Full Text Journal Articles by
Author Qiuyun Liu

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Hydrogen bonding capacity in DNA attracts protons and prompts the formation of mutagenic and carcinogenic HCl.

Xiaoqian Ma, Yuan Wang, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

Cited: 0 times

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Why RNA viruses evolve more quickly than DNA viruses? A concern for cancer patients during the current pandemic.

Chanyuk Lam, Lipeng Liao, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

Cited: 0 times

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Widespread hydrogen bonding in the proteins of HIV-1 may confer carcinogenic risks to AIDS patients.

Shanshan An, Lipeng Liao, Yuhan Lin, Ying Zhang, Min Fu, Qiuyun Liu,

DNA Repair (Amst) (DNA repair)
[2021, 101:103101]

Cited: 0 times

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Prokaryotic Expression of Phosphoenolpyruvate Carboxylase Fragments from Peanut and Analysis of Osmotic Stress Tolerance of Recombinant Strains.

Jiaqi Tu, Lanlan Feng, Yanbin Hong, Qiuyun Liu, Xia Huang, Yin Li,

Phospho<i>enol</i>pyruvate carboxylase (PEPC) is a ubiquitous cytosolic enzyme that catalyzes the irreversible β-carboxylation of phospho<i>enol</i>pyruvate (PEP) in presence of HCO<sub>3</sub><sup>-</sup> to produce oxaloacetate (OAA) during carbon fixation and photosynthesis. It is well accepted that <i>PEPC</i> genes are expressed in plants upon stress. <i>PEPC</i> also supports the biosynthesis of biocompatible osmolytes ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2021, 10(2):]

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The role of zinc in antiviral remedy for cancer patients.

Ying Zhang, Yuan Wang, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2020, Publish Ahead of Print:]

Cited: 0 times

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Secondary Chemical Bonding between Insoluble Calcium Oxalate and Carbonyl Oxygen Atoms of GLY and VAL Residues Triggers the Formation of Aβ Aggregates and Their Deposition in the Brain.

Xiaoxiao Zhang, Xiaoqian Ma, Tao Gan, Yunfan Shi, Yuan Wang, Qiuyun Liu,

Despite intense efforts, the cause of Alzheimer's disease is still not fully understood. A chemical and biochemical perspective could shed light on this disorder. Secondary chemical bonding between calcium and carbonyl oxygen atoms of glycine and valine might give rise to aggregates in the brain, which may later result in ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2020, 11(24):4007-4011]

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Local strong acids: A driving force for metastasis.

Yulin Wan, Xiaoqian Ma, Yin Li, Xia Huang, Tao Gan, Li Xu, Weiguo Cao, Qiuyun Liu,

Carcinogenesis was postulated as the result of the local buildup of strong acids such as hydrogenchloride which may trigger metastasis. A previous study revealed that bicarbonate raised tumor pH and suppressed metastases. The phosphate groups in DNA on neutrophil extracellular traps possess hydrogen bonding capacity and can accept protons. The ... Read more >>

Med Hypotheses (Medical hypotheses)
[2020, 144:110221]

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Characterization Study of Empty Fruit Bunch (EFB) Fibers Reinforcement in Poly(Butylene) Succinate (PBS)/Starch/Glycerol Composite Sheet.

Rafiqah S Ayu, Abdan Khalina, Ahmad Saffian Harmaen, Khairul Zaman, Tawakkal Isma, Qiuyun Liu, R A Ilyas, Ching Hao Lee,

In this study, a mixture of thermoplastic polybutylene succinate (PBS), tapioca starch, glycerol and empty fruit bunch fiber was prepared by a melt compounding method using an industrial extruder. Generally, insertion of starch/glycerol has provided better strength performance, but worse thermal and water uptake to all specimens. The effect of ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(7):]

Cited: 14 times

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Why is COVID-19 virus so deadly for cancer patients?

Sirui Yan, Ying Zhang, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2020, 29(4):365]

Cited: 2 times

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High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy.

Shanshan An, Xiaoxiao Zhang, Yunfan Shi, Jiaming Zhang, Yulin Wan, Yuchuan Wang, Ying Zhang, Qiuyun Liu,

Numerous risk factors for heart disease or dementia harbor over 10% valine plus glycine content. Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences. The two γ-methyl groups in valine enable hyperconjugation, ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(6):300060520929853]

Cited: 1 time

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Cancer Cells’ Low Sensitivity to Oxalate

Qiuyun Liu, Xiaoxia Li, Tianlun Lei, Yilin Zhang, Man Tang, Meng Xing, Jingli Peng, Min Fu, Li Xu, Wenliang Zhou,

The Warburg effect refers to the phenomenon that cancer cells produce energy via glycolysis instead of cellular respiration. Glycolysis generated no net protons. The Warburg effect may be malignant cells&rsquo; built-in mechanism to antagonize the buildup of protons via Krebs cycle and other pathways with compromised cellular respiration. Data described ... Read more >>

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Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

Shanshan An, Sirui Yan, Ying Zhang, Huan Xu, Tao Gan, Qiuyun Liu,

A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation ... Read more >>

Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2020, 27(1):1073274820954453]

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Is Weak Acid Beneficial for Addressing Checkpoint Inhibitor-Triggered Cancer Hyper Progression in Anti-PD1/PD-L1 Immunotherapies?

Yulin Wan, Shanshan An, Yanchao Zhou, Jiaming Zhang, Ying Zhang, Tao Gan, Qiuyun Liu,

Numerous cases of checkpoint inhibitor-triggered cancer hyperprogression have been documented. A previous hypothesis attributes cancer onset to the local buildup of hydrogen chloride, jointly mediated by hydrogen bond donors and acceptors and basic amino acids. The anti-PD1/PD-L1 immunotherapies may have caused a surge of protons or chloride ions for the ... Read more >>

Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2020, 27(1):1073274820944290]

Cited: 0 times

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A Solo Dance or a Tango?

Yulin Wan, Shanshan An, Yanchao Zhou, Man Tang, Qiuyun Liu,

Previous studies have identified genetic factors and Epstein-Barr virus underlying nasopharyngeal carcinoma. A hypothesis postulated that the local buildup of HCl, mediated by hydrogen bond donors and acceptors and basic amino acids, causes cancer. Nasopharyngeal carcinoma incidences are high in the humid southern coastal China, Southeast Asia, and Mediterranean regions, ... Read more >>

Biochem Insights (Biochemistry insights)
[2019, 12:1178626419886280]

Cited: 0 times

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The Roles of N 6-Methyladenosine in Human Diseases.

Shanshan An, Jiaming Zhang, Yuchuan Wang, Ying Zhang, Qiuyun Liu,

N  6-Methyladenosine methylations and demethylations are associated with a number of human diseases. A chemical and biochemical perspective can complement the biological view of the epigenetic mechanism. The orbital of imino nitrogen and nitrogen-hydrogen orbital displays p-π conjugation and σ-σ hyperconjugation. The electron delocalization attenuates secondary chemical bonding, resulting in ... Read more >>

Biochem Insights (Biochemistry insights)
[2019, 12:1178626419883248]

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Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases.

Yulin Wan, Jiaming Zhang, Xiaoxia Li, Yuchuan Wang, Qiuyun Liu,

Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in the non-coastal southern Chinese Yunnan Province. Secondary chemical bonding may underlie such phenomena. Cancer may be caused by strong acids such as HCl, whereas insoluble and rigid salts such as ... Read more >>

Biochem Insights (Biochemistry insights)
[2019, 12:1178626419877846]

Cited: 3 times

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Who will benefit from colorectal cancer prevention measures?

Yulin Wan, Ling Wen, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2019, 28(5):459-460]

Cited: 3 times

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Protection of cancer in patients with neurodegenerative diseases.

Yulin Wan, Xiaoyi Hu, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2019, 28(5):459]

Cited: 2 times

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Vinegar production and cancer risk.

Yulin Wan, Jing Li, Qiuyun Liu,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2019, 28(4):382]

Cited: 2 times

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Functional duality of ethanol on cancer.

Shanshan An, Xiaoxia Li, Man Tang, Sirui Yan, Fan Yang, Xiang Zhu, Ziting Chen, Qiuyun Liu,

A previous study showed that all kinds of wines or ethanol extended lifespan. Skrott et al. described the death-preventing effect of the alcohol-abuse drug disulfiram. However, this effect, perhaps mediated at least in part by overconsumption of ethanol, cannot be excluded. Carcinogenesis can be resulted from the local buildup of ... Read more >>

Med Hypotheses (Medical hypotheses)
[2019, 122:124-125]

Cited: 5 times

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Engineering of grain seed genes for prevention of heart disease and Alzheimer's disease.

Xiaoyi Hu, Yan Cao, Zhixue Wang, Liang Cui, Qiuyun Liu,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, 26(7):NP5-NP6]

Cited: 1 time

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Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance.

Ying Wang, Qiuyun Liu, Haojie Chen, Jun You, Bin Peng, Fanfan Cao, Xue Zhang, Qing Chen, Georges Uzan, Limin Xu, Denghai Zhang,

The development of resistance to therapy continues to be a serious clinical problem in lung cancer management. Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is one of the most common chemotherapy drugs to treat non-small-cell lung cancer. However, almost all treatments fail after ∼1 year of treatment because of ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2018, 29(8):748-755]

Cited: 2 times

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An apple a day, keeps heart disease away.

Ye Gao, Jingli Peng, Yan Cao, Liang Cui, Qiuyun Liu,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(14):1561]

Cited: 0 times

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Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

Yanchao Zhou, Lan Ouyang, Xiao Yi, Tao Gan, Jinhuan Qi, Yulin Wan, Yuchuan Wang, Shanshan An, Yunfan Shi, Wei Yang, Wenze Chen, Zhiyao Luo, Jing Li, Jun Luo, Xiren Nuertai, Xiang Zhu, Fan Yang, Beibei Zhao, Weiwei Zhang, Zi-Wei Ye, Xiaoxiao Zhang, Shaoping Weng, Qiuyun Liu, Weiguo Cao, Jianguo He,

<h4>ABSTRACT</h4> Global warming is escalating with increased temperatures reported worldwide. Given the enormous land mass on the planet, biological capture of CO 2 remains a viable approach to mitigate the crisis as it is economical and easy to implement. In this study, a gene capable of CO 2 capture was ... Read more >>

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The role of mitochondria in NLRP3 inflammasome activation.

Qiuyun Liu, Danyan Zhang, Diyu Hu, Xiangmei Zhou, Yang Zhou,

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory cytokines like interleukin-1β (IL-1β) and IL-18, and an inflammatory form of cell death termed as pyroptosis. Recent studies have unveiled the pivotal roles of mitochondria in initiation ... Read more >>

Mol Immunol (Molecular immunology)
[2018, 103:115-124]

Cited: 67 times

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