Full Text Journal Articles by
Author R Vignesh

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A Change in Domain Cooperativity Drives the Function of Calnuc.

Ravichandran Vignesh, Gopala Krishna Aradhyam,

With the increasing incidence of neurodegenerative disorders, there is an urgent need to understand the protein folding process. Examining the folding process of multidomain proteins remains a prime challenge, as their complex conformational dynamics make them highly susceptible to misfolding and/or aggregation. The presence of multiple domains in a protein ... Read more >>

Biochemistry (Biochemistry)
[2020, :]

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Biodegradable and non-biodegradable fraction of municipal solid waste for multifaceted applications through a closed loop integrated refinery platform: Paving a path towards circular economy.

G Velvizhi, S Shanthakumar, Bhaskar Das, A Pugazhendhi, T Shanmuga Priya, B Ashok, K Nanthagopal, R Vignesh, C Karthick,

An increase in population, rapid urbanization and industrialization has accelerated the rate of municipal solid waste generation. The current disposal of solid waste is a burgeoning issue and it's in immediate need to shift the existing disposal processes to a sustainable manner. Circular economy (CE) is a conceptual model which ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 731:138049]

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Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis: Current Developments and Future Prospects.

Yean K Yong, Hong Y Tan, Alireza Saeidi, Won F Wong, Ramachandran Vignesh, Vijayakumar Velu, Rajaraman Eri, Marie Larsson, Esaki M Shankar,

Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the host biomarkers appears to play a significant role. The currently available diagnostic technology for TB detection is inadequate. Although GeneXpert detects total DNA present in the sample regardless live or dead bacilli present in clinical samples, all the commercial ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2789]

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Bacterial etiology and antibiotic resistance profile of bloodstream infections in human immunodeficiency virus patients from Southern India.

Chinnambedu Ravichandran Swathirajan, Marimuthu Ragavan Rameshkumar, Sunil Suhas Solomon, Amrose Pradeep, Devaraj Ajay Chithra, Ramasamy Balakrishnan, Ramachandran Vignesh, Pachamuthu Balakrishnan,

J Res Med Sci (Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences)
[2019, 24:82]

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Increase of Plasma TNF-α Is Associated with Decreased Levels of Blood Platelets in Clinical Dengue Infection.

Anbalagan A Meena, Amudhan Murugesan, Surliappan Sopnajothi, Yean K Yong, P Sankar Ganesh, Irudhayaraj J Vimali, Ramachandran Vignesh, Manickan Elanchezhiyan, Meganathan Kannan, Aditya P Dash, Esaki M Shankar,

Dengue virus (DENV) infection has become an increasingly common concern in tropical and subtropical regions. It has protean manifestations ranging from febrile phase to severe life-threatening illness. In this study, we estimated Th1 and Th2 cytokines and correlated the levels with dengue severity along with certain hematological and biochemical parameters. ... Read more >>

Viral Immunol. (Viral immunology)
[2020, 33(1):54-60]

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Comparative Evaluation of Extrusion of Apical Debris in Primary Anterior Teeth using Two Different Rotary Systems and Hand Files: An In Vitro Study.

Ahsana Asif, Ganesh Jeevanandan, Lavanya Govindaraju, R Vignesh, E M G Subramanian,

Background:The success of endodontic treatment depends on the chemomechanical preparation of the tooth. However, the debris produced during canal preparation may extrude through the apical foramen causing postoperative complications. Aim:The aim of this study is to compare the apical debris extrusion during root canal preparation in primary anterior teeth using ... Read more >>

Contemp Clin Dent (Contemporary clinical dentistry)
[2019, 10(3):512-516]

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Association of circulatory Tfh-like cells with neutralizing antibody responses among chronic HIV-1 subtype C infected long-term nonprogressors and progressors.

Chinnambedu Ravichandran Swathirajan, Pannerselvam Nandagopal, Ramachandran Vignesh, Aylur Kailasam Srikrishnan, Rajat Goyal, Huma Qureshi, Shanmugam Saravanan, Sunil Suhas Solomon, Luke Elizabeth Hanna, Munusamy Ponnan Sivasankaran, Nikhil Singla, Joyeeta Mukherjee, Shweta Chatrath, Jakub Kopycinski, Kailapuri Gangatharan Murugavel,

HIV-1 vaccine functioning relies on successful induction of broadly neutralizing antibodies (bNAbs). CXCR3- circulatory T-follicular helper (cTfh) cells are necessary for inducing B-cells for generating bNAbs. Recent studies have suggested that CXCR3+ Tfh cells might also influence bNAb production. Plasma samples from 34 ART-Naïve HIV-1 infected individuals [long-term nonprogressors (LTNP)-19; ... Read more >>

Pathog Dis (Pathogens and disease)
[2019, 77(4):]

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Anthracene based AIEgen for picric acid detection in real water samples.

Annasamy Gowri, Rajendran Vignesh, Arunkumar Kathiravan,

In this work, a new anthracene Schiff base derivative (AS) was successfully synthesized and characterized by pivotal analytical techniques. Based on the contented results, the AS molecule was employed for photophysical investigation using UV-Visible absorption, steady state and time resolved fluorescence techniques. The photophysical studies reveal that the AS possesses ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2019, 220:117144]

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Management of Complicated Crown-Root Fracture by Extra-Oral Fragment Reattachment and Intentional Reimplantation with 2 Years Review.

R Vignesh, Ditto Sharmin, C Vishnu Rekha, Sankar Annamalai, Parisa Norouzi Baghkomeh,

Trauma with an accompanying fracture to the anterior teeth gives an agonizing experience for a young individual due to the physical disfigurement and the psychological impact that is imposed on them. This paper reports a case of complicated crown-root fracture in a young child that was treated by extra-oral fragment ... Read more >>

Contemp Clin Dent (Contemporary clinical dentistry)
[2019, 10(2):397-401]

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Retrospective Analysis of Antibiotic Resistance in Streptococcus spp. from HIV Patients (2012-2017) from Southern India.

Chinnambedu Ravichandran Swathirajan, Marimuthu Ragavan Rameshkumar, Sunil Suhas Solomon, Ramachandran Vignesh, Pachamuthu Balakrishnan,

Adv Biomed Res (Advanced biomedical research)
[2019, 8:1]

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Knowledge, attitude, and practical behavior of parents regarding their child's oral health in New Delhi.

Gyanendra Kumar, Jatinder Kaur Dhillon, Ramanand Vignesh, Aditi Garg,

Objective:The objective of this study was to determine the knowledge, attitude, and practical behavior of parents regarding their children's oral health in New Delhi. Methodology:A cross-sectional study was conducted among 500 parents who reported in outpatient department in the Department of General Medicine at Maulana Azad Medical College and in ... Read more >>

J Indian Soc Pedod Prev Dent (Journal of the Indian Society of Pedodontics and Preventive Dentistry)
[2019, 37(1):3-7]

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Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo.

Ravichandran Vignesh, Gopala Krishna Aradhyam,

Protein aggregation and inclusion body formation have been a key causal phenomenon behind a majority of neurodegenerative disorders. Various approaches aimed at preventing the formation/elimination of protein aggregates are being developed to control these diseases. Molecular chaperones are a class of protein that not only direct the functionally relevant fold ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2019, 1929:135-154]

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Detection of bla NDM-1 and bla NDM-5 genes among Gram-negative bacteria isolated from human immunodeficiency virus patients in South India.

Marimuthu Ragavan Rameshkumar, Narasingam Arunagirinathan, Purushothaman Indu, Chinnambedu Ravichandran Swathirajan, Sunil Suhas Solomon, Ramachandran Vignesh, Pachamuthu Balakrishnan,

J Res Med Sci (Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences)
[2018, 23:112]

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High prevalence of poor sleep quality among secondary school students in Malaysia.

R Vignesh, S S Ganesh, M Vengata Subramani, M Ravindran, R H Abdul Karim,

No abstract provided. ... Read more >>

Med. J. Malaysia (The Medical journal of Malaysia)
[2018, 73(6):444]

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Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells.

Suresh Pallikkuth, Rajendra Pahwa, Bagavathi Kausalya, Shanmugam Saravanan, Li Pan, R Vignesh, Syed Iqbal, Sunil S Solomon, Kailapuri G Murugavel, Selvamuthu Poongulali, Nagalingeswaran Kumarasamy, Savita Pahwa,

Recent findings point to a role of Checkpoint Inhibitor (CPI) receptors at the tissue level in immune homeostasis. Here we investigated the role of CPI molecules on immune cells in relation to cardiac function. Participants recruited in Chennai, India consisted of HIV+ ART naive viremic (Gp1 n = 102), HIV+ ... Read more >>

PLoS ONE (PloS one)
[2018, 13(10):e0206256]

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Changing drug resistance profile in Pseudomonas aeruginosa infection among HIV patients from 2010-2017: A retrospective study.

Chinnambedu Ravichandran Swathirajan, Marimuthu Ragavan Rameshkumar, Sunil Suhas Solomon, Ramachandran Vignesh, Pachamuthu Balakrishnan,

OBJECTIVES:Pseudomonas aeruginosa is an important aetiological agent causing pneumonia, urinary tract infections and bacteraemia. High antibiotic use in nosocomial settings and for immunocompromised conditions results in increasing multidrug resistance. This study analysed the antimicrobial resistance profile of P. aeruginosa isolates in an HIV setting. METHODS:A total of 7386 clinical specimens ... Read more >>

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2019, 16:274-277]

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Brief Report: The Anti-HIV-1 ADCC-Mediating Antibodies From Cervicovaginal Secretions of HIV-Infected Women Have an Ability to Mediate Lysing of Autologous CD4+ HIV-Infected Cells.

Jayshree Dhande, Mansa Angadi, K G Murugavel, S Poongulali, Paneerselvam Nandagopal, Ramachandran Vignesh, Manisha Ghate, Smita Kulkarni, Madhuri Thakar,

BACKGROUND:Fragment crystallizable region of antibody-mediated mechanism such as antibody-dependent cellular cytotoxicity (ADCC) has been identified as an important component of immune protection against HIV. We assessed whether the anti-HIV antibodies mediating ADCC from cervicovaginal lavages (CVLs) of HIV-infected women have an ability to mediate lysing of autologous CD4 HIV-infected cells. ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2018, 79(2):277-282]

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Do the clonally different Escherichia coli isolates causing different infections in a HIV positive patient affect the selection of antibiotics for their treatment?

Marimuthu Ragavan Rameshkumar, Narasingam Arunagirinathan, Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Pachamuthu Balakrishnan, Sunil Suhas Solomon,

Indian J. Med. Res. (The Indian journal of medical research)
[2018, 148(3):341-344]

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Could Prevalence of Human Rhinosporidiosis be Attributed to Distribution of Rhinosporidium seeberi in Natural Water Bodies?

Kalyani, Selvan Gowri, Jayalakshmi Krishnan, Jaisheela Vimali, Siva Sundara Kumar, Ramachandran Vignesh, Esaki Shankar,

Rhinosporidiosis is a chronic granulomatous tropical infectious disease that often manifests as a papillomatous vascular polypoidal granulomata, primarily involving the nasal mucosa. Epidemiological data on the prevalence rates of rhinosporidiosis in Southern India are seemingly scarce. Here, we aimed at exploring the prevalence of human rhinosporidiosis as well as the ... Read more >>

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Recent advances on T-cell exhaustion in malaria infection.

Esaki M Shankar, R Vignesh, A P Dash,

T-cell exhaustion reportedly leads to dysfunctional immune responses of antigen-specific T cells. Investigations have revealed that T cells expand into functionally defective phenotypes with poor recall/memory abilities to parasitic antigens. The exploitation of co-inhibitory pathways represent a highly viable area of translational research that has very well been utilized against ... Read more >>

Med. Microbiol. Immunol. (Medical microbiology and immunology)
[2018, 207(3-4):167-174]

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A comparative evaluation between cheiloscopic patterns and canine relationship in primary dentition.

R Vignesh, David Ditto Sharmin,

Objective:The aim of this study was to evaluate the correlation between different cheiloscopic patterns with the canine relationship in deciduous dentition. Materials and Methods:Three-hundred children who were 3-6 years old with complete primary dentition were recruited and the relationships between maxillary and mandibular canines were recorded in the pro forma. ... Read more >>

J Forensic Dent Sci (Journal of forensic dental sciences)
[2018, 10(2):84-87]

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Broad neutralization response in a subset of HIV-1 subtype C-infected viraemic non-progressors from southern India.

Paneerselvam Nandagopal, Jayanta Bhattacharya, Aylur K Srikrishnan, Rajat Goyal, Chinnambedu Ravichandran Swathirajan, Shilpa Patil, Shanmugam Saravanan, Suprit Deshpande, Ramachandran Vignesh, Sunil Suhas Solomon, Nikhil Singla, Joyeeta Mukherjee, Kailapuri G Murugavel,

Broadly neutralizing antibodies (bnAbs) have been considered to be potent therapeutic tools and potential vaccine candidates to enable protection against various clades of human immunodeficiency virus (HIV). The generation of bnAbs has been associated with enhanced exposure to antigen, high viral load and low CD4+ T cell counts, among other factors. ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2018, 99(3):379-392]

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HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.

Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Greer Waldrop, Uma Shanmugasundaram, Pannerselvam Nandagopal, Sunil Suhas Solomon, Amrose Pradeep, Shanmugam Saravanan, Kailapuri Gangatharan Murugavel,

BACKGROUND:Anti-viral cytokine expressions by cytotoxic T-cells and lower activation rates have been reported to correlate with suppressed HIV replication in long-term non-progressors (LTNP). Immune mechanisms underlying disease non-progression in LTNP might vary with HIV-1 subtype and geographical locations. OBJECTIVE:This study evaluates cytokine expression and T-cells activation in relation to disease ... Read more >>

Curr. HIV Res. (Current HIV research)
[2018, 16(4):302-314]

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A Comparative Evaluation between Cheiloscopic Patterns and Terminal Planes in Primary Dentition.

R Vignesh, C Vishnu Rekha, Sankar Annamalai, Parisa Norouzi, Ditto Sharmin,

To assess the correlation between different cheiloscopic patterns with the terminal planes in deciduous dentition.Three hundred children who are 3-6 years old with complete primary dentition were recruited, and the pattern of molar terminal plane was recorded in the pro forma. Lip prints of these children were recorded with lipstick-cellophane ... Read more >>

Contemp Clin Dent (Contemporary clinical dentistry)
[2017, 8(4):522-525]

Cited: 1 time

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Performance of point-of-care Xpert HIV-1 plasma viral load assay at a tertiary HIV care centre in Southern India.

Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Jayaseelan Boobalan, Sunil Suhas Solomon, Shanmugam Saravanan, Pachamuthu Balakrishnan,

BACKGROUND:Sustainable suppression of HIV replication forms the basis of anti-retroviral therapy (ART) medication. Thus, reliable quantification of HIV viral load has become an essential factor to monitor the effectiveness of the ART. Longer turnaround-time (TAT), batch testing and technical skills are major drawbacks of standard real-time PCR assays. METHODS:The performance ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2017, 66(10):1379-1382]

Cited: 2 times

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