Full Text Journal Articles by
Author R Bentley

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Targeted Implementation of Joint Clinics in Resource-Stretched Services Improves Referral Rates.

M O'Cathail, R Bentley, V Crosby,

Ir Med J (Irish medical journal)
[2020, 112(10):1029]

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Left Ventricular Fibrosis in Middle-Age Athletes and Physically Active Adults.

Laura Banks, Mustafa A Altaha, Andrew T Yan, Paul Dorian, Kaja Konieczny, Djeven P Deva, Andre LA Gerche, Farhad Akhavein, Robert F Bentley, Kim A Connelly, Jack M Goodman,

INTRODUCTION:Cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques enable the quantification of focal and diffuse myocardial LGE, respectively. Studies have shown evidence of fibrosis in middle-age athletes, but not relative to physically active (PA) adults who perform recommended physical activity levels. Therefore, we examined cardiac remodeling ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2020, 52(12):2500-2507]

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Housing at the frontline of the COVID-19 challenge: A commentary on “Rising home values and Covid-19 case rates in Massachusetts”

Rebecca Bentley, Emma Baker,

Soc Sci Med (Social science & medicine (1982))
[2020, :]

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Normal and Abnormal Relationships of Pulmonary Artery to Wedge Pressure During Exercise.

Robert F Bentley, Madeleine Barker, Sam Esfandiari, Stephen P Wright, Felipe H Valle, John T Granton, Susanna Mak,

Background Resting right heart catheterization can assess both left heart filling and pulmonary artery (PA) pressures to identify and classify pulmonary hypertension. Although exercise may further elucidate hemodynamic abnormalities, current pulmonary hypertension classifications do not consider the expected interrelationship between PA and left heart filling pressures. This study explored the ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(22):e016339]

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Epithelioid Hyalinizing Sarcoma With MGA-NUTM1 Fusion.

Caroline I M Underwood, Diana M Cardona, Rex C Bentley, Guomiao Shen, Xiaojun Feng, George Jour, Rami N Al-Rohil,

OBJECTIVES:Soft tissue sarcomas are a group of tumors derived from the mesenchymal origin. Historically, they have been classified according to morphologic and immunohistochemical characteristics. The advent of multiplexed next-generation sequencing (NGS), specifically RNA sequencing, has modified the classification of such tumors and others by determining categorization based on molecular alterations. ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2020, 154(6):859-866]

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Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts.

José Luis Calleja-Panero, Raúl J Andrade, Rafael Bañares, Javier Crespo, Rafael Esteban, Isidro Jarque, María Eva Mingot-Castellano, Manuel Romero-Gómez, Rocío Muñoz-Peñín, Roy Bentley, John Shepherd, Alicia Gil Aguirre,

BACKGROUND:chronic liver disease (CLD) patients often present thrombocytopenia (TCP) and when severe, it may prevent them from undergoing necessary invasive procedures due to an increased bleeding risk. The lack of scientific evidence makes it impossible to determine key aspects of the current management and associated healthcare burden of these patients ... Read more >>

Rev Esp Enferm Dig (Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva)
[2020, 112(10):778-783]

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Genes, culture, and the human niche: An overview.

Michael J O'Brien, R Alexander Bentley,

The sharp distinction between biological traits and culturally based traits, which had long been standard in evolutionary approaches to behavior, was blurred in the early 1980s by mathematical models that allowed a co-dependent evolution of genetic transmission and cultural information. Niche-construction theory has since added another contrast to standard evolutionary ... Read more >>

Evol Anthropol (Evolutionary anthropology)
[2020, :]

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General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multicentre observational study.

P M Odor, S Bampoe, S R Moonesinghe, J Andrade, J J Pandit, D N Lucas, ,

There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct reporting of awareness in maternity patients' (DREAMY) study of accidental awareness during obstetric anaesthesia aimed to describe practice for obstetric ... Read more >>

Anaesthesia (Anaesthesia)
[2020, :]

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COVIDTrach; the outcomes of mechanically ventilated COVID-19 patients undergoing tracheostomy in the UK: Interim Report.

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Br J Surg (The British journal of surgery)
[2020, :]

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The One Health Consortium: Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Combination With a Checkpoint Inhibitor in Canine Patients With Sporadic High Grade Gliomas.

M R Chambers, R Timothy Bentley, David K Crossman, Jeremy B Foote, Jey W Koehler, James M Markert, Nidal B Omar, Simon R Platt, D Mitchell Self, Andy Shores, Donald C Sorjonen, Alicia M Waters, Amy B Yanke, G Yancey Gillespie,

As the most common and deadly of primary brain tumors, malignant gliomas have earned their place within one of the most multifaceted and heavily-funded realms of medical research. Numerous avenues of pre-clinical investigation continue to provide valuable insight, but modeling the complex evolution and behavior of these tumors within a ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:59]

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Major incident awareness and preparedness.

J Brar, M Dastaran, R Bentley,

Br J Oral Maxillofac Surg (The British journal of oral & maxillofacial surgery)
[2020, 58(8):1061-1062]

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Letter to the Editor - The future of OMFS lies in creating pathways to implement the PMETB recommendations and inspiring our trainees. Enough time has been spent debating, we need to deliver!: Re: Newman L, Brown J, Kerawala C, et al. Our specialty. The future. Is the writing on the wall? Br J Oral Maxillofac Surg 2020 (online ahead of print).

R Bentley, S Parmar, A Smith, D K Dhariwal, R Banks, D Keith, P A Brennan, P Magennis,

The British Association of Oral and Maxillofacial Surgeons (BAOMS) has been at the centre of the transition of our specialty in the UK from a branch of dentistry to one of the 10 UK surgical specialties. In this role it has, at different times, pushed boundaries against resistance from other ... Read more >>

Br J Oral Maxillofac Surg (The British journal of oral & maxillofacial surgery)
[2020, :]

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Changing the Oral and Maxillofacial Surgery (OMFS) training pathway in the United Kingdom - an illustrative retrospective.

P Magennis, A Begley, P A Brennan, S Parmar, D J W Keith, R J Banks, R Bentley, A Smith,

OMFS training is perceived as a long and expensive pathway although papers have shown it compares favourably with other surgical specialties. Every OMFS clinician has a vested interest and duty continually to improve the quality of training and minimise costs, especially to trainees at junior levels. Any serious proposal to ... Read more >>

Br J Oral Maxillofac Surg (The British journal of oral & maxillofacial surgery)
[2020, :]

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A long view of cumulative technological culture.

Michael J O'Brien, R Alexander Bentley,

We agree that the emergence of cumulative technological culture was tied to nonsocial cognitive skills, namely, technical-reasoning skills, which allowed humans to constantly acquire and improve information. Our concern is with a reading of the history of cumulative technological culture that is based largely on modern experiments in simulated settings ... Read more >>

Behav Brain Sci (The Behavioral and brain sciences)
[2020, 43:e174]

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More Than Meets the Eye? A Cautionary Tale of Malignant Ectomesenchymoma Treated as Low-risk Orbital Rhabdomyosarcoma.

Tooba Rashid, Rochelle Bagatell, Bruce Pawel, Rex C Bentley, Susan G Kreissman, Michael D Deel,

Malignant ectomesenchymoma (MEM) is a rare multiphenotypic tumor comprised of mesenchymal and neuroectodermal components. MEM is typically diagnosed in infants and younger children and outcomes are variable. The current approach for treating MEM includes targeting the more aggressive mesenchymal component of the tumor, which is often rhabdomyosarcoma. Here, we describe ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, :]

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Cultural values predict national COVID-19 death rates

Damian J. Ruck, Joshua Borycz, R. Alexander Bentley,

National responses to a pandemic require populations to comply through personal behaviors that occur in a cultural context. Here we show that aggregated cultural values of nations, derived from World Values Survey data, have been at least as important as top-down government actions in predicting the impact of COVID-19. Whereas ... Read more >>

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Improving pandemic mitigation policies across communities through coupled dynamics of risk perception and infection

Matthew Silk, Simon Carrignon, Alexander Bentley, Nina Fefferman,

Decisions to adhere to health-protective behaviors (e.g. mask-wearing, social distancing, etc.) that impact the spread of COVID-19 are not made in isolation by each individual. They are instead the result of the social construction of perceived risks and resulting community norms. In populations in which disease is unlikely to spread ... Read more >>

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Geographic variation in tobacco use in India: a population-based multilevel cross-sectional study.

Ankur Singh, Monika Arora, Rebecca Bentley, Matthew J Spittal, Loc G Do, Nathan Grills, Dallas R English,

OBJECTIVE:This study aims to quantify the extent to which people's use of tobacco products varies by local areas (city ward and village) across India and the variation in this clustering by tobacco products. DESIGN:Cross-sectional study. SETTING AND PARTICIPANTS:Data on 73 954 adults across 2547 city wards and villages were available for ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e033178]

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Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections.

Jennifer L Chain, Kathy Alvarez, Adita Mascaro-Blanco, Sean Reim, Rebecca Bentley, Rebecca Hommer, Paul Grant, James F Leckman, Ivana Kawikova, Kyle Williams, Julie A Stoner, Susan E Swedo, Madeleine W Cunningham,

Movement, behavioral, and neuropsychiatric disorders in children have been linked to infections and a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. The purpose of this study was to determine if anti-neuronal biomarkers, when used as a group, confirmed the acute disease in Sydenham chorea (SC) ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:564]

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The 'Icarus effect' of preventative health behaviors

Simon Carrignon, Alexander Bentley, Matthew Silk, Nina Fefferman,

Ongoing efforts to combat the global pandemic of COVID-19 via public health policy have revealed the critical importance of understanding how individuals understand and react to infection risks. We here present a model to explore how both individual observation and social learning are likely to shape behavioral, and therefore epidemiological, ... Read more >>

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Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P Intermaggio, Blake Gilks, Tayyebeh M Nazeran, Mila Volchek, Wafaa Elatre, Rex C Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, Samuel C Y Leong, Geyi Liu, Dustin Johnson, Billy Chen, Aocs Group, Jennifer Alsop, Susana N Banerjee, Sabine Behrens, Clara Bodelon, Alison H Brand, Louise Brinton, Michael E Carney, Yoke-Eng Chiew, Kara L Cushing-Haugen, Cezary Cybulski, Darren Ennis, Sian Fereday, Renée T Fortner, Jesús García-Donas, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Teodora Goranova, Casey S Greene, Paul Haluska, Holly R Harris, Joy Hendley, Brenda Y Hernandez, Esther Herpel, Mercedes Jimenez-Linan, Chloe Karpinskyj, Scott H Kaufmann, Gary L Keeney, Catherine J Kennedy, Martin Köbel, Jennifer M Koziak, Melissa C Larson, Jenny Lester, Liz-Anne Lewsley, Jolanta Lissowska, Jan Lubiński, Hugh Luk, Geoff Macintyre, Sven Mahner, Iain A McNeish, Janusz Menkiszak, Nikilyn Nevins, Ana Osorio, Oleg Oszurek, José Palacios, Samantha Hinsley, Celeste L Pearce, Malcolm C Pike, Anna M Piskorz, Isabelle Ray-Coquard, Valerie Rhenius, Cristina Rodriguez-Antona, Raghwa Sharma, Mark E Sherman, Dilrini De Silva, Naveena Singh, Peter Sinn, Dennis Slamon, Honglin Song, Helen Steed, Euan A Stronach, Pamela J Thompson, Aleksandra Tołoczko, Britton Trabert, Nadia Traficante, Chiu-Chen Tseng, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Boris Winterhoff, Alicia Beeghly-Fadiel, Javier Benitez, Andrew Berchuck, James D Brenton, Robert Brown, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Peter A Fasching, María J García, Simon A Gayther, Marc T Goodman, Jacek Gronwald, Michelle J Henderson, Beth Y Karlan, Linda E Kelemen, Usha Menon, Sandra Orsulic, Paul D P Pharoah, Nicolas Wentzensen, Anna H Wu, Joellen M Schildkraut, Mary Anne Rossing, Gottfried E Konecny, David G Huntsman, Ruby Yun-Ju Huang, Ellen L Goode, Susan J Ramus, Jennifer A Doherty, David D Bowtell, Michael S Anglesio,

PURPOSE:Gene expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by nonstandardized methods, which are not applicable in a clinical setting. We sought to generate a clinical grade minimal gene ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(20):5411-5423]

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Prognostic gene expression signature for high-grade serous ovarian cancer.

J Millstein, T Budden, E L Goode, M S Anglesio, A Talhouk, M P Intermaggio, H S Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, R C Bentley, C Wang, D S Chiu, S Kommoss, S C Y Leung, J Senz, A Lum, V Chow, H Sudderuddin, R Mackenzie, J George, , S Fereday, J Hendley, N Traficante, H Steed, J M Koziak, M Köbel, I A McNeish, T Goranova, D Ennis, G Macintyre, D Silva De Silva, T Ramón Y Cajal, J García-Donas, S Hernando Polo, G C Rodriguez, K L Cushing-Haugen, H R Harris, C S Greene, R A Zelaya, S Behrens, R T Fortner, P Sinn, E Herpel, J Lester, J Lubiński, O Oszurek, A Tołoczko, C Cybulski, J Menkiszak, C L Pearce, M C Pike, C Tseng, J Alsop, V Rhenius, H Song, M Jimenez-Linan, A M Piskorz, A Gentry-Maharaj, C Karpinskyj, M Widschwendter, N Singh, C J Kennedy, R Sharma, P R Harnett, B Gao, S E Johnatty, R Sayer, J Boros, S J Winham, G L Keeney, S H Kaufmann, M C Larson, H Luk, B Y Hernandez, P J Thompson, L R Wilkens, M E Carney, B Trabert, J Lissowska, L Brinton, M E Sherman, C Bodelon, S Hinsley, L A Lewsley, R Glasspool, S N Banerjee, E A Stronach, P Haluska, I Ray-Coquard, S Mahner, B Winterhoff, D Slamon, D A Levine, L E Kelemen, J Benitez, J Chang-Claude, J Gronwald, A H Wu, U Menon, M T Goodman, J M Schildkraut, N Wentzensen, R Brown, A Berchuck, G Chenevix-Trench, A deFazio, S A Gayther, M J García, M J Henderson, M A Rossing, A Beeghly-Fadiel, P A Fasching, S Orsulic, B Y Karlan, G E Konecny, D G Huntsman, D D Bowtell, J D Brenton, J A Doherty, P D P Pharoah, S J Ramus,

BACKGROUND:Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust prognostic signature for OS in patients with HGSOC. PATIENTS ... Read more >>

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):1240-1250]

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RE: "PUBLIC TRANSPORTATION USE AND COGNITIVE FUNCTION IN OLDER AGE: A QUASIEXPERIMENTAL EVALUATION OF THE FREE BUS PASS POLICY IN THE UNITED KINGDOM".

Tony Blakely, Anne Kavanagh, Rebecca Bentley, Dennis Petrie,

Am J Epidemiol (American journal of epidemiology)
[2020, 189(6):623]

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Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies.

Erica Shen, Joanne Xiu, Rex Bentley, Giselle Y López, Kyle M Walsh,

INTRODUCTION:Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung cancer (NSCLC) harboring mutations in many canonical NSCLC-driver genes (eg, TP53, KRAS, MET). Protection of telomeres 1 (POT1) mutations are observed in angiosarcoma and chronic lymphocytic leukemia, but their frequency in other solid tumors, including NSCLC subtypes, has not ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2020, 21(6):e523-e527]

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Heart rate variability and recovery following maximal exercise in endurance athletes and physically active individuals.

Robert F Bentley, Emily Vecchiarelli, Laura Banks, Patric E O Gonçalves, Scott G Thomas, Jack M Goodman,

The purpose of this study was to determine potential adverse cardiac effects of chronic endurance training by comparing sympathovagal modulation via heart rate variability (HRV) and heart rate recovery (HRR) in middle-aged endurance athletes (EA) and physically active individuals (PA) following maximal exercise. Thirty-six (age, 53 ± 5 years) EA ... Read more >>

Appl Physiol Nutr Metab (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme)
[2020, 45(10):1138-1144]

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