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Author Qinghua Zhou

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Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans.

Qin-Li Wan, Xiaodie Fu, Xiao Meng, Zhenhuan Luo, Wenyu Dai, Jing Yang, Chongyang Wang, Hao Wang, Qinghua Zhou,

Hypotaurine, an important sulfur-containing and nonpeptidic amino acid, is a precursor of taurine and an antioxidant. Our previous study indicated that hypotaurine levels are associated with the ageing of Caenorhabditis elegans (C. elegans). However, whether hypotaurine plays a role in the lifespan regulation of C. elegans and the mechanism remains ... Read more >>

Food Funct (Food & function)
[2020, 11(1):347-357]

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Age-different extent of resection for clinical IA non-small cell lung cancer: analysis of nodal metastasis.

Han-Yu Deng, Jie Zhou, Ru-Lan Wang, Rui Jiang, Xiao-Ming Qiu, Da-Xing Zhu, Xiao-Jun Tang, Qinghua Zhou,

Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resection ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9587]

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Surgical Consideration Based on Lymph Nodes Spread Patterns in Patients with Peripheral Right Middle Non-small Cell Lung Cancer 3 cm or Less.

Rulan Wang, Han-Yu Deng, Jie Zhou, Rui Jiang, Qinghua Zhou,

BACKGROUND:The optimal extent of lung resection and lymph nodes dissection for peripheral early-stage right middle non-small cell lung cancer (NSCLC) still remains controversial. In this study, we analyzed the patterns of lymph nodes metastasis (LNM) of patients with peripheral right middle NSCLC ≤ 3 cm, aiming to provide evidences for surgical choice for ... Read more >>

World J Surg (World journal of surgery)
[2020, :]

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NGT1 Is Essential for N-Acetylglucosamine-Mediated Filamentous Growth Inhibition and HXK1 Functions as a Positive Regulator of Filamentous Growth in Candida tropicalis.

Qiuyu Zhang, Li Xu, Sheng Yuan, Qinghua Zhou, Xuxia Wang, Lei Wang, Zhiming Hu, Yunjun Yan,

Candida tropicalis is a pathogenic fungus that can cause opportunistic infections in humans. The ability of Candida species to transition between yeast and filamentous growth forms is essential to their ability to undergo environmental adaptation and to maintain virulence. In other fungal species, such as Candida albicans, N-acetylglucosamine (GlcNAc) can ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

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The combination of platelet count and lymphocyte to monocyte ratio is a prognostic factor in patients with resected breast cancer.

Yunfu Deng, Wen Li, Xuejuan Liu, Guangzhi Ma, Qiang Wu, Fang Chen, Zhu Wang, Qinghua Zhou,

Many inflammation indicators have been reported to be related with patient outcomes in various cancers. Previous studies have evaluated the combination of platelet (PLT) and lymphocyte to monocyte ratio (COP-LMR) as a systemic inflammatory marker for prognostication in lung cancer, yet its prognostic role among breast cancer patients remains unclear.In ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(18):e18755]

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[Clinical Effect of Pedicled Pericardial Fat Flap in Prevention of Bronchial Pleural Fistula in Bronchial Sleeve Lobectomy].

Xiaoyun Li, Hanyu Deng, Xi Zheng, Daxing Zhu, Qinghua Zhou, Xiaojun Tang,

BACKGROUND:Bronchial sleeve lobectomy is essential surgical approach to treat centralized lung cancer. It is the best reflected the principle of lung cancer surgery, "remove tumor completely while minimize pulmonary function loss". Bronchial pleural fistula (BPF) is not common but very severe complication of bronchial sleeve lobectomy, that is usually fatal. ... Read more >>

Zhongguo Fei Ai Za Zhi (Zhongguo fei ai za zhi = Chinese journal of lung cancer)
[2020, 23(5):360-364]

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Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer.

Wen Li, Min Li, Ting Wang, Guangzhi Ma, Yunfu Deng, Dan Pu, Zhenkun Liu, Qiang Wu, Xuejuan Liu, Qinghua Zhou,

The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The relationship between CONUT and various clinicopathological factors as ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6633]

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[Pulmonary Nodules/Lung Cancer Comprehensive Management Mode: Design and Application].

Dan Liu, Yan Huang, Qinghua Zhou, Lunxu Liu, Guowei Che, You Lu, Feng Xu, Feng Luo, Hongli Bai, Weimin Li,

BACKGROUND:Mortality of lung cancer can be decreased by early screening effectively. However, consistent and proficient standards & methods have not been established in China. This study was based on pulmonary nodules/lung cancer comprehensive management platform established by West China Hospital, Sichuan University. Early screening of pulmonary nodules was integrated into ... Read more >>

Zhongguo Fei Ai Za Zhi (Zhongguo fei ai za zhi = Chinese journal of lung cancer)
[2020, 23(5):299-305]

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Is surgical resection of primary tumour superior to exploratory thoracotomy without resection in treating lung cancer patients with unexpected pleural metastasis detected during operation?

Han-Yu Deng, Xi Zheng, Da-Xing Zhu, Qinghua Zhou,

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'In lung cancer patients with unexpected pleural metastasis detected during operation, is surgical resection of primary tumour superior to exploratory thoracotomy without resection in improving long-term survival?'. Altogether, 1443 papers were found ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2020, 30(4):582-587]

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The frequency of PTEN germline mutations in Chinese breast cancer patients: The PTEN gene may not be closely associated with breast cancer in the Chinese population.

Yu Wu, Dabing Huang, Huanhuan Zhang, Xiaoling Weng, Honglian Wang, Qinghua Zhou, Ying Wu, Yi Shen, Baining Sun, Zhen Hu,

BACKGROUND:PTEN is a tumour suppressor gene that has been proven to be related to breast cancer incidence and tumour progression. The aim of this study was to investigate the frequency of PTEN mutations in breast carcinomas in China and the relationships of PTEN mutations with clinicopathological parameters and clinical outcomes. ... Read more >>

Gene (Gene)
[2020, 744:144630]

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Invasive thymoma with intravascular growth into the great veins and right atrium: A case report.

Wang Shen, Yang Cao, Xinyun Wang, Peng Zhang, Qinghua Zhou,

Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathological diagnosis indicated ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(5):1326-1329]

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Sublobar resection: an alternative to lobectomy in treating stage I non-small-cell lung cancer?

Han-Yu Deng, Xiaojun Tang, Qinghua Zhou,

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, 57(3):613]

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A novel conservative treatment to reduce cardiac herniation following intrapericardial pneumonectomy.

Yunping Lan, Bin Hu, Xiaozun Yang, Bo Tian, Xiaojun Yang, Qiang Li, Ting Wang, Qinghua Zhou, Yunxia Zuo,

Thorac Cancer (Thoracic cancer)
[2020, 11(3):797-798]

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Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2.

Qin-Li Wan, Xiaodie Fu, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang, Qinghua Zhou,

Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(3):2840-2856]

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Nm23-H1 inhibits lung cancer bone-specific metastasis by upregulating miR-660-5p targeted SMARCA5.

Cheng Ai, Guangzhi Ma, Yunfu Deng, Qiangqiang Zheng, Yingcai Gen, Wen Li, Yang Li, Lingling Zu, Qinghua Zhou,

BACKGROUND:Nm23-H1 gene has been found to be an inhibitor of tumor metastasis in lung cancer. MicroRNAs (miRNAs) play key roles in tumor metastasis through multiple signaling pathways. This study explored whether the nm23-H1 gene could inhibit invasion and metastasis of lung cancer cells by regulating miRNA-660-5p targets. METHODS:Quantitative real-time PCR ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(3):640-650]

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LincRNA00494 Suppresses Non-small Cell Lung Cancer Cell Proliferation by Regulating SRCIN1 Expression as a ceRNA.

Jingsi Dong, Bingjie Li, Dan Lin, Dan Lu, Chang Liu, Xingbing Lu, Xiaojun Tang, Lu Li, Daxing Zhu, Jiewei Liu, Xiaoming Qiu, Long Tian, Qinghua Zhou,

Background: Lung cancer is the most common malignant tumor worldwide. Accumulating results have shown that long non-coding RNAs (lncRNAs) play a key role in tumorigenesis. Patients and Methods: A total of 163 tumor tissues were collected from non-small cell lung cancer (NSCLC) patients from West China Hospital of Sichuan University. ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:79]

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Molecular regulatory network of PD-1/PD-L1 in non-small cell lung cancer.

Zhu Lingling, Liu Jiewei, Wang Li, Yan Danli, Zhou Jie, Li Wen, Pu Dan, Peng Lei, Zhou Qinghua,

Lung cancer remains the most common cancer and the leading cause of cancer death worldwide. Despite effective chemotherapy and molecular-based therapies, the median and overall survival remains poor. Immune checkpoint inhibitors have changed the treatment landscape for patients with non-small cell lung cancer (NSCLC) by inhibiting negative T cell regulators, ... Read more >>

Pathol. Res. Pract. (Pathology, research and practice)
[2020, 216(4):152852]

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Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer.

Yu Wu, Huanhuan Zhang, Xiaoling Weng, Honglian Wang, Qinghua Zhou, Ying Wu, Yi Shen, Zhen Hu,

Background:Breast cancer is a one of the malignant carcinomas partially caused by genetic risk factors. Germline BRCA1 gene mutations are reportedly associated with breast cancers. Identification of BRCA1 mutations greatly improves the preventive strategies and management of breast cancer. The aim of our study was to investigate the frequency of ... Read more >>

Hereditas (Hereditas)
[2020, 157:1]

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High-Level Production of a Thermostable Mutant of Yarrowia lipolytica Lipase 2 in Pichia pastoris.

Qinghua Zhou, Zhixin Su, Liangcheng Jiao, Yao Wang, Kaixin Yang, Wenjuan Li, Yunjun Yan,

As a promising biocatalyst, Yarrowia lipolytica lipase 2 (YlLip2) is limited in its industrial applications due to its low thermostability. In this study, a thermostable YlLip2 mutant was overexpressed in Pichia pastoris and its half-life time was over 30 min at 80 °C. To obtain a higher protein secretion level, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 21(1):]

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The Prognostic Role of MET Protein Expression Among Surgically Resected Non-small Cell Lung Cancer Patients: A Meta-Analysis.

Guangzhi Ma, Yunfu Deng, Wenjie Chen, Zhenkun Liu, Cheng Ai, Xuebing Li, Qinghua Zhou,

Objectives: MET protein expression has been reported to be in relevance with the survival of NSCLC patients in various studies, yet the results were inconsistent. The purpose of our study set out to determine the prognostic role of both c-MET and p-MET expression among NSCLC that underwent surgical resection. Methods: ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1441]

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Surgical Choice for Clinical Stage IA Non-Small Cell Lung Cancer: View From Regional Lymph Node Metastasis.

Han-Yu Deng, Jie Zhou, Ru-Lan Wang, Rui Jiang, Xiao-Ming Qiu, Da-Xing Zhu, Xiao-Jun Tang, Qinghua Zhou,

BACKGROUND:We aimed to investigate the pattern of regional lymph node (LN) metastasis of early-stage non-small cell lung cancer (NSCLC) to provide novel rationale for surgical choice (lobectomy, segmentectomy, or wedge resection) for these patients. METHODS:We retrospectively collected clinical data of patients undergoing lobectomy with systematic mediastinal LN dissection or sampling ... Read more >>

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2020, 109(4):1079-1085]

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International expert consensus on the management of bleeding during VATS lung surgery.

Lunxu Liu, Jiandong Mei, Jie He, Todd L Demmy, Shugeng Gao, Shanqing Li, Jianxing He, Yang Liu, Yunchao Huang, Shidong Xu, Jian Hu, Liang Chen, Yuming Zhu, Qingquan Luo, Weimin Mao, Qunyou Tan, Chun Chen, Xiaofei Li, Zhu Zhang, Gening Jiang, Lin Xu, Lanjun Zhang, Jianhua Fu, Hui Li, Qun Wang, Deruo Liu, Lijie Tan, Qinghua Zhou, Xiangning Fu, Zhongmin Jiang, Haiquan Chen, Wentao Fang, Xun Zhang, Yin Li, Ti Tong, Zhentao Yu, Yongyu Liu, Xiuyi Zhi, Tiansheng Yan, Xingyi Zhang, Qiang Pu, Guowei Che, Yidan Lin, Lin Ma, Raul Embun, Javier Aragón, Serdar Evman, Gregor J Kocher, Luca Bertolaccini, Alessandro Brunelli, Diego Gonzalez-Rivas, Joel Dunning, Hui-Ping Liu, Scott J Swanson, Ryabov Andrey Borisovich, Inderpal S Sarkaria, Alan Dart Loon Sihoe, Takeshi Nagayasu, Takuro Miyazaki, Masayuki Chida, Tadasu Kohno, Agasthian Thirugnanam, Harmic J Soukiasian, Mark W Onaitis, Chia-Chuan Liu, ,

Intraoperative bleeding is the most crucial safety concern of video-assisted thoracic surgery (VATS) for a major pulmonary resection. Despite the advances in surgical techniques and devices, intraoperative bleeding is still not rare and remains the most common and potentially fatal cause of conversion from VATS to open thoracotomy. Therefore, to ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(23):712]

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A Retrospective Analysis of 10-Year Data Assessed the Diagnostic Accuracy and Efficacy of Cytogenomic Abnormalities in Current Prenatal and Pediatric Settings.

Hongyan Chai, Autumn DiAdamo, Brittany Grommisch, Fang Xu, Qinghua Zhou, Jiadi Wen, Maurice Mahoney, Allen Bale, James McGrath, Michele Spencer-Manzon, Peining Li, Hui Zhang,

Background: Array comparative genomic hybridization (aCGH), karyotyping and fluorescence in situ hybridization (FISH) analyses have been used in a clinical cytogenetic laboratory. A systematic analysis on diagnostic findings of cytogenomic abnormalities in current prenatal and pediatric settings provides approaches for future improvement. Methods: A retrospective analysis was performed on abnormal ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:1162]

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A Missed Diagnosis of Hemangioma Mimicking Neurogenic Tumor in the Posterior Mediastinum.

Lei Peng, Han-Yu Deng, Chang-Long Qin, Qinghua Zhou,

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2020, 109(3):e229]

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Detection of Circulating Tumor Cell Molecular Subtype in Pulmonary Vein Predicting Prognosis of Stage I-III Non-small Cell Lung Cancer Patients.

Jingsi Dong, Daxing Zhu, Xiaojun Tang, Xiaoming Qiu, Dan Lu, Bingjie Li, Dan Lin, Qinghua Zhou,

Background: There was rare studies on prognosis of pulmonary venous CTC and early or advanced NSCLC patients. We want to investigate whether CTCs and the subtype of it can predict the prognosis of NSCLC patients. Patients and Methods: One hundred and fourteen patients with stage I-III NSCLC were included CanPatrol™ ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1139]

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