Full Text Journal Articles by
Author Qi Song

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Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.

Xiaofan Ding, Mian He, Anthony W H Chan, Qi Xiu Song, Siu Ching Sze, Hui Chen, Matthew K H Man, Kwan Man, Stephen L Chan, Paul B S Lai, Xin Wang, Nathalie Wong,

BACKGROUND & AIMS:Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver tumors, among hepatic lesions, and between primary and relapsing tumors. METHODS:Tumor and matched non-tumor liver specimens were collected from 113 ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

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Association between fetal growth restriction and maternal exposure to polybrominated diphenyl ethers.

Yuting Jin, Jialin Li, Xiaokai Deng, Bin Xia, Qi Song, Yingya Zhao, Xiaoxiao He, Yimei Li, Zhangye Xu, Ailan Xie, Jing Lin, Yunhui Zhang, Shangqin Chen,

Humans are exposed to polybrominated diphenyl ethers (PBDEs) via ingestion of food, dust inhalation, and dermal absorption. Exposure to PBDEs via the placenta and breast milk is a special and important pathway in infants. This nested case-control study aimed to investigate the levels of PBDEs in maternal serum and colostrum, ... Read more >>

Ecotoxicol. Environ. Saf. (Ecotoxicology and environmental safety)
[2020, 198:110623]

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The efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours: a systematic review and meta-analysis.

Jie Zhang, Qi Song, Liang Cai, Ying Xie, Yue Chen,

PURPOSE:To evaluate the efficacy of 177Lu-DOTA0-Tyr3-octreotate (177Lu-DOTATATE) radionuclide therapy in patients with inoperable or metastatic neuroendocrine tumours (NETs), (PROSPERO ID CRD42019130755). METHODS:All published clinical studies of NETs treated with 177Lu-DOTATATE were identified based on systematic searches in the PubMed, EMBASE, Cochrane Library, Web of Science and ClinicalTrials.gov databases up to ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2020, 146(6):1533-1543]

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Prediction of condition-specific regulatory genes using machine learning.

Qi Song, Jiyoung Lee, Shamima Akter, Matthew Rogers, Ruth Grene, Song Li,

Recent advances in genomic technologies have generated data on large-scale protein-DNA interactions and open chromatin regions for many eukaryotic species. How to identify condition-specific functions of transcription factors using these data has become a major challenge in genomic research. To solve this problem, we have developed a method called ConSReg, ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2020, :]

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Noradrenergic enhancement of object recognition and object location memory in mice.

Qi Song, Youri G Bolsius, Giacomo Ronzoni, Marloes J A G Henckens, Benno Roozendaal,

Extensive evidence indicates that noradrenergic activation is essentially involved in mediating the enhancing effects of emotional arousal on memory consolidation. Our current understanding of the neurobiological mechanisms underlying the memory-modulatory effects of the noradrenergic system is primarily based on pharmacological studies in rats, employing targeted administration of noradrenergic drugs into ... Read more >>

Stress (Stress (Amsterdam, Netherlands))
[2020, :1-8]

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The behaviors of Microcystis aeruginosa and microcystins during the Fe2+/persulfate (PS) preoxidation-coagulation and flocs storage period.

Qi Song, Xiaojun Niu, Dongqing Zhang, Xiaofei Song, Yankun Li, Jinling Ma, Senchao Lai, Zhiquan Yang, Shaoqi Zhou,

The frequent occurrence of toxin-producing cyanobacteria blooms driven by anthropogenic eutrophication has become a major threat to aquaculture ecosystems worldwide. In this study, the behavior of M. aeruginosa cells during flocs storage period of 6 days was first investigated after pre-oxidation and coagulation of Fe2+/PS. Fe2+/PS achieved a superior removal ... Read more >>

Environ. Res. (Environmental research)
[2020, 186:109549]

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Secondary Grain Growth in Organic-Inorganic Perovskite Films with Ethylamine Hydrochloride Additives for Highly Efficient Solar Cells.

Chao Ji, Chunjun Liang, Huimin Zhang, Mengjie Sun, Qi Song, Fulin Sun, Xiaona Feng, Ning Liu, Hongkang Gong, Dan Li, Fangtian You, Zhiqun He,

The grain boundaries of perovskite polycrystalline are regarded as a defect region that not only provides carrier recombination sites but also introduces device degradation pathways. Efforts to enlarging the grain size of a perovskite film and reducing its grain boundary are crucial for highly efficient and stable perovskite solar cells ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(17):20026-20034]

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Activation of Wnt/β-catenin pathway causes insulin resistance and increases lipogenesis in HepG2 cells via regulation of endoplasmic reticulum stress.

Zili Lei, Lanxiang Yang, Yanhong Yang, Jing Yang, Zhenpeng Niu, Xueying Zhang, Qi Song, Yuting Lei, Huijuan Wu, Jiao Guo,

BACKGROUND:Wnt/β-catenin signaling is involved in glucose and lipid metabolism, but the mechanism is not clear yet. AIM:The objective is to study mechanisms of Wnt/β-catenin signaling on regulating hepatocytes metabolism. METHODS:Real-time qPCR, Western blot, and Oil-red O staining methods were used. RESULTS:The Wnt/β-catenin signaling was activated in hepatocytes by CP21R7, and ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 526(3):764-771]

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Appropriate Range of Median Urinary Iodine Concentration in 8- to 10-Year-Old Children Based on Generalized Additive Model.

Zhengyuan Wang, Baozhang Luo, Jiajie Zang, Zehuan Shi, Xueying Cui, Qi Song, Wei Jin, Changyi Guo, Shoujun Liu,

Background: The appropriate range of median urinary iodine concentration (MUI) in children has always been controversial. To prevent the occurrence of a goiter epidemic in Shanghai, we explored the appropriate range of MUI by integrating multiple monitoring results. Methods: This study summarized and analyzed the monitoring data from 1997, 1999, ... Read more >>

Thyroid (Thyroid : official journal of the American Thyroid Association)
[2020, :]

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Kanglaite injection plus fluorouracil-based chemotherapy on the reduction of adverse effects and improvement of clinical effectiveness in patients with advanced malignant tumors of the digestive tract: A meta-analysis of 20 RCTs following the PRISMA guidelines.

Qi Song, Jie Zhang, Qibiao Wu, Guoping Li, Elaine Lai-Han Leung,

BACKGROUND:The digestive tract malignancies are a series of malignant tumor with high morbidity and mortality. Traditional Chinese medicine (TCM) combined with chemotherapy drugs interventions have been applied for the treatment of malignant tumors in Asian countries for dacades. This study aimed to assess the effectiveness and safety on the combination ... Read more >>

Medicine (Madr) (Medicine)
[2020, 99(17):e19480]

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BaLiTe2O5X (X = Cl, Br): mixed alkali/alkaline-earth metal tellurite halides with [Te2O5]∞ chains.

Ting Wang, Yi-Gang Chen, Yao Guo, Fang Wang, Qi Song, Ying-Jie Jia, Xian-Ming Zhang,

Isostructural mixed alkali/alkaline-earth metal tellurite halides BaLiTe2O5X (X = Cl, Br) have been successfully synthesized by a mild hydrothermal method, which possess the [Te2O5]∞ chains formed by the corner-sharing connections of the TeO3 and TeO4 polyhedra. The [Te2O5]∞ chains are bridged via the LiO3 polyhedra to form the [LiTe2O5]∞ layers ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(15):4914-4919]

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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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The antibiotic jinggangmycin increases brown planthopper (BPH) fecundity by enhancing rice plant sugar concentrations and BPH insulin-like signaling.

LinQuan Ge, Ze Zhou, KaiDi Sun, Bo Huang, David Stanley, Qi Sheng Song,

The brown planthopper (BPH), Nilaparvata lugens, is a resurgent pest with an unexpected response to jinggangmycin (JGM), a broadly applied antibiotic used to control rice sheath blight disease. JGM stimulates BPH fecundity, but the underlining molecular mechanisms remain unclear. Here we report that JGM sprays led to increased glucose concentrations, ... Read more >>

Chemosphere (Chemosphere)
[2020, 249:126463]

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Comparison of the prognostic difference between ypTNM and equivalent pTNM stages in esophageal squamous cell carcinoma based on the 8th edition of AJCC classification.

Dongxian Jiang, Hao Wang, Qi Song, Haixing Wang, Qun Wang, Lijie Tan, Yingyong Hou,

Objective: With the separate ypTNM stage groupings established in the 8th edition of AJCC staging system for esophageal squamous cell cancer (ESCC), we aimed to evaluate the prognostic difference between ypTNM stage and equivalent pTNM stage. Methods: ESCC patients with surgery alone (cohort 1) and patients with neoadjuvant therapy plus ... Read more >>

J Cancer (Journal of Cancer)
[2020, 11(7):1808-1815]

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Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA-miRNA-mRNA networks and Cox regression models.

Yan Yao, Tingting Zhang, Lingyu Qi, Ruijuan Liu, Gongxi Liu, Jia Wang, Qi Song, Changgang Sun,

Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, and its underlying mechanism remains unclear. Accumulating evidence has highlighted that long non-coding RNA (lncRNA) acts as competitive endogenous RNA (ceRNA) and plays an important role in the occurrence and development of LUAD. Here, we comprehensively analyzed and provided ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(1):]

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Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma.

Jing Cui, Herui Wang, Rogelio Medina, Qi Zhang, Chen Xu, Iris H Indig, Jingcheng Zhou, Qi Song, Pauline Dmitriev, Mitchell Y Sun, Liemei Guo, Yang Wang, Jared S Rosenblum, John S Kovach, Mark R Gilbert, Zhengping Zhuang,

Chimeric antigen receptor (CAR)-engineered T cells represent a promising modality for treating glioblastoma. Recently, we demonstrated that CAR-T cells targeting carbonic anhydrase IX (CAIX), a protein involved in HIF-1a hypoxic signaling, is a promising CAR-T cell target in an intracranial murine glioblastoma model. Anti-CAIX CAR-T cell therapy is limited by ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(1):]

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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide.

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang,

High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites. This study used the established Yang Huang syndrome (YHS) mouse model to evaluate the efficacy of geniposide (GEN). Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass spectrometry. The non-target screening ... Read more >>

Front Med (Frontiers of medicine)
[2020, :]

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Learning tree-structured representation for 3D coronary artery segmentation.

Bin Kong, Xin Wang, Junjie Bai, Yi Lu, Feng Gao, Kunlin Cao, Jun Xia, Qi Song, Youbing Yin,

Extensive research has been devoted to the segmentation of the coronary artery. However, owing to its complex anatomical structure, it is extremely challenging to automatically segment the coronary artery from 3D coronary computed tomography angiography (CCTA). Inspired by recent ideas to use tree-structured long short-term memory (LSTM) to model the ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2020, 80:101688]

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Bavachin Protects Human Aortic Smooth Muscle Cells Against β-Glycerophosphate-Mediated Vascular Calcification and Apoptosis via Activation of mTOR-Dependent Autophagy and Suppression of β-Catenin Signaling.

Hu-Qiang He, Betty Yuen Kwan Law, Ni Zhang, Cong-Ling Qiu, Yuan-Qing Qu, An-Guo Wu, Yu Han, Qi Song, Wen-Lu Zheng, Yong Liu, Yan-Zheng He, Vincent Kam Wai Wong,

Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds from traditional Chinese medicines (TCM) ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1427]

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Genome Wide Association Study and Genomic Selection of Amino Acid Concentrations in Soybean Seeds.

Jun Qin, Ainong Shi, Qijian Song, Song Li, Fengmin Wang, Yinghao Cao, Waltram Ravelombola, Qi Song, Chunyan Yang, Mengchen Zhang,

Soybean is a major source of protein for human consumption and animal feed. Releasing new cultivars with high nutritional value is one of the major goals in soybean breeding. To achieve this goal, genome-wide association studies of seed amino acid contents were conducted based on 249 soybean accessions from China, ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2019, 10:1445]

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Malus micromalus Makino phenolic extract preserves hepatorenal function by regulating PKC-α signaling pathway and attenuating endoplasmic reticulum stress in lead (II) exposure mice.

Guangliang Wang, Jinlei Tang, Qi Song, Qianqian Yu, Congying Yao, Pengfei Li, Yixin Ding, Mibin Lin, Dai Cheng,

Lead (Pb), which widely recognized as a nonessential heavy metal and a major environmental contamination, is a growing threat to the ecosystem and human body. In the present study, Malus micromalus Makino cv. 'Dong Hong' phenolic extract (MMPE) has been used to antagonise Pb-induced erythrocyte injury, hepatic and renal dysfunction ... Read more >>

J. Inorg. Biochem. (Journal of inorganic biochemistry)
[2020, 203:110925]

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An iterative multi-path fully convolutional neural network for automatic cardiac segmentation in cine MR images.

Zongqing Ma, Xi Wu, Xin Wang, Qi Song, Youbing Yin, Kunlin Cao, Yan Wang, Jiliu Zhou,

PURPOSE:Segmentation of the left ventricle (LV), right ventricle (RV) cavities and the myocardium (MYO) from cine cardiac magnetic resonance (MR) images is an important step for diagnosis and monitoring cardiac diseases. Spatial context information may be highly beneficial for segmentation performance improvement. To this end, this paper proposes an iterative ... Read more >>

Med Phys (Medical physics)
[2019, 46(12):5652-5665]

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Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma.

Jing Cui, Qi Zhang, Qi Song, Herui Wang, Pauline Dmitriev, Mitchell Y Sun, Xiaoyu Cao, Yang Wang, Liemei Guo, Iris H Indig, Jared S Rosenblum, Chunxia Ji, Dongqing Cao, Kaiyong Yang, Mark R Gilbert, Yu Yao, Zhengping Zhuang,

BACKGROUND:Glioblastoma survival remains unchanged despite continuing therapeutic innovation. Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity to a unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic of glioblastoma, and (ii) demonstrate its efficacy with limited off-target effects. ... Read more >>

Neuro-oncology (Neuro-oncology)
[2019, 21(11):1436-1446]

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Associations between in utero exposure to polybrominated diphenyl ethers, pathophysiological state of fetal growth and placental DNA methylation changes.

Yingya Zhao, Qi Song, Wenzhen Ge, Yuting Jin, Shangqin Chen, Yan Zhao, Xirong Xiao, Yunhui Zhang,

BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are environmental chemicals with harmful effects on pregnancy, but their effects on adverse developmental outcomes are not fully understood. The placental DNA methylation is strongly influenced by prenatal environmental factors and has been linked to fetal growth. OBJECTIVE:To evaluate the association between in utero PBDEs exposure, ... Read more >>

Environ Int (Environment international)
[2019, 133(Pt B):105255]

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Bioinformatics analysis of immune infiltration patterns in breast cancer for identification of prognostic markers

Yan Yao, Tingting Zhang, Lingyu Qi, Ruijuan Liu, Gongxi Liu, Jia Wang, Qi Song, Jie Li, Changgang Sun,

Abstract Background/purpose Cancer immunotherapy has revolutionized the clinical treatment of several tumors. Immune infiltration has been found to be closely related to clinical prognosis, but it shows limited activity in breast cancer (BC). Therefore, this study aimed to explore the infiltration pattern of immune cells in BC, and to find ... Read more >>

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