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The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.

John J V McMurray, David L DeMets, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Anna Maria Langkilde, Felipe A Martinez, Olof Bengtsson, Piotr Ponikowski, Marc S Sabatine, Mikaela Sjöstrand, Scott D Solomon, ,

BACKGROUND:The aims of this study were to: (i) report the baseline characteristics of patients enrolled in the Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial, (ii) compare DAPA-HF patients to participants in contemporary heart failure (HF) registries and in other recent HF trials, and (iii) compare individuals with ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Trajectories of Changes in Renal Function in Patients with Acute Heart Failure.

Iris E Beldhuis, Koen W Streng, Peter van der Meer, Jozine M Ter Maaten, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, Gad Cotter, John G F Cleland, Beth A Davison, Michael M Givertz, John R Teerlink, Daniel M Bloomfield, Adriaan A Voors, Kevin Damman,

AIMS:Changes in renal function have been associated with differential outcome in patients with acute heart failure (HF). However, individual trajectories of changes in renal function are unknown and it is unclear whether these relate to different clinical characteristics and clinical outcome. Our aim was to investigate the prognostic importance of ... Read more >>

J. Card. Fail. (Journal of cardiac failure)
[2019, :]

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Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure.

William T Abraham, Piotr Ponikowski, Martina Brueckmann, Cordula Zeller, Hemani Macesic, Barbara Peil, Michèle Brun, Anastasia Ustyugova, Waheed Jamal, Afshin Salsali, JoAnn Lindenfeld, Stefan D Anker, ,

Heart failure (HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium-glucose co-transporter 2 inhibitor empagliflozin reduced the risk of HF hospitalisation and cardiovascular death in patients with type 2 diabetes and established cardiovascular disease in the EMPA-REG OUTCOME trial, and could ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy.

Johann Bauersachs, Tobias König, Peter van der Meer, Mark C Petrie, Denise Hilfiker-Kleiner, Amam Mbakwem, Righab Hamdan, Alice M Jackson, Paul Forsyth, Rudolf A de Boer, Christian Mueller, Alexander R Lyon, Lars H Lund, Massimo F Piepoli, Stephane Heymans, Ovidiu Chioncel, Stefan D Anker, Piotr Ponikowski, Petar M Seferovic, Mark R Johnson, Alexandre Mebazaa, Karen Sliwa,

Peripartum cardiomyopathy (PPCM) is a potentially life-threatening condition typically presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of pregnancy or in the months following delivery in women without another known cause of heart failure. This updated position statement summarizes the knowledge about pathophysiological mechanisms, risk ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Acute heart failure congestion and perfusion status - impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP-HFA Heart Failure Long-Term Registry.

Ovidiu Chioncel, Alexandre Mebazaa, Aldo P Maggioni, Veli-Pekka Harjola, Giuseppe Rosano, Cecile Laroche, Massimo F Piepoli, Maria G Crespo-Leiro, Mitja Lainscak, Piotr Ponikowski, Gerasimos Filippatos, Frank Ruschitzka, Petar Seferovic, Andrew J S Coats, Lars H Lund, ,

AIMS:Classification of acute heart failure (AHF) patients into four clinical profiles defined by evidence of congestion and perfusion is advocated by the 2016 European Society of Cardiology (ESC)guidelines. Based on the ESC-EORP-HFA Heart Failure Long-Term Registry, we compared differences in baseline characteristics, in-hospital management and outcomes among congestion/perfusion profiles using ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Controlled decongestion by Reprieve Therapy™ in acute heart failure: the results of the TARGET-1 and TARGET-2 Studies.

Jan Biegus, Robert Zymlinski, Pawel Siwolowski, Jeffrey Testani, Joanna Szachniewicz, Agnieszka Tycińska, Waldemar Banasiak, Andrew Halpert, Howard Levin, Piotr Ponikowski,

Congestion due to volume overload or volume redistribution characterizes majority of patients with acute heart failure (AHF). The former is mainly driven by sodium and water retention, therefore loop diuretics remain cornerstone of therapy with fast, effective, sustained and safe decongestion as main goals of decongestion in AHF1-3 . ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study.

George Markousis-Mavrogenis, Jasper Tromp, Wouter Ouwerkerk, Matt Devalaraja, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos S Filippatos, Pim van der Harst, Chim C Lang, Marco Metra, Leong L Ng, Piotr Ponikowski, Nilesh J Samani, Faiez Zannad, Aeilko H Zwinderman, Hans L Hillege, Dirk J van Veldhuisen, Rahul Kakkar, Adriaan A Voors, Peter van der Meer,

AIMS:Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful. Interleukin (IL)-6 is an important inflammatory mediator and might constitute a potential pharmacologic target in HF. However, little is known regarding the association between IL-6 and clinical characteristics, ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Effect of ferric carboxymaltose on calculated plasma volume status and clinical congestion: a FAIR-HF substudy.

Darlington O Okonko, Fadi Jouhra, Huda Abu-Own, Gerasimos Filippatos, Josep Comin Colet, Chainey Suki, Claudio Mori, Piotr Ponikowski, Stefan D Anker, ,

AIMS:Iron deficiency worsens symptoms, quality of life, and exercise capacity in chronic heart failure (CHF) and might do so by promoting fluid retention. We assessed whether iron repletion improved congestion in CHF and appraised the prognostic utility of calculated plasma volume status (PVS), a novel index of congestion, in the ... Read more >>

ESC Heart Fail (ESC heart failure)
[2019, :]

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Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of The Heart Failure Association of the European Society of Cardiology.

Petar M Seferovic, Piotr Ponikowski, Stefan D Anker, Johann Bauersachs, Ovidiu Chioncel, John G F Cleland, Rudolf A de Boer, Heinz Drexel, Tuvia Ben Gal, Loreena Hill, Tiny Jaarsma, Ewa A Jankowska, Markus S Anker, Mitja Lainscak, Basil S Lewis, Theresa McDonagh, Marco Metra, Davor Milicic, Wilfried Mullens, Massimo F Piepoli, Giuseppe Rosano, Frank Ruschitzka, Maurizio Volterrani, Adriaan A Voors, Gerasimos Filippatos, Andrew J S Coats,

The ESC has published a series of guidelines on heart failure (HF) over the last 25 years, most recently in 2016. Given the amount of new information that has become available since then, the HFA of the ESC recognized the need to review and summarise recent developments in a consensus ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Trimetazidine in cardiovascular medicine.

Mario Marzilli, Dragos Vinereanu, Gary Lopaschuk, Yundai Chen, Jamshed J Dalal, Nicolas Danchin, El Etriby, Roberto Ferrari, Luis Henrique Gowdak, Yuri Lopatin, Davor Milicic, Alexander Parkhomenko, Fausto Pinto, Piotr Ponikowski, Petar Seferovic, Giuseppe M C Rosano,

Abnormalities of myocardial energy metabolism appear as a common background of the two major cardiac disorders: ischemic heart disease (IHD) and heart failure (HF). Myocardial ischemia has been recently conceived as a multifaceted syndrome that can be precipitated by a number of mechanisms including metabolic abnormalities. HF is a progressive ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, :]

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Rationale and Design of the VITALITY-HFpEF Trial.

Javed Butler, Carolyn S P Lam, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Christopher M O'Connor, Burkert Pieske, Piotr Ponikowski, Sanjiv J Shah, Scott D Solomon, Adriaan A Voors, Yi Wu, Francine Carvalho, Luke Bamber, Robert O Blaustein, Lothar Roessig, Paul W Armstrong,

Background The VITALITY-HFpEF trial (Evaluate the Efficacy and Safety of the Oral sGC Stimulator Vericiguat to Improve Physical Functioning in Daily Living Activities of Patients With Heart Failure and Preserved Ejection Fraction) is designed to determine the efficacy and safety of a novel oral soluble guanylate cyclase stimulator, vericiguat, on ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2019, 12(5):e005998]

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Prognostic importance of serum troponin concentration in patients with an implanted cardioverter‑defibrillator admitted to the emergency department due to electric shock.

Dariusz Jagielski, Dorota Zyśko, Klaudiusz Nadolny, Joanna Wizowska, Bartosz Biel, Waldemar Banasiak, Piotr Ponikowski,

BACKGROUND:High-energy implantable cardioverter-defibrillator (ICD) therapy may increase serum troponin (cTnI) concentration.   Aims: We aimed to assess an impact of cTnI concentration after ICD high-energy therapy on mortality. METHODS:A total of 150 patients aged 64.2 +/- 12.8 years admitted to the Emergency Departments (EDs) due to at least one electrical ... Read more >>

Kardiol Pol (Kardiologia polska)
[2019, 77(6):618-623]

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A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF).

John J V McMurray, David L DeMets, Silvio E Inzucchi, Lars Køber, Mikhail N Kosiborod, Anna M Langkilde, Felipe A Martinez, Olof Bengtsson, Piotr Ponikowski, Marc S Sabatine, Mikaela Sjöstrand, Scott D Solomon, ,

BACKGROUND:Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes who have, or are at high risk of, cardiovascular disease. Most patients in these trials did not have heart failure at baseline and the effect of SGLT2 ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, 21(5):665-675]

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Phrenic nerve stimulation in patients with central sleep apnea: a single‑center experience from pilot and pivotal trials evaluating the remedē System.

Dariusz Jagielski, Adam Kołodziej, Randy Westlund, Bartosz Biel, Krzysztof Nowak, Iwona Szemplińska, Irena Flinta, Magdalena Krawczyk, Katarzyna Kulej, Bartosz Krakowiak, Robin Germany, Antonis Panteleon, Scott McKane, Waldemar Banasiak, William T Abraham, Piotr Ponikowski,

BACKGROUND:Patients with central sleep apnea (CSA) have recently been shown to have improved sleep metrics and quality of life (QoL) with phrenic nerve stimulation (PNS). AIMS:The aim of this study was to report the results of a partnership between cardiology, sleep medicine, and electrophysiology in a single clinical center as ... Read more >>

Kardiol Pol (Kardiologia polska)
[2019, 77(5):553-560]

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Effectiveness of screening for atrial fibrillation and its determinants. A meta-analysis.

Pawel Petryszyn, Piotr Niewinski, Aleksandra Staniak, Patryk Piotrowski, Anna Well, Michal Well, Izabela Jeskowiak, Gregory Lip, Piotr Ponikowski,

BACKGROUND:Many atrial fibrillation patients eligible for oral anticoagulants are unaware of the presence of AF, and improved detection is necessary to facilitate thromboprophylaxis against stroke. OBJECTIVE:To assess the effectiveness of screening for AF compared to no screening and to compare efficacy outcomes of different screening strategies. MATERIALS AND METHODS:Cochrane Central ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0213198]

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Physicians' guideline adherence is associated with long-term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry.

Michel Komajda, Jakob Schöpe, Stefan Wagenpfeil, Luigi Tavazzi, Michael Böhm, Piotr Ponikowski, Stefan D Anker, Gerasimos S Filippatos, Martin R Cowie, ,

BACKGROUND:Physicians' adherence to guideline-recommended therapy is associated with short-term clinical outcomes in heart failure (HF) with reduced ejection fraction (HFrEF). However, its impact on longer-term outcomes is poorly documented. Here, we present results from the 18-month follow-up of the QUALIFY registry. METHODS AND RESULTS:Data at 18 months were available for 6118 ... Read more >>

Eur. J. Heart Fail. (European journal of heart failure)
[2019, :]

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Relationship between the CHA2DS2-VASc score and atrial fibrillation in patients hospitalised due to heart failure.

Agnieszka Kuczaj, Ewa Nowalany-Kozielska, Michał Skrzypek, Grzegorz Opolski, Aneta Ociessa, Ewa Jankowska, Piotr Ponikowski, Beata Wożakowska-Kapłon, Ewa Mirek-Brynarska, Jarosław Drożdż,

BACKGROUND:Heart failure (HF) has become an epidemic. A similar situation is also observed for atrial fibrillation (AF). The CHA2DS2-VASc score is one of the most useful tools for thromboembolic risk assessment. AIM:The aim of the study was to assess the prevalence of AF in patients with decompensated HF, who were ... Read more >>

Kardiol Pol (Kardiologia polska)
[2019, 77(3):380-385]

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Central and Peripheral Determinants of Exercise Capacity in Heart Failure Patients With Preserved Ejection Fraction.

Emil Wolsk, David Kaye, Jan Komtebedde, Sanjiv J Shah, Barry A Borlaug, Daniel Burkhoff, Dalane W Kitzman, Carolyn S P Lam, Dirk J van Veldhuisen, Piotr Ponikowski, Mark C Petrie, Christian Hassager, Jacob E Møller, Finn Gustafsson,

OBJECTIVES:This study sought to discern which central (e.g., heart rate, stroke volume [SV], filling pressure) and peripheral factors (e.g., oxygen use by skeletal muscle, body mass index [BMI]) during exercise were most strongly associated with the presence of heart failure and preserved ejection fraction (HFpEF) as compared with healthy control ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2019, 7(4):321-332]

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Structural and functional abnormalities in iron-depleted heart.

Kamil A Kobak, Malwina Radwańska, Magdalena Dzięgała, Monika Kasztura, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska,

Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact role of ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2019, 24(2):269-277]

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True worsening renal function identifies patients with acute heart failure with an ominous outcome.

Mateusz Sokolski, Robert Zymliński, Justyna M Sokolska, Jan Biegus, Waldemar Banasiak, Piotr Ponikowski,

(Polish archives of internal medicine)
[2019, 129(5):357-360]

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Association between mortality and implantable cardioverter-defibrillators by aetiology of heart failure: a propensity-matched analysis of the WARCEF trial.

Tetz C Lee, Min Qian, Lan Mu, Marco R Di Tullio, Susan Graham, Douglas L Mann, Koki Nakanishi, John R Teerlink, Gregory Y H Lip, Ronald S Freudenberger, Ralph L Sacco, Jay P Mohr, Arthur J Labovitz, Piotr Ponikowski, Dirk J Lok, Conrado Estol, Stefan D Anker, Patrick M Pullicino, Richard Buchsbaum, Bruce Levin, John L P Thompson, Shunichi Homma, Siqin Ye, ,

AIMS:There is debate on whether the beneficial effect of implantable cardioverter-defibrillators (ICDs) is attenuated in patients with non-ischaemic cardiomyopathy (NICM). We assess whether any ICD benefit differs between patients with NICM and those with ischaemic cardiomyopathy (ICM), using data from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) ... Read more >>

ESC Heart Fail (ESC heart failure)
[2019, 6(2):297-307]

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Recommendations on the use of innovative medical technologies in cardiology and cardiac surgery and solutions leading to increased availability for Polish patients.

Dariusz Dudek, Waldemar Banasiak, Wojciech Braksator, Jacek Dubiel, Tomasz Grodzicki, Piotr Hoffman, Mariusz Kuśmierczyk, Grzegorz Opolski, Piotr Ponikowski, Jacek Różański, Jerzy Sadowski, Wojciech Wojakowski, Marcin Grabowski, Katarzyna Bondaryk, Jacek Walczak, Izabela Pieniążek, Maciej Grys, Anna Lesiak-Bednarek, Piotr Przygodzki,

There is a great need for innovative technologies that will improve the health and quality of life (QoL) of Polish patients with cardiac problems. It is important that the safety and effectiveness of the technology are confirmed by scientific evidence on which guidelines and clinical recommendations are based. Scientific evidence ... Read more >>

Cardiol J (Cardiology journal)
[2019, 26(2):114-129]

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Elevated lactate in acute heart failure patients with intracellular iron deficiency as identifier of poor outcome.

Jan Biegus, Robert Zymliński, Mateusz Sokolski, Ewa A Jankowska, Waldemar Banasiak, Piotr Ponikowski,

BACKGROUND:We believe that there is a physiological link between intracellular iron status (assessed by soluble transferrin receptor [sTfR]) and efficiency of energy production/consumption (assessed by lactate, a product of anaerobic cell metabolism), which may further impact the outcome of patients with acute heart failure (AHF). AIM:To examine if elevated levels ... Read more >>

Kardiol Pol (Kardiologia polska)
[2019, 77(3):347-354]

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Persistent hyperlactataemia is related to high rates of in-hospital adverse events and poor outcome in acute heart failure.

Jan Biegus, Robert Zymliński, Piotr Gajewski, Mateusz Sokolski, Paweł Siwołowski, Justyna Sokolska, Katarzyna Swoboda, Maciej Banasiak, Waldemar Banasiak, Piotr Ponikowski,

BACKGROUND:Although lactate is a well-established marker in intensive care, our understanding of its utility in acute heart failure (AHF) is modest and based on studies with a single measurement of this marker. AIM:We aimed to investigate whether persistent elevation of lactate during hospitalisation is related to a higher risk of ... Read more >>

Kardiol Pol (Kardiologia polska)
[2019, 77(3):355-362]

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Hypoxic tachycardia is not a result of increased respiratory activity in healthy subjects.

Bartłomiej Paleczny, Rafał Seredyński, Stanisław Tubek, Dorota Adamiec, Piotr Ponikowski, Beata Ponikowska,

NEW FINDINGS:What is the central question of this research? Does increased ventilation contribute to the increase in heart rate during transient exposure to hypoxia in humans? What is the main finding and its importance? Voluntary suppression of the ventilatory response to transient hypoxia does not affect the magnitude of the ... Read more >>

Exp. Physiol. (Experimental physiology)
[2019, 104(4):476-489]

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