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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

Cited: 0 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

Cited: 0 times

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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50 Years of Sepsis Investigation/Enlightenment Among Adults-The Long and Winding Road.

R Phillip Dellinger, Mitchell M Levy, Christa A Schorr, Sean R Townsend,

Crit Care Med (Critical care medicine)
[2021, 49(10):1606-1625]

Cited: 0 times

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Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study.

Sean R Townsend, Gary S Phillips, Reena Duseja, Lemeneh Tefera, Derek Cruikshank, Robert Dickerson, H Bryant Nguyen, Christa A Schorr, Mitchell M Levy, R Phillip Dellinger, William A Conway, Warren S Browner, Emanuel P Rivers,

<h4>Background</h4>US hospitals have reported compliance with the SEP-1 quality measure to Medicare since 2015. Finding an association between compliance and outcomes is essential to gauge measure effectiveness.<h4>Research question</h4>What is the association between compliance with SEP-1 and 30-day mortality among Medicare beneficiaries?<h4>Study design and methods</h4>Studying patient-level data reported to Medicare by ... Read more >>

Chest (Chest)
[2021, :]

Cited: 0 times

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Machine Learning as a Precision-Medicine Approach to Prescribing COVID-19 Pharmacotherapy with Remdesivir or Corticosteroids.

Carson Lam, Anna Siefkas, Nicole S Zelin, Gina Barnes, R Phillip Dellinger, Jean-Louis Vincent, Gregory Braden, Hoyt Burdick, Jana Hoffman, Jacob Calvert, Qingqing Mao, Ritankar Das,

<h4>Purpose</h4>Coronavirus disease-2019 (COVID-19) continues to be a global threat and remains a significant cause of hospitalizations. Recent clinical guidelines have supported the use of corticosteroids or remdesivir in the treatment of COVID-19. However, uncertainty remains about which patients are most likely to benefit from treatment with either drug; such knowledge ... Read more >>

Clin Ther (Clinical therapeutics)
[2021, 43(5):871-885]

Cited: 1 time

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Safety and Feasibility of a Novel Protocol for Percutaneous Dilatational Tracheostomy in Patients with Respiratory Failure due to COVID-19 Infection: A Single Center Experience.

Ziad Boujaoude, Nagendra Madisi, Bhavi Patel, Jean-Sebastien Rachoin, R Phillip Dellinger, Wissam Abouzgheib,

<h4>Introduction</h4>The rapidly spreading Novel Coronavirus 2019 (COVID-19) appeared to be a highly transmissible pathogen in healthcare environments and had resulted in a significant number of patients with respiratory failure requiring tracheostomy, an aerosol-generating procedure that places healthcare workers at high risk of contracting the infection. Instead of deferring or delaying ... Read more >>

Pulm Med (Pulmonary medicine)
[2021, 2021:8815925]

Cited: 1 time

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Is Machine Learning a Better Way to Identify COVID-19 Patients Who Might Benefit from Hydroxychloroquine Treatment?-The IDENTIFY Trial.

Hoyt Burdick, Carson Lam, Samson Mataraso, Anna Siefkas, Gregory Braden, R Phillip Dellinger, Andrea McCoy, Jean-Louis Vincent, Abigail Green-Saxena, Gina Barnes, Jana Hoffman, Jacob Calvert, Emily Pellegrini, Ritankar Das,

Therapeutic agents for the novel coronavirus disease 2019 (COVID-19) have been proposed, but evidence supporting their use is limited. A machine learning algorithm was developed in order to identify a subpopulation of COVID-19 patients for whom hydroxychloroquine was associated with improved survival; this population might be relevant for study in ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

Cited: 3 times

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A Racially Unbiased, Machine Learning Approach to Prediction of Mortality: Algorithm Development Study.

Angier Allen, Samson Mataraso, Anna Siefkas, Hoyt Burdick, Gregory Braden, R Phillip Dellinger, Andrea McCoy, Emily Pellegrini, Jana Hoffman, Abigail Green-Saxena, Gina Barnes, Jacob Calvert, Ritankar Das,

<h4>Background</h4>Racial disparities in health care are well documented in the United States. As machine learning methods become more common in health care settings, it is important to ensure that these methods do not contribute to racial disparities through biased predictions or differential accuracy across racial groups.<h4>Objective</h4>The goal of the research ... Read more >>

JMIR Public Health Surveill (JMIR public health and surveillance)
[2020, 6(4):e22400]

Cited: 1 time

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Prediction of respiratory decompensation in Covid-19 patients using machine learning: The READY trial.

Hoyt Burdick, Carson Lam, Samson Mataraso, Anna Siefkas, Gregory Braden, R Phillip Dellinger, Andrea McCoy, Jean-Louis Vincent, Abigail Green-Saxena, Gina Barnes, Jana Hoffman, Jacob Calvert, Emily Pellegrini, Ritankar Das,

<h4>Background</h4>Currently, physicians are limited in their ability to provide an accurate prognosis for COVID-19 positive patients. Existing scoring systems have been ineffective for identifying patient decompensation. Machine learning (ML) may offer an alternative strategy. A prospectively validated method to predict the need for ventilation in COVID-19 patients is essential to ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2020, 124:103949]

Cited: 21 times

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Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise.

Thomas P Bleck, Timothy G Buchman, R Phillip Dellinger, Clifford S Deutschman, John C Marshall, David M Maslove, Henry Masur, Margaret M Parker, Donald S Prough, Aarti Sarwal, Jonathan E Sevransky, Jean-Louis Vincent, Jerry J Zimmerman,

Crit Care Med (Critical care medicine)
[2020, 48(8):1099-1102]

Cited: 3 times

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Integrating the evidence: confronting the COVID-19 elephant.

John J Marini, R Phillip Dellinger, Daniel Brodie,

Intensive Care Med (Intensive care medicine)
[2020, 46(10):1904-1907]

Cited: 3 times

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The initial resuscitation of septic shock.

Ismail Cinel, Umut S Kasapoglu, Fethi Gul, R Phillip Dellinger,

Septic shock is the most severe form of sepsis, characterized by (a) persistent hypotension despite fluid resuscitation and (b) the presence of tissue hypoperfusion. Delays in the diagnosis and initiation of treatment of septic shock is associated with increasing risk for mortality. Early and effective fluid resuscitation and vasopressor administration ... Read more >>

J Crit Care (Journal of critical care)
[2020, 57:108-117]

Cited: 2 times

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The Association of Increasing Hospice Use With Decreasing Hospital Mortality: An Analysis of the National Inpatient Sample.

Christa A Schorr, Mark Angelo, Gaughan John, Krista LeCompte, R Phillip Dellinger,

<h4>Executive summary</h4>Usage of hospice services for patients facing life-limiting illness has steadily increased. In these services, hospitals discharge patients to various hospice settings, including the inpatient model, where a patient may remain in the discharging hospital to receive hospice services. In this discharge practice, the patient is considered a hospital ... Read more >>

J Healthc Manag (Journal of healthcare management / American College of Healthcare Executives)
[2020, 65(2):107-120]

Cited: 3 times

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The Role of Endotoxin in Septic Shock-Reply.

John C Marshall, Paul M Walker, R Phillip Dellinger,

JAMA (JAMA)
[2019, 321(9):903]

Cited: 0 times

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A Single Certification Exam in Critical Care?: "It Ain't Over Til It's Over".

R Phillip Dellinger,

Crit Care Med (Critical care medicine)
[2018, 46(10):1686-1688]

Cited: 0 times

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Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial.

R Phillip Dellinger, Sean M Bagshaw, Massimo Antonelli, Debra M Foster, David J Klein, John C Marshall, Paul M Palevsky, Lawrence S Weisberg, Christa A Schorr, Stephen Trzeciak, Paul M Walker, ,

<h4>Importance</h4>Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin activity can be measured in blood with a rapid assay. Treating patients with septic shock and elevated endotoxin activity using polymyxin B hemoperfusion may improve clinical outcomes.<h4>Objective</h4>To test whether adding polymyxin B hemoperfusion to conventional medical therapy improves survival compared ... Read more >>

JAMA (JAMA)
[2018, 320(14):1455-1463]

Cited: 62 times

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Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).

Tobias Welte, R Phillip Dellinger, Henning Ebelt, Miguel Ferrer, Steven M Opal, Mervyn Singer, Jean-Louis Vincent, Karl Werdan, Ignacio Martin-Loeches, Jordi Almirall, Antonio Artigas, Jose Ignacio Ayestarán, Sebastian Nuding, Ricard Ferrer, Gonzalo Sirgo Rodríguez, Manu Shankar-Hari, Francisco Álvarez-Lerma, Reimer Riessen, Josep-Maria Sirvent, Stefan Kluge, Kai Zacharowski, Juan Bonastre Mora, Harald Lapp, Gabriele Wöbker, Ute Achtzehn, David Brealey, Axel Kempa, Miguel Sánchez García, Jörg Brederlau, Matthias Kochanek, Henrik Peer Reschreiter, Matthew P Wise, Bernd H Belohradsky, Iris Bobenhausen, Benjamin Dälken, Patrick Dubovy, Patrick Langohr, Monika Mayer, Jörg Schüttrumpf, Andrea Wartenberg-Demand, Ulrike Wippermann, Daniele Wolf, Antoni Torres,

<h4>Purpose</h4>The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP).<h4>Methods</h4>In this double-blind, phase II study (NCT01420744), 160 patients with sCAP requiring invasive mechanical ventilation were randomized (1:1) to trimodulin (42 mg IgM/kg/day) or placebo for ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(4):438-448]

Cited: 29 times

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From Barcelona to New York: 15 years of transition of sepsis performance improvement.

R Phillip Dellinger, Shawana Hussain,

J Thorac Dis (Journal of thoracic disease)
[2017, 9(10):3453-3455]

Cited: 1 time

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Angiotensin II for the Treatment of Vasodilatory Shock - Promise and Caution.

R Phillip Dellinger, Stephen Trzeciak,

N Engl J Med (The New England journal of medicine)
[2017, 377(5):486-487]

Cited: 1 time

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Electrolyte Disturbances in Critically Ill Cancer Patients: An Endocrine Perspective.

Maryam I Khan, R Phillip Dellinger, Steven G Waguespack,

Electrolyte disturbances are frequently encountered in critically ill oncology patients. Hyponatremia and hypernatremia as well as hypocalcemia and hypercalcemia are among the most commonly encountered electrolyte abnormalities. In the intensive care unit, management of critical electrolyte disturbances is focused on initial evaluation and immediate treatment plan to prevent severe complications. ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2018, 33(3):147-158]

Cited: 2 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuck Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger,

<h4>Objective</h4>To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012."<h4>Design</h4>A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was ... Read more >>

Crit Care Med (Critical care medicine)
[2017, 45(3):486-552]

Cited: 809 times

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A Users' Guide to the 2016 Surviving Sepsis Guidelines.

R Phillip Dellinger, Christa A Schorr, Mitchell M Levy,

Crit Care Med (Critical care medicine)
[2017, 45(3):381-385]

Cited: 12 times

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A users' guide to the 2016 Surviving Sepsis Guidelines.

R Phillip Dellinger, Christa A Schorr, Mitchell M Levy,

Intensive Care Med (Intensive care medicine)
[2017, 43(3):299-303]

Cited: 14 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger,

<h4>Objective</h4>To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012".<h4>Design</h4>A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was ... Read more >>

Intensive Care Med (Intensive care medicine)
[2017, 43(3):304-377]

Cited: 1460 times

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