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Assessing risk of postoperative acute kidney injury in very elderly surgical patients using estimated glomerular filtration rate: we still need more researches.

Qin Wu, Hao Yang, Xi Zhong, Yan Kang,

Ren Fail (Renal failure)
[2020, 42(1):391-392]

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Stable and Efficient Single-Atom Zn Catalyst for CO2 Reduction to CH4.

Lili Han, Shoujie Song, Mingjie Liu, Siyu Yao, Zhixiu Liang, Hao Cheng, Zhouhong Ren, Wei Liu, Ruoqian Lin, Gaocan Qi, Xijun Liu, Qin Wu, Jun Luo, Huolin L Xin,

The development of highly active and durable catalysts for electrochemical reduction of CO2 (ERC) to CH4 in aqueous media is an efficient and environmentally friendly solution to address global problems in energy and sustainability. In this work, an electrocatalyst consisting of single Zn atoms supported on microporous N-doped carbon was ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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A novel system to rapidly detect protein-protein interactions (PPIs) based on fluorescence co-localization.

Nan Hu, Zhan-Qi Dong, Ting-Ting Chen, Ning Zheng, Qin Wu, Peng Chen, Cheng Lu, Min-Hui Pan,

OBJECTIVE:Rapid and convenient detection of protein-protein interactions (PPIs) is of great significance for understanding function of protein. RESULTS:For efficiently detecting PPIs, we used the changes of proteins fluorescence localization to design a novel system, fluorescence translocation co-localization (FTCL), based on nuclear localization signal (NLS) in living cells. Depending on the ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2020, :]

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Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.

Jinxin Zhou, Ya Zhang, Shiyue Li, Qian Zhou, Yuanfu Lu, Jingshan Shi, Jie Liu, Qin Wu, Shaoyu Zhou,

The activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway has been involved in the mechanisms of a variety of protective agents against cellular oxidative stress. We recently demonstrated that Dendrobium nobile Lindl. alkaloids (DNLA), the active ingredients of Dendrobium, protects mice from CCl4-induced liver injury, dependent on ... Read more >>

Biomed. Pharmacother. (Biomedicine & Pharmacotherapy)
[2020, 129:110351]

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Dendrobium nobile Lindl Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.

Ling-Li Lv, Bo Liu, Jing Liu, Li-Sheng Li, Feng Jin, Yun-Yan Xu, Qin Wu, Jie Liu, Jing-Shan Shi,

BACKGROUND:Dendrobium nobile is a well-known traditional Chinese herbal medicine used for age-related diseases. Dendrobium nobile Lindl alkaloid (DNLA) is the active ingredient to improve learning and memory deficits in laboratory animals. OBJECTIVE:The aim of the present study was to examine the anti-aging effects of long-term administration of DNLA and metformin ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, :]

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Modulation of inflammatory factors predicts the outcome following spinal cord injury

Zepeng Yu, Xingwei Sun, Rui Xia, Qian Chen, Qin Wu, Weiwei Zheng,

Abstract BACKGROUND: The correlation between inflammatory responses caused by spinal cord injury (SCI) and the prognosis of patients with SCI still remains controversial.METHODS: In the present study, we preliminary investigated the serum levels of interleukin (IL)-4, IL-10, major histocompatibility complex (MHC)-I and inducible nitric oxide synthase (iNOS), and compared the ... Read more >>

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Gut microbiota modulates stress-induced hypertension through the HPA axis.

Qin Wu, Ziyang Xu, Siyuan Song, Hong Zhang, Wenying Zhang, Liping Liu, Yuping Chen, Jihu Sun,

Stress is associated with an increased risk of hypertension, and the incidence of stress-related hypertension has risen rapidly in recent years; however, the underlying mechanisms remain elusive. Gut dysbiosis has been demonstrated to contribute to hypertension and hyperactivation of the hypothalamus-pituitary-adrenal (HPA) axis. Based on our previous findings showing the ... Read more >>

Brain Res. Bull. (Brain research bulletin)
[2020, 162:49-58]

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Modulation of inflammatory factors predicts the outcome following spinal cord injury.

Zepeng Yu, Xingwei Sun, Rui Xia, Qian Chen, Qin Wu, Weiwei Zheng,

BACKGROUND:The correlation between inflammatory responses caused by spinal cord injury (SCI) and the prognosis of patients with SCI still remains controversial. METHODS:In the present study, we preliminary investigated the serum levels of interleukin (IL)-4, IL-10, major histocompatibility complex (MHC)-I, and inducible nitric oxide synthase (iNOS) and compared the serum IL-4 ... Read more >>

J Orthop Surg Res (Journal of Orthopaedic Surgery and Research)
[2020, 15(1):199]

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A Physical Model for Understanding the Activation of MoS2 Basal-Plane Sulfur Atoms for the Hydrogen Evolution Reaction.

Mingjie Liu, Mark S Hybertsen, Qin Wu,

Weak binding of hydrogen atoms to the 2H-MoS2 basal plane renders MoS2 inert as an electrocatalyst for the hydrogen evolution reaction. Transition-metal doping can activate neighboring sulfur atoms in the MoS2 basal plane to bind hydrogen more strongly. Our theoretical studies show strong variation in the degree of activation by ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Coinfection and Other Clinical Characteristics of COVID-19 in Children.

Qin Wu, Yuhan Xing, Lei Shi, Wenjie Li, Yang Gao, Silin Pan, Ying Wang, Wendi Wang, Quansheng Xing,

BACKGROUND AND OBJECTIVES:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified pathogen that mainly spreads by droplets. Most published studies have been focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients are limited. In this study, we aimed to determine epidemiological characteristics and ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(1):]

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Identification of KIAA0196 as a novel susceptibility gene for myofibril structural disorganization in cardiac development.

Haisong Bu, Yifeng Yang, Qin Wu, Zhiping Tan, Xueyang Gong, Shijun Hu, Tianli Zhao,

BACKGROUND:Congenital heart disease is one of the most common cardiac malformation-related diseases worldwide. Some causative genes have been identified but can explain only a small proportion of all cases; therefore, the discovery of novel susceptibility genes and/or modifier genes for abnormal cardiac development remains a major challenge. METHODS:We used a ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, 314:81-88]

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Biventricular surgical repair of “Swiss Cheese” ventricular septal defects with two-patch and right ventricle apex excluding technique: preliminary experience and clinical results

Qin Wu, Lei Shi, Rui Chen, Quansheng Xing,

Abstract Background “Swiss Cheese” ventricular septal defects (VSDs) is a kind of rare and complex congenital heart defects and the surgical management remains controversial and a challenge. We reviewed our preliminary clinical experience on biventricular surgical repair of “Swiss Cheese” VSDs with two-patch and right ventricle apex excluding technique in ... Read more >>

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Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China.

Hang Zhou, Zheng Feei Ma, Yiming Lu, Yanyan Du, Jian Shao, Liya Wang, Qin Wu, Binyu Pan, Wenxi Zhu, Qihua Zhao, Hua Wei,

Background Elevated serum uric acid concentrations have been associated with metabolic syndrome. However, only limited information is available on the prevalence of hyperuricaemia in adolescents. Therefore, the aim of our cross-sectional study was to study the prevalence of hyperuricaemia and dietary patterns in adolescents aged 13-16 years living in Yangzhou, ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(4):487-493]

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Dynamics of faecal SARS-CoV-2 in infected children during the convalescent phase.

Yuhan Xing, Wei Ni, Qin Wu, Wenjie Li, Guoju Li, Wendi Wang, Jianning Tong, Xiufeng Song, Gary Wing Kin Wong, Quansheng Xing,

J. Infect. (The Journal of infection)
[2020, :]

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Epidemiological and Clinical Characteristics of Children with Coronavirus Disease 2019

Qin Wu, Yuhan Xing, Lei Shi, Wenjie Li, Yang Gao, Silin Pan, Ying Wang, Wendi Wang, Quansheng Xing,

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified pathogen which mainly spreads by droplets. Most published studies focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients is limited. This study aimed to determine epidemiological characteristics and clinical features of pediatric patients ... Read more >>

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Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase

Yuhan Xing, Wei Ni, Qin Wu, Wenjie Li, Guoju Li, Jianning Tong, Xiufeng Song, Quansheng Xing,

Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus which mainly spreads from person-to-person. Fecal shedding of SARS-CoV-2 has been constantly reported in patients with coronavirus disease 2019 (COVID-19). Most published studies focus on adult populations, whereas data concerning pediatric patients is relatively scarce. Methods: From January ... Read more >>

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Critical Care for Severe COVID-19: A Population-based Study from a Province with Low Case-fatality Rate in China

Xuelian Liao, Hong Chen, Bo Wang, Zhen Li, Zhongwei Zhang, Weimin Li, Zongan Liang, Jin Tang, Jian Wang, Rui Shi, Xiangde Zhen, Maojuan Wang, Xianying Lei, Yu Gong, Sheng Lv, Chao Jia, Li Chen, Juan Shang, Min Yang, Hailong Wei, Yuanjun Zhang, Xiong Yang, Huaqiang Shen, Xianhua Xiao, Jie Yang, Qin Wu, Wen Wang, Jin Yang, Chang Liu, Wanhong Yin, Xiaoqi Xie, Yongming Tian, Huan Liu, Bingxing Shuai, Wei Zhang, Xiangrong Song, Xiaodong Jin, Yan Kang,

Background Data regarding critical care for patients with severe COVID-19 are limited. We aimed to describe the clinical course, multi-strategy management, and respiratory support usage for the severe COVID-19 at the provincial level. Methods Using data from Sichuan Provincial Department of Health and the multicentre cohort study, all microbiologically confirmed ... Read more >>

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Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens

Quansheng Xing, Guoju Li, Yuhan Xing, Ting Chen, Wenjie Li, Wei Ni, Kai Deng, Ruqin Gao, Changzheng Chen, Yang Gao, Qiang Li, Guiling Yu, Jianning Tong, Wei Li, Guiliang Hao, Yue Sun, Ai Zhang, Qin Wu, Zipu Li, Silin Pan,

Background: With the ongoing outbreak of Coronavirus Disease 2019 (COVID-19), infected patients within and beyond the epidemic area, Wuhan, China, showed different epidemiological and clinical characteristics. There is a paucity of data concerning coinfection with other common respiratory pathogens in COVID-19 patients outside of Wuhan. Methods: We conducted a double-centre ... Read more >>

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Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019.

Yu-Han Xing, Wei Ni, Qin Wu, Wen-Jie Li, Guo-Ju Li, Wen-Di Wang, Jian-Ning Tong, Xiu-Feng Song, Gary Wing-Kin Wong, Quan-Sheng Xing,

OBJECTIVE:To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19). METHODS:From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and ... Read more >>

J Microbiol Immunol Infect (Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi)
[2020, 53(3):473-480]

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A Physical Model for Understanding the Activation of MoS2 Basalplane Sulfur Atoms for the Hydrogen Evolution Reaction

Qin Wu, Mingjie Liu, Mark Hybertsen,

All the DFT calculations are done with the Vienna Ab Initio Simulation Package (VASP) using the projector augmented wave method. The Bayesian error estimation exchange-correlation functionals (BEEF) with van der Waals interactions are employed. A plane-wave cutoff energy of 400 eV is used together with PAW-PBE potentials where semi core ... Read more >>

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ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis.

Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, Liwen Shen, Jingshan Shi, Ning Gao,

BACKGROUND:Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. METHODS:MDA-MB-231 cells and xenografted mice were treated with arnidiol. Mitochondrial fission ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):37]

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Second urgent endoscopy within 48-hour benefits cirrhosis patients with acute esophageal variceal bleeding.

Zheng Lu, Xiaotian Sun, Wenhui Zhang, Bo Jin, Jingjing Han, Yanling Wang, Jun Han, Xuemei Ma, Bo Liu, Libing Wu, Qin Wu, Xiaoli Yu, Hanwei Li,

Urgent endoscopy (UE) is important to the diagnosis and treatment of liver cirrhosis patients with esophageal variceal bleeding (EVB). It was reported that a second-look endoscopy may benefit acute upper gastrointestinal bleeding (UGIB) caused by peptic ulcer, while whether it could improve UGIB caused by liver cirrhosis associated EVB remains ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(11):e19485]

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Microarray Analysis of Differential Gene Expression in Alzheimer's Disease Identifies Potential Biomarkers with Diagnostic Value.

Liping Liu, Qin Wu, Weiwei Zhong, Yuping Chen, Wenying Zhang, Huiling Ren, Ling Sun, Jihu Sun,

BACKGROUND Alzheimer disease (AD) is a common and fatal subtype of dementia that remains a challenge to diagnose and treat. This study aimed to identify potential biomarkers that influence the prognosis of AD. MATERIAL AND METHODS A total of 6 gene expression profiles from the Gene Expression Omnibus (GEO) database ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919249]

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Percutaneous Puncture Closure of Postoperative Residual Ventricular Septal Defects Without Radiation.

Haisong Bu, Yifeng Yang, Qin Wu, Tianli Zhao,

A redo surgical approach to residual ventricular septal defect (VSD) is technically demanding. Sternum reentry has to be performed very carefully to avoid any uncontrolled bleeding, and preparation of the adhesions must be made to expose the most important structures (ascending aorta, caval veins). However, percutaneous transcatheter device closure of ... Read more >>

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2020, 109(6):e457-e459]

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Plantamajoside represses the growth and metastasis of malignant melanoma.

Yan Wang, Mingzhu Liu, Shenglan Chen, Qin Wu,

Plantamajoside (PMS) has been shown to have anticancer effects and is the main compound of Plantago asiatica. The aim of the present study was to investigate the effects of PMS on malignant melanoma and its molecular mechanisms. The malignant melanoma cell line A2058 was treated with different concentrations of PMS ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(3):2296-2302]

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