Full Text Journal Articles by
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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Visible Light Excitation of BODIPYs Enables Dehydrogenative Enamination at Their α-Positions with Aliphatic Amines.

Dandan Wang, Xing Guo, Hao Wu, Qinghua Wu, Hua Wang, Xiankang Zhang, Erhong Hao, Lijuan Jiao,

A photoredox-mediated route to enamination of boron dipyrromethene (BODIPY) dyes with aliphatic amines is reported by activating both the β-C(sp3)-H bond of amines and the α-C(sp2)-H bond of BODIPYs under visible light illumination. Dehydrogenation of amines by excited-state BODIPYs and/or photoredox catalyst gave enamine intermediates, which were further trapped by ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2020, 85(13):8360-8370]

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Achieving blood pressure control targets in hypertensive patients of rural China - a pilot randomized trial.

Xiao Huang, Lishun Liu, Yun Song, Lan Gao, Min Zhao, Huihui Bao, Xianhui Qin, Yanqing Wu, Qinghua Wu, Chonglei Bi, Aiping Yue, Chongqian Fang, Hai Ma, Yimin Cui, Genfu Tang, Ping Li, Yan Zhang, Jianping Li, Binyan Wang, Xiping Xu, Hong Wang, Gianfranco Parati, J David Spence, Xiaobin Wang, Yong Huo, Guangliang Chen, Xiaoshu Cheng, ,

BACKGROUND:This study aimed to test the feasibility and titration methods used to achieve specific blood pressure (BP) control targets in hypertensive patients of rural China. METHODS:A randomized, controlled, open-label trial was conducted in Rongcheng, China. We enrolled 105 hypertensive participants aged over 60 years, and who had no history of stroke ... Read more >>

Trials (Trials)
[2020, 21(1):515]

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A novel strategy for the diagnosis, prognosis, treatment, and chemoresistance of hepatocellular carcinoma: DNA methylation.

Aimei Liu, Qinghua Wu, Dapeng Peng, Irma Ares, Arturo Anadón, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Xu Wang, María-Aránzazu Martínez,

The cancer mortality rate of hepatocellular carcinoma (HCC) is the second highest in the world and the therapeutic options are limited. The incidence of this deadly cancer is rising at an alarming rate because of the high degree of resistance to chemo- and radiotherapy, lack of proper, and adequate vaccination ... Read more >>

Med Res Rev (Medicinal research reviews)
[2020, :]

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Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink.

Qinghua Wu, Kamil Kuca, Eugenie Nepovimova, Wenda Wu,

The trichothecene mycotoxins contaminate cereal grains and have been related to alimentary toxicosis resulted in emetic response. This family of mycotoxins comprises type A to D groups of toxic sesquiterpene chemicals. Diacetoxyscirpenol (DAS), one of the most toxic type A trichothecenes, is considered to be a potential risk for human ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(6):]

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Transcriptome profiling of the flowering transition in saffron (Crocus sativus L.).

Jing Hu, Yuping Liu, Xiaohui Tang, Huajing Rao, Chaoxiang Ren, Jiang Chen, Qinghua Wu, Yi Jiang, Fuchang Geng, Jin Pei,

Saffron, derived from the stigma of Crocus sativus, is not only a valuable traditional Chinese medicine but also the expensive spice and dye. Its yield and quality are seriously influenced by its flowering transition. However, the molecular regulatory mechanism of the flowering transition in C. sativus is still unknown. In ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9680]

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Association of +138I/D and Lys198Asn Polymorphisms in the Endothelin-1 Gene with Early Onset of Coronary Artery Disease among the Chinese Han Population.

Guosheng Tu, Zhengxu Fang, Yu Zhao, Qinghua Wu,

BACKGROUND Human endothelin-1 (ET-1) gene polymorphism is closely associated with coronary artery disease (CAD). This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921542]

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Single-wavelength phototheranostics for colon cancer via the thiolytic reaction.

Yucheng Zhu, Chao Chen, Qinghua Wu, Guoliang Yang, Zhiyong Liu, Erhong Hao, Hongliang Cao, Yun Gao, Weian Zhang,

It's a huge challenge to develop effective nanosystems that combine the capabilities of diagnoses and therapies together for colon cancer in the clinic. Herein, we constructed a far-red absorbing phototheranostic nanosystem (FR-H2S) based on the thiolytic reaction of a dinitrophenyl modified phototheranostic prodrug and over-expressed H2S in colon cancer sites ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(22):12165-12171]

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Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters.

Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou, Mengying Hou, Xudong Li, Yong Liu, Lichen Yin,

The anticancer performance of nanomedicine is largely impeded by insufficient intratumoral penetration. Herein, tumor microenvironment (TME)-amendatory and self-adaptive nanoclusters (NCs) capable of cancer-associated fibroblasts (CAFs) depletion and size/charge conversion were engineered to mediate light-assisted, hierarchical intratumoral penetration. Particularly, large-sized NCs (~50 nm) were prepared via self-assembly of FAP-α-targeting peptide-modified, 1O2-sensitive polymers, ... Read more >>

Biomaterials (Biomaterials)
[2020, 255:120166]

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Assessing the equivalence between traditional medicinal varieties and nontraditional medicinal varieties of Citri reticulata Semen

Bin Xian, Li Wang, Rui Wang, Chaoxiang Ren, Jiang Chen, Cuiping Chen, Wanting Zhong, Qinghua Wu, Jin Pei,

Abstract Background Juhe, which is derived from seeds of citrus ( Citri reticulata Semen), is wildly used as a traditional Chinese medicine. Its original plants have numinous variety, and new varieties are constantly emerging, especially in recent years. The decline in the market share of traditional varieties each year, ... Read more >>

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[Genetic testing and prenatal diagnosis for two families affected with Joubert syndrome].

Zhouxian Bai, Shuang Hu, Ning Liu, Qinghua Wu, Xiangdong Kong,

OBJECTIVE:To identify pathogenic variants in two families with patients suspected for Joubert syndrome(UBST) by cerebellar vermis hypoplasia. METHODS:Clinical data and peripheral venous blood and skin tissue samples were collected for the extraction of genomic DNA. Potential variants were screened by using targeted capture and next generation sequencing. Suspected variants were ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2020, 37(5):509-513]

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Dexmedetomidine for prevention of propofol injection pain upon induction of anesthesia: a meta-analysis.

Liting Ji, Weihua Sun, Yunping Lan, Changxing Xia, Gongmin Yu, Qinghua Wu, Shufen Yang, Xiaofeng Xu,

PURPOSE:Propofol injection pain is a very common problem during the induction of general anesthesia. The purpose of this review is to evaluate the effectiveness of dexmedetomidine for the prevention of propofol injection pain so as to provide evidence for future clinical applications. METHODS:PubMed, Embase, Cochrane library, and Google Scholar databases ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2020, :]

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Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway.

Biming Zhan, Zongyu Xu, Yang Zhang, Kefei Wan, Hanyue Deng, Dimeng Wang, Huihui Bao, Qinghua Wu, Xiaohong Hu, Hong Wang, Xiao Huang, Xiaoshu Cheng,

OBJECTIVE:Nicorandil exerts a protective effect against coronary microvascular dysfunction in acute myocardial infarction (AMI) patients. However, the mechanism and effect of nicorandil in hyperhomocysteinemia (HHcy) AMI patients remain unclear. METHODS:C57/BL6 mice with mild to moderate HHcy and human coronary artery endothelial cells (HCAECs) cotreated with HHcy (1 mmol/L) for 24 ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 127:110121]

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Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology.

Jiri Patocka, Qinghua Wu, Eugenie Nepovimova, Kamil Kuca,

Phenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also been evaluated in the context of many other illnesses in addition to its original epilepsy indication. The narrow therapeutic index of phenytoin and its ubiquitous daily use pose a high risk of poisoning. This review article ... Read more >>

Food Chem. Toxicol. (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2020, 142:111393]

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Targeting JNK and its role in tumor development and chemoresistance.

Qinghua Wu, Kamil Kuca, Wenda Wu,

Future Med Chem (Future medicinal chemistry)
[2020, 12(12):1103-1105]

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A Family of BODIPY-like Highly Fluorescent and Unsymmetrical Bis(BF2) Pyrrolyl-Acylhydrazone Chromophores: BOAPY.

Changjiang Yu, Xingbao Fang, Qinghua Wu, Lijuan Jiao, Lilin Sun, Zikang Li, Pui-Kin So, Wai-Yeung Wong, Erhong Hao,

A new family of pyrrolyl-acylhydrazones anchored with two BF2 units, named BOAPY, have been developed as BODIPY-like and unsymmetrical bis(BF2) chromophores via a simple one-pot reaction. The easily accessible scaffold enjoys excellent diversity due to the structural versatilities of 2-formylpyrroles and acylhydrazines. BOAPYs exhibit good molar absorption coefficients, large Stokes ... Read more >>

Org. Lett. (Organic letters)
[2020, 22(12):4588-4592]

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[Ultrasonographic manifestation and genetic analysis of a fetus with nephronophthisis type 2].

Qinghua Wu, Saisai Yang, Can Wang, Huirong Shi, Shumin Ren, Zhihui Jiao, Xiangdong Kong,

OBJECTIVE:To carry out genetic analysis for a family with a fetus manifesting bilateral polycystic renal dysplasia and oligohydramnios at 16+ gestational week and a previous history for fetal renal anomaly. METHODS:Ultrasound scan was carried out to detect the morphological changes. Following genetic counselling, the parents had decided to terminate the ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2020, 37(5):559-562]

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[Clinical phenotype and genetic analysis of three pedigrees with 17q12 microdeletion syndrome].

Qinghua Wu, Saisai Yang, Can Wang, Huirong Shi, Xiangdong Kong, Shumin Ren, Zhihui Jiao, Ning Liu, Panlai Shi,

OBJECTIVE:To explore the genetic etiology of three pedigrees with a gestational history of fetal renal anomalies. METHODS:Peripheral venous blood or skin samples were derived from the probands of the three pedigrees. Copy number variation sequencing (CNV-seq) was applied to detect alterations of genome CNVs. RESULTS:The patient from pedigree 1 and ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2020, 37(4):397-400]

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Is the blood pressure of right arm measured with synchronous four-limb method is equal to that with single arm method?

Tao Yang, Qinghua Wu, Weitong Hu, Hai Su,

OBJECTIVE:Synchronous four-limb blood pressure (BP) measurement (four-limb method) is widely used for diagnosing peripheral artery diseases in clinical practise, but it is unclear whether the BP of right arm measured with this method is similar to that measured with single arm method. METHODS:This study included 198 in-patients (aged 18-89, mean ... Read more >>

Blood Press Monit (Blood pressure monitoring)
[2020, 25(2):95-99]

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Interrupted or Uninterrupted Oral Anticoagulants in Patients Undergoing Atrial Fibrillation Ablation.

Pingping Yang, Chenxi Wang, Yinquan Ye, Tieqiu Huang, Shuai Yang, Wen Shen, Gaosi Xu, Qinghua Wu,

BACKGROUND AND PURPOSE:The safety and efficacy of uninterrupted, minimally interrupted (one dose skipped) or completely interrupted (24 h skipped) oral anticoagulant therapy in patients with atrial fibrillation (AF) ablation are poorly defined. We conducted a network meta-analysis to explore the effect of interrupted or uninterrupted oral anticoagulants in patients with AF ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2020, 34(3):371-381]

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MiR-155-5p plays as a "janus" in the expression of inflammatory cytokines induced by T-2 toxin.

Pu Guo, Fang Qiao, Deyu Huang, Qinghua Wu, Tianlun Chen, Sara Badawy, Guyue Cheng, Haihong Hao, Shuyu Xie, Xu Wang,

Although many studies have shown that inflammatory response plays a crucial role in the various toxic effects of T-2 toxin, there are relatively few reports on the mechanism of this phenomenon. Meanwhile, accumulating evidence has shown that miR-155-5p is activated in the inflammatory response. As molecular pathways and mechanisms involved ... Read more >>

Food Chem. Toxicol. (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2020, 140:111258]

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How Far is between Cancer and Health?

Chunsong Hu, Tengiz Tkebuchava, Qinghua Wu, Dayi Hu,

Iran. J. Public Health (Iranian journal of public health)
[2019, 48(5):974-976]

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Anorexic responses to trichothecene deoxynivalenol and its congeners correspond to secretion of tumor necrosis factor-α and interleukin-1β.

Qinghua Wu, Jianming Yue, Haibin Zhang, Kamil Kuca, Wenda Wu,

Type B trichothecene mycotoxins comprise deoxynivalenol ("Vomitoxin", DON) and four structually related congeners: 15-acetyl- and 3-acetyl-deoxynivalenol (15-ADON and 3-ADON), nivalenol (NIV), 4-acetyl-nivalenol (fusarenon X, FX). These foodborne mycotoxins has been linked to food poisoning leading to anorexic response in human and several animal species. However, the pathophysiological basis for anorexic ... Read more >>

Environ. Toxicol. Pharmacol. (Environmental toxicology and pharmacology)
[2020, 77:103371]

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The effects of Japanese encephalitis virus antibodies on Zika virus infection.

Xiaoen He, Xinyue Lang, Jianhai Yu, Li Zhu, Zhiran Qin, Xuling Liu, Pei Chen, Chengguqiu Dai, Tingting Chen, Xujuan Li, Yangyang Chen, Dongrui Zhou, Wanyi Fang, Weiwei Xiao, Bao Zhang, Qian Xie, Qinghua Wu, Wei Zhao,

Recently, Zika virus (ZIKV) has become more widespread, thus attracting global attention. The vaccine against Japanese encephalitis virus (JEV) is currently used in China, being included in planned immunisation regimes. Although ZIKV and JEV are closely related mosquito-borne Flaviviruses, and a complex cross-immune response within flaviviruses has been demonstrated, the ... Read more >>

Med. Microbiol. Immunol. (Medical microbiology and immunology)
[2020, 209(2):177-188]

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Achieving blood pressure control targets in hypertensive patients of rural China – A pilot randomized trial

Xiao Huang, Lishun Liu, Yun Song, Lan Gao, Min Zhao, Huihui Bao, Xianhui Qin, Yanqing Wu, Qinghua Wu, Chonglei Bi, Aiping Yue, Chongqian Fang, Hai Ma, Yimin Cui, Genfu Tang, Ping Li, Yan Zhang, Jianping Li, Binyan Wang, Xiping Xu, Hong Wang, Gianfranco Parati, David Spence, Xiaobin Wang, Yong Huo, Guangliang Chen, Xiaoshu Cheng,

Abstract Background: This study aimed to test the feasibility and titration methods to achieve specific BP control targets in hypertensive patients of rural China. Methods: A randomized, controlled, open-label trial was conducted in Rongcheng, China. We enrolled 105 hypertensive participants aged over 60 years, and who had no history of ... Read more >>

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