Full Text Journal Articles by
Author Rachel Brown

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Expanding the Toolkit for Genome Editing in a Disease Vector, Aedes aegypti: Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient Mutagenesis.

Guan-Heng Zhu, Najla M Albishi, Xien Chen, Rachel L Brown, Subba Reddy Palli,

CRISPR-Cas9 mediated genome editing methods are being used for the analysis of gene function. However, it is hard to identify gene knockout mutants for genes whose knockout does not cause distinct phenotypes. To overcome this issue in the disease vector, <i>Aedes aegypti</i>, a transgenic Cas9/single guide RNA (sgRNA) method, was ... Read more >>

CRISPR J (The CRISPR journal)
[2021, :]

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Modeling thiamine fortification: a case study from Kuria atoll, Republic of Kiribati.

Tim J Green, Kyly C Whitfield, Lisa Daniels, Rachel C Brown, Lisa A Houghton,

In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes ... Read more >>

Ann N Y Acad Sci (Annals of the New York Academy of Sciences)
[2021, :]

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Barriers and Facilitators to Nut Consumption: A Narrative Review.

Elizabeth P Neale, Georgie Tran, Rachel C Brown,

Habitual nut intake is associated with a range of health benefits; however, population consumption data suggests that most individuals do not meet current recommendations for nut intake. The literature has highlighted a range of barriers and facilitators to nut consumption, which should be considered when designing strategies to promote nut ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(23):]

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Pacific Fono: a community-based initiative to improve rheumatic fever service delivery for Pacific Peoples in South Auckland.

, Anneka Anderson, Rachel Brown, Jadene Wheeler, Rawiri McKree Jansen,

BACKGROUND AND CONTEXT Rheumatic fever inequitably affects Māori and Pacific children in New Zealand. School-based throat swabbing services, such as the South Auckland Mana Kidz programme, are a key element of rheumatic fever prevention interventions. ASSESSMENT OF THE PROBLEM Counties Manukau has the highest national rates of rheumatic fever (4.7 ... Read more >>

J Prim Health Care (Journal of primary health care)
[2020, 12(4):384-390]

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Reply: Concentric demyelination pattern in COVID-19-associated acute haemorrhagic leukoencephalitis: a lurking catastrophe?

Ross W Paterson, Rachel L Brown, Vinojini Vivekanandam, Alexander J M Foulkes, Maria Thom, Sarah Wiethoff, Laura Benjamin, Gerry Christofi, Patricia McNamara, Jasper Morrow, Thomas D Miller, Ross Nortley, Ruth Geraldes, David Attwell, Guru Kumar, Alex D Everitt, Nicholas W S Davies, S Anand Trip, Eli Silber, Robin Howard, Richard J Perry, David J Werring, Anna Checkley, Nicky Longley, Jennifer Spillane, Michael P Lunn, Chandrashekar Hoskote, Hans Rolf Jäger, Hadi Manji, Michael S Zandi, ,

Brain (Brain : a journal of neurology)
[2020, 143(12):e101]

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Observations by and Conversations with Health Workers and Hospital Personnel Involved in Transferring Māori Patients and Whānau to Waikato Hospital in Aotearoa New Zealand.

Bridgette Masters-Awatere, Donna Cormack, Rebekah Graham, Rachel Brown,

The predominant focus of Aotearoa New Zealand's public health system on biomedical models of health has left little room for meaningful engagement with holistic indigenous approaches. Culturally appropriate provision and support are recognized for their relevance and importance during hospital transferals. Hospital staff involved in transfers to one of New ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(23):]

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NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype.

Francesca Marcon, Jianmin Zuo, Hayden Pearce, Samantha Nicol, Sandra Margielewska-Davies, Mustafa Farhat, Brinder Mahon, Gary Middleton, Rachel Brown, Keith J Roberts, Paul Moss,

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and remains associated with very poor survival. T cell infiltration into tumor tissue is associated with improved clinical outcome but little is known regarding the potential role of NK cells in disease control. Here we analyze the phenotype ... Read more >>

Oncoimmunology (Oncoimmunology)
[2020, 9(1):1845424]

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Collecting genetic samples and linked mental health data from adolescents in schools: Protocol co-production and a mixed-methods pilot of feasibility and acceptability

Naomi Warne, Sarah Rook, Rhys Bevan-Jones, Rachel Brown, Lesley Bates, Lucinda Hopkins-Jones, Alexandra Evans, Jeremy Hall, Kate Langley, Anita Thapar, James Walters, Simon Murphy, Graham Moore, Frances Rice, Stephan Collishaw,

<h4>Objectives</h4> To co-produce a school-based protocol and examine acceptability and feasibility of collecting saliva samples for genetic studies from young adolescent students in schools for the purpose of mental health research. <h4>Design</h4> Protocol co-production and mixed-methods feasibility pilot. <h4>Setting:</h4> Secondary schools in Wales, UK. <h4>Participants</h4> Year 7 and 8 secondary ... Read more >>

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Dynamic acoustic salience evokes motor responses.

Benjamin G Schultz, Rachel M Brown, Sonja A Kotz,

Audio-motor integration is currently viewed as a predictive process in which the brain simulates upcoming sounds based on voluntary actions. This perspective does not consider how our auditory environment may trigger involuntary action in the absence of prediction. We address this issue by examining the relationship between acoustic salience and ... Read more >>

Cortex (Cortex; a journal devoted to the study of the nervous system and behavior)
[2020, 134:320-332]

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The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.

Ross W Paterson, Rachel L Brown, Laura Benjamin, Ross Nortley, Sarah Wiethoff, Tehmina Bharucha, Dipa L Jayaseelan, Guru Kumar, Rhian E Raftopoulos, Laura Zambreanu, Vinojini Vivekanandam, Anthony Khoo, Ruth Geraldes, Krishna Chinthapalli, Elena Boyd, Hatice Tuzlali, Gary Price, Gerry Christofi, Jasper Morrow, Patricia McNamara, Benjamin McLoughlin, Soon Tjin Lim, Puja R Mehta, Viva Levee, Stephen Keddie, Wisdom Yong, S Anand Trip, Alexander J M Foulkes, Gary Hotton, Thomas D Miller, Alex D Everitt, Christopher Carswell, Nicholas W S Davies, Michael Yoong, David Attwell, Jemeen Sreedharan, Eli Silber, Jonathan M Schott, Arvind Chandratheva, Richard J Perry, Robert Simister, Anna Checkley, Nicky Longley, Simon F Farmer, Francesco Carletti, Catherine Houlihan, Maria Thom, Michael P Lunn, Jennifer Spillane, Robin Howard, Angela Vincent, David J Werring, Chandrashekar Hoskote, Hans Rolf Jäger, Hadi Manji, Michael S Zandi,

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(10):3104-3120]

Cited: 24 times

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Cryptic partial insertion of the RARA gene into the PML gene without reciprocal RARA-PML fusion: a case report and review of literature.

Waqas Mahmud, Rachel Brown, Lela Buckingham, Adrian Tira, Deborah A Katz,

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2020, 59(12):1496-1499]

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Young people's use of e-cigarettes in Wales, England and Scotland before and after introduction of EU Tobacco Products Directive regulations: a mixed-method natural experimental evaluation.

Graham Moore, Rachel Brown, Nicholas Page, Britt Hallingberg, Olivia Maynard, Jennifer McKell, Linsay Gray, Anna Blackwell, Emily Lowthian, Marcus Munafò, Anne-Marie Mackintosh, Linda Bauld,

<h4>Background</h4>Young people's experimentation with e-cigarettes has increased in recent years, although regular use remains limited. EU Tobacco Products Directive (TPD) regulations introduced packet warnings, advertising restrictions, and regulated nicotine strength from 2016, in part due to concerns regarding use by young people. This paper examines e-cigarette use trajectories before and ... Read more >>

Int J Drug Policy (The International journal on drug policy)
[2020, 85:102795]

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Paneth Cell Alterations During Ischemia-reperfusion, Follow-up, and Graft Rejection After Intestinal Transplantation.

Anna M Kip, Laurens J Ceulemans, Inca H R Hundscheid, Emilio Canovai, Hermien Hartog, Rachel M Brown, Olivier Corcos, Francisca Joly, Gert De Hertogh, Girish Gupte, Cornelis H C Dejong, Steven W M Olde Damink, Jacques Pirenne, Darius Mirza, Kaatje Lenaerts,

BACKGROUND:Ischemia-reperfusion injury is inevitable during intestinal transplantation (ITx) and executes a key role in the evolution towards rejection. Paneth cells (PCs) are crucial for epithelial immune defense and highly vulnerable to ischemia-reperfusion injury. We investigated the effect of ITx on PC after reperfusion (T0), during follow-up, and rejection. Moreover, we ... Read more >>

Transplantation (Transplantation)
[2020, 104(9):1952-1958]

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Ecological Exploration of Knowledge and Attitudes Towards Tobacco and E-Cigarettes Among Primary School Children, Teachers, and Parents in Wales: A Qualitative Study.

Rachel Brown, Jordan Van Godwin, Lauren Copeland, Britt Hallingberg, Lianna Angel, Sarah MacDonald, Jeremy Segrott, Graham Moore,

Experimentation with e-cigarettes has grown rapidly among UK adolescents. To date, this topic has been primarily researched in secondary schools, with less understanding of development of attitudes and behaviours at an earlier age. This research reports qualitative data from interviews with pupils, parents, and teachers at 4 case study schools ... Read more >>

Tob Use Insights (Tobacco use insights)
[2020, 13:1179173X20938770]

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Sources of potential bias when combining routine data linkage and a national survey of secondary school-aged children: a record linkage study.

Kelly Morgan, Nicholas Page, Rachel Brown, Sara Long, Gillian Hewitt, Marcos Del Pozo-Banos, Ann John, Simon Murphy, Graham Moore,

<h4>Background</h4>Linking survey data to administrative records requires informed participant consent. When linkage includes child data, this includes parental and child consent. Little is known of the potential impacts of introducing consent to data linkage on response rates and biases in school-based surveys. This paper assessed: i) the impact on overall ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2020, 20(1):178]

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SARS-CoV-2: Is the liver merely a bystander to severe disease?

Mansoor N Bangash, Jaimin M Patel, Dhruv Parekh, Nicholas Murphy, Rachel M Brown, Ahmed M Elsharkawy, Gautam Mehta, Matthew J Armstrong, Desley Neil,

J Hepatol (Journal of hepatology)
[2020, 73(4):995-996]

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Dietary Intake Nutritional Status and Lifestyle of Adolescent Vegetarian and Nonvegetarian Girls in New Zealand (The SuNDiAL Project): Protocol for a Clustered, Cross-Sectional Survey.

Meredith Peddie, Chaya Ranasinghe, Tessa Scott, Anne-Louise Heath, Caroline Horwath, Rosalind Gibson, Rachel Brown, Lisa Houghton, Jillian Haszard,

BACKGROUND:Anecdotally, vegetarian eating patterns seem to be increasing in parallel with growing concerns about environmental sustainability. While this pattern of eating is widely believed to be associated with benefits for the planet and individual health, it may increase the risk of inadequate intakes and nutrient deficiency if not planned carefully. ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(5):e17310]

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Guidance is an intervention: experiences and reflections of message mediators and message recipients for ‘alcohol in pregnancy’ guidance.

Heather Trickey, Rachel Brown,

<h4>Background: </h4> Heavy alcohol use in pregnancy is associated with poorer outcomes for babies, while evidence of harm from drinking at low levels is limited. UK guidance has been progressively strengthened, so that current guidance, underpinned by a precautionary principle, is to abstain from drinking alcohol if pregnant or planning ... Read more >>

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An uncommon cause of early infantile liver disease and raised chitotriosidase.

Srividya Sreekantam, Hina Rizvi, Rachel Brown, Saikat Santra, Julian Raiman, Suresh Vijay, Patrick J Mckiernan, Girish L Gupte,

Our subject presented at 11 months of age, following a varicella zoster infection, with acute on chronic liver disease and was found to have raised serum chitotriosidase. White cell enzyme analysis for Gaucher, Niemann Pick A, B and lysosomal acid lipase deficiency were normal. Niemann Pick type C (NPC) disease was ... Read more >>

JIMD Rep (JIMD reports)
[2020, 54(1):22-24]

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Corrigendum to: Using Lean Six Sigma to improve rates of day of surgery admission in a national thoracic surgery department.

Rachel Brown, Petra Grehan, Marie Brennan, Denise Carter, Aoife Brady, Eoin Moore, SeÁn Paul Teeling, Marie Ward, Donna Eaton,

Int J Qual Health Care (International journal for quality in health care : journal of the International Society for Quality in Health Care)
[2020, :]

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Intermittent fasting, Paleolithic, or Mediterranean diets in the real world: exploratory secondary analyses of a weight-loss trial that included choice of diet and exercise.

Michelle R Jospe, Melyssa Roy, Rachel C Brown, Jillian J Haszard, Kim Meredith-Jones, Louise J Fangupo, Hamish Osborne, Elizabeth A Fleming, Rachael W Taylor,

BACKGROUND:Intermittent fasting (IF) and Paleolithic (Paleo) diets produce weight loss in controlled trials, but minimal evidence exists regarding long-term efficacy under free-living conditions without intense dietetic support. OBJECTIVES:This exploratory, observational analysis examined adherence, dietary intake, weight loss, and metabolic outcomes in overweight adults who could choose to follow Mediterranean, IF, ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2020, 111(3):503-514]

Cited: 1 time

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IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.

Shima Yasin, Ndate Fall, Rachel A Brown, Maggie Henderlight, Scott W Canna, Charlotte Girard-Guyonvarc'h, Cem Gabay, Alexei A Grom, Grant S Schulert,

<h4>Objectives</h4>Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(2):361-366]

Cited: 3 times

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Does 'activating' nuts affect nutrient bioavailability?

Shivani Kumari, Andrew R Gray, Kirsten Webster, Karl Bailey, Malcolm Reid, Kylie Anne Han Kelvin, Siew Ling Tey, Alexandra Chisholm, Rachel C Brown,

Claims in the lay literature suggest soaking nuts enhances mineral bioavailability. Research on legumes and grains indicate soaking reduces phytate levels, however, there is no evidence to support or refute these claims for nuts. We assessed the effects of different soaking regimes on phytate and mineral concentrations of whole and ... Read more >>

Food Chem (Food chemistry)
[2020, 319:126529]

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Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.

Andrew T Hale, Rachel E Brown, Zigmund Luka, Benjamin H Hudson, Pranathi Matta, Christopher S Williams, John D York,

Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3'-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic toxicity caused ... Read more >>

Adv Biol Regul (Advances in biological regulation)
[2020, 76:100694]

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Liver injury in children with long-term low-dose methotrexate.

Chayarani Kelgeri, Somashekara H Ramakrishna, Rachel M Brown, Eslam Al-Abadi, Girish L Gupte,

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(5):1067-1070]

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