Full Text Journal Articles by
Author Rachel L Tomko

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Mobile, remote, and individual-focused: Comparing breath carbon monoxide readings and abstinence between smartphone-enabled and stand-alone monitors.

Breanna M Tuck, Joshua L Karelitz, Rachel L Tomko, Jennifer Dahne, Patrick Cato, Erin A McClure,

INTRODUCTION:Newly available, smartphone-enabled carbon monoxide (CO) monitors are lower in cost than traditional stand-alone monitors and represent a marked advancement for smoking research. New products are promising, but data are needed to compare breath CO readings between smartphone-enabled and stand-alone monitors. The purpose of this study was to: 1) determine ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, :]

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Impact of disaster exposure severity: Cascading effects across parental distress, adolescent PTSD symptoms, as well as parent-child conflict and communication.

Kaitlin E Bountress, Amanda K Gilmore, Isha W Metzger, Steven H Aggen, Rachel L Tomko, Carla Kmett Danielson, Vernell Williamson, Vladimir Vladmirov, Kenneth Ruggiero, Ananda B Amstadter,

RATIONALE:Natural disasters are common and have potentially deleterious impacts on individuals, as well as on the relationships among family members (Adams et al., 2015; Paul, 2015). Additionally, caregiver-, offspring-, and family-level outcomes are often correlated following disaster. OBJECTIVE:Thus, longitudinal work is needed to clarify the prospective associations among such constructs ... Read more >>

Soc Sci Med (Social science & medicine (1982))
[2020, 264:113293]

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Piloting of the Just Say Know prevention program: a psychoeducational approach to translating the neuroscience of addiction to youth.

Lindsay R Meredith, Anna M Maralit, Suzanne E Thomas, Sylvia L Rivers, Claudia A Salazar, Raymond F Anton, Rachel L Tomko, Lindsay M Squeglia,

BACKGROUND:Substance use during adolescence can have a number of negative consequences and interfere with normal brain development. Given limited time and resources, brief group- and school-based prevention programs are an efficient strategy for educating youth about the effects of substance use on health outcomes. OBJECTIVES:To determine if a science-based, interactive ... Read more >>

Am J Drug Alcohol Abuse (The American journal of drug and alcohol abuse)
[2020, :1-10]

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Cannabis and Alcohol Co-Use in a Smoking Cessation Pharmacotherapy Trial for Adolescents and Emerging Adults.

Erin A McClure, Nathaniel L Baker, Caitlyn O Hood, Rachel L Tomko, Lindsay M Squeglia, Julianne C Flanagan, Matthew J Carpenter, Kevin M Gray,

INTRODUCTION:The co-use of cannabis and alcohol among tobacco-using youth is common. Alcohol co-use is associated with worse tobacco cessation outcomes, but results are mixed regarding the impact of cannabis on tobacco outcomes and if co-use leads to increased use of non-treated substances. This secondary analysis from a youth smoking cessation ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, 22(8):1374-1382]

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Increases in endogenous progesterone attenuate smoking in a cohort of nontreatment seeking women: An exploratory prospective study.

Nathaniel L Baker, Kevin M Gray, Viswanathan Ramakrishnan, Rachel L Tomko, Erin A McClure, Matthew J Carpenter, Michael E Saladin,

Despite advances in prevention and treatment, cigarette smoking remains a leading cause of preventable death in the United States. Although men and women are equally likely to attempt to quit smoking cigarettes, women are far less likely to achieve abstinence both during and following cessation treatment. Recent evidence suggests that ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12918]

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Remote Methods for Conducting Tobacco-Focused Clinical Trials.

Jennifer Dahne, Rachel L Tomko, Erin A McClure, Jihad S Obeid, Matthew J Carpenter,

Most tobacco-focused clinical trials are based on locally-conducted studies that face significant challenges to implementation and successful execution. These challenges include the need for large, diverse, yet still representative study samples. This often means a protracted, costly, and inefficient recruitment process. Multi-site clinical trials can overcome some of these hurdles ... Read more >>

Nicotine Tob. Res. (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, :]

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Examining sex, adverse childhood experiences, and oxytocin on neuroendocrine reactivity in smokers.

Caitlyn O Hood, Rachel L Tomko, Nathaniel L Baker, Breanna M Tuck, Julianne C Flanagan, Matthew J Carpenter, Kevin M Gray, Michael E Saladin, Erin A McClure,

Adverse childhood experiences (ACE) are associated with greater neuroendocrine responses to social stress in substance users. The neuropeptide oxytocin might attenuate this relationship. Given sex differences in ACE exposure and neuroendocrine stress reactivity, it is unknown whether this association is similar for males and females. Therefore, this secondary analysis evaluated ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2020, 120:104752]

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Making pharmacotherapy trials for substance use disorder more efficient: Leveraging real-world data capture to maximize power and expedite the medication development pipeline.

Ryan W Carpenter, Lindsay M Squeglia, Noah N Emery, Erin A McClure, Kevin M Gray, Robert Miranda, Rachel L Tomko,

Drug Alcohol Depend (Drug and alcohol dependence)
[2020, 209:107897]

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Sex Differences in Subjective and Behavioral Responses to Stressful and Smoking Cues Presented in the Natural Environment of Smokers.

Rachel L Tomko, Michael E Saladin, Nathaniel L Baker, Erin A McClure, Matthew J Carpenter, Viswanathan R Ramakrishnan, Bryan W Heckman, Jennifer M Wray, Katherine T Foster, Stephen T Tiffany, Christopher L Metts, Kevin M Gray,

INTRODUCTION:Some evidence suggests that female smokers may show more context-dependent smoking and that males may show more stereotyped smoking (regardless of stress or cue exposure). The goal of this study was to characterize sex differences in response to stressful and smoking cues ecologically presented in daily life and variability in ... Read more >>

Nicotine Tob. Res. (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, 22(1):81-88]

Cited: 1 time

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The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm.

Erin A McClure, Nathaniel L Baker, Kevin M Gray, Caitlyn O Hood, Rachel L Tomko, Matthew J Carpenter, Viswanathan R Ramakrishnan, Cole J Buchanan, Michael E Saladin,

RATIONALE:Female cigarette smokers tend to show greater cessation failure compared with males. Variables that contribute to the maintenance of smoking, including stress and craving, may differentially impact male and female smokers. Novel pharmacotherapies, such as oxytocin, may attenuate stress reactivity and craving in smokers, but work in this area is ... Read more >>

Psychopharmacology (Berl.) (Psychopharmacology)
[2020, 237(2):543-555]

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Measuring Within-Individual Cannabis Reduction in Clinical Trials: A Review of the Methodological Challenges.

Rachel L Tomko, Kevin M Gray, Marilyn A Huestis, Lindsay M Squeglia, Nathaniel L Baker, Erin A McClure,

Purpose:Cannabis abstinence traditionally is the primary outcome in cannabis use disorder (CUD) treatment trials. Due to the changing legality of cannabis, patient goals, and preliminary evidence that suggests individuals who reduce their cannabis use may show functional improvements, cannabis reduction is a desirable alternative outcome in CUD trials. We review ... Read more >>

(Current addiction reports)
[2019, 6(4):429-436]

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Depressive symptoms and cannabis use in a placebo-controlled trial of N-Acetylcysteine for adult cannabis use disorder.

Rachel L Tomko, Nathaniel L Baker, Caitlyn O Hood, Amanda K Gilmore, Erin A McClure, Lindsay M Squeglia, Aimee L McRae-Clark, Susan C Sonne, Kevin M Gray,

RATIONALE:Depression is common among individuals with cannabis use disorder (CUD), particularly individuals who present to CUD treatment. Treatments that consider this comorbidity are essential. OBJECTIVES:The goal of this secondary analysis was to examine whether N-acetylcysteine (NAC) reduced depressive symptoms among adults (age 18-50) with CUD (Nā€‰=ā€‰302) and whether the effect ... Read more >>

Psychopharmacology (Berl.) (Psychopharmacology)
[2020, 237(2):479-490]

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Behavioral Treatments for Adolescent Cannabis Use Disorder: a Rationale for Cognitive Retraining.

Laika D Aguinaldo, Lindsay M Squeglia, Kevin M Gray, Clarisa Coronado, Briana Lees, Rachel L Tomko, Joanna Jacobus,

Purpose of Review:Adolescent cannabis use represents a significant public health concern. Cannabis experimentation typically begins in adolescence and increases the odds of meeting criteria for cannabis use disorder. Cannabis use disorder is associated with numerous short- and long-term adverse consequences for adolescents, highlighting the critical need for efficacious behavioral treatments. ... Read more >>

(Current addiction reports)
[2019, 6(4):437-442]

Cited: 2 times

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Efficacy and Safety of Varenicline for Adolescent Smoking Cessation: A Randomized Clinical Trial.

Kevin M Gray, Nathaniel L Baker, Erin A McClure, Rachel L Tomko, Lindsay M Squeglia, Michael E Saladin, Matthew J Carpenter,

Importance:Cigarette smoking is the leading cause of preventable morbidity and mortality in the United States and worldwide, and most tobacco users begin smoking in adolescence. Although advances have yielded efficacious pharmacotherapies to complement smoking cessation counseling in adults, far less progress has been made in addressing tobacco use in adolescence. ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2019, :]

Cited: 1 time

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Adolescent Substance Use Disorder Treatment: an Update on Evidence-Based Strategies.

Matthew C Fadus, Lindsay M Squeglia, Emilio A Valadez, Rachel L Tomko, Brittany E Bryant, Kevin M Gray,

PURPOSE OF REVIEW:To examine the most recent published evidence (2016-2019) regarding the treatment of adolescent substance use disorders and to provide an update on evidence-based strategies, adjunctive interventions, and methods to improve currently established treatment approaches. RECENT FINDINGS:Recent evidence suggests that psychosocial treatments such as family-based therapy, cognitive behavioral therapy, ... Read more >>

Curr Psychiatry Rep (Current psychiatry reports)
[2019, 21(10):96]

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An electronic, smart lighter to measure cigarette smoking: A pilot study to assess feasibility and initial validity.

Rachel L Tomko, Erin A McClure, Patrick A Cato, Julie B Wang, Matthew J Carpenter, Joshua L Karelitz, Brett Froeliger, Michael E Saladin, Kevin M Gray,

Understanding variability in smoking patterns may inform smoking cessation interventions. Retrospective reports of cigarettes smoked per day may be biased and typically do not provide temporal precision regarding when cigarettes are smoked. However, real-time, user-initiated tracking, such as logging each time a cigarette is smoked, can be burdensome over long ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 98:106052]

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Blunts versus joints: Cannabis use characteristics and consequences among treatment-seeking adults.

LaTrice Montgomery, Erin A McClure, Rachel L Tomko, Susan C Sonne, Theresa Winhusen, Garth E Terry, Jason T Grossman, Kevin M Gray,

BACKGROUND:Despite the high prevalence of blunt smoking among cannabis users, very few studies examine the clinical profile of blunt smokers relative to those using more common methods of cannabis use, such as joints. METHODS:The current study uses baseline data from the ACCENT (Achieving Cannabis Cessation-Evaluating N-acetylcysteine Treatment) study, a multi-site ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2019, 198:105-111]

Cited: 1 time

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Pharmacological Treatment of Youth Substance Use Disorders.

Lindsay M Squeglia, Matthew C Fadus, Erin A McClure, Rachel L Tomko, Kevin M Gray,

While the majority of youth who experiment with alcohol and drugs do not develop problematic levels of use, 5% of adolescents and 15% of young adults meet criteria for a substance use disorder (SUD). Pharmacotherapy, in combination with behavioral interventions, has the potential to increase the likelihood of successful treatment ... Read more >>

J Child Adolesc Psychopharmacol (Journal of child and adolescent psychopharmacology)
[2019, 29(7):559-572]

Cited: 2 times

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Medical Cannabis Use among Adults in the Southeastern United States.

Claudia A Salazar, Rachel L Tomko, Saima A Akbar, Lindsay M Squeglia, Erin A McClure,

Objectives:To assess the self-reported reasons for medical cannabis use within the southeastern United States and compare recreational and medical cannabis users. Methods:This study was a cross-sectional survey administered in 2017 through Amazon's Mechanical Turk and enrolled 432 adult, regular cannabis users. Measures included demographics, cannabis use characteristics, and medical reasons ... Read more >>

(Cannabis (Research Society on Marijuana))
[2019, 2(1):53-65]

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Methods to reduce the incidence of false negative trial results in substance use treatment research.

Rachel L Tomko, Erin A McClure, Lindsay M Squeglia, Hayley Treloar Padovano, Aimee L McRae-Clark, Nathaniel L Baker, Matthew J Carpenter, Kevin M Gray,

Treatment development and evaluation for substance use disorders are hindered when randomized controlled trials fail to show a treatment effect when one exists. This manuscript provides an overview of addressable methodological factors that may contribute to incorrect trial results. The collection of remote, naturalistic, real-time adherence and substance use data ... Read more >>

Curr Opin Psychol (Current opinion in psychology)
[2019, 30:35-41]

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Tobacco and cannabis co-use: Drug substitution, quit interest, and cessation preferences.

Erin A McClure, Rachel L Tomko, Claudia A Salazar, Saima A Akbar, Lindsay M Squeglia, Evan Herrmann, Matthew J Carpenter, Erica N Peters,

The co-use of tobacco and cannabis is a common practice worldwide and carries with it substantial public health burden. Few interventions exist that target both substances and little is known about quit interest, treatment preferences, and drug substitution during past cessation attempts, which is critical to guide the development of ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2019, 27(3):265-275]

Cited: 1 time

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Corrigendum to The role of depressive symptoms in treatment of adolescent cannabis use disorder with N-Acetylcysteine Addictive Behaviors 85 (2018) 26-30.

Rachel L Tomko, Amanda K Gilmore, Kevin M Gray,

Addict Behav (Addictive behaviors)
[2019, 89:263]

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Tobacco and cannabis co-use and interrelatedness among adults.

Saima A Akbar, Rachel L Tomko, Claudia A Salazar, Lindsay M Squeglia, Erin A McClure,

Cannabis and tobacco co-use is prevalent, but consensus regarding the reasons for co-use among adults and the degree of interrelatedness between these substances is lacking. Reasons for co-use have been explored with younger users, but little data exists for more experienced users with entrenched patterns of co-use. The goal of ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 90:354-361]

Cited: 1 time

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Tobacco use during cannabis cessation: Use patterns and impact on abstinence in a National Drug Abuse Treatment Clinical Trials Network study.

Erin A McClure, Nathaniel L Baker, Susan C Sonne, Udi E Ghitza, Rachel L Tomko, LaTrice Montgomery, Shanna Babalonis, Garth E Terry, Kevin M Gray,

BACKGROUND:It is common for cannabis users to also use tobacco. While data suggest that tobacco users have more difficulty achieving cannabis cessation, secondary analyses of clinical trial data sets may provide insight into the moderating variables contributing to this relationship, as well as changes in tobacco use during cannabis treatment. ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2018, 192:59-66]

Cited: 4 times

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Introduction to the special issue: Utilizing ambulatory assessment to better understand the etiology, maintenance, treatment, and remission of addictive disorders.

Rachel L Tomko, Erin A McClure,

Addict Behav (Addictive behaviors)
[2018, 83:1-4]

Cited: 1 time

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