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Grading of clear cell renal cell carcinoma using diffusion MRI with a fractional order calculus model.

Bowen Shi, Ke Xue, Yili Yin, Qing Xu, Binbin Shi, Dongmei Wu, Jing Ye,

<h4>Background</h4>The fractional order calculus (FROC) model has been developed to describe restrained motion of water molecules as well as microstructural heterogeneity, providing a novel tool for non-invasive tumor grading.<h4>Purpose</h4>To evaluate the role of the FROC model in characterizing clear cell renal cell carcinoma (ccRCC) grades.<h4>Material and methods</h4>A total of 59 ... Read more >>

Acta Radiol (Acta radiologica (Stockholm, Sweden : 1987))
[2022, :2841851211072482]

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Enhancement of central norepinephrinergic neurotransmission contributes to inhibition of seizure-induced respiratory arrest by targeting the beta-1 adrenergic receptor (β1-AR) locating in the cardiomyocytes in the DBA/1 mouse SUDEP model

XiTing Lian, Qian Yu, HaiXiang Ma, LeYuan Gu, Qing Xu, HongHai Zhang,

Sudden unexpected death of epilepsy (SUDEP) is the key cause of of death in patients with epilepsy. Due to the complicated pathogenesis of SUDEP, however, the exact mechanism of SUDEP remains elusive. Currently, although it is recognized that the seizure-induced respiratory arrest (S-IRA) may be a main cause for SUDEP, ... Read more >>

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Pharmacological agents targeting autophagy and their effects on lipolysis in human adipocytes.

Qing Xu, Edwin Cm Mariman, Ellen E Blaak, Johan We Jocken,

Adipose tissue of metabolically compromised humans with obesity is often characterized by impaired regulation of autophagy pathway. However, data on the role of autophagy in human adipocyte lipid catabolism is scarce. Therefore, we investigated the effect of pharmacological agents (including 3-methyladenine (3MA), bafilomycin A1 (BAF), chloroquine (CQ) and lalistat-2 (L-stat), ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2022, :111555]

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Glutamine Antagonist Synergizes with Electrodynamic Therapy to Induce Tumor Regression and Systemic Antitumor Immunity.

Gui Chen, Qing Xu, Zhenzhen Feng, Qinqin Xu, Xuhui Zhang, Yuanyuan Yang, Yuxuan Zhang, Xing-Jie Liang, Zhiqiang Yu, Meng Yu,

Electrodynamic therapy (EDT) combining nanotechnology with electronic current was used in this study to generate highly cytotoxic oxidative hydroxyl radicals (·OH) for tumor destruction. However, increasing evidence suggests that EDT treatment alone for one time still faces great challenges in achieving long-term tumor suppression in an immunosuppressive environment, which would ... Read more >>

ACS Nano (ACS nano)
[2022, :]

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Encapsulating quercetin in cyclodextrin metal-organic frameworks improved its solubility and bioavailability.

Zhenjiong Wang, Yiding Ma, Ying Jiang, Feng Zhou, Yulong Wu, Haitao Jiang, Renlei Wang, Qing Xu, Chun Hua,

<h4>Background</h4>Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid-lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ-Cyclodextrin metal-organic frameworks (γ-CD-MOFs) are novel porous carriers for loading functional products. In this study, Que was successfully loaded into γ-CD-MOFs, ... Read more >>

J Sci Food Agric (Journal of the science of food and agriculture)
[2021, :]

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Intestinal epithelial glucocorticoid receptor promotes chronic inflammation-associated colorectal cancer.

Shuang Tang, Zhan Zhang, Robert H Oakley, Wenling Li, Weijing He, Xiaojiang Xu, Ming Ji, Qing Xu, Liang Chen, Alicia S Wellman, Qingguo Li, Leping Li, Jian-Liang Li, Xinxiang Li, John A Cidlowski, Xiaoling Li,

Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory bowel disease (IBD). However, the impact of GC signaling on intestinal tumorigenesis remains controversial. Here, we report that intestinal epithelial GC receptor (GR), but not whole intestinal tissue GR, promoted chronic intestinal inflammation-associated colorectal cancer in both humans and mice. ... Read more >>

JCI Insight (JCI insight)
[2021, 6(24):]

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Correction To: Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.

Yaohui Gao, Dexi Bi, Ruting Xie, Man Li, Jing Guo, Hu Liu, Xianling Guo, Juemin Fang, Tingting Ding, Huiyuan Zhu, Yuan Cao, Meichun Xing, Jiayi Zheng, Qing Xu, Qian Xu, Qing Wei, Huanlong Qin,

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):434]

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Comparative Study on Molecular Epidemiology of Measles H1a Outbreak and Sporadic Cases in Shandong Province, 2013-2019

Suting Wang, Changyin Wang, Xiaodong Liu, Ping Xiong, Yao Liu, Zexin Tao, Meng Chen, Qing Xu, Li Zhang, Aiqiang Xu,

<h4>Background: </h4> Measles caused by measles virus (MeV) is a highly contagious viral disease which has also been associated with complications including pneumonia, myocarditis, encephalitis, and subacute sclerosing panencephalitis. The current study collected33 strains from 2013 to 2019 in 13 cities of Shandong province and separate them into 2 group, ... Read more >>

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Diagnostic and prognostic significance of miR-451a in patients with atherosclerosis.

Baizhi Wang, Xingliang Duan, Qing Xu, Yani Li,

OBJECTIVES:Atherosclerosis (AS) is a chronic inflammatory vascular disease. This study aimed to detect the expression level of miR-451a and investigate the diagnostic and prognostic values of miR-451a for AS patients. METHODS:The relative expression of miR-451a was assessed by qRT-PCR. Comparison of groups was analyzed with the t-test and chi-squared test. ... Read more >>

Vascular (Vascular)
[2021, :17085381211058571]

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Prevalence and Risk Factors Analysis for Low Back Pain Among Occupational Groups in Key Industries of China

Ning JIA, Meibian ZHANG, Huadong Zhang, Ruijie Ling, Yimin Liu, Gang Li, Yan YIN, Hua SHAO, Hengdong ZHANG, Bing QIU, Dongxia Li, Dayu WANG, Qiang ZENG, Rugang WANG, Jianchao CHEN, Danying ZHANG, Liangying MEI, Xinglin Fang, Yongquan LIU, Jixiang LIU, Chengyun ZHANG, Tianlai LI, Qing XU, Ying QU, Xueyan ZHANG, Xin SUN, Zhongxu WANG,

<h4>Background: </h4> With the acceleration of industrialization and the growth of population aging, LBP has become the main disease of life loss caused by disability, which brings huge economic burden to society and is a global public health problem that needs to be solved urgently. The purpose of this study ... Read more >>

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Therapeutic advances in non-small cell lung cancer: Focus on clinical development of targeted therapy and immunotherapy.

Yuan Cheng, Tao Zhang, Qing Xu,

Lung cancer still contributes to nearly one-quarter cancer-related deaths in the past decades, despite the rapid development of targeted therapy and immunotherapy in non-small cell lung cancer (NSCLC). The development and availability of comprehensive genomic profiling make the classification of NSCLC more precise and personalized. Most treatment decisions of advanced-stage ... Read more >>

MedComm (2020) (MedComm)
[2021, 2(4):692-729]

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Chloroplast Genomes for Five Skeletonema Species: Comparative and Phylogenetic Analysis.

Shuya Liu, Qing Xu, Kuiyan Liu, Yongfang Zhao, Nansheng Chen,

<i>Skeletonema</i> species are cosmopolitan coastal diatoms that exhibit important roles in ecological system. The chloroplast genomes (cpDNAs) have been proven to be important in the study of molecular evolution and genetic diversity. However, cpDNA of only a single <i>Skeletonema</i> species (<i>S. pseudocostatum</i>) has been constructed, hindering in-depth investigation on <i>Skeletonema</i> ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:774617]

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Sleep problems in fragile X syndrome: Cross-sectional analysis of a large clinic-based cohort.

Dejan B Budimirovic, Dragana D Protic, Carol M Delahunty, Howard F Andrews, Tse-Hwei Choo, Qing Xu, Elizabeth Berry-Kravis, Walter E Kaufmann, ,

Fragile X syndrome (FXS), the leading cause of inherited intellectual disability and autism spectrum disorder, is associated with multiple neurobehavioral abnormalities including sleep difficulties. Nonetheless, frequency, severity, and consequences of sleep problems are still unclear. The Fragile X Online Registry with Accessible Research Database (FORWARD-version-3), including Clinician Report and Parent ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, :]

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Knockdown of KLF7 inhibits the differentiation of both intramuscular and subcutaneous preadipocytes in goat.

Yanyan Li, Qing Xu, Yong Wang, Dingshuang Chen, Yu Du, Ruiwen Li, Kehan Liu, Jiangjiang Zhu, Yaqiu Lin,

<i>KLF7 b</i>elongs to the Krüppel-like factors (KLFs) family, which function as transcriptional regulators controlling a number of basic cellular processes, involving proliferation, differentiation, and migration. Here, we reveal insights into the differentiated expression of <i>KLF7</i> in different goat tissues and different stages of growth, and the inhibition role of <i>KLF7</i> ... Read more >>

Anim Biotechnol (Animal biotechnology)
[2021, :1-11]

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Stable and enhanced electrochemical performance based on hierarchical core-shell structure of CoMn2O4@Ni3S2electrode for hybrid supercapacitor.

Qing Xu, Yintao Wang, Suci Meng, Deli Jiang, Min Chen,

Herein, accessible and low-cost CoMn<sub>2</sub>O<sub>4</sub>@Ni<sub>3</sub>S<sub>2</sub>core-shell nanoneedle arrays have been prepared via a two-step approach comprised with hydrothermal-calcination and electrochemical deposition procedures, successfully. In the beginning, CoMn<sub>2</sub>O<sub>4</sub>nanoneedle arrays took root on Ni foam to form the core skeleton and subsequently, hierarchical Ni<sub>3</sub>S<sub>2</sub>nanosheets uniformly overlaid on the surface of CoMn<sub>2</sub>O<sub>4</sub>nanoneedles shaping the ... Read more >>

Nanotechnology (Nanotechnology)
[2021, 33(9):]

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Factors associated with the elasticity of asymptomatic carotid plaques in hypertension Tibetan population.

Guyue Liu, Qing Xu, Min Sun, Rong Xiao,

<h4>Aims</h4>Hypertension is a major risk factor for coronary, cerebrovascular, and the greatest cause of stroke. Half of stroke events are the result of cerebrovascular atherosclerosis, including carotid plaques. It is of major importance to detect which plaques are vulnerable, even though not yet ruptured. Due to the particularity of the ... Read more >>

Vascular (Vascular)
[2021, :17085381211060938]

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Transcriptome analysis of Rhizopus oryzae seed pellet formation using triethanolamine.

Na Wu, Jiahui Zhang, Wen Ou, Yaru Chen, Ru Wang, Ke Li, Xiao-Man Sun, Yingfeng Li, Qing Xu, He Huang,

Rhizopus oryzae (R. oryzae) can effectively produce organic acids, and its pellet formation in seed cultures has been shown to significantly enhance subsequent fermentation processes. Despite advances in strain development, simple and effective methods for inducing pellet morphology and a basic understanding of the mechanisms controlling this process could facilitate ... Read more >>

Biotechnol Biofuels (Biotechnology for biofuels)
[2021, 14(1):230]

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Effects of microscopic testa color and morphologyon the water uptake ability and drought tolerance of germination-stage rapeseed (Brassica napus L.).

Zong He Zhu, Abdul Sami, Zhi Peng Chen, Maliha Fatima, Wen Yin Zheng, Qing Qing Xu, Yu Hang Lei, Xue Zhi Jin, Hong Zhang, Yong Li, Yan Yu, Ke Jin Zhou,

Drought is one of the most important abiotic stressors that affect crop yield. Therefore, the aim of the present study was to investigate correlations between germination-stage drought tolerance and the microscopic testa (i.e., seed coat) characteristics (color and papilla morphology) and imbibition abilities of 35 rapeseed (<i>Brassica napus</i> L.) accessions. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9341-9355]

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Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway.

Li Zhang, Liwen Wang, Li Huang, Yanni Zhao, Hongling Ding, Binglong Li, Lingmiao Wen, Wei Xiong, Yanjun Liu, Tinglan Zhang, Liudai Zhang, Lanlan Wu, Qing Xu, Yuqing Fan, Guihua Wei, Qiaozhi Yin, Yunhui Chen, Tiane Zhang, Zhiyong Yan,

<h4>Context</h4><i>Valeriana jatamansi</i> Jones [syn. <i>V. wallichii</i> DC, (Valerianaceae)] (VJJ) is used to treat depression.<h4>Objective</h4>To explore the effects of total iridoids of VJJ extract (TIV) on chronic unpredictable mild stress (CUMS) in mice.<h4>Materials and methods</h4>VJJ roots and rhizomes were extracted with 70% ethanol. CUMS rats were treated daily with fluoxetine (2.6 mg/kg, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):912-921]

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End-to-End Joint Multi-Object Detection and Tracking for Intelligent Transportation Systems

Qing Xu, Xuewu Lin, Mengchi CAI, Yu-ang Guo, Chuang Zhang, Kai Li, Keqiang Li, Jianqiang Wang, Dongpu Cao,

Environment perception is one of the most critical technology of intelligent transportation systems (ITS). Motion interaction between multiple vehicles in ITS makes it important to perform multi-object tracking (MOT). However, most existing MOT algorithms follow the tracking-by-detection framework, which separates detection and tracking into two independent segments and limit the ... Read more >>

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Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma.

Shuyuan Chu, Libing Ma, Jianghong Wei, Jiying Wang, Qing Xu, Meixi Chen, Ming Jiang, Miao Luo, Jingjie Wu, Lin Mai, Guofang Tang, Biwen Mo,

<h4>Background</h4>Cigarette smoking and Th2-inflammation are both crucial in the pathogenesis of asthma. However, it is unknown whether smoking can affect the association between Th2-inflammation and small airway obstruction in adults with asthma.<h4>Methods</h4>Adults diagnosed with asthma by a pulmonologist according to Global Initiative for Asthma guidelines were recruited from September 2016 ... Read more >>

Can Respir J (Canadian respiratory journal)
[2021, 2021:1918518]

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Leaf functional traits differentiation in relation to covering materials of urban tree pits.

Jiyou Zhu, Yujuan Cao, Weijun He, Qing Xu, Chengyang Xu, Xinna Zhang,

<h4>Background</h4>Understanding the ecological strategies of urban trees to the urban environment is crucial to the selection and management of urban trees. However, it is still unclear whether urban tree pit cover will affect plant functional traits. Here, we study the response of urban trees to different tree pit covers, analyzed ... Read more >>

BMC Plant Biol (BMC plant biology)
[2021, 21(1):556]

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Spatiotemporal Quantification of Metastatic Tumour Cell Growth and Distribution in Lymph Nodes by Whole-Mount Tissue 3D Imaging

Zhi-Gang Zhang, Jun Li, Chun-Jie Xu, Guang-Ang Tian, Qing Li, Dong-Xue Li, Fang Yan, Xu Wang, Shu-Heng Jiang, Ya-Hui Wang, Yao-Qi Zhou, Jian Song, Xue-Li Zhang, Qing Xu, Li-Peng Hu, Xiaowei Li,

Lymph nodes (LNs) are a common site of metastasis in many solid cancers. Tumour cells can migrate to LNs for further metastatic colonization of distant organs, indicating poor prognosis and requiring different clinical interventions. The current histopathological diagnostic methods used for the detection of clinical lymph node metastasis (LNM) still ... Read more >>

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Diagnostic Efficiency of Diffusion Sequences and a Clinical Nomogram for Detecting Lymph Node Metastases from Rectal Cancer.

Chen Wang, Jing Yu, Ming Lu, Yang Li, Hongyuan Shi, Qing Xu,

<h4>Rationale and objectives</h4>First, to evaluate and compare three different diffusion sequences (i.e., standard DWI, IVIM, and DKI) for nodal staging. Second, to combine the DWI, and anatomic information to assess metastatic lymph node (LN).<h4>Materials and methods</h4>We retrospectively identified 136 patients of rectal adenocarcinoma who met the inclusion criteria. Three diffusion ... Read more >>

Acad Radiol (Academic radiology)
[2021, :]

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Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.

Yaohui Gao, Dexi Bi, Ruting Xie, Man Li, Jing Guo, Hu Liu, Xianling Guo, Juemin Fang, Tingting Ding, Huiyuan Zhu, Yuan Cao, Meichun Xing, Jiayi Zheng, Qing Xu, Qian Xu, Qing Wei, Huanlong Qin,

Given that only a subset of patients with colorectal cancer (CRC) benefit from immune checkpoint therapy, efforts are ongoing to identify markers that predict immunotherapeutic response. Increasing evidence suggests that microbes influence the efficacy of cancer therapies. Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability (MSI) statuses. ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):398]

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