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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Methylphosphonium Tin Bromide: A 3D Perovskite Molecular Ferroelectric Semiconductor.

Han-Yue Zhang, Xiao-Gang Chen, Zhi-Xu Zhang, Xian-Jiang Song, Tie Zhang, Qiang Pan, Yi Zhang, Ren-Gen Xiong,

3D ABX<sub>3</sub> organic-inorganic halide perovskite (OIHP) semiconductors like [CH<sub>3</sub> NH<sub>3</sub> ]PbI<sub>3</sub> have received great attention because of their various properties for wide applications. However, although a number of low-dimensional lead-based OIHP ferroelectric semiconductors have been documented, obtaining 3D ABX<sub>3</sub> OIHP ferroelectric semiconductors is challenging. Herein, an A-site cation [CH<sub>3</sub> PH<sub>3</sub> ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2020, 32(47):e2005213]

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Cyanide-Free Synthesis of Glycosyl Carboxylic Acids and Application for the Synthesis of Scleropentaside A.

Liang-Jing Zou, Qiang Pan, Cai-Yi Li, Ze-Ting Zhang, Xiao-Wei Zhang, Xiang-Guo Hu,

We have developed a cyanide-free strategy for the synthesis of glycosyl carboxylic acids, which can provide 1,2-<i>trans</i> or 1,2-<i>cis</i> glycosyl carboxylic acids and is compatible with common protecting groups. The synthetic utility was demonstrated by the synthesis of 12 unreported glycosyl acids and the total synthesis of scleropentaside A. ... Read more >>

Org Lett (Organic letters)
[2020, 22(21):8302-8306]

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.

Huairui Yuan, Ying Han, Xuege Wang, Ni Li, Qiuli Liu, Yuye Yin, Hanling Wang, Lulu Pan, Li Li, Kun Song, Tong Qiu, Qiang Pan, Qilong Chen, Guoying Zhang, Yi Zang, Minjia Tan, Jian Zhang, Qintong Li, Xiaoming Wang, Jun Jiang, Jun Qin,

The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are molecularly intertwined. Here, we report that SETD2 delays prostate cancer (PCa) metastasis via its substrate EZH2. We show that SETD2 methylates EZH2 which promotes EZH2 degradation. SETD2 ... Read more >>

Cancer Cell (Cancer cell)
[2020, 38(3):350-365.e7]

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Isolation and characterization of Vibrio parahaemolyticus bacteriophage vB_VpaS_PG07.

Tongyan Ding, Huzhi Sun, Qiang Pan, Feiyang Zhao, Zhaozuo Zhang, Huiying Ren,

A novel bacteriophage vB_VpaS_PG07 (hereafter designated PG07) that infects Vibrio parahaemolyticus was isolated. The bacteriophage was examined by transmission electron microscopy, and the result showed that PG07 belonged to family Siphoviridae, with an isometric polyhedral head (80 nm in diameter) and a long tail (175 nm in length). The one-step ... Read more >>

Virus Res (Virus research)
[2020, 286:198080]

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Bistable State of Protons for Low-Voltage Memories.

Xian-Jiang Song, Zhi-Xu Zhang, Xiao-Gang Chen, Han-Yue Zhang, Qiang Pan, Jie Yao, Yu-Meng You, Ren-Gen Xiong,

Molecular ferroelectrics are attracting tremendous interest because of their easy and environmental-friendly processing, low acoustic impedance, and mechanical flexibility. Their ferroelectric mechanism is mainly ascribed to the order-disorder transition of molecules such as spherical 1,4-diazabicyclo[2.2.2] octane (DABCO) and quinuclidine. Here, we present two molecular ferroelectrics, [HDABCO][TFSA] and its deuterated one ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(19):9000-9006]

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Epidemiological characteristics of patients with residual SARS-Cov-2 in Linyi, China

Qiang Pan, Feng Gao, Rensheng Peng, Mingshan Li,

Patients with 2019 novel Coronavirus infection are probably show positive testing results again. In order to better treat these patients and provide basis for further control measures, we analyze the epidemiological outcomes and clinical features of patients with residual Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) in Linyi city. From ... Read more >>

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Confinement-Driven Ferroelectricity in a Two-Dimensional Hybrid Lead Iodide Perovskite.

Xiao-Gang Chen, Xian-Jiang Song, Zhi-Xu Zhang, Han-Yue Zhang, Qiang Pan, Jie Yao, Yu-Meng You, Ren-Gen Xiong,

Organic-inorganic hybrid perovskites (OIHPs) hold a great potential for scientific and technological endeavors in the field of ferroelectrics, solar cells, and electroluminescent devices, because of their structural diversity, low cost of manufacture, and ease of fabrication. However, lead iodide perovskite ferroelectrics with narrow band gap have rarely been reported. Here, ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(22):10212-10218]

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Characterization and Complete Genome Analysis of Pseudomonas aeruginosa Bacteriophage vB_PaeP_LP14 Belonging to Genus Litunavirus.

Xiaojie Shi, Feiyang Zhao, Huzhi Sun, Xiaoyan Yu, Can Zhang, Wenhua Liu, Qiang Pan, Huiying Ren,

A lytic Pseudomonas aeruginosa phage vB_PaeP_LP14 belonging to the family Podoviridae was isolated from infected mink. The microbiological characterization revealed that LP14 was stable at 40 to 50 °C and stable over a broad range of pH (5 to 12). The latent period was 5 min, and the burst size ... Read more >>

Curr Microbiol (Current microbiology)
[2020, 77(9):2465-2474]

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Small Area Estimation of Cancer Risk Factors and Screening Behaviors in US Counties by Combining Two Large National Health Surveys.

Benmei Liu, Van Parsons, Eric J Feuer, Qiang Pan, Machell Town, Trivellore E Raghunathan, Nathaniel Schenker, Dawei Xie,

<h4>Background</h4>National health surveys, such as the National Health Interview Survey (NHIS) and the Behavioral Risk Factor Surveillance System (BRFSS), collect data on cancer screening and smoking-related measures in the US noninstitutionalized population. These surveys are designed to produce reliable estimates at the national and state levels. However, county-level data are ... Read more >>

Prev Chronic Dis (Preventing chronic disease)
[2019, 16:E119]

Cited: 1 time

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Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.

Tao Yu, Shucheng Gan, Qingchen Zhu, Dongfang Dai, Ni Li, Hui Wang, Xiaosong Chen, Dan Hou, Yan Wang, Qiang Pan, Jing Xu, Xingli Zhang, Junli Liu, Siyu Pei, Chao Peng, Ping Wu, Simona Romano, Chaoming Mao, Mingzhu Huang, Xiaodong Zhu, Kunwei Shen, Jun Qin, Yichuan Xiao,

Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 polarization. Mechanistically, Trim24, a CBP-associated E3 ligase, promotes Stat6 ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):4353]

Cited: 10 times

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Fluorinated 2D Lead Iodide Perovskite Ferroelectrics.

Tai-Ting Sha, Yu-An Xiong, Qiang Pan, Xiao-Gang Chen, Xian-Jiang Song, Jie Yao, Shu-Rong Miao, Zheng-Yin Jing, Zi-Jie Feng, Yu-Meng You, Ren-Gen Xiong,

Hybrid perovskite materials are famous for their great application potential in photovoltaics and optoelectronics. Among them, lead-iodide-based perovskites receive great attention because of their good optical absorption ability and excellent electrical transport properties. Although many believe the ferroelectric photovoltaic effect (FEPV) plays a crucial role for the high conversion efficiency, ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2019, 31(30):e1901843]

Cited: 1 time

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A Nickel(II) Nitrite Based Molecular Perovskite Ferroelectric.

Yu-An Xiong, Tai-Ting Sha, Qiang Pan, Xian-Jiang Song, Shu-Rong Miao, Zheng-Yin Jing, Zi-Jie Feng, Yu-Meng You, Ren-Gen Xiong,

The X-site ion in organic-inorganic hybrid ABX<sub>3</sub> perovskites (OHPs) varies from halide ion to bridging linkers like HCOO<sup>-</sup> , N<sub>3</sub> <sup>-</sup> , NO<sub>2</sub> <sup>-</sup> , and CN<sup>-</sup> . However, no nitrite-based OHP ferroelectrics have been reported so far. Now, based on non-ferroelectric [(CH<sub>3</sub> )<sub>4</sub> N][Ni(NO<sub>2</sub> )<sub>3</sub> ], through the combined ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2019, 58(26):8857-8861]

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Exercise ameliorates the FGF21-adiponectin axis impairment in diet-induced obese mice.

Wenqi Yang, Ling Liu, Yuan Wei, Chunlu Fang, Fu Zhou, Jinbao Chen, Qinghua Han, Meifang Huang, Xuan Tan, Qiuyue Liu, Qiang Pan, Lu Zhang, Xiaojuan Lei, Liangming Li,

<h4>Objective</h4>The protective effects of exercise against glucose dysmetabolism have been generally reported. However, the mechanism by which exercise improves glucose homeostasis remains poorly understood. The FGF21-adiponectin axis participates in the regulation of glucose metabolism. Elevated levels of FGF21 and decreased levels of adiponectin in obesity indicate FGF21-adiponectin axis dysfunction. Hence, ... Read more >>

Endocr Connect (Endocrine connections)
[2019, 8(5):596-604]

Cited: 2 times

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A Fast Beamforming Method to Localize an Acoustic Emission Source under Unknown Wave Speed.

Junfei Tai, Tian He, Qiang Pan, Dayi Zhang, Xiaoran Wang,

The beamforming method is capable of localizing the acoustic emission source in a large-scale structure but its accuracy relies strongly on the assumed propagation speed and it is quite time consuming to apply in online monitoring. This paper proposes a fast beamforming method to localize an acoustic emission source in ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2019, 12(5):]

Cited: 1 time

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Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer.

Yufeng Ding, Ni Li, Baijun Dong, Wangxin Guo, Hui Wei, Qilong Chen, Huairui Yuan, Ying Han, Hanwen Chang, Shan Kan, Xuege Wang, Qiang Pan, Ping Wu, Chao Peng, Tong Qiu, Qintong Li, Dong Gao, Wei Xue, Jun Qin,

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss might expose cells to unique epigenetic vulnerabilities. ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2019, 129(2):759-773]

Cited: 4 times

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Premorbid Activity Limitation Stages Are Associated With Posthospitalization Discharge Disposition.

Ling Na, Sean Hennessy, Dawei Xie, Debra Saliba, Qiang Pan, Pui L Kwong, Jibby E Kurichi, Hillary R Bogner, Joel E Streim,

OBJECTIVE:Activity of daily living stages and instrumental activity of daily living stage have demonstrated associations with mortality and health service use among older adults. This cohort study aims to assess the associations of premorbid activity limitation stages with acute hospital discharge disposition among community-dwelling older adults. DESIGN:Study participants were Medicare ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2018, 97(6):440-449]

Cited: 0 times

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A near-infrared fluorescent probe for rapid detection of carbon monoxide in living cells.

Liqiang Yan, Ding Nan, Cheng Lin, Yi Wan, Qiang Pan, Zhengjian Qi,

A near-infrared (NIR) and colorimetric fluorescent probe system was developed for Carbon Monoxide (CO) via a Pd0-mediated Tsuji-Trost reaction. In this probe, phenoxide anion formation (DPCO-) was acted as the signal unit and an allyl carbonate group was used as the recognition unit. This non-fluorescent probe molecule can release the ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2018, 202:284-289]

Cited: 3 times

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Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease.

Mahboob Rahman, Jesse Yenchih Hsu, Niraj Desai, Chi-Yuan Hsu, Amanda H Anderson, Lawrence J Appel, Jing Chen, Debbie L Cohen, Paul E Drawz, Jiang He, Pan Qiang, Ana C Ricardo, Susan Steigerwalt, Matthew R Weir, Jackson T Wright, Xiaoming Zhang, Raymond R Townsend, ,

BACKGROUND AND OBJECTIVES:Central BP measurements provide noninvasive measurement of aortic BP; our objectives were to examine the association of central and brachial BP measurements with risk of cardiovascular outcomes and mortality in patients with CKD and to determine the role of central BP measurement in conjunction with brachial BP in ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2018, 13(4):585-595]

Cited: 2 times

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Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma.

Fengming Lan, Qin Qing, Qiang Pan, Man Hu, Huiming Yu, Xiao Yue,

Exosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers. The aim of this study was to determine the diagnostic/prognostic significance of serum exosomal miR-301a in glioma patients.Quantitative real-time PCR was used to determine the serum exosomal ... Read more >>

Cell Oncol (Dordr) (Cellular oncology (Dordrecht))
[2018, 41(1):25-33]

Cited: 23 times

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Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.

Huairui Yuan, Ni Li, Da Fu, Jiale Ren, Jingyi Hui, Junjie Peng, Yongfeng Liu, Tong Qiu, Min Jiang, Qiang Pan, Ying Han, Xiaoming Wang, Qintong Li, Jun Qin,

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse models of colorectal cancer (CRC). SETD2 was ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2017, 127(9):3375-3391]

Cited: 26 times

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MicroRNA-18a regulates invasive meningiomas via hypoxia-inducible factor-1α.

Puxian Li, Yong Gao, Fengjia Li, Qiang Pan, Zhenrui Liu, Xiangdong Lu, Chunyu Song, Xingtao Diao,

The aim of the present study was to investigate the effects of microRNA-18a (miR-18a) on the invasiveness and metastasis of invasive meningiomas and the underlying mechanism. A total of 69 patients with meningiomas (30 patients in the invasive meningioma group and 39 patients in the non-invasive meningioma group) and 48 ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2015, 10(3):1165-1170]

Cited: 4 times

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The Association Between Activity Limitation Stages and Admission to Facilities Providing Long-term Care Among Older Medicare Beneficiaries.

Jibby E Kurichi, Joel E Streim, Dawei Xie, Sean Hennessy, Ling Na, Debra Saliba, Qiang Pan, Pui L Kwong, Hillary R Bogner,

<h4>Objective</h4>This study aimed to examine whether activity limitation stages are associated with admission to facilities providing long-term care (LTC).<h4>Design</h4>Cohort study using Medicare Current Beneficiary Survey data from the 2005-2009 entry panels. A total of 14,580 community-dwelling Medicare beneficiaries 65 years or older were included. Proportional subhazard models examined associations between ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2017, 96(7):464-472]

Cited: 1 time

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A Molecular Polycrystalline Ferroelectric with Record-High Phase Transition Temperature.

Qiang Pan, Zhi-Bo Liu, Han-Yue Zhang, Wan-Ying Zhang, Yuan-Yuan Tang, Yu-Meng You, Peng-Fei Li, Wei-Qiang Liao, Ping-Ping Shi, Rong-Wei Ma, Ru-Yuan Wei, Ren-Gen Xiong,

An outstanding advantage of inorganic ceramic ferroelectrics is their usability in the polycrystalline ceramic or thin film forms, which has dominated applications in the ferroelectric, dielectric, and piezoelectric fields. Although the history of ferroelectrics began with the molecular ferroelectric Rochelle salt in 1921, so far there have been very few ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2017, 29(29):]

Cited: 6 times

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AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.

Ni Li, Wei Xue, Huairui Yuan, Baijun Dong, Yufeng Ding, Yongfeng Liu, Min Jiang, Shan Kan, Tongyu Sun, Jiale Ren, Qiang Pan, Xiang Li, Peiyuan Zhang, Guohong Hu, Yan Wang, Xiaoming Wang, Qintong Li, Jun Qin,

Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling pathway are hallmarks of prostate cancer (PCa). However, these alterations alone are insufficient for cells to acquire metastatic traits. Here, we have shown that the histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors to become metastatic ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2017, 127(4):1284-1302]

Cited: 27 times

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