

Paul A Cohen, Aime Powell, Steffen Böhm, C Blake Gilks, Colin J R Stewart, Tarek M Meniawy, Max Bulsara, Stefanie Avril, Eleanor C Brockbank, Tjalling Bosse, Gustavo Rubino de Azevedo Focchi, Raji Ganesan, Rosalind M Glasspool, Brooke E Howitt, Hyun-Soo Kim, Jung-Yun Lee, Nhu D Le, Michelle Lockley, Ranjit Manchanda, Trupti Mandalia, W Glenn McCluggage, Iain McNeish, Divya Midha, Radhika Srinivasan, Yun Yi Tan, Rachael van der Griend, Mayu Yunokawa, Gian F Zannoni, , Naveena Singh,

Gynecol. Oncol. (Gynecologic oncology)
[2020, 157(2):558-559]

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Challenging diagnosis of two neoplasms, Langerhans cell histiocytosis and papillary thyroid carcinoma, from fine needle aspiration of the thyroid by cell-block immunocytochemistry and molecular testing for BRAF V600E mutation.

Ariba Zaidi, Upasana Gautam, Radhika Srinivasan, Amanjit Bal, Gaurav Prakash, Ashwani Sood,

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, :]

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Fine needle aspiration cytology of primary and metastatic gastrointestinal stromal tumour.

Gargi Kapatia, Nalini Gupta, Uma Nahar Saikia, Parikshaa Gupta, Manish Rohilla, Ojas Gupta, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey,

AIM:To explore the cytological spectrum of the gastrointestinal stromal tumour (GIST) including its metastatic sites. MATERIAL AND METHODS:A total of 42 patients (45 sites) diagnosed with GIST or its metastases on fine needle aspiration cytology were studied over a period of 5 years. May-Grünwald Giemsa- and haematoxylin and eosin-stained smears were ... Read more >>

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, 31(2):136-143]

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Neuroendocrine carcinomas: Cytological mimics and diagnostic dilemmas.

Saumya Gupta, Parikshaa Gupta, Manish Rohilla, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Uma N Saikia, Pranab Dey,

BACKGROUND:Neuroendocrine carcinomas (NEC) are rare tumours with multiple morphologic mimics. The cytologist may miss these cases if not aware. AIMS AND OBJECTS:We focused upon the clinical presentation, cytological features and problems in the diagnosis of NEC. MATERIALS AND METHODS:We studied the detailed cytomorphology of 19 cases of NEC (histopathology proved). ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2020, 48(5):440-445]

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Contrast-enhanced EUS in the evaluation of peritoneum and omentum in undiagnosed ascites.

Surinder Singh Rana, Ravi Sharma, Radhika Srinivasan, Manish Rohilla, Rajesh Gupta,

Endosc Ultrasound (Endoscopic ultrasound)
[2020, 9(1):69-70]

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Indian Academy of Cytologists Guidelines for Collection, Preparation, Interpretation, and Reporting of Serous Effusion Fluid Samples.

, Radhika Srinivasan, Bharat Rekhi, Arvind Rajwanshi, Saleem Pathuthara, Sandeep Mathur, Deepali Jain, Nalini Gupta, Upasana Gautam, Naresh Rai, Vijay Shrawan Nijhawan, Venkat Iyer, Pranab Dey, Prabal Deb, Dev Prasoon,

Cytological examination plays an important role in the initial work-up of the serous cavity effusion fluids to find out the possible etiology as benign or malignant. Among malignant effusions, cytology is helpful in determining the exact type, site, and stage of the tumor. However, for reporting effusion cytology specimens, there ... Read more >>

J Cytol (Journal of cytology)
[2020, 37(1):1-11]

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Fine-needle aspiration cytology of extra-salivary adenoid cystic carcinoma.

Gargi Kapatia, Sangamitra Rajasekaran, Manish Rohilla, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Arvind Rajwanshi, Uma Nahar Saikia, Pranab Dey,

INTRODUCTION:Adenoid cystic carcinoma (ACC) is a ubiquitous tumour which can occur in several sites of the human body. Commonly, it affects the salivary glands but also can rarely occur in various extra-salivary locations. AIM:To study the clinical and cytological features of extra-salivary ACC on fine needle aspiration cytology. METHODS:In this ... Read more >>

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, 31(3):215-222]

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