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Author Qian Lin

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SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90.

Bin Lian, Qian Lin, Wei Tang, Xin Qi, Jing Li,

Hsp90 is often overexpressed with activated form in cancer cells, and many key cellular proteins are dependent upon the Hsp90 machinery (these proteins are called "client protein"). Nowadays, more client proteins and more inhibitors of Hsp90 are being discovered. Chaetocin has been identified as an inhibitor of histone methyl transferase ... Read more >>

Biomol Ther (Seoul) (Biomolecules & therapeutics)
[2021, 29(1):73-82]

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Determination and phylogenetic analysis of the complete mitochondrial genome of Bubalus bubalis Linnaeus, 1758 breed Murrah (Artiodactyla: Bovidae)

Qian Lin, Meng-Wei Li, Yan-Zhou Wang, Hua-Jiao Qiu,

Abstract Murrah buffalo (Bubalus bubalis Linnaeus, 1758 breed Murrah, MB) is a most productive water buffalo breed. It is the first time that the complete mitochondrial genome sequence of the MB was reported. The total length of the mtDNA is 16,359 bp, It contains the typical structure, including 22 transfer RNA ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[0, 5(1):432-433]

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Photodegradation of Perfluorooctanesulfonic Acid on Fe-Zeolites in Water.

Lin Qian, Frank-Dieter Kopinke, Anett Georgi,

Perfluorooctanesulfonic acid (PFOS) decomposition in an aqueous environment remains a huge challenge because of its extreme chemical and biological inertness even when compared with other per- and polyfluoroalkyl substances (PFAS). In this work, we demonstrate for the first time a successful photochemical PFOS degradation by irradiation with 254 nm ultraviolet ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, 55(1):614-622]

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Molecular Diagnosis of Panel-Based Next-Generation Sequencing Approach and Clinical Symptoms in Patients With Glycogen Storage Disease: A Single Center Retrospective Study.

Shen Ying, Zhang Zhihua, Zheng Yucan, Jin Yu, Lin Qian, Zheng Bixia, Cheng Weixia, Liu Zhifeng,

<b>Aim:</b> The aim of this study was to investigate the clinical utility of panel-based next-generation sequencing (NGS) in the diagnostic approach of glycogen storage disease (GSD). <b>Methods:</b> We performed a retrospective review of the 32 cases with suspected GSDs between April 2013 and November 2019 through panel-based NGS, clinical and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:600446]

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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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Fermented traditional Chinese medicine alters the intestinal microbiota composition of broiler chickens.

Peng Huang, Peng Wang, Jiaxin Xu, Mengshan Sun, Xiubin Liu, Qian Lin, Wei Liu, Zhixing Qing, Jianguo Zeng,

For a long time, phytogenic resources have been widely used as substitutes for antibiotics in livestock production. However, few studies have examined the relationship between the intestinal microbiota and fermented herbal medicines. Here, 252 Arbor Acres broiler plus broiler chickens were randomly assigned to a control group, which was fed ... Read more >>

Res Vet Sci (Research in veterinary science)
[2020, 135:8-14]

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Coronary Artery Calcification Under Statin Therapy and Its Effect on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.

Runmin Lai, Jianqing Ju, Qian Lin, Hao Xu,

<b>Objective:</b> To compare Agatston scores between patients without statin therapy and those under standard and intensive statin therapy and to systematically review the relationship between coronary artery calcification (CAC) progression under statin therapy and cardiovascular outcomes. <b>Methods:</b> Literature search was conducted across databases. Randomized controlled trials and observational studies that ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:600497]

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Single Head-Neck Irradiation Intervention Increases Thyroid Hormone Level and Enhances Energy Metabolism in High-Fat Diet Mice

Qian Lin, Caishun Zhang, Manwen Li, Haidan Wang, Kaizhen Su, Defeng Liu, Jvchen Zhang, Peng Jiang, Peige Wang, Jing Dong,

Radiotherapy, an established treatment of malignant diseases of the head and neck, increases the risk of chronic metabolic disorders. However, the molecular mechanisms responsible for metabolic dysfunction after irradiation remain unknown. We aimed to determine whether single head-neck irradiation intervention changes the levels of thyroid hormones and affects energy metabolism ... Read more >>

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ERP evidence for asymmetric orthographic transfer between traditional and simplified Chinese.

Jiushu Xie, Yanli Huang, Ke Chen, Qian Lin, John X Zhang, Lei Mo,

Transferring orthographic processing skills from one language to new languages is important for language learning. However, the specific orthography hypothesis and condition-based transfer hypothesis have debated orthographic transfer. No study has ever examined these debates in a logographic language, and the neural correlates of orthographic transfer in a logographic language ... Read more >>

Exp Brain Res (Experimental brain research)
[2020, :]

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Eugenol protects cells against oxidative stress via Nrf2

Leina Ma, Jia Liu, Qian Lin, Yuchao Gu, Wengong Yu,

Eugenol is a naturally occurring compound that is present in a variety of plants and has previous been demonstrated to exert a number of bioactivities. However, the potential effects of Eugenol on cellular protection against oxidative stress remain poorly understood. In the present study, HEK-293 cells and the mouse fibroblast ... Read more >>

(Experimental and Therapeutic Medicine)
[2020, 21(2):]

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Human β-Defensin 118 Attenuates Escherichia coli K88-Induced Inflammation and Intestinal Injury in Mice.

Qian Lin, Qingqing Fu, Xiang Li, Yuheng Luo, Junqiu Luo, Daiwen Chen, Xiangbing Mao, Bing Yu, Ping Zheng, Zhiqing Huang, Jie Yu, Hui Yan, Jun He,

Antibiotics are widely used to treat various inflammatory bowel diseases caused by enterotoxigenic Escherichia coli (ETEC). However, continuous use of antibiotics may lead to drug resistance. In this study, we investigated the role of human β-defensin 118 (DEFB118) in regulating the ETEC-induced inflammation and intestinal injury. ETEC-challenged or non-challenged mice ... Read more >>

Probiotics Antimicrob Proteins (Probiotics and antimicrobial proteins)
[2020, :]

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Expression and Functional Characterization of a Novel Antimicrobial Peptide: Human Beta-Defensin 118.

Qian Lin, Kunhong Xie, Daiwen Chen, Bing Yu, Xiangbing Mao, Jie Yu, Junqiu Luo, Ping Zheng, Yuheng Luo, Hui Yan, Jun He,

<h4>Purpose</h4><i>β</i>-Defensin 118 (DEFB118) is a novel host defense peptide (HDP) identified in humans. To evaluate its potentials for future utilization, the DEFB118 gene was expressed in <i>Escherichia coli</i> (<i>E. coli</i>) and the recombinant protein was fully characterized.<h4>Methods</h4>The DEFB118 protein was obtained by heterologous expression using <i>E. coli</i> Rosetta (DE3). Antibacterial ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:1395304]

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Immobilization and enzymatic properties of glutamate decarboxylase from Enterococcus faecium by affinity adsorption on regenerated chitin.

Sheng-Yuan Yang, Shu-Min Liu, Yan-Yan Wu, Qian Lin, Gui-Lian Liang, Jiao-Fen Liu, Zi-Zhan Liang, Jia-Rong Liang,

Glutamate decarboxylase (GAD, EC 4.1.1.15) is an important enzyme in gamma-aminobutyric acid biosynthesis and DL-glutamic acid resolution. In this study, the Enterococcus faecium-derived GAD was successfully immobilized by regenerated chitin (RC) via specific adsorption of cellulose-binding domain (CBD). The optimal binding buffer was 20 mmol/L phosphate buffer saline (pH 8.0), and ... Read more >>

Amino Acids (Amino acids)
[2020, 52(11-12):1479-1489]

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Ghrelin in the lateral parabrachial nucleus influences the excitability of glucosensing neurons, increases food intake and body weight.

Caishun Zhang, Junhua Yuan, Qian Lin, Manwen Li, Liuxin Wang, Rui Wang, Xi Chen, Zhengyao Jiang, Kun Zhu, Xiaoli Chang, Bin Wang, Jing Dong,

Ghrelin plays a pivotal role in the regulation of food intake, body weight and energy metabolism. However, these effects of ghrelin in the lateral parabrachial nucleus (LPBN) are unexplored. C57BL/6J mice and GHSR-/- mice were implanted with cannula above the right LPBN and ghrelin was microinjected via the cannula to ... Read more >>

Endocr Connect (Endocrine connections)
[2020, 9(12):1168-1177]

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Eugenol protects cells against oxidative stress via Nrf2.

Leina Ma, Jia Liu, Qian Lin, Yuchao Gu, Wengong Yu,

Eugenol is a naturally occurring compound that is present in a variety of plants and has previous been demonstrated to exert a number of bioactivities. However, the potential effects of Eugenol on cellular protection against oxidative stress remain poorly understood. In the present study, HEK-293 cells and the mouse fibroblast ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2021, 21(2):107]

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Poor cardiovascular health status among Chinese women.

Tian-Wen Han, Yu-Qi Liu, Wei Dong, Xiao-Juan Bai, Yu-Yang Liu, Xi Su, Yu-Ming Li, Ju-Ying Qian, Mei-Xiang Xiang, Lin Cai, Qian Lin, Jing-Bo Hou, Jie Yang, Dan-Dan Li, Huan-Wan Yang, Shan-Shan Zhou, Jing Wang, Feng Tian, Xue-Qiao Zhao, Yun-Dai Chen,

<h4>Background</h4>Systematic investigation and analysis of cardiovascular health status (CVHS) of Chinese women is rare. This study aimed to assess CVHS and atherosclerotic cardiovascular disease (ASCVD) burden in the Chinese women physicians (CWP) and community-based non-physician cohort (NPC).<h4>Methods</h4>In this prospective, multicenter, observational study, CVHS using the American Heart Association (AHA) defined ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):497]

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Association Between Serum Insulin and C-Peptide Levels and Breast Cancer: An Updated Systematic Review and Meta-Analysis.

Manwen Li, Limin Song, Junhua Yuan, Di Zhang, Caishun Zhang, Yuan Liu, Qian Lin, Haidan Wang, Kaizhen Su, Yanrun Li, Zhengye Ma, Defeng Liu, Jing Dong,

<h4>Background</h4>Several studies have reported that hyperinsulinemia plays a part in the etiology of breast cancer. However, no consensus has been reached. Therefore, we conducted a meta-analysis to explore the role of insulin and C-peptide in breast cancer.<h4>Methods</h4>A systematic search in PubMed, Embase, and The Cochrane Library was conducted up to ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:553332]

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Cultural Adaptation, Validation, and Primary Application of a Questionnaire to Assess Intentions to Eat Low-Glycemic Index Foods among Rural Chinese Women.

Mingshu Li, Fang Li, Qian Lin, Jingzheng Shi, Jing Luo, Qing Long, Qiping Yang, Yufeng Ouyang, Hanmei Liu, Rhonda C Bell, Jia Guo,

Different lines of evidence indicate that knowledge of low-glycemic index (GI) foods and the practice of eating them play important roles in blood glucose management and preventing T2DM in women with prior gestational diabetes mellitus (GDM). According to the theory of planned behavior (TPB), intention is a critical factor in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(20):]

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Engineered cardiac tissues: a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy.

Xiang Wang, Xin-Xin Chen, Hai-Tao Yu, Yi Tan, Qian Lin, Bradley B Keller, Yang Zheng, Lu Cai,

Rodent diabetic models, used to understand the pathophysiology of diabetic cardiomyopathy (DCM), remain several limitations. Engineered cardiac tissues (ECTs) have emerged as robust 3D in vitro models to investigate structure-function relationships as well as cardiac injury and repair. Advanced glycation end-products (AGEs), produced through glycation of proteins or lipids in ... Read more >>

Acta Pharmacol Sin (Acta pharmacologica Sinica)
[2020, :]

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Efficacy of Sodium Tanshinone IIA Sulfonate in Patients with Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Results from a Multicentre, Controlled, Randomized Trial.

Shuai Mao, Lei Wang, Xujie Zhao, Liheng Guo, Qian Lin, Xiaofeng Wang, Xiaohua Dai, Hongcai Shang, Minzhou Zhang, Aleksander Hinek,

<h4>Background</h4>Sodium tanshinone IIA sulfonate (STS) has been widely used by Chinese medicine practitioners for chronic cardiovascular diseases. However, its direct clinical efficacy in patients with acute coronary syndrome following percutaneous coronary intervention (PCI) has not been reported yet. The present trial aimed to investigate potential cardioprotection of STS in patients ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2020, :]

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Surface-Enhanced Raman Scattering Monitoring of Oxidation States in Defect-Engineered Two-Dimensional Transition Metal Dichalcogenides.

Xiangyu Hou, Qian Lin, Yunjia Wei, Qi Hao, Zhenhua Ni, Teng Qiu,

Recent studies have found that some transition metal dichalcogenides (TMDs) with their own defects are difficult to store in the air for a long time. Worse stability of TMDs under extreme conditions has also been reported. Therefore, monitoring the oxidation and degradation processes of TMDs can directly guide the stability ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2020, 11(19):7981-7987]

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Transurethral laser versus open simple prostatectomy for large volume prostates: a systematic review and meta-analysis of randomized controlled trials.

Wei Haibin, Qian Lin, Wu Junxiu, Wang Heng, Zhang Qi, Wang Yanpeng, Zhang Dahong,

The benefit of transurethral laser prostatectomy over open simple prostatectomy (OSP) is controversial in aged symptomatic benign prostatic hyperplasia (BPH) patients with large volume prostates, and the aim of this study is to compare the safety and efficiency of these two methods. Meta-analysis was applied using the Review Manager V5.3 ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2020, :]

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Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin‑induced type 1 diabetes mouse model.

Limin Song, Junhua Yuan, Yuan Liu, Di Zhang, Caishun Zhang, Qian Lin, Manwen Li, Kaizhen Su, Yanrun Li, Guangkai Gao, Ruixia Ma, Jing Dong,

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder for which the only effective therapy is insulin replacement. Hyperbaric oxygen (HBO) therapy has demonstrated potential in improving hyperglycemia and as a treatment option for T1DM. Ghrelin and HBO have been previously reported to exert proliferative, anti‑apoptotic and anti‑inflammatory effects in pancreatic ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 22(5):3767-3776]

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Activating AMP-activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice.

Qian Lin, Zhifeng Huang, Genxiang Cai, Xia Fan, Xiaoqing Yan, Zhengshuai Liu, Zehua Zhao, Jingya Li, Jia Li, Hongxue Shi, Maiying Kong, Ming-Hua Zheng, Daniel J Conklin, Paul N Epstein, A Wintergerst Kupper, Moosa Mohammadi, Lu Cai, Xiaokun Li, Yu Li, Yi Tan,

<h4>Background and aims</h4>Fibroblast growth factor 1 (FGF1) demonstrated protection against nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic and obese mice by an uncertain mechanism. This study investigated the therapeutic activity and mechanism of a non-mitogenic FGF1 variant (FGF1<sup>△HBS</sup> ) against NAFLD. Approach and Results FGF1<sup>△HBS</sup> administration was effective ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

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A Time Delay Neural Network Based Technique for Nonlinear Microwave Device Modeling.

Wenyuan Liu, Lin Zhu, Feng Feng, Wei Zhang, Qi-Jun Zhang, Qian Lin, Gaohua Liu,

This paper presents a nonlinear microwave device modeling technique that is based on time delay neural network (TDNN). The proposed technique can accurately model the nonlinear microwave devices when compared to static neural network modeling method. A new formulation is developed to allow for the proposed TDNN model to be ... Read more >>

Micromachines (Basel) (Micromachines)
[2020, 11(9):]

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