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Author Qi Bing Liu

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Cost-effectiveness analysis of combining traditional Chinese medicine in the treatment of hypertension: compound Apocynum tablets combined with Nifedipine sustained-release tablets vs Nifedipine sustained-release tablets alone.

Qian Xu, Nan Yang, Shuang Feng, Jianfei Guo, Qi-Bing Liu, Ming Hu,

<h4>Background</h4>We evaluated the long-term cost-effectiveness of antihypertensive traditional Chinese medicines (TCMs) and to compare the cost-effectiveness of a combined treatment consisting of compound Apocynum tablets and Nifedipine sustained-release tablets with the cost-effectiveness of treatment with Nifedipine sustained-release tablets alone.<h4>Methods</h4>A Markov model was used to simulate the potential incremental cost-effectiveness per ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):330]

Cited: 0 times

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FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signaling pathways.

Xiao Cui, Chong-Mei Liu, Qi-Bing Liu,

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that Fc-receptor like-3 (FCRL3) is closely related to MS, but the specific role of FCRL3 in MS has not yet been clarified. This ... Read more >>

Cell Biol Int (Cell biology international)
[2020, 44(9):1811-1819]

Cited: 1 time

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Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia.

Kai-Xin Yao, Hang Lyu, Mei-Hua Liao, Lin Yang, Yin-Ping Gao, Qi-Bing Liu, Cheng-Kun Wang, Ying-Mei Lu, Guo-Jun Jiang, Feng Han, Ping Wang,

Vascular dementia (VaD) is a complex disorder caused by reduced blood flow in the brain. However, there is no effective pharmacological treatment option available until now. Here, we reported that low-dose levamlodipine besylate could reverse the cognitive impairment in VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO). ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18248]

Cited: 1 time

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Bone marrow mesenchymal stem cell-derived exosome uptake and retrograde transport can occur at peripheral nerve endings.

Rui Ren, Xiao-Hong Tan, Jiu-Hong Zhao, Quan-Peng Zhang, Xian-Fang Zhang, Zhi-Jian Ma, Ya-Nan Peng, Qi-Bing Liu, Hai-Ying Zhang, Yun-Qing Li, Rui He, Zhen-Qiang Zhao, Xi-Nan Yi,

We investigated the occurrence of mesenchymal stem cell (MSC)-derived exosome uptake and retrograde transport at peripheral nerve endings using bone marrow MSCs (bMSCs) transduced with recombinant CD63-green fluorescent protein (GFP) lentiviral plasmid. GFP was used to track the release of bMSC-derived exosomes and the uptake and transport at peripheral nerve ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2019, 47(1):2918-2929]

Cited: 9 times

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MicroRNA-9 overexpression suppresses vulnerable atherosclerotic plaque and enhances vascular remodeling through negative regulation of the p38MAPK pathway via OLR1 in acute coronary syndrome.

Dao-Rui Yu, Tao Wang, Jing Huang, Xing-Yue Fang, Hao-Fei Fan, Guo-Hui Yi, Qiang Liu, Yu Zhang, Xiang-Zhou Zeng, Qi-Bing Liu,

Acute coronary syndrome (ACS) is characterized by atherosclerotic plaque rupture with a high incidence of recurrent ischemic events. Several microRNAs are found to be aberrantly expressed in atherosclerotic plaques. This study aims to investigate the effects of microRNA-9 (miR-9) on vulnerable atherosclerotic plaque and vascular remodeling in ACS and underlying ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2020, 121(1):49-62]

Cited: 6 times

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Multimodal Rehabilitation Program Promotes Motor Function Recovery of Rats After Ischemic Stroke by Upregulating Expressions of GAP-43, SYN, HSP70, and C-MYC.

Tao Wang, Dao-Rui Yu, Jing Huang, Qiang Liu, Dan-Xin Wang, Nan Luo, Hao Jia, Hao-Fei Fan, Qi-Bing Liu,

<h4>Background</h4>Despite the intense efforts devoted to preventing and treating cerebral ischemia, some individuals will continue to have completed infarctions. Failure of prevention or intervention does not, however, preclude therapeutic approaches to enhance recovery. Our study aims to explore the effect of multimodal rehabilitation program on the motor function recovery of ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2018, 27(10):2829-2839]

Cited: 8 times

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Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury.

Quan Jiang, Gang Wu, Lin Yang, Ya-Ping Lu, Xiu-Xiu Liu, Feng Han, Ya-Ping Deng, Xu-Chun Fu, Qi-Bing Liu, Ying-Mei Lu,

<h4>Background/aims</h4>Peptidyl-prolyl cis-trans isomerase FKBP25 is a member of the FK506-binding proteins family which has peptidyl-prolyl cis/trans isomerase domain. The biological function and pathophysiologic role of FKBP25 remain elusive.<h4>Methods</h4>The spatio-temporal changes in expression of endothelial FKBP25 upon oxygen-glucose deprivation (OGD) treatment were examined by Western blot and immunofluorescence. The immunoprecipitation and ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2018, 47(5):2018-2030]

Cited: 3 times

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Variant of EOMES Associated with Increasing Risk in Chinese Patients with Relapsing-remitting Multiple Sclerosis.

Sheng Chen, Juan Zhang, Qi-Bing Liu, Jing-Cong Zhuang, Lei Wu, Yong-Feng Xu, Hong-Fu Li, Zhi-Ying Wu, Bao-Gou Xiao,

<h4>Background</h4>Multiple sclerosis (MS) is a common central nervous system autoimmune disorder. Increasing number of genome-wide association study (GWAS) analyses hint that MS is strongly associated with genetics. Unfortunately, almost all the GWAS analyses were Caucasian population based. Numbers of risk loci might not be replicated in Chinese MS patients. Hence, ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2018, 131(6):643-647]

Cited: 4 times

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Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation.

Dong-Mei Gong, Yan-Li Zhang, Dan-Yang Chen, Ling-Juan Hong, Feng Han, Qi-Bing Liu, Jian-Jun Jiang, Ying-Mei Lu,

<h4>Background/aims</h4>Endothelial cell dysfunction is the principal pathological process underlying atherosclerotic cardiovascular disease. G protein-coupled receptor 124 (GPR124), an orphan receptor in the adhesion GPCR subfamily, promotes angiogenesis in the brain. In the present study, we explored the role of endothelial GPR124 in the development and progression of atherosclerosis in adult ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2018, 45(2):547-557]

Cited: 6 times

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Endothelial ErbB4 deficit induces alterations in exploratory behavior and brain energy metabolism in mice.

Gang Wu, Xiu-Xiu Liu, Nan-Nan Lu, Qi-Bing Liu, Yun Tian, Wei-Feng Ye, Guo-Jun Jiang, Rong-Rong Tao, Feng Han, Ying-Mei Lu,

<h4>Aims</h4>The receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain.<h4>Results</h4>Here, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2017, 23(6):510-517]

Cited: 4 times

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Neuroprotective activity of two active chemical constituents from Tinospora hainanensis.

Dao-Rui Yu, Li-Ping Ji, Tao Wang, Xi-Nan Yi, Guo-Hui Yi, Tong He, Yong-Xiao Cao, En-Wu Long, Qi-Bing Liu,

<h4>Objective</h4>To determine the chemical structure of the new compound and investigate the protective effects of Tinosporaic acid A and B towards in-vitro neuro.<h4>Methods</h4>The structures of two new compounds were established by analyzing its 1D and 2D NMR spectra as well as HRESIMS. Their neuroprotective effects with respect to the antioxidant ... Read more >>

Asian Pac J Trop Med (Asian Pacific journal of tropical medicine)
[2017, 10(2):114-120]

Cited: 0 times

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The protective effect and underlying mechanism of Hainan papaya water extract against neuronal apoptosis induced by Aβ40.

Jiu-Hong Zhao, Hai-Ying Zhang, Xian-Fang Zhang, Xu Dong, Qi-Bing Liu, Yue-Li Liu, Yi-Di Huang, Quan-Peng Zhang, Gang Luo, Zhi-Jian Ma, Xi-Nan Yi,

<h4>Objective</h4>To investigate whether Hainan papayas has protective effects in an Aβ40-induced primary neuron injury model and elucidate the underlying molecular mechanism.<h4>Methods</h4>Cultured primary neurons from the dorsal root ganglia (DRG) of Sprague-Dawley (SD) rats were treated with 20 μM Aβ40 peptide, 100 μg/L Hainan papaya water extract, peptide plus extract, or culture medium ... Read more >>

Asian Pac J Trop Med (Asian Pacific journal of tropical medicine)
[2016, 9(7):707-712]

Cited: 0 times

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Two new cassane-type diterpenes from the seeds of Caesalpinia crista.

Qi-Bing Liu, Ling Huang, Li Zhang, Qiang Liu, Qiao-Qin Xu, Xian-Jing Qin, Xing-Yue Fang, Yu Zeng,

Two new cassane-type diterpenes, phangininoxys D and E (1 and 2), together with five known compounds were isolated from the seeds of Caesalpinia crista Linn. The structures of these compounds were elucidated by means of various spectroscopic analyses. All the isolated compounds were evaluated for cytotoxicity activities against HeLa, HT-29 ... Read more >>

J Asian Nat Prod Res (Journal of Asian natural products research)
[2015, 17(11):1073-1078]

Cited: 1 time

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Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population.

Qi-Bing Liu, Lei Wu, Gui-Xian Zhao, Ping-Ping Cai, Zhen-Xin Li, Zhi-Ying Wu,

<h4>Background</h4>Neuromyelitis optica (NMO) and multiple sclerosis (MS) are demyelinating disorders of the central nervous system. Interferon regulatory factor 5 (IRF5) is a common susceptibility gene to different autoimmune disorders. However, the association of IRF5 variants with NMO and MS patients has not been well studied. Therefore, we aimed to evaluate ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2015, 128(13):1743-1747]

Cited: 2 times

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Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China.

Jing-Cong Zhuang, Lei Wu, Mei-Zhen Qian, Ping-Ping Cai, Qi-Bing Liu, Gui-Xian Zhao, Zhen-Xin Li, Zhi-Ying Wu,

<h4>Background</h4>Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune demyelinating diseases of the central nerve system. Interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) were proved to be important in the pathogenesis of both diseases because of the roles they played in the differentiations of autoimmune lymphocytes. The variants of both ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2015, 128(22):3062-3068]

Cited: 6 times

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Variants of autophagy-related gene 5 are associated with neuromyelitis optica in the Southern Han Chinese population.

Ping-Ping Cai, Hong-Xia Wang, Jing-Cong Zhuang, Qi-Bing Liu, Gui-Xian Zhao, Zhen-Xin Li, Zhi-Ying Wu,

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune demyelinating diseases of the central nervous system. The discovery of NMO immunoglobulin G (NMO-IgG) antibody has improved the clinical definition of NMO. Recently, the autophagy-related genes (ATGs) have been proved to be associated with several autoimmune and inflammation diseases. Increased T ... Read more >>

Autoimmunity (Autoimmunity)
[2014, 47(8):563-566]

Cited: 7 times

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No association between identified multiple sclerosis non-MHC risk loci and neuromyelitis optica.

Qi-Bing Liu, Zhen-Xin Li, Gui-Xian Zhao, Hai Yu, Zhi-Ying Wu,

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are both autoimmune inflammatory and demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibility single-nucleotide polymorphisms (SNPs) have been detected outside the major histocompatibility complex (MHC) region. In this study, we aimed to evaluate the association of these identified non-MHC ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2014, 30(6):1036-1044]

Cited: 6 times

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The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells.

Qi-Bing Liu, Lu-Lu Liu, Ying-Mei Lu, Rong-Rong Tao, Ji-Yun Huang, Feng Han, Yi-Jia Lou,

The pathophysiological relevance of S-nitrosoglutathione (GSNO)-induced endothelial cell injury remains unclear. The main objective of this study was to elucidate the molecular mechanisms of GSNO-induced oxidative stress in endothelial cells. Morphological evaluation through DAPI staining and propidium iodide (PI) flow cytometry was used to detect apoptosis. In cultured EA.hy926 endothelial ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2010, 244(3):374-384]

Cited: 25 times

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