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Resonant scattering-enhanced photothermal microscopy.

Qiang Li, Zhonghong Shi, Lijun Wu, Hong Wei,

Photothermal (PT) microscopy is currently the most efficient approach for the detection and spectroscopy of individual non-fluorescent nano-objects based solely on their absorption. The nano-objects in current PT microscopy are usually non-resonant with the probe laser light, and the PT signal is mainly generated from the interactions of the incident ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(15):8397-8403]

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Resonant scattering enhanced interferometric scattering microscopy.

Zhonghong Shi, Jiufeng Huang, Xi Huang, Yangwei Huang, Lijun Wu, Qiang Li,

Interferometric scattering (iSCAT) microscopy is a powerful tool for high-sensitive label-free imaging and sensing of nano-objects with high spatial-temporal resolution. The nano-objects imaged with the current iSCAT microscopy are usually non-resonant under laser light illumination and the iSCAT signal contrast is simply proportional to the volume and weight of the ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(14):7969-7975]

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Novel perylene probe-encapsulated metal-organic framework nanocomposites for ratiometric fluorescence detection of ATP.

Xiaomeng Zhou, Juanmin Li, Li-Li Tan, Qiang Li, Li Shang,

Adenosine triphosphate (ATP) plays an important role in various biological processes and the ATP level is closely associated with many diseases. Herein, a novel ratiometric fluorescence assay for ATP was developed based on the excimer-monomer transfer of a perylene probe. By encapsulating a perylene probe, N,N'-bis(6-caproic acid)-3,4:9,10-perylenediimide (PDI), into zeolitic ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(16):3661-3666]

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Hierarchical nanotwins in single-crystal-like nickel with high strength and corrosion resistance produced via a hybrid technique.

Qiang Li, Sichuang Xue, Patrick Price, Xing Sun, Jie Ding, Zhongxia Shang, Zhe Fan, Han Wang, Yifan Zhang, Youxing Chen, Haiyan Wang, Khalid Hattar, Xinghang Zhang,

High-density growth nanotwins enable high-strength and good ductility in metallic materials. However, twinning propensity is greatly reduced in metals with high stacking fault energy. Here we adopted a hybrid technique coupled with template-directed heteroepitaxial growth method to fabricate single-crystal-like, nanotwinned (nt) Ni. The nt Ni primarily contains hierarchical twin structures ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):1356-1365]

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Phenobarbital-induced anticonvulsant hypersensitivity syndrome in a cat.

Sang-June Sohn, So-Young Jeung, Hyung-Kyu Chae, Hee-Seon Cho, Ju-Hyun An, Qiang Li, Woo-Jin Song, Hwa-Young Youn,

In this study, we document a case of phenobarbital-induced anticonvulsant hypersensitivity syndrome (AHS), which has been rarely reported in veterinary medicine. A 2-year-old, 5.4 kg, neutered male Russian Blue cat was diagnosed with idiopathic epilepsy and started on phenobarbital treatment. Eight days after initiation of phenobarbital treatment, the cat showed ... Read more >>

J. Vet. Med. Sci. (The Journal of veterinary medical science)
[2019, 81(12):1850-1852]

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Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling.

Aryung Nam, Taewon Kim, Qiang Li, Robert B Rebhun, Hwa-Young Youn, Kyoung-Won Seo,

The Hedgehog-GLI signaling pathway is activated in human and canine osteosarcoma (OSA) and represents a potential therapeutic target for cancers, including OSA. Arsenic trioxide represses GLI expression. Melarsomine, an arsenic compound-containing drug, has been approved for the treatment of canine heartworm disease. Hence, we hypothesized that melarsomine inhibits GLI signaling ... Read more >>

J. Vet. Med. Sci. (The Journal of veterinary medical science)
[2019, 81(12):1722-1729]

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Hypoglycemic effects of wheat bran alkyresorcinols in high-fat/high-sucrose diet and low-dose streptozotocin-induced type 2 diabetic male mice and protection of pancreatic β cells.

Jie Tu, Guanhui Liu, Xitao Cao, Shuyun Zhu, Qiang Li, Gengsheng Ji, Yanhui Han, Hang Xiao,

In the present study, the hypoglycemic effects of wheat bran alkyresorcinols (ARs) were investigated in type 2 diabetes mellitus (T2DM) mice induced by a high-fat/high-sucrose diet (HFSD) combined with low dose streptozotocin (STZ). After the consumption of 5 mg kg-1 d-1 acarbose (positive control) and different doses of wheat bran ... Read more >>

Food Funct (Food & function)
[2019, 10(6):3282-3290]

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Enhanced angiogenic activity of dimethyloxalylglycine-treated canine adipose tissue-derived mesenchymal stem cells.

Sang-Min Kim, Qiang Li, Ju-Hyun An, Hyung-Kyu Chae, Ji-In Yang, Min-Ok Ryu, Aryung Nam, Woo-Jin Song, Hwa-Young Youn,

The paracrine function of mesenchymal stem cells (MSCs) during transplantation has been recently studied due to its poor differentiation ratio. Dimethyloxalylglycine (DMOG) has been used to promote angiogenesis in experimental animal models, however, comparable approaches for canine MSCs are not sufficient. In the present study, we assessed whether DMOG improves ... Read more >>

J. Vet. Med. Sci. (The Journal of veterinary medical science)
[2019, 81(11):1663-1670]

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Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation.

Chenxu Ge, Minxuan Xu, Yuting Qin, Tingting Gu, Deshuai Lou, Qiang Li, Linfeng Hu, Xuyuan Nie, Mingxing Wang, Jun Tan,

Obesity-related renal disease is related to caloric excess promoting deleterious cellular responses. However, a full understanding of the molecular mechanisms involved in progressive kidney disease, as well as a therapeutic strategy, is still absent. Fisetin (FIS), as a natural flavonoid, possesses various bioactivities in a number of disease models. However, ... Read more >>

Food Funct (Food & function)
[2019, 10(5):2970-2985]

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PNO1, which is negatively regulated by miR-340-5p, promotes lung adenocarcinoma progression through Notch signaling pathway.

Dongming Liu, Li Lin, Yajie Wang, Lu Chen, Yuchao He, Yi Luo, Lisha Qi, Yan Guo, Liwei Chen, Zhiqiang Han, Guangtao Li, Qiang Li, Zhiyong Liu, Peng Chen, Hua Guo,

Many studies have shown that the hyperactivation of ribosome biogenesis plays essential roles in the initiation and progression of cancers. As a ribosome assembly factor, PNO1 plays an important role in ribosome biogenesis. However, little is known about the expression and function of PNO1 in human tumors. In our present ... Read more >>

Oncogenesis (Oncogenesis)
[2020, 9(5):58]

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Fe doped SrWO4 with tunable band structure for photocatalytic nitrogen fixation.

Qiang Li, Xiaoxia Bai, Jingying Luo, Chunyuan Li, Zhenni Wang, Weiwei Wu, Yanping Liang, Zhenhuan Zhao,

Doping with exotic elements has become a general effective method for the synthesis of efficient nitrogen fixation photocatalyst. Wide bandgap semiconductors, thermodynamically, could be potential photocatalysts for nitrogen reduction reaction (NRR). In this study, we report an active photocatalyst of Fe doped SrWO4 from a facile solvothermal method. The band ... Read more >>

Nanotechnology (Nanotechnology)
[2020, :]

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Open Stented Elephant Trunk for Complicated Stanford Type B Aortic Dissection: A Single-Center Experience

Hongtao Tie, Lingwen Kong, Zhengjie Tu, Delai Zheng, Dan Chen, Qingchen Wu, Qiang Li,

Abstract Background: Open stented elephant trunk (SET) or SET with left subclavian artery to left common carotid artery bypass (LSCA-LCCA) is proven to a potentially alternative treatment for complex Stanford type B aortic dissection (TBAD). In the current study, we reported our experience with 10 consecutive patients who underwent open ... Read more >>

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Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study.

Jieli Lu, Mian Li, Yu Xu, Yufang Bi, Yingfen Qin, Qiang Li, Tiange Wang, Ruying Hu, Lixin Shi, Qing Su, Min Xu, Zhiyun Zhao, Yuhong Chen, Xuefeng Yu, Li Yan, Rui Du, Chunyan Hu, Guijun Qin, Qin Wan, Gang Chen, Meng Dai, Di Zhang, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Yanan Huo, Zhen Ye, Xulei Tang, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Zachary T Bloomgarden, Lulu Chen, Jiajun Zhao, Yiming Mu, Guang Ning, Weiqing Wang, ,

OBJECTIVE:We aim to investigate the impact of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and adulthood diabetes risk. RESEARCH DESIGN AND METHODS:This study included 77,925 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study who were born around the time of the Chinese Great ... Read more >>

Diabetes Care (Diabetes care)
[2020, :]

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U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study.

Yanbo Xue, Wei Jiang, Qiong Ma, Xiqiang Wang, Pu Jia, Qiang Li, Shuping Chen, Bingxue Song, Ya Wang, Jingwen Zhang, Jing Liu, Guodong Yang, Yuyao Lin, Jing Liu, Linyan Wei, Caijuan Dong, Haiquan Li, Zhonglei Xie, Ling Bai, Aiqun Ma,

BACKGROUND:The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our study was to identify the distribution characteristics of S1P in systolic heart failure patients and the prognostic value of S1P for long-term ... Read more >>

Lipids Health Dis (Lipids in health and disease)
[2020, 19(1):125]

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Oral Administration of Chitosan Attenuates Bleomycin-induced Pulmonary Fibrosis in Rats.

You-Seok Kim, Qiang Li, Hwa-Young Youn, Dae Young Kim,

BACKGROUND/AIM:Idiopathic pulmonary fibrosis (PF) is a fatal disorder of unknown aetiology with limited treatment options. Chitosan has antibacterial, antifungal, antioxidant, antitumour, and anti-inflammatory effects. This study aimed to investigate the effects of chitosan administration on bleomycin (BLM)-induced PF in rats. MATERIALS AND METHODS:A PF rat model was established by endotracheal ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2019, 33(5):1455-1461]

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Association between intraoperative administration of dexamethasone and survival after curative resection for non-small cell lung cancer (NSCLC): A propensity score matching analysis

Fang Yan, Gang Chen, Jingdun Xie, Huaqiang Zhou, Wei Xing, Qiang Li, Weian Zeng, Dongtai Chen,

Abstract Background: Few studies have suggested the correlation between intraoperative dexamethasone and oncological outcomes in non-small cell lung cancer (NSCLC) patients with radical resection. The existing data are inconsistent and inadequate, and more evidence is needed. We therefore undertook a propensity-matched cohort study to investigate the correlation. Methods: 832 patients ... Read more >>

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Lipid metabolic gene-wide profile and signature of lung adenocarcinoma

Jinyou Li, Qiang Li, Zhenyu Su, Qi Sun, Yong Zhao, Tienan Feng, Jiayuan Jiang, Haitao Ma, Feng Zhang,

Abstract Background Lung cancer is a worldwide cancer with high morbidity and mortality. More and more evidence shows that the disorder of lipid metabolism is the key to the development of cancer, and analysis of lipid-related genes may lead to diagnosis and prognostic biomarkers related to lung cancer. Methods ... Read more >>

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KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint

Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li, Liming Zhao,

Abstract Background Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel therapy for non-small cell lung cancer (NSCLC). UbcH10 is considered to be associated with SAC function and the pathological types ... Read more >>

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Accuracy of FibroScan in analysis of liver fibrosis in patients with concomitant chronic Hepatitis B and nonalcoholic fatty liver disease.

Qiang Li, Chenlu Huang, Wei Xu, Qiankun Hu, Liang Chen,

Liver steatosis could affect the accuracy of FibroScan in patients with chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD). This study aimed to assess the accuracy and cut-off values of FibroScan for diagnosing liver fibrosis and cirrhosis in patients with concomitant CHB and NAFLD.A total of 116 patients ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(23):e20616]

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Enhanced removal of pharmaceuticals and personal care products from real municipal wastewater using an electrochemical membrane bioreactor.

Mei Chen, Lehui Ren, Kangquan Qi, Qiang Li, Miaoju Lai, Yang Li, Xuesong Li, Zhiwei Wang,

A novel electrochemical membrane bioreactor (EMBR) was developed for enhancing PPCPs removal from real municipal wastewater. Compared to the control MBR (CMBR) without applying electric field, EMBR exhibited higher removal efficiencies for 14 PPCPs among all investigated PPCPs, including 3 fluoroquinolones, 2 macrolides, 6 sulfonamides and 3 anti-inflammatory drugs, while ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 311:123579]

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Purification, structural characterization and in vivo immunoregulatory activity of a novel polysaccharide from Polygonatum sibiricum.

Yongjie Wang, Na Liu, Xia Xue, Qiang Li, Deqing Sun, Zhongxi Zhao,

The purpose of this study was to study polysaccharides isolated from Polygonatum sibiricum to establish the structure-activity relationships of the active substances and to discover the optimal fraction for further development and application. Four polysaccharides fractions (PSP1, PSP2, PSP3 and PSP4) from P. sibiricum were obtained by DEAE-Sepharose Fast Flow ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2020, :]

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Immunotherapy as second-line treatment and beyond for non-small cell lung cancer in a single center of China: Outcomes, toxicities, and clinical predictive factors from a real-world retrospective analysis.

Minjiang Chen, Qiang Li, Yan Xu, Jing Zhao, Li Zhang, Lijuan Wei, Wei Zhong, Mengzhao Wang,

BACKGROUND:Real-world evidence of second-line treatment and beyond with immune checkpoint inhibitors (ICIs) in Chinese patients is lacking. Here, we aimed to assess the efficacy, responses, and immune-related side effects of anti-PD-1 agents in real-life practice. METHODS:We retrospectively analyzed consecutive patients who received nivolumab or pembrolizumab monotherapy at Peking Medical College ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, :]

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The up-regulated hsa-circRNA9102-5 may be a risk factor for essential hypertension.

Shuying Zheng, Xin He, Jihan Sun, Qiang Li, Tao Zhang, Lina Zhang,

BACKGROUND:The present study was aimed to investigate the expression levels of circular RNAs (circRNAs) in the peripheral blood of essential hypertension (EH) patients and healthy controls (HC). On this basis, we tried to explain the possible role of circRNAs in the progression of EH and their potential as diagnostic biomarkers ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, :e23339]

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Effects of methylation of deiodinase 3 gene on gene expression and severity of Kashin-Beck disease.

Zhaofang Li, Di Zhang, Qiang Li, Xiaoli Yang, Rongqiang Zhang, Dandan Zhang, Xuena Yang, Chen Wang, Xiwang Tan, Yongmin Xiong,

Kashin-Beck disease (KBD) is a complex endemic osteoarthropathy, which mainly occurs in the northeast to southwest China. Iodothyronine deiodinases 3 (DIO3) is one of the selenoproteins, which is closely related to bone metabolism and unclear to KBD. This study aims to investigate the role and associated mechanisms of methylation and ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, :]

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Association between age and clinical characteristics and outcomes of COVID-19.

Yang Liu, Bei Mao, Shuo Liang, Jia-Wei Yang, Hai-Wen Lu, Yan-Hua Chai, Lan Wang, Li Zhang, Qiu-Hong Li, Lan Zhao, Yan He, Xiao-Long Gu, Xiao-Bin Ji, Li Li, Zhi-Jun Jie, Qiang Li, Xiang-Yang Li, Hong-Zhou Lu, Wen-Hong Zhang, Yuan-Lin Song, Jie-Ming Qu, Jin-Fu Xu, ,

Eur. Respir. J. (The European respiratory journal)
[2020, 55(5):]

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