Full Text Journal Articles by
Author Rachel L Medernach

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A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children.

Latania K Logan, Jared R Rispens, Rachel L Medernach, T Nicholas Domitrovic, Andrea M Hujer, Steven H Marshall, Susan D Rudin, Nadia K Qureshi, Xiaotian Zheng, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent).<h4>Methods</h4>A retrospective case-control analysis of children with TEM-SHV-Ent infections ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):39-43]

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594. A Multi-Centered Study of the Clinical and Molecular Epidemiology of AmpC Cephalosporinase-Producing (AmpC) Enterobacteriaceae (Ent) Infections in Children

Rachel L Medernach, T Nicholas Domitrovic, Karen C Hayani, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Jared R Rispens, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

Abstract Background AmpC producing Ent are an important cause of multidrug-resistant (MDR) infections in pediatrics. Since most AmpC Ent studies have been conducted in adults, we characterized the molecular epidemiology of AmpC Ent strains with transmissible resistance and identified factors associated with AmpC Ent infections in children. Methods A case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S280-S280]

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Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, Jared R Rispens, Steven H Marshall, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Sreenivas Konda, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):595-599]

Cited: 2 times

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Sreenivas Konda, Robert A Weinstein, Robert A Bonomo,

<h4>Introduction</h4>The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).<h4>Methods</h4>A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2019, 8(2):243-254]

Cited: 2 times

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2336. Resistance Mechanisms and Factors Associated With CTX-M-9 Group Extended-Spectrum β-Lactamase (ESBL)-Producing Infections in Children.

Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundThere is an increasing incidence of extended-spectrum β-lactamase (ESBL) producing infections in children. However, most studies focus only on CTX-M-1 group (CTX-M-15). We sought to define the epidemiology of the CTX-M-9 group (CTX-M-9) producing infections in children to devise more effective treatment and prevention strategies.MethodsA case–control study of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S694-S694]

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268. Cardiothoracic Surgery Antimicrobial Prophylaxis in Pediatric Patients: Reducing Antimicrobial Exposure

Rachel L Medernach, Betty Vu, Jessica Jacobson, Kristen Welsh, Sara Brown, Amy Wilhelmi, Colleen Nash,

Abstract <h4>Background</h4> Pediatric cardiothoracic (CT) surgery poses significant infectious risks, mitigated by antimicrobial prophylaxis and standardized infection control practices. Little is known about the most appropriate postoperative antimicrobial regimen and duration of therapy. In efforts to decrease exposure to broad-spectrum (BS) antimicrobial prophylaxis while preventing postoperative infection, we implemented a ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S111-S112]

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The Growing Threat of Antibiotic Resistance in Children.

Rachel L Medernach, Latania K Logan,

Antimicrobial resistance is a global public health threat and a danger that continues to escalate. These menacing bacteria are having an impact on all populations; however, until recently, the increasing trend in drug-resistant infections in infants and children has gone relatively unrecognized. This article highlights the current clinical and molecular ... Read more >>

Infect Dis Clin North Am (Infectious disease clinics of North America)
[2018, 32(1):1-17]

Cited: 5 times

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A Multicenter Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended- Spectrum β-Lactamase producing (ESBL) () Infections in Children.

Jared R Rispens, Rachel L Medernach, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Mary K Hayden, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundESBL infections are increasingly prevalent in the pediatric population; however, most ESBL studies have focused on adults and/or CTX-M-type strains. We sought to characterize the molecular epidemiology of ESBL strains and to identify factors associated with TEM- and SHV-type ESBL (TEMSHV ) infections in children.MethodsA case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S679-S679]

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