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Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age: Insights From DAPA-HF.

Felipe A Martinez, Matteo Serenelli, Jose C Nicolau, Mark C Petrie, Chern-En Chiang, Sergey Tereshchenko, Scott D Solomon, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Piotr Ponikowski, Marc S Sabatine, David L Demets, Monika Dutkiewicz-Piasecka, Olof Bengtsson, Mikaela Sjöstrand, Anna Maria Langkilde, Pardeep S Jhund, John J V McMurray,

Circulation (Circulation)
[2019, :]

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Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial.

Mikhail N Kosiborod, Pardeep Jhund, Kieran F Docherty, Mirta Diez, Mark C Petrie, Subodh Verma, Jose C Nicolau, Béla Merkely, Masafumi Kitakaze, David L DeMets, Silvio E Inzucchi, Lars Køeber, Felipe A Martinez, Piotr Ponikowski, Marc S Sabatine, Scott D Solomon, Olof Bengtsson, Daniel Lindholm, Anna Niklasson, Mikaela Sjöstrand, Anna Maria Langkilde, John J V McMurray,

Background: Goals of management in patients with heart failure and reduced ejection fraction (HFrEF) include reducing death and hospitalizations, and improving health status (symptoms, physical function and quality of life). In the Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial, sodium-glucose cotransporter-2 inhibitor, dapagliflozin, reduced death and hospitalizations, ... Read more >>

Circulation (Circulation)
[2019, :]

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Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment.

Jan F Nauta, Yoran M Hummel, Jasper Tromp, Wouter Ouwerkerk, Peter van der Meer, Xuanyi Jin, Carolyn S P Lam, Jeroen J Bax, Marco Metra, Nilesh J Samani, Piotr Ponikowski, Kenneth Dickstein, Stefan D Anker, Chim C Lang, Leong L Ng, Faiez Zannad, Gerasimos S Filippatos, Dirk J van Veldhuisen, Joost P van Melle, Adriaan A Voors,

AIMS:Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis.

Marat Fudim, Andrew R Spector, Maria-Rosa Costanzo, Sean D Pokorney, Robert J Mentz, Dariusz Jagielski, Ralph Augostini, William T Abraham, Piotr P Ponikowski, Scott W McKane, Jonathan P Piccini,

STUDY OBJECTIVES:Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective experience with PNS in order to better characterize its efficacy and safety, including in ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2019, :]

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Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets.

Thong H Cao, Donald J L Jones, Adriaan A Voors, Paulene A Quinn, Jatinderpal K Sandhu, Daniel C S Chan, Helen M Parry, Mohapradeep Mohan, Ify R Mordi, Iziah E Sama, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L Hillege, Marco Metra, Piotr Ponikowski, Nilesh J Samani, Dirk J Van Veldhuisen, Faiez Zannad, Chim C Lang, Leong L Ng,

AIMS:To provide insights into pathogenesis of disease progression and potential novel treatment targets for patients with heart failure by investigation of the plasma proteome using network analysis. METHODS AND RESULTS:The plasma proteome of 50 patients with heart failure who died or were rehospitalised were compared with 50 patients with heart ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Comprehensive Heart Failure Care pilot study: starting point and expected developments.

Jadwiga Nessler, Adam Kozierkiewicz, Andrzej Gackowski, Piotr Ponikowski, Tomasz Hryniewiecki, Marcin Gruchała, Mariusz Gąsior, Tomasz Grodzicki, Jarosław Kaźmierczak, Jacek Legutko, Przemysław Leszek, Maciej Miłkowski, Piotr Rozentryt, Radosław Sierpiński, Ewa Straburzyńska-Migaj, Andrzej Śliwczyński, Izabella Uchmanowicz, Adam Windak, Adam Witkowski, Andrzej Zapaśnik, Łukasz Szumowski,

Kardiol Pol (Kardiologia polska)
[2019, 77(10):994-999]

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Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST-AHF trial.

Rayan Jo Rachwan, Javed Butler, Sean P Collins, Gad Cotter, Beth A Davison, Stefanie Senger, Justin A Ezekowitz, Gerasimos Filippatos, Phillip D Levy, Marco Metra, Piotr Ponikowski, John R Teerlink, Adriaan A Voors, Rudolf A de Boer, David G Soergel, G Michael Felker, Peter S Pang,

AIMS:Neurohormonal activation characterizes chronic heart failure (HF) and is a well-established therapeutic target. Neurohormonal activation may also play a key role in acute HF (AHF). We aim to describe the association between plasma renin activity (PRA) and three AHF outcomes: (i) worsening HF or death through day 5 of hospitalization; ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Heart Failure Association/European Society of Cardiology position paper on frailty in patients with heart failure.

Cristiana Vitale, Ewa Jankowska, Loreena Hill, Massimo Piepoli, Wolfram Doehner, Stefan D Anker, Mitja Lainscak, Tiny Jaarsma, Piotr Ponikowski, Giuseppe M C Rosano, Petar Seferovic, Andrew J Coats,

Heart failure (HF) and frailty are two distinct yet commonly associated conditions. The interplay between the two conditions is complex, due to overlaps in underlying mechanisms, symptoms and prognosis. The assessment of frailty in patients with HF is crucial, as it is associated with both unfavourable outcomes and reduced access ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Burkert Pieske, Carsten Tschöpe, Rudolf A de Boer, Alan G Fraser, Stefan D Anker, Erwan Donal, Frank Edelmann, Michael Fu, Marco Guazzi, Carolyn S P Lam, Patrizio Lancellotti, Vojtech Melenovsky, Daniel A Morris, Eike Nagel, Elisabeth Pieske-Kraigher, Piotr Ponikowski, Scott D Solomon, Ramachandran S Vasan, Frans H Rutten, Adriaan A Voors, Frank Ruschitzka, Walter J Paulus, Petar Seferovic, Gerasimos Filippatos,

Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF) remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA-PEFF diagnostic algorithm'. Step 1 (P=Pre-test assessment) is typically performed in the ambulatory setting and includes assessment for HF symptoms and signs, typical clinical demographics (obesity, ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(40):3297-3317]

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Hyperkalemia and Treatment With RAAS Inhibitors During Acute Heart Failure Hospitalizations and Their Association With Mortality.

Joost C Beusekamp, Jasper Tromp, John G F Cleland, Michael M Givertz, Marco Metra, Christopher M O'Connor, John R Teerlink, Piotr Ponikowski, Wouter Ouwerkerk, Dirk J van Veldhuisen, Adriaan A Voors, Peter van der Meer,

OBJECTIVES:This study investigated associations between incident hyperkalemia during acute heart failure (HF) hospitalizations and changes in renin-angiotensin-aldosterone system (RAAS) inhibitors. BACKGROUND:Hyperkalemia is a potential complication of RAAS inhibitors. For patients with HF, fear of hyperkalemia may lead to failure to deliver guideline-recommended doses of RAAS inhibitors. METHODS:Serum potassium concentrations were ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2019, 7(11):970-979]

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Hepatorenal dysfunction identifies high-risk patients with acute heart failure: insights from the RELAX-AHF trial.

Jan Biegus, Biniyam Demissei, Douwe Postmus, Gad Cotter, Beth A Davison, G Michael Felker, Gerasimos Filippatos, Claudio Gimpelewicz, Barry Greenberg, Marco Metra, Thomas Severin, John R Teerlink, Adriaan A Voors, Piotr Ponikowski,

AIMS:Episodes of acute heart failure (AHF) may lead to end-organ dysfunction. In this post hoc analysis of the Relaxin in Acute Heart Failure trial, we used the MELD-XI (Model of End-Stage Liver Dysfunction) score to examine hepatorenal dysfunction in patients with AHF. METHODS AND RESULTS:On admission, the MELD-XI score was ... Read more >>

ESC Heart Fail (ESC heart failure)
[2019, :]

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Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.

John J V McMurray, Scott D Solomon, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Felipe A Martinez, Piotr Ponikowski, Marc S Sabatine, Inder S Anand, Jan Bělohlávek, Michael Böhm, Chern-En Chiang, Vijay K Chopra, Rudolf A de Boer, Akshay S Desai, Mirta Diez, Jaroslaw Drozdz, Andrej Dukát, Junbo Ge, Jonathan G Howlett, Tzvetana Katova, Masafumi Kitakaze, Charlotta E A Ljungman, Béla Merkely, Jose C Nicolau, Eileen O'Meara, Mark C Petrie, Pham N Vinh, Morten Schou, Sergey Tereshchenko, Subodh Verma, Claes Held, David L DeMets, Kieran F Docherty, Pardeep S Jhund, Olof Bengtsson, Mikaela Sjöstrand, Anna-Maria Langkilde, ,

BACKGROUND:In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, :]

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Long-term efficacy and safety of phrenic nerve stimulation for the treatment of central sleep apnea.

Henrik Fox, Olaf Oldenburg, Shahrokh Javaheri, Piotr Ponikowski, Ralph Augostini, Lee R Goldberg, Christoph Stellbrink, Scott Mckane, Timothy E Meyer, William T Abraham, Maria Rosa Costanzo,

STUDY OBJECTIVE:To evaluate long-term efficacy and safety of phrenic nerve stimulation (PNS) in patients with moderate-to-severe central sleep apnea (CSA) through 3 years of therapy. METHODS:Patients in the remedē System Pivotal Trial were observed every 3 months after implant until US Food and Drug Administration approval. At the time of ... Read more >>

Sleep (Sleep)
[2019, 42(11):]

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Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved Trial.

Stefan D Anker, Javed Butler, Gerasimos S Filippatos, Waheed Jamal, Afshin Salsali, Janet Schnee, Karen Kimura, Cordula Zeller, Jyothis George, Martina Brueckmann, Faiez Zannad, Milton Packer, ,

BACKGROUND:The principal biological processes that characterize heart failure with a preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue accumulation, coronary microcirculatory rarefaction, myocardial fibrosis and vascular stiffness; the resulting impairment of left ventricular and aortic distensibility (especially when accompanied by impaired glomerular function and sodium retention) causes increases ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(10):1279-1287]

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Controlled decongestion by Reprieve therapy in acute heart failure: results of the TARGET-1 and TARGET-2 studies.

Jan Biegus, Robert Zymlinski, Pawel Siwolowski, Jeffrey Testani, Joanna Szachniewicz, Agnieszka Tycińska, Waldemar Banasiak, Andrew Halpert, Howard Levin, Piotr Ponikowski,

AIMS:Safe and effective decongestion is the main goal of therapy in acute heart failure (AHF). In the non-randomized, prospective TARGET-1 and TARGET-2 studies (NCT03897842), we investigated whether adding the Reprieve System® (which continuously monitors urine output and delivers a matched volume of hydration fluid sufficient to maintain the set fluid ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(9):1079-1087]

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Safety, Tolerability and efficacy of Rapid Optimization, helped by NT-proBNP and GDF-15, of Heart Failure therapies (STRONG-HF): rationale and design for a multicentre, randomized, parallel-group study.

Antoine Kimmoun, Gad Cotter, Beth Davison, Koji Takagi, Faouzi Addad, Jelena Celutkiene, Ovidiu Chioncel, Alain Cohen Solal, Rafael Diaz, Albertino Damasceno, Hans-Dirk Duengen, Gerasimos Filippatos, Eva Goncalvesova, Imad Merai, Marco Metra, Piotr Ponikowski, Dmitry Privalov, Karen Sliwa, Mahmoud Umar Sani, Adriaan A Voors, Zaur Shogenov, Alexandre Mebazaa,

AIMS:Patients admitted for acute heart failure (HF) are at high risk of readmission and death, especially in the 90 days following discharge. We aimed to assess the safety and efficacy of early optimization of oral HF therapy with beta-blockers (BB), angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) or angiotensin ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of the Heart Failure Association of the European Society of Cardiology.

Petar M Seferovic, Piotr Ponikowski, Stefan D Anker, Johann Bauersachs, Ovidiu Chioncel, John G F Cleland, Rudolf A de Boer, Heinz Drexel, Tuvia Ben Gal, Loreena Hill, Tiny Jaarsma, Ewa A Jankowska, Markus S Anker, Mitja Lainscak, Basil S Lewis, Theresa McDonagh, Marco Metra, Davor Milicic, Wilfried Mullens, Massimo F Piepoli, Giuseppe Rosano, Frank Ruschitzka, Maurizio Volterrani, Adriaan A Voors, Gerasimos Filippatos, Andrew J S Coats,

The European Society of Cardiology (ESC) has published a series of guidelines on heart failure (HF) over the last 25 years, most recently in 2016. Given the amount of new information that has become available since then, the Heart Failure Association (HFA) of the ESC recognized the need to review and ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(10):1169-1186]

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Effects of Serelaxin in Patients with Acute Heart Failure.

Marco Metra, John R Teerlink, Gad Cotter, Beth A Davison, G Michael Felker, Gerasimos Filippatos, Barry H Greenberg, Peter S Pang, Piotr Ponikowski, Adriaan A Voors, Kirkwood F Adams, Stefan D Anker, Alexandra Arias-Mendoza, Patricio Avendaño, Fernando Bacal, Michael Böhm, Guillermo Bortman, John G F Cleland, Alain Cohen-Solal, Maria G Crespo-Leiro, Maria Dorobantu, Luis E Echeverría, Roberto Ferrari, Sorel Goland, Eva Goncalvesová, Assen Goudev, Lars Køber, Juan Lema-Osores, Phillip D Levy, Kenneth McDonald, Pravin Manga, Béla Merkely, Christian Mueller, Burkert Pieske, Jose Silva-Cardoso, Jindřich Špinar, Iain Squire, Janina Stępińska, Walter Van Mieghem, Dirk von Lewinski, Gerhard Wikström, Mehmet B Yilmaz, Nicole Hagner, Thomas Holbro, Tsushung A Hua, Shalini V Sabarwal, Thomas Severin, Peter Szecsödy, Claudio Gimpelewicz, ,

BACKGROUND:Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure. METHODS:In this multicenter, double-blind, placebo-controlled, event-driven ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(8):716-726]

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The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.

John J V McMurray, David L DeMets, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Anna Maria Langkilde, Felipe A Martinez, Olof Bengtsson, Piotr Ponikowski, Marc S Sabatine, Mikaela Sjöstrand, Scott D Solomon, ,

BACKGROUND:The aims of this study were to: (i) report the baseline characteristics of patients enrolled in the Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial, (ii) compare DAPA-HF patients to participants in contemporary heart failure (HF) registries and in other recent HF trials, and (iii) compare individuals with ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Evaluation of the effect of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR-Reduced trial.

Milton Packer, Javed Butler, Gerasimos S Filippatos, Waheed Jamal, Afshin Salsali, Janet Schnee, Karen Kimura, Cordula Zeller, Jyothis George, Martina Brueckmann, Stefan D Anker, Faiez Zannad, ,

Drugs that inhibit the sodium-glucose co-transporter 2 (SGLT2) have been shown to reduce the risk of hospitalizations for heart failure in patients with type 2 diabetes. In populations that largely did not have heart failure at the time of enrolment, empagliflozin, canagliflozin and dapagliflozin decreased the risk of serious new-onset ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(10):1270-1278]

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Trajectories of Changes in Renal Function in Patients with Acute Heart Failure.

Iris E Beldhuis, Koen W Streng, Peter van der Meer, Jozine M Ter Maaten, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, Gad Cotter, John G F Cleland, Beth A Davison, Michael M Givertz, John R Teerlink, Daniel M Bloomfield, Adriaan A Voors, Kevin Damman,

BACKGROUND:Changes in renal function have been associated with differential outcomes in patients with acute heart failure (HF). However, individual trajectories of changes in renal function are unknown, and it is unclear whether they relate to different clinical characteristics and clinical outcomes. Our aim was to investigate the prognostic importance of ... Read more >>

J. Card. Fail. (Journal of cardiac failure)
[2019, :]

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Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy.

Johann Bauersachs, Tobias König, Peter van der Meer, Mark C Petrie, Denise Hilfiker-Kleiner, Amam Mbakwem, Righab Hamdan, Alice M Jackson, Paul Forsyth, Rudolf A de Boer, Christian Mueller, Alexander R Lyon, Lars H Lund, Massimo F Piepoli, Stephane Heymans, Ovidiu Chioncel, Stefan D Anker, Piotr Ponikowski, Petar M Seferovic, Mark R Johnson, Alexandre Mebazaa, Karen Sliwa,

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening condition typically presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of pregnancy or in the months following delivery in women without another known cause of heart failure. This updated position statement summarizes the knowledge about pathophysiological mechanisms, risk ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(7):827-843]

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Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure.

William T Abraham, Piotr Ponikowski, Martina Brueckmann, Cordula Zeller, Hemani Macesic, Barbara Peil, Michèle Brun, Anastasia Ustyugova, Waheed Jamal, Afshin Salsali, JoAnn Lindenfeld, Stefan D Anker, ,

AIMS:Heart failure (HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium-glucose co-transporter 2 inhibitor empagliflozin reduced the risk of HF hospitalisation and cardiovascular death in patients with type 2 diabetes and established cardiovascular disease in the EMPA-REG OUTCOME trial, and could ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(7):932-942]

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Acute heart failure congestion and perfusion status - impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP-HFA Heart Failure Long-Term Registry.

Ovidiu Chioncel, Alexandre Mebazaa, Aldo P Maggioni, Veli-Pekka Harjola, Giuseppe Rosano, Cecile Laroche, Massimo F Piepoli, Maria G Crespo-Leiro, Mitja Lainscak, Piotr Ponikowski, Gerasimos Filippatos, Frank Ruschitzka, Petar Seferovic, Andrew J S Coats, Lars H Lund, ,

AIMS:Classification of acute heart failure (AHF) patients into four clinical profiles defined by evidence of congestion and perfusion is advocated by the 2016 European Society of Cardiology (ESC)guidelines. Based on the ESC-EORP-HFA Heart Failure Long-Term Registry, we compared differences in baseline characteristics, in-hospital management and outcomes among congestion/perfusion profiles using ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Effect of ferric carboxymaltose on calculated plasma volume status and clinical congestion: a FAIR-HF substudy.

Darlington O Okonko, Fadi Jouhra, Huda Abu-Own, Gerasimos Filippatos, Josep Comin Colet, Chainey Suki, Claudio Mori, Piotr Ponikowski, Stefan D Anker, ,

AIMS:Iron deficiency worsens symptoms, quality of life, and exercise capacity in chronic heart failure (CHF) and might do so by promoting fluid retention. We assessed whether iron repletion improved congestion in CHF and appraised the prognostic utility of calculated plasma volume status (PVS), a novel index of congestion, in the ... Read more >>

ESC Heart Fail (ESC heart failure)
[2019, 6(4):621-628]

Cited: 1 time

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