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Multiparametric MRI of the prostate underestimates tumor volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at mpMRI (MRIvol) and at radical prostatectomy (RPvol), stratifying it according to PI-RADS score.<h4>Materials and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS≥3) who underwent systematic plus targeted biopsy and subsequent RP at ... Read more >>

BJU Int (BJU international)
[2021, :]

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A Contemporary Analysis of Urethral Recurrence following Radical Cystectomy.

Abhinav Khanna, Andrew Zganjar, Timothy Lyon, Paras Shah, Matthew K Tollefson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, R Houston Thompson, Igor Frank, Stephen A Boorjian,

<h4>Introduction</h4>Oncologic outcomes following UR remain incompletely described, with reports limited by small cohort sizes. We evaluated risk factors for UR as well as cancer-specific survival (CSS) and overall survival (OS) among patients with UR.<h4>Methods</h4>We reviewed our institutional RC registry to identify patients with UR. Cox proportional hazards regression was used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001842]

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Patient Satisfaction of Telemedicine Visits in an Advanced Prostate Cancer Clinic During the COVID-19 Pandemic.

Mohamed E Ahmed, Jack R Andrews, Vidhu B Joshi, Lance A Mynderse, Matthew K Tollefson, R Jeffrey Karnes, Eugene D Kwon,

Mayo Clin Proc Innov Qual Outcomes (Mayo Clinic proceedings. Innovations, quality & outcomes)
[2021, :]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Oligometastatic prostatic cancer recurrence: role of salvage lymph node dissection (sLND) and radiation therapy-stereotactic body radiation therapy (RT-SBRT).

Mohamed E Ahmed, Ryan M Phillips, Vidit Sharma, Brian J Davis, R Jeffrey Karnes,

<h4>Purpose of review</h4>Metastases directed therapy (MDT) is an increasingly utilized modality in patients with oligometastatic prostate cancer (OMPC) recurrence. The purpose of our review is to discuss the recent literature on the safety and oncologic outcomes of this treatment approach.<h4>Recent findings</h4>Metastases directed therapy, in particular, stereotactic body radiation therapy (SBRT) ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):199-205]

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Expression of ISL1 and its partners in prostate cancer progression and neuroendocrine differentiation.

Mohammed Alshalalfa, Hatem Abou-Ouf, Elai Davicioni, R Jeffrey Karnes, Reda Alhajj, Tarek A Bismar,

<h4>Introduction and objectives</h4>ISL1 serves as a biomarker of metastasis and neuroendocrine neoplasia in multiple tumors. However, the expression and relation of ISL1 to other biomarkers in prostate cancer have not been fully elucidated. Here, we characterize the expression of ISL1 and its partners in PCa and document its association to disease ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, :]

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer.

Deli Liu, Michael A Augello, Ivana Grbesa, Davide Prandi, Yang Liu, Jonathan E Shoag, R Jeffrey Karnes, Bruce J Trock, Eric A Klein, Robert B Den, Francesca Demichelis, Elai Davicioni, Andrea Sboner, Christopher E Barbieri,

BACKGROUNDMolecular characterization of prostate cancer (PCa) has revealed distinct subclasses based on underlying genomic alterations occurring early in the natural history of the disease. However, how these early alterations influence subsequent molecular events and the course of the disease over its long natural history remains unclear.METHODSWe explored the molecular and ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(10):]

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Editorial: Salvage therapy in uro-oncology.

Axel Heidenreich, R Jeffrey Karnes,

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):177]

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Age and gleason score upgrading between prostate biopsy and radical prostatectomy: Is this still true in the multiparametric resonance imaging era?

Elio Mazzone, Armando Stabile, Gabriele Sorce, Francesco Pellegrino, Francesco Barletta, Giovanni Motterle, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Giorgio Brembilla, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Introduction</h4>Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still unknown. We hypothesized that the introduction of multiparametric magnetic resonance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer.

Carissa E Chu, Mohammed Alshalalfa, Martin Sjöström, Shuang G Zhao, Yang Liu, Jonathan Chou, Annika Herlemann, Brandon Mahal, Amar U Kishan, Daniel E Spratt, Matthew Cooperberg, Eric Small, Anthony Wong, Sima Porten, Thomas A Hope, Ashley E Ross, Elai Davicioni, Paul Nguyen, R Jeffrey Karnes, Peter R Carroll, Edward Schaeffer, Felix Y Feng,

<sup>18</sup>F-Fluciclovine-based positron emission tomography (PET) imaging is recommended in the USA for biochemical recurrence (BCR) after prostate cancer treatment. However, prostate-specific membrane antigen (PSMA)-based PET imaging is more common worldwide, supported by international guidelines, and is now approved by the Food and Drug Administration in the USA for initial staging ... Read more >>

Eur Urol (European urology)
[2021, 79(6):717-721]

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Prostate cancer in young men represents a distinct clinical phenotype: gene expression signature to predict early metastases.

Yuan C Ding, Huiqing Wu, Elai Davicioni, R Jeffrey Karnes, Eric A Klein, Robert B Den, Linda Steele, Susan L Neuhausen,

<h4>Aim</h4>Several genomic signatures are available to predict Prostate Cancer (CaP) outcomes based on gene expression in prostate tissue. However, no signature was tailored to predict aggressive CaP in younger men. We attempted to develop a gene signature to predict the development of metastatic CaP in young men.<h4>Methods</h4>We measured genome-wide gene ... Read more >>

J Transl Genet Genom (Journal of translational genetics and genomics)
[2021, 5:50-61]

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Impact of Pelvic Lymph Node Dissection and Its Extent on Perioperative Morbidity in Patients Undergoing Radical Prostatectomy for Prostate Cancer: A Comprehensive Systematic Review and Meta-analysis.

Giovanni E Cacciamani, Marissa Maas, Nima Nassiri, David Ortega, Karanvir Gill, Paolo Dell'Oglio, George N Thalmann, Axel Heidenreich, James A Eastham, Christopher P Evans, R Jeffrey Karnes, Andre L De Castro Abreu, Alberto Briganti, Walter Artibani, Inderbir Gill, Francesco Montorsi,

<h4>Context</h4>Pelvic lymph node dissection (PLND) yields the most accurate staging in patients undergoing radical prostatectomy (RP) for prostate cancer (PCa), although it can be associated with morbidity.<h4>Objective</h4>To systematically evaluate the impact of PLND extent on perioperative morbidity in patients undergoing RP. A new PLND-related complication assessment tool is proposed.<h4>Evidence acquisition</h4>A ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(2):134-149]

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Re: Jean F.P. Lestingi, Giuliano B. Guglielmetti, Quoc-Dien Trinh, et al. Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.11.040: Time for a Change? Clinically Meaningful Reasons Why We Will Continue Performing Extended Pelvic Lymph Node Dissection in Selected Patients with Prostate Cancer.

Alberto Briganti, Giorgio Gandaglia, Markus Graefen, Steven Joniau, R Jeffrey Karnes, Francesco Montorsi,

Eur Urol (European urology)
[2021, 79(5):e154-e156]

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A comparative study of PCS and PAM50 prostate cancer classification schemes.

Junhee Yoon, Minhyung Kim, Edwin M Posadas, Stephen J Freedland, Yang Liu, Elai Davicioni, Robert B Den, Bruce J Trock, R Jeffrey Karnes, Eric A Klein, Michael R Freeman, Sungyong You,

<h4>Background</h4>Two prostate cancer (PC) classification methods based on transcriptome profiles, a de novo method referred to as the "Prostate Cancer Classification System" (PCS) and a variation of the established PAM50 breast cancer algorithm, were recently proposed. Both studies concluded that most human PC can be assigned to one of three ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma.

Tanner S Miest, Vidit Sharma, R Jeffrey Karnes, Stephen A Boorjian, R Houston Thompson, Igor Frank, Matthew K Tollefson,

<h4>Introduction</h4>Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and predictors of occult preoperative deep vein thrombosis prior to radical cystectomy for urothelial carcinoma.<h4>Methods</h4>We prospectively screened 52 asymptomatic patients with urothelial ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Prostate MRI characteristics in patients with inflammatory bowel disease.

Hiroaki Takahashi, Adam T Froemming, David H Bruining, R Jeffrey Karnes, Rafael E Jimenez, Naoki Takahashi,

<h4>Purpose</h4>Previous studies have indicated an increased risk of prostate carcinoma (PCa) associated with inflammatory bowel disease (IBD). Prostate MRI of IBD patients could be expected to show a mixture of inflammation as well as higher than normal rates of PCa, which could impact interpretation and MRI performance. The purpose of ... Read more >>

Eur J Radiol (European journal of radiology)
[2021, 135:109503]

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The association of salvage intravesical therapy following BCG with pathologic outcomes and survival after radical cystectomy for patients with high-grade non-muscle invasive bladder cancer: A multi-institution analysis.

Vignesh T Packiam, Craig V Labbate, Stephen A Boorjian, Robert Tarrell, John C Cheville, Svetlana Avulova, Vidit Sharma, Matvey Tsivian, Brittany Adamic, Mohammad Mahmoud, Ryan P Werntz, Norm D Smith, R Jeffrey Karnes, Matthew K Tollefson, Gary D Steinberg, Igor Frank,

<h4>Introduction</h4>While numerous current clinical trials are testing novel salvage therapies (ST) for patients with recurrent nonmuscle invasive bladder cancer (NMIBC) after bacillus Calmette-Guérin (BCG), the natural history of this disease state has been poorly defined to date. Herein, we evaluated oncologic outcomes in patients previously treated with BCG and ST ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

Cited: 1 time

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Radium-223 in the Third-Line Setting in Metastatic Castration-Resistant Prostate Cancer: Impact of Concomitant Use of Enzalutamide on Overall Survival (OS) and Predictors of Improved OS.

Mohamed E Ahmed, Vidhu B Joshi, Mohamed Badawy, Lance C Pagliaro, R Jeffrey Karnes, Val Lowe, Matthew P Thorpe, Eugene D Kwon, A Tuba Kendi,

<h4>Introduction</h4>Radium-223 (Ra-223) has been recommended for bone-dominant metastatic castration-resistant prostate cancer (mCRPC). Second-generation hormone therapy in combination with Ra-223 in mCRPC has been utilized, yet its benefit has not been well elucidated. We investigated the potential survival benefit of concomitant enzalutamide with Ra-223 in the third-line setting and predictors of ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Genomic and clinical characterization of stromal infiltration markers in prostate cancer.

Brandon A Mahal, Mohammed Alshalalfa, Shuang G Zhao, Himisha Beltran, William S Chen, Fallon Chipidza, Elai Davicioni, R Jeffrey Karnes, Sheng-Yu Ku, Tamara L Lotan, Vinayak Muralidhar, Timothy R Rebbeck, Edward M Schaeffer, Daniel E Spratt, Felix Y Feng, Paul L Nguyen,

<h4>Background</h4>The progression of prostate cancer is a complex, multistep process that involves molecular alterations in cells of the tumor and the microenvironment, with associated interactions between the stroma and epithelium. Genomic expression analyses of stromal infiltration markers were performed to determine the significance thereof in prostate cancer.<h4>Methods</h4>Genome-wide expression profiles of ... Read more >>

Cancer (Cancer)
[2020, 126(7):1407-1412]

Cited: 3 times

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A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer.

Neil K Jairath, Alan Dal Pra, Randy Vince, Robert T Dess, William C Jackson, Jeffrey J Tosoian, Sean M McBride, Shuang G Zhao, Alejandro Berlin, Brandon A Mahal, Amar U Kishan, Robert B Den, Stephen J Freedland, Simpa S Salami, Samuel D Kaffenberger, Alan Pollack, Phuoc Tran, Rohit Mehra, Todd M Morgan, Adam B Weiner, Osama Mohamad, Peter R Carroll, Matthew R Cooperberg, R Jeffrey Karnes, Paul L Nguyen, Jeff M Michalski, Jonathan D Tward, Felix Y Feng, Edward M Schaeffer, Daniel E Spratt,

<h4>Context</h4>Molecular biomarkers aim to address the established limitations of clinicopathologic factors to accurately risk stratify patients with prostate cancer (PCa). Questions remain as to whether sufficient evidence supports adoption of these biomarkers for clinical use.<h4>Objective</h4>To perform a systematic review of the available evidence supporting the clinical utility of the Decipher ... Read more >>

Eur Urol (European urology)
[2021, 79(3):374-383]

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Development and Validation of a Clinical Prognostic Stage Group System for Nonmetastatic Prostate Cancer Using Disease-Specific Mortality Results From the International Staging Collaboration for Cancer of the Prostate.

Robert T Dess, Krithika Suresh, Michael J Zelefsky, Stephen J Freedland, Brandon A Mahal, Matthew R Cooperberg, Brian J Davis, Eric M Horwitz, Martha K Terris, Christopher L Amling, William J Aronson, Christopher J Kane, William C Jackson, Jason W D Hearn, Curtiland Deville, Theodore L DeWeese, Stephen Greco, Todd R McNutt, Daniel Y Song, Yilun Sun, Rohit Mehra, Samuel D Kaffenberger, Todd M Morgan, Paul L Nguyen, Felix Y Feng, Vidit Sharma, Phuoc T Tran, Bradley J Stish, Thomas M Pisansky, Nicholas G Zaorsky, Fabio Ynoe Moraes, Alejandro Berlin, Antonio Finelli, Nicola Fossati, Giorgio Gandaglia, Alberto Briganti, Peter R Carroll, R Jeffrey Karnes, Michael W Kattan, Matthew J Schipper, Daniel E Spratt,

<h4>Importance</h4>In 2016, the American Joint Committee on Cancer (AJCC) established criteria to evaluate prediction models for staging. No localized prostate cancer models were endorsed by the Precision Medicine Core committee, and 8th edition staging was based on expert consensus.<h4>Objective</h4>To develop and validate a pretreatment clinical prognostic stage group system for ... Read more >>

JAMA Oncol (JAMA oncology)
[2020, 6(12):1912-1920]

Cited: 3 times

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Oligorecurrent prostate cancer treated with metastases-directed therapy or standard of care: a single-center experience.

Luca Boeri, Vidit Sharma, Eugene Kwon, Bradley J Stish, Brian J Davis, R Jeffrey Karnes,

<h4>Background</h4>The optimal treatment for oligorecurrent prostate cancer (PCa) is a matter of debate. We aimed to assess oncologic outcomes of patients treated with metastasis-directed therapy (MDT) vs. androgen deprivation therapy (ADT) for oligorecurrent PCa.<h4>Methods</h4>We analyzed data from patients with oligorecurrent PCa treated with ADT (n = 121), salvage lymph node dissection (sLND) ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, 24(2):514-523]

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Progress on Management of Penile Cancer in 2020.

Mohamed E Ahmed, Mahmoud I Khalil, Mohamed H Kamel, R Jeffrey Karnes, Philippe E Spiess,

<h4>Opinion statement</h4>Management of penile cancer represents a challenge to urologic oncologists due to the disease's rarity and sparse data in the literature. Squamous cell carcinoma represents the most common histologic subtype of penile cancer. Penile cancer has a disastrous effect on patients' psychological and physical health. Penile cancer accounts for ... Read more >>

Curr Treat Options Oncol (Current treatment options in oncology)
[2020, 22(1):4]

Cited: 1 time

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Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence.

Fabio Zattoni, Iliana Bednarova, Alessandro Morlacco, Giovanni Motterle, Paolo Beltrami, Fabrizio Dal Moro, R Jeffrey Karnes,

<h4>Introduction</h4>Transitional cell carcinoma recurrence within an intestinal urinary diversion (TCCUD) after radical cystectomy (RC) is a rare condition with unknown origin, prognosis and treatment. The aim of this study was to describe treatment options and oncologic outcomes of this understudied site of recurrence in a multi-institutional case series.<h4>Material and methods</h4>TCCUD ... Read more >>

Cent European J Urol (Central European journal of urology)
[2020, 73(4):445-456]

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