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Author R Suzanne Zukin

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The Role of NF-κB Triggered Inflammation in Cerebral Ischemia.

Teresa Jover-Mengual, Jee-Yeon Hwang, Hyae-Ran Byun, Brenda L Court-Vazquez, José M Centeno, María C Burguete, R Suzanne Zukin,

Cerebral ischemia is a devastating disease that affects many people worldwide every year. The neurodegenerative damage as a consequence of oxygen and energy deprivation, to date, has no known effective treatment. The ischemic insult is followed by an inflammatory response that involves a complex interaction between inflammatory cells and molecules ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2021, 15:633610]

Cited: 0 times

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A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.

Claudia Bagni, R Suzanne Zukin,

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS), autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are therefore classified as synaptopathies. FXS and ASDs, while clinically and genetically distinct, share significant comorbidity, suggesting that there may be a common molecular and/or cellular ... Read more >>

Neuron (Neuron)
[2019, 101(6):1070-1088]

Cited: 51 times

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Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death.

Chang Hoon Cho, Hyae-Ran Byun, Teresa Jover-Mengual, Fabrizio Pontarelli, Christopher Dejesus, Ah-Rhang Cho, R Suzanne Zukin, Jee-Yeon Hwang,

PURPOSE:Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment. Growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b) is a wellknown molecule in both DNA damage-related pathogenesis and therapies. Emerging evidence suggests that Gadd45b is an anti-apoptotic factor in ... Read more >>

Int Neurourol J (International neurourology journal)
[2019, 23(Suppl 1):S11-21]

Cited: 6 times

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Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection.

Jee-Yeon Hwang, Kelly A Aromolaran, R Suzanne Zukin,

In Box 1 of this article, the positioning of the amino acid residues on the tail of histone H3 in part b of the figure was incorrect. These should have been oriented so that the K4 residue was the most distal labelled residue from the nucleosome core region. The corrected ... Read more >>

Nat Rev Neurosci (Nature reviews. Neuroscience)
[2018, 19(12):771]

Cited: 2 times

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Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice.

Jingqi Yan, Morgan W Porch, Brenda Court-Vazquez, Michael V L Bennett, R Suzanne Zukin,

Fragile X syndrome (FXS) is the most frequent form of heritable intellectual disability and autism. Fragile X (<i>Fmr1</i>-KO) mice exhibit aberrant dendritic spine structure, synaptic plasticity, and cognition. Autophagy is a catabolic process of programmed degradation and recycling of proteins and cellular components via the lysosomal pathway. However, a role ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(41):E9707-E9716]

Cited: 26 times

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REST, a master transcriptional regulator in neurodegenerative disease.

Jee-Yeon Hwang, R Suzanne Zukin,

The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the ... Read more >>

Curr Opin Neurobiol (Current opinion in neurobiology)
[2018, 48:193-200]

Cited: 49 times

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Early uneven ear input induces long-lasting differences in left-right motor function.

Michelle W Antoine, Xiaoxia Zhu, Marianne Dieterich, Thomas Brandt, Sarath Vijayakumar, Nicholas McKeehan, Joseph C Arezzo, R Suzanne Zukin, David A Borkholder, Sherri M Jones, Robert D Frisina, Jean M Hébert,

How asymmetries in motor behavior become established normally or atypically in mammals remains unclear. An established model for motor asymmetry that is conserved across mammals can be obtained by experimentally inducing asymmetric striatal dopamine activity. However, the factors that can cause motor asymmetries in the absence of experimental manipulations to ... Read more >>

PLoS Biol (PLoS biology)
[2018, 16(3):e2002988]

Cited: 1 time

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Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.

Alexander Pyronneau, Qionger He, Jee-Yeon Hwang, Morgan Porch, Anis Contractor, R Suzanne Zukin,

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disabilities and a leading cause of autism. FXS is caused by a trinucleotide expansion in the gene <i>FMR1</i> on the X chromosome. The neuroanatomical hallmark of FXS is an overabundance of immature dendritic spines, a factor thought to ... Read more >>

Sci Signal (Science signaling)
[2017, 10(504):]

Cited: 34 times

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The emerging field of epigenetics in neurodegeneration and neuroprotection.

Jee-Yeon Hwang, Kelly A Aromolaran, R Suzanne Zukin,

Epigenetic mechanisms - including DNA methylation, histone post-translational modifications and changes in nucleosome positioning - regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates ... Read more >>

Nat Rev Neurosci (Nature reviews. Neuroscience)
[2017, 18(6):347-361]

Cited: 66 times

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Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice.

Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zukin,

Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and a leading genetic form of autism. The Fmr1 KO mouse, a model of FXS, exhibits elevated translation in the hippocampus and the cortex. ERK (extracellular signal-regulated kinase) and mTOR (mechanistic target of rapamycin) signaling regulate protein ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(41):E6290-E6297]

Cited: 27 times

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hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms.

Akil Puckerin, Kelly A Aromolaran, Donald D Chang, R Suzanne Zukin, Henry M Colecraft, Mohamed Boutjdir, Ademuyiwa S Aromolaran,

<h4>Background</h4>The human ether-à-go-go-related gene (hERG 1a) potassium channel is critical for cardiac repolarization. hERG 1b, another variant subunit, co-assembles with hERG 1a, modulates channel biophysical properties and plays an important role in repolarization. Mutations of hERG 1a lead to type 2 long QT syndrome (LQT2), and increased risk for fatal ... Read more >>

Heart Rhythm (Heart rhythm)
[2016, 13(5):1121-1130]

Cited: 10 times

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Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

Catherine H Choi, Brian P Schoenfeld, Aaron J Bell, Joseph Hinchey, Cory Rosenfelt, Michael J Gertner, Sean R Campbell, Danielle Emerson, Paul Hinchey, Maria Kollaros, Neal J Ferrick, Daniel B Chambers, Steven Langer, Steven Sust, Aatika Malik, Allison M Terlizzi, David A Liebelt, David Ferreiro, Ali Sharma, Eric Koenigsberg, Richard J Choi, Natalia Louneva, Steven E Arnold, Robert E Featherstone, Steven J Siegel, R Suzanne Zukin, Thomas V McDonald, Francois V Bolduc, Thomas A Jongens, Sean M J McBride,

Fragile X is the most common monogenic disorder associated with intellectual disability (ID) and autism spectrum disorders (ASD). Additionally, many patients are afflicted with executive dysfunction, ADHD, seizure disorder and sleep disturbances. Fragile X is caused by loss of FMRP expression, which is encoded by the FMR1 gene. Both the ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2016, 10:136]

Cited: 18 times

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Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.

Kimberly M Huber, Eric Klann, Mauro Costa-Mattioli, R Suzanne Zukin,

The mammalian target of rapamycin (mTOR) is a central regulator of a diverse array of cellular processes, including cell growth, proliferation, autophagy, translation, and actin polymerization. Components of the mTOR cascade are present at synapses and influence synaptic plasticity and spine morphogenesis. A prevailing view is that the study of ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(41):13836-13842]

Cited: 72 times

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PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.

Catherine H Choi, Brian P Schoenfeld, Eliana D Weisz, Aaron J Bell, Daniel B Chambers, Joseph Hinchey, Richard J Choi, Paul Hinchey, Maria Kollaros, Michael J Gertner, Neal J Ferrick, Allison M Terlizzi, Nicole Yohn, Eric Koenigsberg, David A Liebelt, R Suzanne Zukin, Newton H Woo, Michael R Tranfaglia, Natalia Louneva, Steven E Arnold, Steven J Siegel, Francois V Bolduc, Thomas V McDonald, Thomas A Jongens, Sean M J McBride,

Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments were rescued by treatment with metabotropic glutamate receptor (mGluR) antagonists ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(1):396-408]

Cited: 25 times

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Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia.

Koichi Takeuchi, Yupeng Yang, Yukihiro Takayasu, Michael Gertner, Jee-Yeon Hwang, Kelly Aromolaran, Michael V L Bennett, R Suzanne Zukin,

Global ischemia in humans or induced experimentally in animals causes selective and delayed neuronal death in pyramidal neurons of the hippocampal CA1. The ovarian hormone estradiol administered before or immediately after insult affords histological protection in experimental models of focal and global ischemia and ameliorates the cognitive deficits associated with ... Read more >>

Brain Res (Brain research)
[2015, 1621:222-230]

Cited: 8 times

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The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die.

Jee-Yeon Hwang, Naoki Kaneko, Kyung-Min Noh, Fabrizio Pontarelli, R Suzanne Zukin,

The gene silencing transcription factor REST [repressor element 1 silencing transcription factor]/NRSF (neuron-restrictive silencer factor) actively represses a large array of coding and noncoding neuron-specific genes important to synaptic plasticity including miR-132. miR-132 is a neuron-specific microRNA and plays a pivotal role in synaptogenesis, synaptic plasticity and structural remodeling. However, ... Read more >>

J Mol Biol (Journal of molecular biology)
[2014, 426(20):3454-3466]

Cited: 44 times

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Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death.

Naoki Kaneko, Jee-Yeon Hwang, Michael Gertner, Fabrizio Pontarelli, R Suzanne Zukin,

Repressor Element-1 (RE1) Silencing Transcription Factor/Neuron-Restrictive Silencer Factor (REST/NRSF) is a gene-silencing factor that is widely expressed during embryogenesis and plays a strategic role in neuronal differentiation. Recent studies indicate that REST can be activated in differentiated neurons during a critical window of time in postnatal development and in adult ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(17):6030-6039]

Cited: 31 times

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Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines.

Jessica A Murphy, Ivar S Stein, C Geoffrey Lau, Rui T Peixoto, Teresa K Aman, Naoki Kaneko, Kelly Aromolaran, Jessica L Saulnier, Gabriela K Popescu, Bernardo L Sabatini, Johannes W Hell, R Suzanne Zukin,

The NMDA-type glutamate receptor (NMDAR) is essential for synaptogenesis, synaptic plasticity, and higher cognitive function. Emerging evidence indicates that NMDAR Ca(2+) permeability is under the control of cAMP/protein kinase A (PKA) signaling. Whereas the functional impact of PKA on NMDAR-dependent Ca(2+) signaling is well established, the molecular target remains unknown. ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(3):869-879]

Cited: 50 times

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Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia.

Yoshihide Sehara, Kirsty Sawicka, Jee-Yeon Hwang, Adrianna Latuszek-Barrantes, Anne M Etgen, R Suzanne Zukin,

Transient global ischemia causes selective, delayed death of hippocampal CA1 pyramidal neurons in humans and animals. It is well established that estrogens ameliorate neuronal death in animal models of focal and global ischemia. However, the role of signal transducer and activator of transcription-3 (STAT3) and its target genes in estradiol ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(30):12364-12374]

Cited: 31 times

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Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors.

Tae-Joon Shin, Hyeon-Joong Kim, Byeong-Jae Kwon, Sun-Hye Choi, Hyun-Bum Kim, Sung-Hee Hwang, Byung-Hwan Lee, Sang-Mok Lee, R Suzanne Zukin, Ji-Ho Park, Hyoung-Chun Kim, Hyewhon Rhim, Joon-Hee Lee, Seung-Yeol Nah,

Ginseng has been shown to have memory-improving effects in human. However, little is known about the active components and the molecular mechanisms underlying its effects. Recently, we isolated novel lysophosphatidic acids (LPAs)-ginseng protein complex derived from ginseng, gintonin. Gintonin activates G protein-coupled LPA receptors with high affinity. Gintonin activated Ca²⁺-activated ... Read more >>

Mol Cells (Molecules and cells)
[2012, 34(6):563-572]

Cited: 28 times

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REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.

Alma Rodenas-Ruano, Andrés E Chávez, Maria J Cossio, Pablo E Castillo, R Suzanne Zukin,

NMDA receptors (NMDARs) are critical to synaptogenesis, neural circuitry and higher cognitive functions. A hallmark feature of NMDARs is an early postnatal developmental switch from those containing primarily GluN2B to primarily GluN2A subunits. Although the switch in phenotype has been an area of intense interest for two decades, the mechanisms ... Read more >>

Nat Neurosci (Nature neuroscience)
[2012, 15(10):1382-1390]

Cited: 106 times

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Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Koichi Takeuchi, Michael J Gertner, Jing Zhou, Luis F Parada, Michael V L Bennett, R Suzanne Zukin,

The phosphoinositide signaling system is a crucial regulator of neural development, cell survival, and plasticity. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negatively regulates phosphatidylinositol 3-kinase signaling and downstream targets. Nse-Cre Pten conditional knockout mice, in which Pten is ablated in granule cells of the dentate gyrus and ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2013, 110(12):4738-4743]

Cited: 62 times

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Mouse Transient Global Ischemia Two-Vessel Occlusion Model.

Fabrizio Pontarelli, Dimitry Ofengeim, R Suzanne Zukin, Elizabeth A Jonas,

Transient global ischemia in rodents induces delayed death of hippocampal CA1 neurons, as well as in some hilar neurons of the dentate gyrus, medium aspiny neurons of the striatum, pyramidal neurons in neocortical layers II, V and VI, and Purkinje neurons of the cerebellum. In contrast to focal ischemia that ... Read more >>

Bio Protoc (Bio-protocol)
[2012, 2(18):]

Cited: 3 times

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Dysregulation of mTOR signaling in neuropsychiatric disorders: therapeutic implications.

Kirsty Sawicka, R Suzanne Zukin,

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2012, 37(1):305-306]

Cited: 23 times

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Epigenetic mechanisms in stroke and epilepsy.

Jee-Yeon Hwang, Kelly A Aromolaran, R Suzanne Zukin,

Epigenetic remodeling and modifications of chromatin structure by DNA methylation and histone modifications represent central mechanisms for the regulation of neuronal gene expression during brain development, higher-order processing, and memory formation. Emerging evidence implicates epigenetic modifications not only in normal brain function, but also in neuropsychiatric disorders. This review focuses ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2013, 38(1):167-182]

Cited: 55 times

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