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Author Prateek Bhatia

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A look inside the body of a BCR-ABL1-like acute lymphoblastic leukemia patient: the first case report highlighting the continued relevance of autopsy practice.

Pulkit Rastogi, Prateek Bhatia, Sreejesh Sreedharanunni, Deepesh Lad,

Blood Res (Blood research)
[2021, :]

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Hurler Phenotype with Vacuolated Lymphocytes and Elevated Lysosomal Hydrolases - Is it Mucolipidosis?

Indar K Sharawat, Ananthanarayanan Kasinathan, Gargi Das, Prateek Bhatia, Naveen Sankhyan,

Neurol India (Neurology India)
[2021, 69(5):1456-1458]

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Immunoglobulins and Lymphocyte Subsets in Children with Infantile Tremor Syndrome.

Amanpreet Kaur, Himanshi Chaudhary, Amit Rawat, Jitendra Kumar Sahu, Prateek Bhatia, Savita Verma, Naveen Sankhyan,

In this hospital-based, cross-sectional study, immunoglobulin levels and lymphocyte subsets status were evaluated in children with infantile tremor syndrome (ITS) [neurocutaneous infantile B12 deficiency (NIB) syndrome]. Blood samples were drawn at the baseline (n = 28) and at 6 wk (n = 25) after treatment. A low IgG/IgA or IgM was more likely in ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2021, 88(11):1139-1141]

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TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India.

Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S Mandavdhare, Jayanta Samanta, Kaushal K Prasad, Usha Dutta, Vishal Sharma,

<h4>Background</h4>Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively. Exact role of these polymorphisms in South Asian population with inflammatory bowel disease (IBD) is uncertain.<h4>Methods</h4>We included consecutive patients with IBD who ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2021, 21(1):327]

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Neonatal Dengue With HLH: Perks of Early Diagnosis and Management.

Archana Krishnappa, Jeyaraj Munusamy, Somosri Ray, Monisha Rameshbabu, Prateek Bhatia, Pritam S Roy, Venkataseshan Sundaram, Praveen Kumar,

<h4>Background</h4>Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, aggressive syndrome. It can be primary, which involves genetic mutation with an early presentation, or secondary to infections, malignancies, etc., due to absence of immune downregulation. It is a very rare condition in newborns. Dengue is a potential virus causing HLH, but, in newborns, ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(6):e770-e773]

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Rare chromosomal aberrations detected in children with multiple congenital anomalies: utility of multiple ligation dependant probe amplification for developing countries.

Shirisha Pulipaka, Anit Kaur, Prateek Bhatia, Inusha Panigrahi, Anupriya Kaur,

Chromosomal aberrations are an important cause of multiple malformation syndromes. Multiple ligation-dependent probe amplification (MLPA) a molecular cytogenetic technique has been suggested as a screening tool for the detection of chromosomal aberrations in resource-limited settings. MLPA can detect chromosomal microdeletions or duplications at approximately 40 chromosomal regions in a single ... Read more >>

Clin Dysmorphol (Clinical dysmorphology)
[2021, 30(3):125-129]

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Assessment of the Effect of Complete Dentures on Respiratory Performance: A Spirometric Analysis.

Jawaz Ahmad Shah Bukhari, Sidhant Sudan, Bhushan Bangar, Neeraj Kumar, Prateek Bhatia, Rohit Duggal,

<h4>Background</h4>Among the vital functions, respiration can be claimed to be one of the most important. A thorough understanding of the patient should be an important aspect a prosthodontist should dwell into so as to predispose patients to acknowledge the kind of prosthesis they require. Hence, the present study was conducted ... Read more >>

J Pharm Bioallied Sci (Journal of pharmacy & bioallied sciences)
[2021, 13(Suppl 1):S440-S443]

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Fatal thiopurine toxicity: pre-emptive testing of NUDT15 415C>T polymorphism may be life saving in South Asian population.

Amit Yadav, Anuraag Jena, Rozy Thakur, Pankaj Kumar, Prateek Bhatia, Vishal Sharma,

Drug Metab Pers Ther (Drug metabolism and personalized therapy)
[2021, :]

Cited: 1 time

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De novo double-hit B-cell precursor leukemia/lymphoma - an unusual presentation as peritoneal lymphomatosis.

Balamurugan Thirunavukkarasu, Jayanta Samanta, Prateek Bhatia, Amanjit Bal,

Peritoneal lymphomatosis (PL) is a rare presentation of extranodal precursor leukemia/lymphoma. The presentation is often non-specific, leading to delayed diagnosis and treatment. In this case, though the preliminary diagnosis was established on ascitic fluid cytology, the disease progressed rapidly, leading to demise before initiating chemotherapy. Immunophenotyping and molecular studies, performed ... Read more >>

Autops Case Rep (Autopsy & case reports)
[2021, 11:e2021278]

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Wiskott Aldrich Syndrome: A Multi-Institutional Experience From India.

Deepti Suri, Rashmi Rikhi, Ankur K Jindal, Amit Rawat, Murugan Sudhakar, Pandiarajan Vignesh, Anju Gupta, Anit Kaur, Jyoti Sharma, Jasmina Ahluwalia, Prateek Bhatia, Alka Khadwal, Revathi Raj, Ramya Uppuluri, Mukesh Desai, Prasad Taur, Ambreen A Pandrowala, Vijaya Gowri, Manisha R Madkaikar, Harsha Prasada Lashkari, Sagar Bhattad, Harish Kumar, Sanjeev Verma, Kohsuke Imai, Shigeaki Nonoyama, Osamu Ohara, Koon W Chan, Pamela P Lee, Yu Lung Lau, Surjit Singh,

<h4>Background</h4>Wiskott Aldrich syndrome (WAS) is characterized by bleeding manifestations, recurrent infections, eczema, autoimmunity, and malignancy. Over the last decade, improved awareness and better in-house diagnostic facilities at several centers in India has resulted in increased recognition of WAS. This study reports collated data across major primary immunodeficiency diseases (PID) centers ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:627651]

Cited: 1 time

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A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene.

Pankaj Sharma, Prateek Bhatia, Minu Singh, Reena Das, Richa Jain, Deepak Bansal, Savita Verma Attri, Amita Trehan,

In current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes ... Read more >>

Blood Cells Mol Dis (Blood cells, molecules & diseases)
[2021, 89:102569]

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Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.

Anuraag Jena, Daya Krishna Jha, Praveen Kumar-M, Kripa Shanker Kasudhan, Ankit Kumar, Dhruv Sarwal, Shubhra Mishra, Anupam Kumar Singh, Prateek Bhatia, Amol Patil, Vishal Sharma,

<b>Background</b>: Prevalence and impact of thiopurine S-methyltransferase (<i>TPMT</i>) and Nudix hydrolase (<i>NUDT15</i>) minor allele frequencies in South Asian population is unclear.<b>Methods</b>: We searched PubMed and Embase with keywords-<i>TPMT</i> and <i>NUDT15</i> combined with South Asian countries. We included studies reporting frequency of <i>TPMT</i> and <i>NUDT15</i> polymorphisms. We estimated the pooled prevalence ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2021, 14(4):491-501]

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Clinico-Hematological Profile and Copy Number Abnormalities in a Cohort of STIL-TAL1 and NUP214-ABL1 Positive Pediatric T-Cell Acute Lymphoblastic Leukemia.

Nilamani Patra, Minu Singh, Pankaj Sharma, Amita Trehan, Shano Naseem, Deepak Bansal, Prateek Bhatia,

T cell acute lymphoblastic leukaemia (T-ALL) is a genetically heterogeneous and aggressive form of malignancy. Although a number of recurrent fusion genes are reported in T-ALL, their involvement in disease stratification and therapeutic intervention is still controversial. Considering the prognostic value of <i>STIL-TAL1</i> fusion and tyrosine kinase inhibitor (TKI) based ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2021, 37(4):555-562]

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Hyperferritinemia in children hospitalized with scrub typhus.

Vijai Williams, Nisha Menon, Prateek Bhatia, Manisha Biswal, Sreejesh Sreedharanunni, Muralidharan Jayashree, Karthi Nallasamy,

<h4>Background</h4>Hyperferritinemia is increasingly associated with mortality in sepsis. Studies estimating the prevalence of hyperferritinemia in pediatric scrub typhus are limited.<h4>Methods</h4>This was a secondary analysis of a prospective observational study (FERRIS) from a tertiary care teaching hospital in North India where 72 children with confirmed scrub typhus, 4 (5.5%) PCR positive, ... Read more >>

Trop Med Health (Tropical medicine and health)
[2021, 49(1):15]

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A Case of Novel GATA-1 Mutation-positive Transient Abnormal Myelopoiesis With Life-threatening Complications in a Neonate With Down Syndrome.

Ritesh R Sah, Somosri Ray, Prateek Bhatia, Shashi K Dhir, Sidharth Totadri, Narender Kumar, Praveen Kumar,

Transient abnormal myelopoiesis is a transient myeloproliferative disorder seen in ∼15% to 20% of infants with Down syndrome. These infants are usually asymptomatic, requiring only monitoring, but they can have variable severity of symptoms up to multisystemic dysfunction requiring chemotherapy. GATA-1 somatic mutations acquired in utero are pathognomic of this ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(2):e292-e295]

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Epigenetic analysis reveals significant differential expression of miR-378C and miR-128-2-5p in a cohort of relapsed pediatric B-acute lymphoblastic leukemia cases.

Prateek Bhatia, Minu Singh, Aditya Singh, Pankaj Sharma, Amita Trehan, Neelam Varma,

<h4>Introduction and objective</h4>Epigenetic changes play a major role in mediating chemoresistance and relapse in pediatric ALL, and hence in current pilot study, we tried to identify DNA methylation, miRNA expression, and copy number variations (CNVs) in a cohort of relapse pediatric B-ALL cases.<h4>Methodology</h4>DNA methylation, miRNA expression, and CNV analysis were ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2021, 43(5):1016-1023]

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Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a.

Aditya Singh, Prateek Bhatia,

<h4>Aim</h4>To induce BCR-ABL gene silencing using CRISPR Cas13a.<h4>Background</h4>CML is a clonal myeloproliferative disorder of pluripotent stem cells driven by a reciprocal translocation between chromosomes 9 and 22 forming a BCR-ABL fusion gene. Tyrosine- kinase inhibitor drugs like imatinib are the mainstay of treatment and cases resistant to these drugs have ... Read more >>

Curr Gene Ther (Current gene therapy)
[2021, 21(3):270-277]

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Effect of Sepsis on Iron Parameters in a Population with High Prevalence of Malnutrition and Iron Deficiency: A Cross-Sectional Case-Control Pilot Study.

Arun K Baranwal, Reena Das, Ramachandran Rameshkumar, Praveen Kumar-M, Prateek Bhatia, Ashwini Nair,

There is lack of data on iron metabolism in critically ill sepsis children from population with high prevalence of iron deficiency (ID). The study was designed to study impact of sepsis on iron parameters in children with ID. Sepsis patients (age 6-59 months) and their apparently healthy sibling/cousin as controls were ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2021, 37(4):609-615]

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Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.

Aman Sharma, Gsrsnk Naidu, Vikas Sharma, Saket Jha, Aaadhar Dhooria, Varun Dhir, Prateek Bhatia, Vishal Sharma, Sagar Bhattad, K G Chengappa, Vikas Gupta, Durga Prasanna Misra, Pallavi Pimpale Chavan, Sourabh Malaviya, Rajkiran Dudam, Banwari Sharma, Sathish Kumar, Rajesh Bhojwani, Pankaj Gupta, Vikas Agarwal, Kusum Sharma, Manphool Singhal, Manish Rathi, Ritambhra Nada, Ranjana W Minz, Ved Chaturvedi, Amita Aggarwal, Rohini Handa, Alice Grossi, Marco Gattorno, Zhengping Huang, Jun Wang, Ramesh Jois, V S Negi, Raju Khubchandani, Sanjay Jain, Juan I Arostegui, Eugene P Chambers, Michael S Hershfield, Ivona Aksentijevich, Qing Zhou, Pui Y Lee,

<h4>Objective</h4>Deficiency of adenosine deaminase 2 (DADA2) is a potentially fatal monogenic syndrome characterized by variable manifestations of systemic vasculitis, bone marrow failure, and immunodeficiency. Most cases are diagnosed by pediatric care providers, given the typical early age of disease onset. This study was undertaken to describe the clinical phenotypes and ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, 73(2):276-285]

Cited: 6 times

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Characterisation of LDL receptor gene mutations in a North Indian cohort of children with homozygous familial hypercholesterolaemia.

Shagun Singh, Minu Singh, Devi Dayal, Prateek Bhatia, Sandeep Negi, Savita V Attri,

<h4>Introduction</h4>Homozygous familial hypercholesterolaemia (HoFH) carries a grave prognosis but is often underdiagnosed and undertreated. Confirmation of molecular diagnosis helps in planning effective management and determining prognosis accurately. Aim of the study: To determine the spectrum of mutations in the LDLR gene in a cohort of children with a clinical diagnosis of HoFH.<h4>Material and ... Read more >>

Pediatr Endocrinol Diabetes Metab (Pediatric endocrinology, diabetes, and metabolism)
[2021, 27(1):32-36]

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Serum Ferritin Predicts Neither Organ Dysfunction Nor Mortality in Pediatric Sepsis Due to Tropical Infections.

Vijai Williams, Nisha Menon, Prateek Bhatia, Manisha Biswal, Sreejesh Sreedharanunni, Amit Rawat, Muralidharan Jayashree, Karthi Nallasamy,

<b>Objective:</b> To evaluate serial ferritin levels measured in the initial 72 h of admission as a biomarker for new and progressive multi organ dysfunction syndrome (NPMODS) and mortality (unfavorable outcomes) in critically ill children with sepsis due to tropical infections. <b>Material and Methods:</b> In this prospective observational study from a ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:607673]

Cited: 1 time

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Pediatric bone marrow failure: Clinical, hematological and targeted next generation sequencing data.

Prashant Chhabra, Prateek Bhatia, Minu Singh, Deepak Bansal, Richa Jain, Neelam Varma, Amita Trehan,

<h4>Objective</h4>In this study, clinico-hematological, genetic and outcome profile of children with BMF was evaluated to delineate the underlying genotype and phenotype.<h4>Design</h4>Cases were evaluated as two groups: Group 1 (n = 56; DBA-23, FA-18, DC-2, UBMFS-13) included children with suspected IBMFS based on clinical phenotype and accessible lab investigations and Group 2 (n = 53) ... Read more >>

Blood Cells Mol Dis (Blood cells, molecules & diseases)
[2021, 87:102510]

Cited: 1 time

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Hyperferritinemia in pediatric scrub typhus: A prospective observational study

Vijai Williams, Nisha Menon, Prateek Bhatia, Manisha Biswal, Sreejesh Sreedharanu, Muralidharan Jayashree, Karthi Nallasamy,

<h4>Background: </h4> Hyperferritinemia is increasingly associated with mortality in sepsis. Studies estimating the prevalence of hyperferritinemia in pediatric scrub typhus is limited. <h4>Methods: </h4>: We conducted a prospective observational study from a tertiary care teaching hospital in North India where 72 children with confirmed scrub typhus;17(24%)-PCR positive, 68(94%)-IgM ELISA positive ... Read more >>

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Comparative sequencing data analysis of Ion Torrent and MinION sequencing platforms using a clinical diagnostic haematology panel.

Aditya Singh, Prateek Bhatia,

<h4>Introduction</h4>Currently, two second-generation sequencing platforms-Ion Torrent and Illumina are being widely used for clinical testing and reporting of human samples. However, third-generation long read platforms like single molecule (PacBio) or direct sequencing (Nanopore) are gaining widespread interest in clinical genomics.<h4>Aims and objectives</h4>The current study attempts to analyse and compare MinION ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, 42(6):833-841]

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Usefulness of automated fragmented red blood cell percentage in the diagnosis of paediatric haemolytic uraemic syndrome.

Srinivasavaradan Govindarajan, Prateek Bhatia, Lesa Dawman, Karalanglin Tiewsoh,

<h4>Introduction</h4>Presence of schistocytes in peripheral blood smear supporting haemolysis is important for diagnosis and decision-making in paediatric haemolytic uraemic syndrome (HUS). High observer dependency and requirement of expertise for peripheral smear evaluation propels us to think of other modalities to overcome these issues. We envisage that newer techniques like automated ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2021, 43(1):40-43]

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