Full Text Journal Articles by
Author Pradip Kamat

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Severe acute respiratory syndrome coronavirus 2 infection and critically ill children.

Rahul Damania, Whitney Moore, Heather C Viamonte, Pradip Kamat, Rajit K Basu,

<h4>Purpose of review</h4>Amidst an ongoing pandemic, the delineation of the pediatric consequence of infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus is emerging. This review summarizes available pediatric data and covers the aspects of epidemiology, critical illness with acute infection [coronavirus disease 2019 (COVID-19)], the discovered ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):286-291]

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"Difficult to Sedate": Successful Implementation of a Benzodiazepine-Sparing Analgosedation-Protocol in Mechanically Ventilated Children.

Nataly Shildt, Chani Traube, Mary Dealmeida, Ishaan Dave, Scott Gillespie, Whitney Moore, Lillian D Long, Pradip P Kamat,

We sought to evaluate the success rate of a benzodiazepine-sparing analgosedation protocol (ASP) in mechanically ventilated children and determine the effect of compliance with ASP on in-hospital outcome measures. In this single center study from a quaternary pediatric intensive care unit, our objective was to evaluate the ASP protocol, which ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2021, 8(5):]

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Trends in Outpatient Procedural Sedation: 2007-2018.

Pradip P Kamat, Courtney E McCracken, Harold K Simon, Anne Stormorken, Michael Mallory, Corrie E Chumpitazi, Joseph P Cravero,

<h4>Background</h4>Pediatric subspecialists routinely provide procedural sedation outside the operating room. No large study has reported trends in outpatient pediatric procedural sedation. Our purpose in this study was to identify significant trends in outpatient procedural sedation using the Pediatric Sedation Research Consortium.<h4>Methods</h4>Prospectively collected data from 2007 to 2018 were used for ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(5):]

Cited: 1 time

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Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States.

Sapna R Kudchadkar, Archana Nelliot, Ronke Awojoodu, Dhananjay Vaidya, Chani Traube, Tracie Walker, Dale M Needham, ,

<h4>Objectives</h4>With decreasing mortality in PICUs, a growing number of survivors experience long-lasting physical impairments. Early physical rehabilitation and mobilization during critical illness are safe and feasible, but little is known about the prevalence in PICUs. We aimed to evaluate the prevalence of rehabilitation for critically ill children and associated barriers.<h4>Design</h4>National ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(5):634-644]

Cited: 4 times

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Sedatives used in children to obtain head CT in the emergency department.

Rebecca Kriss Burger, Janet Figueroa, Courtney McCracken, Michael D Mallory, Pradip P Kamat,

OBJECTIVES:Children in the emergency department who require computerized tomography (CT) of the head often are given sedative medications to facilitate completion of the study with adequate imaging. A prior study found the two most common medications used to obtain head CT in children were pentobarbital and chloral hydrate; however, these ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2020, :]

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The Use of Intranasal Dexmedetomidine and Midazolam for Sedated Magnetic Resonance Imaging in Children: A Report From the Pediatric Sedation Research Consortium.

Carmen Sulton, Pradip Kamat, Michael Mallory, Jason Reynolds,

<h4>Objective</h4>The objective of this study was to describe the use of intranasal dexmedetomidine (IN DEX) for sedated magnetic resonance imaging (MRI) examinations in children. The use of IN DEX for MRI in children has not been well described in the literature.<h4>Materials and methods</h4>The Pediatric Sedation Research Consortium (PSRC) is a ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, 36(3):138-142]

Cited: 6 times

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Critical care resource use, cost, and mortality associated with firearm-related injuries in US children's hospitals.

Pradip P Kamat, Mathew T Santore, Katherine E M Hoops, Martha Wetzel, Courtney McCracken, Dennis Sullivan, Matthew Hall, Jocelyn R Grunwell,

BACKGROUND/PURPOSE:To assess trends and resource use attributable to firearm-related injuries in US pediatric intensive care units (PICUs). METHODS:Retrospective data from Pediatric Health Information Systems (PHIS) database from 2004 to 2017. RESULTS:Of 5,984,938 admissions to 28 children's hospitals, 3707 were for firearm injuries. A total of 1088 of 3707 hospitalizations (29.9%) ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2020, 55(11):2475-2479]

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Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke.

Gangling Chen, Pradip Kumar Kamat, Abdullah Shafique Ahmad, Sylvain Doré,

Limb remote ischemic postconditioning (LRIP) has been reported as an effective method to reduce the induced experimental stroke damage after ischemic reperfusion (IR) injury. Studies suggest that anesthetics used during induction of ischemic stroke can reduce IR injury, which could affect the actual mechanisms of neuroprotection by LRIP. This study ... Read more >>

PLoS One (PloS one)
[2020, 15(1):e0227624]

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Effect of Experimental Ischemic Stroke and PGE2 EP1 Selective Antagonism in Alzheimer's Disease Mouse Models.

Fúlvio R Mendes, Jenna L Leclerc, Lei Liu, Pradip K Kamat, Arash Naziripour, Damian Hernandez, Chris Li, Abdullah S Ahmad, Sylvain Doré,

BACKGROUND:Neuroinflammation has been recognized as an important factor in the pathogenesis of Alzheimer's disease (AD). One of the most recognized pathways in mediating neuroinflammation is the prostaglandin E2-EP1 receptor pathway. OBJECTIVE:Here, we examined the efficacy of the selective EP1 antagonist ONO-8713 in limiting amyloid-β (Aβ), lesion volumes, and behavioral indexes ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, 74(1):173-187]

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Analysis of 207,543 children with acute opioid poisonings from the United States National Poison Data System.

Megan E Land, Martha Wetzel, Robert J Geller, Pradip P Kamat, Jocelyn R Grunwell,

<b>Introduction:</b> Previous studies using administrative data have demonstrated that the United States opioid epidemic is harming both adults and children, and is straining health care systems. Our objective is to describe the outcomes and trends in resource use among children with acute opioid ingestions using patient-level case report data.<b>Materials and ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2019, :1-8]

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Radiologic Imaging in Trauma Patients with Cervical Spine Immobilization at a Pediatric Trauma Center.

Brandi C Barnes, Pradip P Kamat, Courtney M McCracken, Matthew T Santore, Michael D Mallory, Harold K Simon, Carmen Denease Sulton,

<h4>Background</h4>Pediatric trauma patients with cervical spine (CS) immobilization using a cervical collar often require procedural sedation (PS) for radiologic imaging. The limited ability to perform airway maneuvers while CS immobilized with a cervical collar is a concern for emergency department (ED) staff providing PS.<h4>Objective</h4>To describe the use of PS and ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2019, 57(4):429-436]

Cited: 0 times

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Carbon monoxide attenuates vasospasm and improves neurobehavioral function after subarachnoid hemorrhage.

Pradip K Kamat, Abdullah S Ahmad, Sylvain Doré,

Subarachnoid hemorrhage (SAH) is a devastating form of hemorrhagic stroke and is a serious medical condition caused by bleeding usually due to a ruptured aneurysm. Oxidative stress and inflammation from hemoglobin and heme released from lysed red blood cells are some postulated causes of vasospasm during SAH, which could lead ... Read more >>

Arch Biochem Biophys (Archives of biochemistry and biophysics)
[2019, 676:108117]

Cited: 4 times

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A high methionine, low folate and vitamin B6/B12 containing diet can be associated with memory loss by epigenetic silencing of netrin-1.

Anuradha Kalani, Pankaj Chaturvedi, Komal Kalani, Pradip K Kamat, Poonam Chaturvedi,

Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current study. We hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing ... Read more >>

Neural Regen Res (Neural regeneration research)
[2019, 14(7):1247-1254]

Cited: 4 times

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Chest Wall Swelling in a Child With Pneumonia.

John McAteer, Laura A Wang, Alice Chan, Vanessa Natalie Raabe, Pradip Kamat, Ashley Freeman, Inci Yildirim,

Clin Pediatr (Phila) (Clinical pediatrics)
[2019, 58(13):1462-1465]

Cited: 0 times

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Unscheduled Procedural Sedation: A Multidisciplinary Consensus Practice Guideline.

Steven M Green, Mark G Roback, Baruch S Krauss, James R Miner, Sandra Schneider, Paul D Kivela, Lewis S Nelson, Corrie E Chumpitazi, John D Fisher, Dan Gesek, Benjamin Jackson, Pradip Kamat, Terry Kowalenko, Brandon Lewis, Michele Papo, Don Phillips, Sonny Ruff, Daniel Runde, Thomas Tobin, Nathan Vafaie, John Vargo, Eric Walser, Donald M Yealy, Robert E O'Connor,

The American College of Emergency Physicians (ACEP) organized a multidisciplinary effort to create a clinical practice guideline specific to unscheduled, time-sensitive procedural sedation, which differs in important ways from scheduled, elective procedural sedation. The purpose of this guideline is to serve as a resource for practitioners who perform unscheduled procedural ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2019, 73(5):e51-e65]

Cited: 1 time

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Prospective evaluation of a clinical decision tool to reduce childhood admissions to PICUs for poisoning: ReCAP2.

Jocelyn R Grunwell, Courtney E McCracken, Curtis D Travers, Robert J Geller, Pradip P Kamat,

<b>Aim:</b> To prospectively validate a pediatric clinical prediction model to identify children at low risk of clinically significant ingestions to prevent unnecessary pediatric intensive care unit (PICU) admissions.<b>Methods:</b> Calls received by the Georgia Poison Center about children for acute ingestions between May 25, 2017 and May 17, 2018 were scored ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2019, 57(12):1137-1141]

Cited: 0 times

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Procedural Sedation Outside the Operating Room and Potential Neurotoxicity: Analysis of an At-Risk Pediatric Population.

Pradip P Kamat, Carmen Sulton, Sapna R Kudchadkar, Courtney E McCracken, Khristopher M Nguyen, Stephen F Simoneaux, Michael D Mallory, Harold K Simon,

<h4>Objectives</h4>To determine the characteristics of children who met the risk criteria for potential neurotoxicity defined by the US Food and Drug Administration (FDA; 2016 warning) in a procedural sedation (PS) service.<h4>Study design</h4>A single-center retrospective review of all infants and children aged <3 years receiving PS outside the operating room from ... Read more >>

Acad Pediatr (Academic pediatrics)
[2019, 19(8):978-984]

Cited: 0 times

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Evaluating the Need for Pediatric Procedural Sedation Training in Pediatric Critical Care Medicine Fellowship.

Michael C Hooper, Pradip P Kamat, Kevin G Couloures,

<h4>Objectives</h4>Pediatric procedural sedation has been increasingly performed by pediatric intensivists over the past decade. Pediatric Critical Care Medicine fellowship guidelines do not specify how fellows obtain proficiency in pediatric procedural sedation. We sought to survey the state of pediatric procedural sedation training during fellowship and whether fellows thought it was ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(3):259-261]

Cited: 0 times

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Sedative and Anesthetic Neurotoxicity in Infants and Young Children: Not Just an Operating Room Concern.

Pradip P Kamat, Sapna R Kudchadkar, Harold K Simon,

J Pediatr (The Journal of pediatrics)
[2019, 204:285-290]

Cited: 2 times

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Factors affecting same-day cancelation of outpatient pediatric oncologic procedural sedation.

Jocelyn R Grunwell, Lillian D Long, Leah N Bryan, Tammy Kelley, Himalee S Sabnis, Harold K Simon, Pradip P Kamat,

BACKGROUND:Children with cancer undergo serial invasive, painful procedures as a part of their diagnosis, treatment, and surveillance regimens that require procedural sedation (PS). Some may have a delay in their treatment plan due to same-day cancelation (SDC) of the procedure due to issues related to sedation or other factors. The ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2018, 35(5-6):309-315]

Cited: 0 times

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IV Clonidine in the PICU: Time for Dexmedetomidine to Share the Limelight?

Pradip P Kamat, Sapna R Kudchadkar,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):792-794]

Cited: 0 times

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Shifting the Paradigm: The Quiet Revolution of Pediatric Procedural Sedation Practice.

Patricia D Scherrer, Amber P Rogers, Pradip P Kamat,

Hosp Pediatr (Hospital pediatrics)
[2018, 8(6):372-374]

Cited: 0 times

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Procedural sedation in children with autism spectrum disorders: A survey of current practice patterns of the society for pediatric sedation members.

Pradip P Kamat, Leah N Bryan, Courtney E McCracken, Harold K Simon, John W Berkenbosch, Jocelyn R Grunwell,

<h4>Background</h4>Children with autism spectrum disorder are challenging to sedate because of communication, sensory, and behavioral challenges.<h4>Aims</h4>The aim of this survey was to determine how procedural sedation is provided to children with autism spectrum disorders and whether sedation programs have specialized protocols for procedural sedation of these children.<h4>Methods</h4>We surveyed physician Medical ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(6):552-557]

Cited: 0 times

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Outpatient Procedural Sedation of Patients With Autism Spectrum Disorders for Magnetic Resonance Imaging of the Brain Using Propofol.

Pradip P Kamat, Marie K Karaga, Benjamin L Wisniewski, Courtney E McCracken, Harold K Simon, Reet Sidhu, Jocelyn R Grunwell,

OBJECTIVE:To quantify the number of personnel, time to induce and complete sedation using propofol for outpatient magnetic resonance imaging (MRI) of the brain, and the frequency of serious adverse events (SAEs) in children with autism spectrum disorder (ASD) compared with children without ASD. RESULTS:Baseline characteristics were the same between both ... Read more >>

J Child Neurol (Journal of child neurology)
[2018, 33(5):313-319]

Cited: 0 times

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Reducing Childhood Admissions to the PICU for Poisoning (ReCAP2) by Predicting Unnecessary PICU Admissions After Acute Intoxication.

Meral M Patel, Curtis D Travers, Jana A Stockwell, Ezaldeen A Numur, Robert J Geller, Pradip P Kamat, Jocelyn R Grunwell,

OBJECTIVE:To derive and validate clinical prediction models to identify children at low risk of clinically significant intoxications for whom intensive care admission is unnecessary. DESIGN:Retrospective review of data in the National Poison Data Systems from 2011 to 2014 and Georgia Poison Center cases from July to December 2016. SETTING:United States ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(2):e120-e129]

Cited: 0 times

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