Full Text Journal Articles by
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Recent developments of nanoenzyme-based colorimetric sensors for heavy metal detection and the interaction mechanism.

Zhengquan Yan, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu, Wenli Yao,

Heavy metal contamination has posed a great threat to human survival and social development. For this, a series of nanoenzyme-based colorimetric sensors, e.g., metal nanoparticles, metal oxides, metal sulfides, graphene-based nanomaterials, G-quadruplex and so on, were developed for the rapid and efficient detection of toxic heavy metal ions, whose detection ... Read more >>

Analyst (The Analyst)
[2020, 145(9):3173-3187]

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Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy.

Lipeng Zhu, Jie Liu, Guangyu Zhou, Hoi Man Ng, Irene L Ang, Guofang Ma, Yubin Liu, Shuo Yang, Fengjuan Zhang, Kai Miao, Terence C W Poon, Xuanjun Zhang, Zhen Yuan, Chu-Xia Deng, Qi Zhao,

In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging. The B7-H3-Ce6 conjugates could display effective tumor diagnosis and therapy and provide a novel approach for immunotherapy. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(95):14255-14258]

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PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10-mediated anti-inflammatory response.

Xingyong Wan, Xudong Zhu, Hu Wang, Ye Feng, Weihua Zhou, Peihao Liu, Weiyan Shen, Lingling Zhang, Leiming Liu, Tangliang Li, Daojun Diao, Fan Yang, Qi Zhao, Li Chen, Jian Ren, Sheng Yan, Jing Li, Chaohui Yu, Zhenyu Ju,

Inflammatory responses are pivotal incidences in hepatic metabolic derangements. However, the underlying mechanism remains elusive. The present study aimed to evaluate the role of peroxisome proliferator-activated receptor-gamma, coactivator 1 alpha (PGC1α) in IL10-mediated anti-inflammatory response, and its role in hepatic steatosis and insulin resistance. Hepatocyte-specific PGC1α knock-in (LivPGC1α) mice and ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, :]

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Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer.

Ranliang Cui, Chaomin Wang, Qi Zhao, Yichao Wang, Yueguo Li,

BACKGROUND:The incidence and mortality of breast cancer are increasing annually. Breast cancer seriously threatens women's health and quality of life. We aimed to measure the clinical value of CPN1, a new serum marker of breast cancer and to evaluate the efficacy of CPN1 in combination with CA15-3. METHODS:Seventy samples of ... Read more >>

Anticancer Agents Med Chem (Anti-cancer agents in medicinal chemistry)
[2020, :]

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A Retrospective Case-Control Study of the Determinants of Iron Deficiency Anemia in Infants in an Urban Community in Shanghai, China Between 2010-2015.

Jian Wang, Yuan Liu, Qi Zhao, Tianwei Liu, Zhigang Zhou,

BACKGROUND Iron deficiency anemia (IDA) is a global public health problem. This study aimed to analyze the social determinants of IDA in infants living in Shanghai, China, between 2010-2015. MATERIAL AND METHODS Data were analyzed retrospectively from the Shanghai Children's Health Check Record system in the Tangqiao Community Health Service ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921463]

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Impacts of triglycerides-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang, Yu-jie Zhou,

Abstract Background: The relationship between triglycerides-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing ... Read more >>

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A self-calibrated luminescent thermometer based on nanodiamond-Eu/Tb hybrid materials.

Xue-Ying Wu, Qi Zhao, Dong-Xue Zhang, Ya-Chuan Liang, Kui-Kui Zhang, Qian Liu, Lin Dong, Chong-Xin Shan,

Luminescent hybrid materials based on nanodiamonds (NDs) and rare earth ions have been successfully synthesized by covalently modifying NDs with pyromellitic acid (PMA) which is capable of coordinating to Eu3+ and Tb3+ ions. With NDs acting as a host matrix, the PMA and rare earth ions serve as an organic ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(22):7910-7917]

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Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer.

Zekun Liu, Qi Zhao, Zhi-Xiang Zuo, Shu-Qiang Yuan, Kai Yu, Qingfeng Zhang, Xiaolong Zhang, Hui Sheng, Huai-Qiang Ju, Han Cheng, Feng Wang, Rui-Hua Xu, Ze-Xian Liu,

Ferroptosis is a type of cell death related to cancer; however, the characteristics of ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we found that most ferroptosis regulator genes (FRGs) were differentially expressed in tumors, somatic copy number alterations (SCNA) and DNA methylation ... Read more >>

iScience (iScience)
[2020, 23(7):101302]

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The Ratio of ssDNA to dsDNA in Circulating Cell-Free DNA Extract is a Stable Indicator for Diagnosis of Gastric Cancer.

Xuewen Huang, Qi Zhao, Xianyuan An, Jie Pan, Lanjing Zhao, Lanfeng Shen, Yiqiu Xu, Dandan Yuan,

Due to the different mechanisms of cell-free DNA production, the single-stranded DNA to double-stranded DNA ratio in blood maybe different between healthy individuals and gastric cancer (GC) patients. We aimed to explore the potential application of this ratio in GC diagnosis. The plasma cell-free DNA extracts from 118 healthy individuals ... Read more >>

Pathol. Oncol. Res. (Pathology oncology research : POR)
[2020, :]

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Impact of immunization programs on 11 vaccine-preventable diseases in China: 1950-2018

Jinhua Pan, Yesheng Wang, Zundong Yin, Zhixi Liu, Ying Wang, Qi Zhao, Weibing Wang,

Introduction: Chinese immunization program has caused dramatic declines in morbidity and mortality from vaccine-preventable diseases (VPDs). To further evaluate the achievements of this program, we explored patterns in the morbidity and mortality of VPDs in China based on national surveillance data. Methods: According to the times at which vaccines were ... Read more >>

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Effect of voluntary breathing exercises on stable coronary artery disease in heart rate variability and rate-pressure product: a study protocol for a single-blind, prospective, randomized controlled trial.

Qing Wu, Lin Liu, Xin Jiang, Yao-Yao Hu, Qiu-Shi Liang, Zhi-Song He, Yuan Xue, Wei Zhu, Zai-Xiang Tang, Yun-Ying Hou, Qi Zhao, Xiao-Hua Wang,

BACKGROUND:At present, China has more than 11 million patients with stable coronary heart disease and this is becoming a major public health problem. The pathological changes of coronary heart disease can lead to dysfunction of the cardiac autonomic nervous system, which increases the risk of complications such as malignant arrhythmia ... Read more >>

Trials (Trials)
[2020, 21(1):602]

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Bufalin-induced cardiotoxicity: new findings into mechanisms.

Min Li, Xi-Jie Wang, Qi Zhao, Jia-Xian Wang, Hong-Yan Xing, Yi-Zhe Zhang, Xue-Xia Zhang, Yang-Yang Zhi, Hua Li, Jing Ma,

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine preparations. The cardiotoxicity clearly limits its application to patients living in countries. Hence, an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse ... Read more >>

Chin J Nat Med (Chinese journal of natural medicines)
[2020, 18(7):550-560]

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pH-sensitive loaded retinal/indocyanine green micelles as an "all-in-one" theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy.

Lipeng Zhu, Ping Li, Duyang Gao, Jie Liu, Yubin Liu, Chen Sun, Mengze Xu, Xin Chen, Zonghai Sheng, Ruibing Wang, Zhen Yuan, Lintao Cai, Yifan Ma, Qi Zhao,

In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed to realize novel approaches for cellular senescence-photothermal synergistic therapy to treat cancer. The micelles could enable effective multi-modal imaging in vivo guided therapy and show anticancer activity in vitro and in vivo with satisfactory biosafety. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(44):6209-6212]

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Electromagnetic Interference Shielding of Graphene Aerogel with Layered Microstructure Fabricated via Mechanical Compression.

Chuan-Bing Li, Yu-Jun Li, Qi Zhao, Yue Luo, Guo-Yu Yang, Yi Hu, Jian-Jun Jiang,

Graphene aerogel is a promising electromagnetic interference (EMI) shielding material because of its light weight, excellent electrical conductivity, uniform three-dimensional (3D) microporous structure, and good mechanical strength. The graphene aerogel with high EMI shielding performance is attracting considerable critical attention. In this study, a novel procedure to fabricate high EMI ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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An experimental application of laser-scattering sensor to estimate the traffic-induced PM2.5 in Beijing.

Xiaoting Liu, Qi Zhao, Sicong Zhu, Wenjie Peng, Lei Yu,

Traffic-induced air pollutant emissions are currently rising rapidly. However, measurement of the roadside environment and calculation of the emission factors for traffic-induced PM2.5 are restricted to certain locations and periods due to the limitations of conventional air monitoring techniques. This paper introduces a portable sensor package with a laser light-scattering ... Read more >>

Environ Monit Assess (Environmental monitoring and assessment)
[2020, 192(7):450]

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Distribution of ABO blood groups and association to low risk of COVID-19 infection in patients

Minfei Peng, Shigao Huang, Shitu Zhu, Chaochao Chen, Jiajia Qin, Minmin He, Jie Yang, Qi Zhao,

Abstract Background Since December 2019, the novel coronavirus pandemic (COVID-19) has become a global health emergency. To date, studies on the correlation between ABO blood groups and COVID-19 infected risk had rarely reported. This study aimed to describe the ABO blood groups distribution and association to low risk of ... Read more >>

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gutMEGA: a database of the human gut MEtaGenome Atlas.

Qingfeng Zhang, Kai Yu, Shihua Li, Xiaolong Zhang, Qi Zhao, Xia Zhao, Zekun Liu, Han Cheng, Ze-Xian Liu, Xiaoxing Li,

The gut microbiota plays important roles in human health through regulating both physiological homeostasis and disease emergence. The accumulation of metagenomic sequencing studies enables us to better understand the temporal and spatial variations of the gut microbiota under different physiological and pathological conditions. However, it is inconvenient for scientists to ... Read more >>

Brief. Bioinformatics (Briefings in bioinformatics)
[2020, :]

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Clinical and genomic characterization of neutral tumor evolution in Head and Neck Squamous Cell Carcinoma.

Rui Li, Jingsi Dong, Hongwan Zhang, Qi Zhao, Xingyang Li, Xuefei Liu, Ying Ye, Shuang Deng, Dongxin Lin, Jian Zheng, Zhixiang Zuo,

Recent studies suggest that a significant proportion of cancers undergo neutral tumor evolution. We applied neutral evolution model in HNSCC patients from The Cancer Genome Atlas (TCGA). To ensure the accuracy of classification results, a sample with the purity of tumor <0.7 was excluded. A tumor sample was considered to ... Read more >>

Genomics (Genomics)
[2020, :]

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Rising challenge of multidrug-resistant tuberculosis in China: a predictive study using Markov modeling.

Bing-Ying Li, Wen-Pei Shi, Chang-Ming Zhou, Qi Zhao, Vinod K Diwan, Xu-Bin Zheng, Yang Li, Sven Hoffner, Biao Xu,

BACKGROUND:Multidrug-resistant tuberculosis (MDR-TB) is on the rise in China. This study used a dynamic Markov model to predict the longitudinal trends of MDR-TB in China by 2050 and to assess the effects of alternative control measures. METHODS:Eight states of tuberculosis transmission were set up in the Markov model using a ... Read more >>

Infect Dis Poverty (Infectious diseases of poverty)
[2020, 9(1):65]

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Biofertilizers with beneficial rhizobacteria improved plant growth and yield in chili (Capsicum annuum L.).

Jing-Yi Gou, Sheng-Zhou Suo, Kun-Zhong Shao, Qi Zhao, Dan Yao, Hui-Ping Li, Jin-Lin Zhang, Christopher Rensing,

Chemical fertilizers can supply essential nutrients to crops increasing their yield, however, they can also cause serious environmental problems. Biofertilizer has received more and more attention because of its environmentally friendly and pollution-free characteristics. Haloxylon ammodendron, a desert succulent shrub, has become an important plant species for vegetation restoration in ... Read more >>

World J. Microbiol. Biotechnol. (World journal of microbiology & biotechnology)
[2020, 36(6):86]

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Short-term Outcomes of Modified Y-Graft Technique in Acute Type A Aortic Dissection Using the Femoral Artery Bypass and One Minute Systemic Circulatory Arrest Technique

Xiangfei Sun, Qi Zhao, Yufeng Huo, Jinfeng Zhou, Fen Zhao, Yimin Liu, Yonghai Du, Songxiong He, Chao Liu, Detian Jiang, Wenyu Sun,

Abstract Objective: Aortic arch replacement in acute type A aortic dissection patients remains the most challenging cardiovascular operation. Herein, we described our modified Y-graft technique using the Femoral Artery Bypass (FAB) and the One Minute Systemic Circulatory Arrest (OSCA) technique, and assessed the short-term outcomes of the patients. Methods: Between ... Read more >>

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The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review.

Kai Liu, Minying Zheng, Rui Lu, Jiaxing Du, Qi Zhao, Zugui Li, Yuwei Li, Shiwu Zhang,

One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasive, metastatic, drug-resistance, and anti-apoptotic abilities. Recently, an increasing number of cell cycle-associated proteins have become the candidate biomarkers ... Read more >>

Cancer Cell Int. (Cancer cell international)
[2020, 20:213]

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Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report.

Yi Bao, Shu Yu Lin, Zhao Hui Cheng, Jun Xia, Yan Peng Sun, Qi Zhao, Guang Jian Liu,

COVID-19 is currently a pandemic in the world, can invade multiple systems, and has a high morbidity and mortality. So far, no cases of acute cerebrovascular disease have been reported. This article reports the clinical features of a COVID-19 patient whose first symptom was cerebral hemorrhage. More importantly, after the ... Read more >>

SN Compr Clin Med (Sn Comprehensive Clinical Medicine)
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An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method.

Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,

ETHNOPHARMACOLOGICAL RELEVANCE:Neuropathic pain, the incidence of which ranges from 5 to 8% in the general population, remains challenge in the treatment. Shaoyao Gancao decoction (SGD) is a Chinese classical formula used to relieve pain for thousands of years and has been applied for neuropathic pain nowadays. However, the effective components ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 260:113050]

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Celastrol ameliorates acute liver injury through modulation of PPARα.

Qi Zhao, Ping Tang, Ting Zhang, Jian-Feng Huang, Xue-Rong Xiao, Wei-Feng Zhu, Frank J Gonzalez, Fei Li,

Celastrol, derived from the roots of the Tripterygium Wilfordi, has attracted interest for its potential anti-inflammatory and lipid-lowering activities. In the present study, the protective effect of celastrol on carbon tetrachloride (CCl4)-induced acute liver injury was investigated. Celastrol improved the increased transaminase activity, inflammation, and oxidative stress induced by CCl4, ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2020, 178:114058]

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