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Author R Morgan

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Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo.

Fiona K Jones, Andrei Stefan, Alasdair G Kay, Mairead Hyland, Rebecca Morgan, Nicholas R Forsyth, Addolorata Pisconti, Oksana Kehoe,

Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by the accumulation of leukocytes in the synovium, cartilage destruction and bone erosion. The immunomodulatory effects of bone marrow derived mesenchymal stem cells (MSCs) has been widely studied and the recent observations that syndecan-3 (SDC3) is selectively pro-inflammatory ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20487]

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Pediatric In-Hospital Cardiac Arrest and Cardiopulmonary Resuscitation in the United States: A Review.

Ryan W Morgan, Matthew P Kirschen, Todd J Kilbaugh, Robert M Sutton, Alexis A Topjian,

Importance:Pediatric in-hospital cardiac arrest (IHCA) occurs frequently and is associated with high morbidity and mortality. The objective of this narrative review is to summarize the current knowledge and recommendations regarding pediatric IHCA and cardiopulmonary resuscitation (CPR). Observations:Each year, more than 15 000 children receive CPR for cardiac arrest during hospitalization in ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2020, :]

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Normal or reactive minor cell populations in bone marrow and peripheral blood mimic minimal residual leukemia by flow cytometry.

Weijie Li, Ruth Morgan, Roxanne Nieder, Sa Truong, Sahibu Sultan M Habeebu, Atif A Ahmed,

BACKGROUND:Measurable residual disease (MRD) is a strong independent poor prognostic factor for acute leukemia. Multiparameter flow cytometry (FCM) is a commonly used MRD detection method. However, FCM MRD detection is not well standardized, and the interpretation is subjective. There are normal/reactive minor cell populations in bone marrow (BM) and peripheral ... Read more >>

Cytometry B Clin Cytom (Cytometry. Part B, Clinical cytometry)
[2020, :]

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Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic.

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AIM:This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. METHOD:This was an international cohort study of patients undergoing elective colon or rectal cancer resection, without preoperative suspicion of ... Read more >>

Colorectal Dis (Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland)
[2020, :]

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Physical restraint of patients in Australia and New Zealand intensive care units.

Matthew J Maiden, Allison Bone, Megan Fitzpatrick, ,

Intensive Care Med (Intensive care medicine)
[2020, :]

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Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease

Bo Qin, Gregory Craven, Pengjiao Hou, Xinran Lu, Emma Child, Rhodri Morgan, Alan Armstrong, David Mann, Sheng Cui,

ABSTRACT RNA viruses are critically dependent upon virally encoded proteases that cleave the viral polyproteins into functional mature proteins. Many of these proteases are structurally conserved with an essential catalytic cysteine and this offers the opportunity to irreversibly inhibit these enzymes with electrophilic small molecules. Here we describe the successful ... Read more >>

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COVID-19 and the Gendered Use of Emojis on Twitter: Infodemiology Study.

Ahmed Al-Rawi, Maliha Siddiqi, Rosemary Morgan, Nimisha Vandan, Julia Smith, Clare Wenham,

BACKGROUND:The online discussion around the COVID-19 pandemic is multifaceted, and it is important to examine the different ways by which online users express themselves. Since emojis are used as effective vehicles to convey ideas and sentiments, they can offer important insight into the public's gendered discourses about the pandemic. OBJECTIVE:This ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(11):e21646]

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Management of Opioid-Induced and Non-Opioid-Related Constipation in Patients With Cancer: Systematic Review and Meta-Analysis.

Pamela K Ginex, Brian J Hanson, Kristine B LeFebvre, Yufen Lin, Kerri A Moriarty, Christine Maloney, Mark Vrabel, Rebecca L Morgan,

PROBLEM IDENTIFICATION:A systematic review and meta-analysis was conducted to inform the development of national clinical practice guidelines on the management of cancer constipation. LITERATURE SEARCH:PubMed®, Wiley Cochrane Library, and CINAHL® were searched for studies published from May 2009 to May 2019. DATA EVALUATION:Two investigators independently reviewed and extracted data from ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2020, 47(6):E211-E224]

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Radiodermatitis in Patients With Cancer: Systematic Review and Meta-Analysis.

Pamela K Ginex, Chelsea Backler, Elizabeth Croson, Lindsey N Horrell, Kerri A Moriarty, Christine Maloney, Mark Vrabel, Rebecca L Morgan,

PROBLEM IDENTIFICATION:A systematic review and meta-analysis was conducted to inform the development of guidelines on the management of radiodermatitis among patients with cancer. LITERATURE SEARCH:The authors updated a systematic review to include available literature published through September 30, 2019. DATA EVALUATION:Two investigators assessed risk of bias using the Cochrane Collaboration ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2020, 47(6):E225-E236]

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ONS Guidelines™ for Opioid-Induced and Non-Opioid-Related Cancer Constipation.

Barbara Rogers, Pamela K Ginex, Allison Anbari, Brian J Hanson, Kristine B LeFebvre, Rachael Lopez, Deborah M Thorpe, Brenda Wolles, Kerri A Moriarty, Christine Maloney, Mark Vrabel, Rebecca L Morgan,

PURPOSE:This evidence-based guideline intends to support clinicians, patients, and others in decisions regarding the treatment of constipation in patients with cancer. METHODOLOGIC APPROACH:An interprofessional panel of healthcare professionals with patient representation prioritized clinical questions and patient outcomes for the management of cancer-related constipation. Systematic reviews of the literature were conducted. ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2020, 47(6):671-691]

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Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer.

Rustain L Morgan, Megan M Eguchi, Jessica McDermott, Adam C Mueller, Arya Amini, Julie A Goddard, Premal S Trivedi, Sana D Karam,

BACKGROUND:Persistent controversy exists with regard to how and when patients with head and neck cancer should undergo imaging after definitive therapy. The current study was conducted to evaluate whether the type of imaging modality used in posttreatment imaging impacts cancer-specific survival for patients with advanced head and neck squamous cell ... Read more >>

Cancer (Cancer)
[2020, :]

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Computed Tomographic Assessment of Individual Paranasal Sinus Compartment and Nasal Conchal Bulla Involvement in 300 Cases of Equine Sinonasal Disease.

Padraic M Dixon, Tim P Barnett, Rhiannon E Morgan, Richard J M Reardon,

Background: Computed tomographic (CT) imaging has allowed new anatomical studies and detailed clinical imaging of the complex, overlapping equine sinonasal structures. Despite the widespread use of CT, no study has specifically identified which compartments are most commonly affected with sinus disorders. CT has also shown the presence of intercurrent, ipsilateral ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2020, 7:580356]

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Examining Criminogenic Risk Levels Among People with Mental Illness Incarcerated in US Jails and Prisons.

Amy Blank Wilson, Karen J Ishler, Robert Morgan, Jonathan Phillips, Jeff Draine, Kathleen J Farkas,

This study examines criminogenic risk levels of individuals with serious mental illness (SMI) involved in the justice system compared to justice-involved individuals without mental illness. The sample (N = 436) consisted of ninety-three individuals with SMI incarcerated in a county jail in a mid-size Midwest city, 217 individuals with SMI incarcerated in ... Read more >>

J Behav Health Serv Res (The journal of behavioral health services & research)
[2020, :]

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Maternal health challenges experienced by adolescents; could community score cards address them? A case study of Kibuku District- Uganda.

Rebecca R Apolot, Moses Tetui, Evelyne B Nyachwo, Linda Waldman, Rosemary Morgan, Christine Aanyu, Aloysius Mutebi, Suzanne N Kiwanuka, Elizabeth Ekirapa,

INTRODUCTION:Approximately 34.8% of the Ugandan population is adolescents. The national teenage pregnancy rate is 25% and in Kibuku district, 17.6% of adolescents aged 12-19 years have begun child bearing. Adolescents mothers are vulnerable to many maternal health challenges including; stigma, unfriendly services and early marriages. The community score card (CSC) is ... Read more >>

Int J Equity Health (International journal for equity in health)
[2020, 19(1):191]

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ONS Guidelines™ for Cancer Treatment-Related Radiodermatitis.

Tracy Gosselin, Pamela K Ginex, Chelsea Backler, Susan D Bruce, Andrea Hutton, Carol M Marquez, Lisa A McGee, Anne Marie Shaftic, Lauren V Suarez, Kerri A Moriarty, Christine Maloney, Mark Vrabel, Rebecca L Morgan,

PURPOSE:Radiodermatitis is a side effect of radiation therapy. Evidence-based interventions to minimize severity or delay progression are important for clinical care. This guideline intends to support individuals with cancer, clinicians, and others in decisions regarding radiodermatitis treatment. METHODOLOGIC APPROACH:A panel of healthcare professionals with patient representation was convened to develop ... Read more >>

Oncol Nurs Forum (Oncology nursing forum)
[2020, 47(6):654-670]

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Part 4: Pediatric Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Alexis A Topjian, Tia T Raymond, Dianne Atkins, Melissa Chan, Jonathan P Duff, Benny L Joyner, Javier J Lasa, Eric J Lavonas, Arielle Levy, Melissa Mahgoub, Garth D Meckler, Kathryn E Roberts, Robert M Sutton, Stephen M Schexnayder, ,

Circulation (Circulation)
[2020, 142(16_suppl_2):S469-S523]

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Role of interventional radiology in line insertion on intensive care during the Covid-19 pandemic.

Tom Cavenagh, Sofia Katsari, Bhavin Kawa, Raham Karimaghaei, Vyzantios Pavlidis, Vasileios Patsiogiannis, Nikolaos Ntagiantas, Joo-Young Chun, Seyed Renani, Leto Mailli, Michael Gonsalves, Lakshmi Ratnam, Raj Das, Robert Morgan,

CVIR Endovasc (CVIR endovascular)
[2020, 3(1):77]

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Redox-Resistant SERCA Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice.

Jena B Goodman, Fuzhong Qin, Robert Morgan, Jordan M Chambers, Dominique Croteau, Deborah A Siwik, Ion Hobai, Marcello Panagia, Ivan Luptak, Markus Bachschmid, Xiao Yong Tong, David R Pimentel, Richard A Cohen, Wilson S Colucci,

Background: Sarco(endo)plasmic reticulum calcium ATPase (SERCA) is regulated by oxidative post-translational modifications at cysteine 674 (C674). Since sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in response to reactive oxygen species (ROS), we hypothesized that SERCA oxidation at C674 would modulate the ... Read more >>

Circulation (Circulation)
[2020, :]

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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19).

Daniel J Ryan, Sinead Toomey, Stephen F Madden, Michelle Casey, Oscar S Breathnach, Patrick G Morris, Liam Grogan, Peter Branagan, Richard W Costello, Eoghan De Barra, Killian Hurley, Cedric Gunaratnam, Noel G McElvaney, Michael Emmet OBrien, Imran Sulaiman, Ross K Morgan, Bryan T Hennessy,

False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial ... Read more >>

Thorax (Thorax)
[2020, :]

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Systematic review and meta-analysis on exposure to long working hours and risk of ischaemic heart disease - Conclusions are supported by the evidence.

Jian Li, Reiner Rugulies, Rebecca L Morgan, Tracey Woodruff, Johannes Siegrist, ,

Environ Int (Environment international)
[2020, 144:106118]

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Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

Ian K Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne-Marie Guerguerian, Vinay M Nadkarni, Kee-Chong Ng, Gabrielle A Nuthall, Gene Y K Ong, Amelia G Reis, Stephen M Schexnayder, Barnaby R Scholefield, Janice A Tijssen, Jerry P Nolan, Peter T Morley, Patrick Van de Voorde, Arno L Zaritsky, Allan R de Caen, ,

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping ... Read more >>

Resuscitation (Resuscitation)
[2020, 156:A120-A155]

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Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

Ian K Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne-Marie Guerguerian, Vinay M Nadkarni, Kee-Chong Ng, Gabrielle A Nuthall, Gene Y K Ong, Amelia G Reis, Stephen M Schexnayder, Barnaby R Scholefield, Janice A Tijssen, Jerry P Nolan, Peter T Morley, Patrick Van de Voorde, Arno L Zaritsky, Allan R de Caen, ,

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping ... Read more >>

Circulation (Circulation)
[2020, 142(16_suppl_1):S140-S184]

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Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.

Stephan B Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W Wright, Fraser Duthie, Karin Oien, Lisa Evers, Colin J McKay, Grant A McGregor, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephan Pettitt, Michele L Dziubinski, Juliana Candido, Frances Balkwill, Simon T Barry, Robert Grützmann, Lola Rahib, , , Amber Johns, Marina Pajic, Fieke E M Froeling, Phillip Beer, Elizabeth A Musgrove, Gloria M Petersen, Alan Ashworth, Margaret C Frame, Howard C Crawford, Diane M Simeone, Chris Lord, Debabrata Mukhopadhyay, Christian Pilarsky, David A Tuveson, Susanna L Cooke, Nigel B Jamieson, Jennifer P Morton, Owen J Sansom, Peter J Bailey, Andrew V Biankin, David K Chang,

BACKGROUND & AIMS:Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

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Rapid-warming tolerance correlates with tolerance to slow warming but not growth at non-optimal temperatures in zebrafish.

E R Åsheim, A H Andreassen, R Morgan, F Jutfelt,

Global warming is predicted to increase both acute and prolonged thermal challenges for aquatic ectotherms. Severe short and medium-term thermal stress over hours to days may cause mortality, while longer sub-lethal thermal challenges may cause performance declines. The interrelationship between the responses to short, medium and longer thermal challenges is ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2020, :]

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The effect of antiretroviral therapy guideline change on health outcomes among youth living with HIV in Uganda.

Hilda Sekabira Nakalema, Suja S Rajan, Robert O Morgan, Minjae Lee, Susan L Gillespie, Adeodata Kekitiinwa,

ABSTRACT Opportunistic infections (OIs) are the primary cause of HIV-related morbidity and mortality. To reduce the risk, the ART eligibility criteria were revised to start treatment before advanced disease onset. We evaluated the effect of 2014 HIV clinical guideline changes in Uganda on opportunistic infections and survival among Youth Living ... Read more >>

AIDS Care (AIDS care)
[2020, :1-10]

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