Full Text Journal Articles by
Author Radhika Patel

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Adherence to Topical Medication in Patients with Inflammatory Eye Disease.

Hedayat Javidi, Nat Poonit, Radhika P Patel, Robert J Barry, Saaeha Rauz, Philip I Murray,

Purpose: To evaluate adherence to topical medication in patients with inflammatory eye disease.Methods: Questionnaire survey of patients attending inflammatory eye disease clinics. Treatment regimen was validated against hospital-generated clinic letters.Results: There were 86 patients (52 uveitis and 34 ocular surface disease) with 30% (26/86) failing to identify one or more ... Read more >>

Ocul. Immunol. Inflamm. (Ocular immunology and inflammation)
[2020, :1-6]

Cited: 0 times

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Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models.

Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N Metz, S Paul Oh, Lionel Blanc, Fabien Campagne, Philippe Marambaud,

Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(2):942-957]

Cited: 2 times

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Sirolimus plus nintedanib treats vascular pathology in HHT mouse models

Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine Metz, Paul Oh, Lionel Blanc, Fabien Campagne, Philippe Marambaud,

ABSTRACT Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1-ENG-Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K-Akt-mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, ... Read more >>

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Myeloid-Derived Lymphatic Endothelial Cell Progenitors Significantly Contribute to Lymphatic Metastasis in Clinical Breast Cancer.

Lisa Volk-Draper, Radhika Patel, Nihit Bhattarai, Jie Yang, Andrew Wilber, David DeNardo, Sophia Ran,

Lymphatic metastasis is a high-impact prognostic factor for mortality of breast cancer (BC) patients, and it directly depends on tumor-associated lymphatic vessels. We previously reported that lipopolysaccharide-induced inflammatory lymphangiogenesis is strongly promoted by myeloid-derived lymphatic endothelial cell progenitors (M-LECPs) derived from the bone marrow (BM). As BC recruits massive numbers ... Read more >>

Am. J. Pathol. (The American Journal of Pathology)
[2019, 189(11):2269-2292]

Cited: 2 times

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Comparison of Transcranial Direct Current Stimulation Electrode Montages for the Lower Limb Motor Cortex.

Radhika Patel, Sangeetha Madhavan,

Transcranial direct current stimulation (tDCS) has been widely explored as a neuromodulatory adjunct to modulate corticomotor excitability and improve motor behavior. However, issues with the effectiveness of tDCS have led to the exploration of empirical and experimental alternate electrode placements to enhance neuromodulatory effects. Here, we conducted a preliminary study ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(8):]

Cited: 1 time

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Twenty-four-month real-world visual outcomes of intravitreal aflibercept as monotherapy for the treatment of neovascular age-related macular degeneration.

Thomas Siempis, Mariam El Abiary, Radhika Patel, Manish Gupta,

BACKGROUND:Aflibercept is widely used as a treatment for neovascular age-related macular degeneration (nAMD). Nevertheless, there is no consensus in the optimal injection frequency in the 2nd year of treatment along with little real-world data on visual outcomes. On that basis, the primary aim of this study was to assess the ... Read more >>

Oman J Ophthalmol (Oman journal of ophthalmology)
[2019, 12(2):99-103]

Cited: 0 times

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PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma.

Henry G Smith, David Mansfield, Victoria Roulstone, Joan N Kyula-Currie, Martin McLaughlin, Radhika R Patel, Katharina F Bergerhoff, James T Paget, Magnus T Dillon, Aadil Khan, Alan Melcher, Khin Thway, Kevin J Harrington, Andrew J Hayes,

PURPOSE:The prevention and treatment of metastatic sarcoma are areas of significant unmet need. Immune checkpoint inhibitor monotherapy has shown little activity in sarcoma and there is great interest in identifying novel treatment combinations that may augment responses. In vitro and in vivo, we investigated the potential for an oncolytic vaccinia ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(11):3443-3454]

Cited: 0 times

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Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS disease.

Radhika Patel, Cillian Brophy, Mark Hickling, Jonathan Neve, André Furger,

BACKGROUND:Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a critical regulator of gene expression during disease. However, the effect of APA in the context of neurodegenerative ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2019, 12(1):60]

Cited: 2 times

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ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment.

Magnus T Dillon, Katharina F Bergerhoff, Malin Pedersen, Harriet Whittock, Eva Crespo-Rodriguez, Emmanuel C Patin, Alex Pearson, Henry G Smith, James T E Paget, Radhika R Patel, Shane Foo, Galabina Bozhanova, Chanthirika Ragulan, Elisa Fontana, Krisha Desai, Anna C Wilkins, Anguraj Sadanandam, Alan Melcher, Martin McLaughlin, Kevin J Harrington,

PURPOSE:ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitize to chemotherapy and radiotherapy preclinically. Limited data have been published about the effect of these drugs on the tumor microenvironment.Experimental Design: We used an immunocompetent mouse model of HPV-driven malignancies to investigate the ATR inhibitor ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(11):3392-3403]

Cited: 5 times

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10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study.

Akhilesh Pradhan, Radhika Patel, A J Said, Manasvi Upadhyaya,

INTRODUCTION: Balanitis xerotica obliterans (BXO) is uncommon in children. Diagnosis of the condition is almost always clinical and supported by histology. Our aim was to evaluate the outcomes of children undergoing circumcision for BXO and explore the correlation between surgical and histological findings. MATERIALS AND METHODS: A 10-year retrospective review (2007-2017) of ... Read more >>

Eur J Pediatr Surg (European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie)
[2019, 29(3):302-306]

Cited: 0 times

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Does presentation at a national meeting lead to publication? Evaluating the quality of the Scottish Ophthalmological Club.

Radhika Patel, David Lockington,

Eye (Lond) (Eye (London, England))
[2018, 32(10):1553-1554]

Cited: 0 times

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Single axonal morphology and termination to cerebellar aldolase C stripes characterize distinct spinocerebellar projection systems originating from the thoracic spinal cord in the mouse.

Yuanjun Luo, Radhika Pooja Patel, Gideon Anokye Sarpong, Kazuma Sasamura, Izumi Sugihara,

The spinocerebellar projection has an essential role in sensorimotor coordination of limbs and the trunk. Multiple groups of spinocerebellar projections have been identified in retrograde labeling studies. In this study, we aimed at characterizing projection patterns of these groups using a combination of anterograde labeling of the thoracic spinal cord ... Read more >>

J. Comp. Neurol. (The Journal of comparative neurology)
[2018, 526(4):681-706]

Cited: 3 times

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Hybrid endovascular repair of aneurysmal right-sided aortic arch and Kommerell's diverticulum using a two-vessel branched stent graft: Case report and review of literature.

Mo Hamady, Paritosh M Sharma, Radhika Patel, Anthony D Godfrey, Colin D Bicknell,

Right-sided aortic arches are rare, affecting approximately 0.1% of the population. They are a result of abnormal development of the primitive aortic arches and may present later in life with later life with aneurysmal expansion of the aberrant left subclavian artery 'Kommerell's diverticulum'. These can be challenging to treat effectively. ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2017, 5:2050313X17749082]

Cited: 1 time

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HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation.

Martin McLaughlin, Holly E Barker, Aadil A Khan, Malin Pedersen, Magnus Dillon, David C Mansfield, Radhika Patel, Joan N Kyula, Shreerang A Bhide, Kate L Newbold, Christopher M Nutting, Kevin J Harrington,

BACKGROUND:Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is frequently ineffective in patients with advanced disease. It has previously been shown that HSP90 inhibitors act as radiosensitizers, but these studies have not focused on CCRT in HNSCC. Here, ... Read more >>

BMC Cancer (BMC cancer)
[2017, 17(1):86]

Cited: 7 times

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The anatomy of helping hands: why medical educators volunteer.

Michael Malley, Marie Monaghan, Joanna K Dykes, Tania Bhaduri, Alison Dykes, Radhika Patel,

Clin Teach (The clinical teacher)
[2017, 14(5):365-367]

Cited: 0 times

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An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation.

Radhika Patel, Holly E Barker, Joan Kyula, Martin McLaughlin, Magnus T Dillon, Ulrike Schick, Hind Hafsi, Alan Thompson, Vincent Khoo, Kevin Harrington, Shane Zaidi,

PURPOSE:Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities. MATERIALS AND METHODS:We characterized the radiosensitizing activity of CCT244747, the ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2017, 122(3):470-475]

Cited: 4 times

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CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy.

Holly E Barker, Radhika Patel, Martin McLaughlin, Ulrike Schick, Shane Zaidi, Christopher M Nutting, Katie L Newbold, Shreerang Bhide, Kevin J Harrington,

Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related deaths, with increasingly more cases arising due to high-risk human papillomavirus (HPV) infection. Cisplatin-based chemoradiotherapy is a standard-of-care for locally advanced head and neck cancer but is frequently ineffective. Research into enhancing radiation responses as a means ... Read more >>

Mol. Cancer Ther. (Molecular cancer therapeutics)
[2016, 15(9):2042-2054]

Cited: 8 times

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Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation.

Jonathan Neve, Kaspar Burger, Wencheng Li, Mainul Hoque, Radhika Patel, Bin Tian, Monika Gullerova, Andre Furger,

Alternative cleavage and polyadenylation (APA) plays a crucial role in the regulation of gene expression across eukaryotes. Although APA is extensively studied, its regulation within cellular compartments and its physiological impact remains largely enigmatic. Here, we used a rigorous subcellular fractionation approach to compare APA profiles of cytoplasmic and nuclear ... Read more >>

Genome Res. (Genome Research)
[2016, 26(1):24-35]

Cited: 28 times

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Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence.

Ulrike Schick, Joan Kyula, Holly Barker, Radhika Patel, Shane Zaidi, Claire Gregory, Hind Hafsi, Victoria Roulstone, Eric Deutsch, Martin McLaughlin, Kevin Harrington,

Radiotherapy (RT) is used frequently in patients with melanoma, but results are suboptimal because the disease is often radioresistant. This may be due to constitutive activation of MAPK pathway signalling through mutations involving RAS/RAF. Thus, we studied whether trametinib, a potent and selective allosteric inhibitor of MEK1/2 could improve the ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2015, 117(2):364-375]

Cited: 11 times

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Effects of osteoarthritis on load transfer after cemented total shoulder arthroplasty.

Radhika J Patel, Lawrence Gulotta, Timothy M Wright, Yingxin Gao,

Total shoulder arthroplasty is commonly performed to treat glenohumeral osteoarthritis (OA); however, little is understood of the mechanics of the reconstructed OA shoulder. We sought to establish the effects of OA-induced changes in bone density and retroversion angle on load transfer and stress distribution in the bone-implant system of the ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2015, 24(3):407-415]

Cited: 0 times

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Nonconforming glenoid increases posterior glenohumeral translation after a total shoulder replacement.

Radhika J Patel, Daniel Choi, Timothy Wright, Yingxin Gao,

The major complication in nonconforming total shoulder replacement (TSR) is glenoid loosening and is attributed to posteriorly directed humeral head translations. Whether the posterior translations observed clinically are induced by radial mismatch is unclear. The objective of our study was to explain the posterior glenohumeral translations observed clinically after TSR ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2014, 23(12):1831-1837]

Cited: 3 times

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Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results.

Helmut Butzkueven, Ludwig Kappos, Fabio Pellegrini, Maria Trojano, Heinz Wiendl, Radhika N Patel, Annie Zhang, Christophe Hotermans, Shibeshih Belachew, ,

Clinical trials established the efficacy and safety of natalizumab. Data are needed over longer periods of time and in the clinical practice setting.To evaluate long-term safety of natalizumab and its impact on annualised relapse rate and Expanded Disability Status Scale (EDSS) progression in patients with relapsing-remitting multiple sclerosis (RRMS).The Tysabri ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2014, 85(11):1190-1197]

Cited: 58 times

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Load transfer after cemented total shoulder arthroplasty.

Radhika J Patel, Timothy M Wright, Yingxin Gao,

Glenoid loosening is the primary reason for failure after a total shoulder arthroplasty (TSA), but the failure mechanism is not yet known. This study determined how the load transfer and stress distribution are affected by the introduction of a glenoid implant.We developed a finite-element model of a scapula with and ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2014, 23(10):1553-1562]

Cited: 4 times

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Patterns of tropomyosin and troponin-T isoform expression in jaw-closing muscles of mammals and reptiles that express masticatory myosin.

Sabahattin Bicer, Radhika J Patel, Joseph B Williams, Peter J Reiser,

We recently reported that masticatory ('superfast') myosin is expressed in jaw-closing muscles of some rodent species. Most mammalian limb muscle fibers express tropomyosin-β (Tm-β), along with fast-type or slow-type tropomyosin-β (Tm-β), but jaw-closing muscle fibers in members of Carnivora express a unique isoform of Tm [Tm-masticatory (Tm-M)] and little or ... Read more >>

J. Exp. Biol. (The Journal of experimental biology)
[2011, 214(Pt 7):1077-1085]

Cited: 3 times

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The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1.

Peter J Reiser, Sabahattin Bicer, Radhika Patel, Ying An, Qun Chen, Ning Quan,

We recently reported that masticatory myosin heavy chain (MHC-M) is expressed as the exclusive or predominant MHC isoform in masseter and temporalis muscles of several rodent species, contrary to the prevailing dogma that rodents express almost exclusively MHC isoforms that are typically found in fast limb muscles and not masticatory ... Read more >>

J. Exp. Biol. (The Journal of experimental biology)
[2010, 213(Pt 10):1633-1642]

Cited: 6 times

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