Full Text Journal Articles by
Author Purva Gopal

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Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.

Nicole C Panarelli, Suntrea T G Hammer, Jingmei Lin, Purva Gopal, ILKe Nalbantoglu, Lili Zhao, Jerome Cheng, Adam J Gersten, Jonathan B McHugh, Vinita Parkash, Elena Lucas, Maria Westerhoff,

The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1381-1388]

Cited: 0 times

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Colorectal Neoplasia among Patients with and without Human Immunodeficiency Virus.

Adil Faqih, Amit G Singal, Hannah M Fullington, Benjamin Hewitt, Ezra Burstein, Purva Gopal, Annika Wylie, John Abrams, Caitlin C Murphy,

BACKGROUND:Increasing availability of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has led to prolonged survival and rising incidence of non-HIV-defining cancers among patients with HIV. Compared with the general population, risk of colorectal cancer may differ among those with HIV due to immunosuppression, oncogenic viral coinfections, and ... Read more >>

Cancer Epidemiol. Biomarkers Prev. (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, 29(8):1689-1691]

Cited: 0 times

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Hepatocellular carcinoma tumour volume doubling time: a systemic review and meta-analysis.

Piyush Nathani, Purva Gopal, Nicole Rich, Adam Yopp, Takeshi Yokoo, Binu John, Jorge Marrero, Neehar Parikh, Amit G Singal,

BACKGROUND:Tumour growth patterns have important implications for surveillance intervals, prognostication and treatment decisions but have not been well described for hepatocellular carcinoma (HCC). The aim of our study was to characterise HCC doubling time and identify correlates for indolent and rapid growth patterns. METHODS:We performed a systematic literature review of ... Read more >>

Gut (Gut)
[2020, :]

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SARS-CoV-2-related Hypercoagulable State Leading to Ischemic Enteritis Secondary to Superior Mesenteric Artery Thrombosis.

James Michael Mitchell, Dinesh Rakheja, Purva Gopal,

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, :]

Cited: 0 times

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Increased Frequency of Heterozygous Alpha-1-Antitrypsin Deficiency in Liver Explants From Nonalcoholic Steatohepatitis Patients.

Gregory Cheeney, Lincoln J Pac, Purva Gopal, Charles S Landis, Eric Q Konnick, Paul E Swanson, Dina N Greene, Christina M Lockwood, Maria Westerhoff,

Cirrhotic explanted livers occasionally have unexpected periodic acid-Schiff-diastase (PASD)-positive globules within the hepatocyte cytoplasm. It is often unclear whether this finding is a nonspecific consequence of cirrhosis or is indicative of an underlying alpha-1-antitrypsin deficiency (A1ATD) contributing to the cirrhosis. In this study, explanted livers were retrospectively evaluated for histopathology ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2020, 26(1):17-24]

Cited: 1 time

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Intracranial anaplastic hemangiopericytoma presenting with simultaneous extra-cranial metastases: A case report and review of the literature.

Sumanth Reddy, Aaron Plitt, Jack Raisanen, Ankur R Patel, Purva Gopal, Robert Timmerman, Toral R Patel,

Background:Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare mesenchymal tumor with a propensity to recur and metastasize extracranially years after treatment. Accordingly, there are no reported cases of a patient presenting with a simultaneous intracranial primary and extracranial metastases. We present the case of a patient presenting with an intracranial ... Read more >>

(Surgical neurology international)
[2019, 10:148]

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Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection Is Associated With Increased Survival in Patients With a History of Hepatocellular Carcinoma.

Amit G Singal, Nicole E Rich, Neil Mehta, Andrea D Branch, Anjana Pillai, Maarouf Hoteit, Michael Volk, Mobolaji Odewole, Steven Scaglione, Jennifer Guy, Adnan Said, Jordan J Feld, Binu V John, Catherine Frenette, Parvez Mantry, Amol S Rangnekar, Omobonike Oloruntoba, Michael Leise, Janice H Jou, Kalyan Ram Bhamidimarri, Laura Kulik, George N Ioannou, Annsa Huang, Tram Tran, Hrishikesh Samant, Renumathy Dhanasekaran, Andres Duarte-Rojo, Reena Salgia, Sheila Eswaran, Prasun Jalal, Avegail Flores, Sanjaya K Satapathy, Sofia Kagan, Purva Gopal, Robert Wong, Neehar D Parikh, Caitlin C Murphy,

BACKGROUND & AIMS:There is controversy regarding the benefits of direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection for patients with a history of hepatocellular carcinoma (HCC). We performed a multicenter cohort study to compare overall survival between patients with HCV infection treated with DAAs and patients who did ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 157(5):1253-1263.e2]

Cited: 1 time

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Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.

Wenhan Zhu, Naoteru Miyata, Maria G Winter, Alexandre Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, Petro Starokadomskyy, Purva Gopal, Mariana X Byndloss, Renato L Santos, Ezra Burstein, Sebastian E Winter,

Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-producing E. coli strains, are risk factors for the development of colorectal cancer. Here, we sought to determine whether precision editing of gut microbiota metabolism and composition could decrease the risk for tumor development in mouse models of colitis-associated ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2019, 216(10):2378-2393]

Cited: 2 times

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Arid1a Loss Drives Nonalcoholic Steatohepatitis in Mice Through Epigenetic Dysregulation of Hepatic Lipogenesis and Fatty Acid Oxidation.

Austin Moore, Linwei Wu, Jen-Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu,

Nonalcoholic steatohepatitis (NASH) is a rapidly growing cause of chronic liver damage, cirrhosis, and hepatocellular carcinoma. How fatty liver pathogenesis is subject to epigenetic regulation is unknown. We hypothesized that chromatin remodeling is important for the pathogenesis of fatty liver disease. AT-rich interactive domain-containing protein 1A (ARID1A), a DNA-binding component ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, 69(5):1931-1945]

Cited: 1 time

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The Clinical Significance of Crohn Disease Activity at Resection Margins.

Sasan Setoodeh, Li Liu, Sarag A Boukhar, Amit G Singal, Maria Westerhoff, Akbar K Waljee, Tasneem Ahmed, Purva Gopal,

CONTEXT.—:Conflicting data about the clinical significance of microscopic Crohn disease (CD) activity at resection margins have led to varying practice patterns for routine reporting by pathologists. OBJECTIVE.—:To characterize the association between active disease at resection margins with postoperative CD recurrence and time-to-recurrence in the era of anti-tumor necrosis factor therapy. ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2019, 143(4):505-509]

Cited: 0 times

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver.

Shuyuan Zhang, Kejin Zhou, Xin Luo, Lin Li, Ho-Chou Tu, Alfica Sehgal, Liem H Nguyen, Yu Zhang, Purva Gopal, Branden D Tarlow, Daniel J Siegwart, Hao Zhu,

Dev Cell (Developmental cell)
[2018, 47(3):390]

Cited: 4 times

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Impact of a Clinical Decision Support System on Guideline Adherence of Surveillance Recommendations for Colonoscopy After Polypectomy.

Melissa Magrath, Edward Yang, Chul Ahn, Christian A Mayorga, Purva Gopal, Caitlin C Murphy, Samir Gupta, Deepak Agrawal, Ethan A Halm, Eric K Borton, Celette Sugg Skinner, Amit G Singal,

Background: Surveillance colonoscopy is required in patients with polyps due to an elevated colorectal cancer (CRC) risk; however, studies suggest substantial overuse and underuse of surveillance colonoscopy. The goal of this study was to characterize guideline adherence of surveillance recommendations after implementation of an electronic medical record (EMR)-based Colonoscopy Pathology ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2018, 16(11):1321-1328]

Cited: 0 times

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Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the In Vitro Integrity of T Cells from Cancer Patients.

Masato Kobayashi, Jin-Sung Chung, Muhammad Beg, Yull Arriaga, Udit Verma, Kevin Courtney, John Mansour, Barbara Haley, Saad Khan, Yutaka Horiuchi, Vijay Ramani, David Harker, Purva Gopal, Farshid Araghizadeh, Ponciano D Cruz, Kiyoshi Ariizumi,

PURPOSE:Blocking the function of myeloid-derived suppressor cells (MDSC) is an attractive approach for cancer immunotherapy. Having shown DC-HIL/GPNMB to be the T-cell-inhibitory receptor mediating the suppressor function of MDSCs, we evaluated the potential of anti-DC-HIL mAb as an MDSC-targeting cancer treatment. EXPERIMENTAL DESIGN:Patients with metastatic cancer (n = 198) were ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(2):828-838]

Cited: 3 times

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Unique causes of esophageal inflammation: a histopathologic perspective.

Purva Gopal, Joanna A Gibson, Mikhail Lisovsky, ILKe Nalbantoglu,

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2018, 1434(1):219-226]

Cited: 1 time

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Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.

Xuxu Sun, Sam C Wang, Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen-Chieh Chuang, Thomas Maples, Cemre Celen, Liem H Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan Zhang, Mahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C Yopp, Amit G Singal, Hao Zhu,

Cancer Cell (Cancer cell)
[2018, 33(1):151-152]

Cited: 4 times

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Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.

Shuyuan Zhang, Liem H Nguyen, Kejin Zhou, Ho-Chou Tu, Alfica Sehgal, Ibrahim Nassour, Lin Li, Purva Gopal, Joshua Goodman, Amit G Singal, Adam Yopp, Yu Zhang, Daniel J Siegwart, Hao Zhu,

BACKGROUND & AIMS:Cytokinesis can fail during normal postnatal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver slows tumor growth without compromising the health of normal hepatocytes. We inhibited cytokinesis in cancer cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and ... Read more >>

Gastroenterology (Gastroenterology)
[2018, 154(5):1421-1434]

Cited: 15 times

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver.

Shuyuan Zhang, Kejin Zhou, Xin Luo, Lin Li, Ho-Chou Tu, Alfica Sehgal, Liem H Nguyen, Yu Zhang, Purva Gopal, Branden D Tarlow, Daniel J Siegwart, Hao Zhu,

Most cells in the liver are polyploid, but the functional role of polyploidy is unknown. Polyploidization occurs through cytokinesis failure and endoreduplication around the time of weaning. To interrogate polyploidy while avoiding irreversible manipulations of essential cell-cycle genes, we developed orthogonal mouse models to transiently and potently alter liver ploidy. Premature ... Read more >>

Dev Cell (Developmental cell)
[2018, 44(4):447-459.e5]

Cited: 17 times

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Sarcina ventriculi in a Patient With Slipped Gastric Band and Gastric Distention.

Li Liu, Purva Gopal,

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(4):A25-A26]

Cited: 0 times

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Follicular Dendritic Cell Sarcoma.

Tiffany Chen, Purva Gopal,

Follicular dendritic cell sarcoma is a rare tumor that typically arises within lymph nodes but can also occur extranodally. It is important to have a high index of suspicion, so follicular dendritic cell sarcoma is included in the differential diagnosis of a spindle cell neoplasm in the appropriate clinical and ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2017, 141(4):596-599]

Cited: 7 times

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Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities.

Santosh K Sanganalmath, Purva Gopal, John R Parker, Richard K Downs, Joseph C Parker, Buddhadeb Dawn,

Circulatory arrest (CA) remains a major unresolved public health problem in the United States; the annual incidence of which is ~0.50 to 0.55 per 1000 population. Despite seminal advances in therapeutic approaches over the past several decades, brain injury continues to be the leading cause of morbidity and mortality after CA. ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2017, 426(1-2):111-127]

Cited: 8 times

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Metachronous Uterine Endometrioid Adenocarcinoma and Peritoneal Mesothelioma in Lynch Syndrome: A Case Report.

Yuxin Lu, Sara Milchgrub, Gaurav Khatri, Purva Gopal,

Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma that developed in a Lynch ... Read more >>

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2017, 25(3):253-257]

Cited: 2 times

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Single-Agent Brentuximab as Bridging Therapy for Hodgkin Lymphoma Patients With Hepatic Impairment.

Arjun Gupta, Jan Petrasek, Shiraj Sen, Purva Gopal, Harris V Naina,

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2016, 16(2):e11-4]

Cited: 1 time

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The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury.

Yonas Getachew, Frank A Cusimano, Purva Gopal, Scott A Reisman, Jerry W Shay,

Patients with cirrhosis have an increased risk of developing liver cancer and a higher rate of mortality. Cirrhosis currently has no known cure, and patients may benefit from new agents aimed at alleviating their complications and slowing down the rate of disease progression. Therefore, the effects of the orally bioavailable ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2016, 149(1):111-120]

Cited: 8 times

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Predictors of guideline concordance for surveillance colonoscopy recommendations in patients at a safety-net health system.

Ben Kahn, Zachary Freeland, Purva Gopal, Deepak Agrawal, Christian A Mayorga, Rozina Mithani, Celette Sugg Skinner, Ethan A Halm, Amit G Singal,

PURPOSE:Appropriate surveillance intervals for colorectal cancer (CRC) screening is one of the Centers for Medicare and Medicaid Services 2014 physician quality reporting system measures. Appropriateness of surveillance intervals will continue to be monitored closely, particularly as reimbursements become tied to quality measures. AIMS:Quantify and identify predictors for guideline-concordant surveillance recommendations ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2015, 26(11):1653-1660]

Cited: 6 times

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Primary Anal Canal Syphilis in Men: The Clinicopathologic Spectrum of an Easily Overlooked Diagnosis.

Purva Gopal, Rajal B Shah,

The incidence of syphilis is on the rise, particularly in male patients who are human immunodeficiency virus (HIV) positive, and men who have sex with men.To describe 4 cases of primary syphilis presenting in the anal canal to increase awareness of its presentation and morphology in this location, as the ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2015, 139(9):1156-1160]

Cited: 3 times

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