Full Text Journal Articles by
Author Rachel K Toth


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Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer.

Rachel K Toth, Noel A Warfel,

Cancer progression and the onset of therapeutic resistance are often the results of uncontrolled activation of survival kinases. The proviral integration for the Moloney murine leukemia virus (PIM) kinases are oncogenic serine/threonine kinases that regulate tumorigenesis by phosphorylating a wide range of substrates that control cellular metabolism, proliferation, and survival. ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2021, 20(1):3-10]

Cited: 0 times

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PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer.

Shailender S Chauhan, Rachel K Toth, Corbin C Jensen, Andrea L Casillas, David F Kashatus, Noel A Warfel,

Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small-cell lung cancer (NSCLC). The goal of this study was to determine how PIM kinases impact mitochondrial dynamics, ROS production, and response to chemotherapy in lung cancer. Live-cell imaging and microscopy were used to determine the effect of ... Read more >>

Oncogene (Oncogene)
[2020, 39(12):2597-2611]

Cited: 4 times

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Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC.

Rachel K Toth, Jack D Tran, Michelle T Muldong, Eric A Nollet, Veronique V Schulz, Corbin C Jensen, Lori A Hazlehurst, Eva Corey, Donald Durden, Christina Jamieson, Cindy K Miranti, Noel A Warfel,

Bone-metastatic castration-resistant prostate cancer (CRPC) is lethal due to inherent resistance to androgen deprivation therapy, chemotherapy, and targeted therapies. Despite the fact that a majority of CRPC patients (approximately 70%) harbor a constitutively active PI3K survival pathway, targeting the PI3K/mTOR pathway has failed to increase overall survival in clinical trials. ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(4):297-312]

Cited: 1 time

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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.

Andrea L Casillas, Rachel K Toth, Alva G Sainz, Neha Singh, Ankit A Desai, Andrew S Kraft, Noel A Warfel,

Purpose: Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their expression increases in hypoxia. The goal of this study was to determine whether targeting hypoxia-induced PIM kinase expression is effective in combination with VEGF-targeting agents. The rationale ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(1):169-180]

Cited: 11 times

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Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia.

Rachel K Toth, Noel A Warfel,

The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to successful cancer therapy. In response to hypoxia, cancer cells activate a transcriptional ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2017, 6(2):]

Cited: 14 times

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 53 times

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