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Author Ping Wang

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Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy.

Menghong Xu, Ping Wang, Suhui Sun, Liquan Gao, Lihong Sun, Lulu Zhang, Jinxia Zhang, Shumin Wang, Xiaolong Liang,

Hypoxia, as a typical factor in a tumor microenvironment, plays a vital role in tumor treatment resistance, tumor invasion and migration. Hypoxia inducible factor (HIF), as the vital response element of hypoxia, mediates these untoward effects through a series of downstream reactions. Cancer treatments such as photodynamic therapy (PDT), radiotherapy ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(42):21519-21533]

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Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkinson's disease motor subtypes: a prospective pilot study with 3-month follow-up.

Ke-Ke Chen, Zhao-Hui Jin, Lei Gao, Lin Qi, Qiao-Xia Zhen, Cui Liu, Ping Wang, Yong-Hong Liu, Rui-Dan Wang, Yan-Jun Liu, Jin-Ping Fang, Yuan Su, Xiao-Yan Yan, Ai-Xian Liu, Bo-Yan Fang,

Parkinson's disease (PD) can be classified into three motor-based subtypes: postural instability/gait difficulty (PIGD), tremor dominant (TD), and indeterminate. The neuropathophysiological mechanisms of the three motor subtypes are different, which may lead to different responses to therapy. Sixty-nine patients with idiopathic Parkinson's disease (Hoehn-Yahr stage ≤ 3) were screened from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(7):1336-1343]

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Effects of plant oils with different fatty acid composition on cardiovascular risk factors in moderately hypercholesteremic Chinese adults: a randomized, double-blinded, parallel-designed trial.

Chao-Gang Chen, Ping Wang, Zhe-Qing Zhang, Yan-Bin Ye, Shu-Yu Zhuo, Quan Zhou, Yu-Ming Chen, Yi-Xiang Su, Bo Zhang,

<h4>Objectives</h4>Plant oil for cooking typically provides 40% to 50% of dietary fat, 65% of linoleic acid, 44% of α-linolenic acid and 41% of oleic acid in the Chinese diet. However, the comparative effects of fatty acids derived from plant oil on cardiovascular risk factors in Chinese are still inconclusive. Hence, ... Read more >>

Food Funct (Food & function)
[2020, 11(8):7164-7174]

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Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability.

Yuanyuan Guo, Jiao Zhang, Gaifang Pan, Chung Hang Jonathan Choi, Ping Wang, Yuehua Li, Xinyuan Zhu, Chuan Zhang,

A multitude of maleimides are grafted onto the backbone of a phosphorothioate antisense oligonucleotide (ASO) to generate the construct of maleimide-grafted ASO (Mal-g-ASO). Through click conjugation with cell membrane thiols that triggers endocytosis-independent cellular internalization, Mal-g-ASO exhibited enhanced cellular uptake efficiency, resulting in a remarkable improvement of ASO-based gene silencing. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(54):7439-7442]

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Electric-field-mediated magnetic properties of all-oxide CoFe2O4/La0.67Sr0.33MnO3/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructures.

Ping Wang, Chao Jin, Dong Li, Yuchen Wang, Shasha Liu, Xinyue Wang, Xin Pang, Dongxing Zheng, Wanchao Zheng, Rongkun Zheng, Haili Bai,

Electric-field-mediated magnetic properties were investigated in CoFe2O4/La0.67Sr0.33MnO3/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 (CFO/LSMO/PMN-PT) heterostructures. The butterfly-like behavior of the magnetization under different electric fields indicates that the strain effect plays a critical role in the electric-field-mediated magnetic properties, leading to an increase in magnetization along the [100] direction but a decrease along the [01-1] direction ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(22):12651-12657]

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Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity.

Qize Xuan, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang, Yibing Wang, Ping Wang,

We utilized solution-phase biopanning to obtain a de novo peptide (LA12) that specifically bound to the core region of the human amylin monomer. LA12 stabilized the random coil conformation of amylin to suppress aggregation in a dose-dependent manner with the highest suppression effect of 78% and reduced the cytotoxicity of ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(11):1633-1636]

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Vanillin enhances the passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure.

Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen, Ping Wang,

Vanillin is a popular flavoring agent in the food, tobacco, and perfume industries. In this paper, we investigated the effect of vanillin on the transport rates of drugs with different levels of permeability (acyclovir, hydrochlorothiazide, propranolol and carbamazepine) through a Caco-2 cell bidirectional transport experiment. We also explored the underlying ... Read more >>

Food Funct (Food & function)
[2020, 11(1):700-710]

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Application of Hydrogen Peroxide Sensitive Fluorescen Nanoparticles in Atherosclerosis.

Yuchao Zhang, Gang Xu, Maozhen Chen, Ziliang Chen, Mingyang Shen, Ping Wang,

ROS plays an important role in the formation of atherosclerotic plaque, especially hydrogen peroxide, which can stimulate macrophages to express pro-inflammatory cytokines and chemokines to enhance the inflammatory activity of macrophages. Therefore, the development of drugs with sensitive release of hydrogen peroxide is safe and effective for the treatment of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):833-842]

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The complete chloroplast genome sequence of Thymus mongolicus (Labiatae), a special spice plant

Li Huaizhu, Liang Bai, Jiqing Bai, Ping Wang, Caihua Zhou, Dou Lingling, Jiaojiao Jiang, Jun Liu, Qiaoli Wang,

Abstract Thymus mongolicus is well-known spice plant and resource of traditional Chinese herbal medicine, belonging to the Thymus of the Labiatae family. In this study, the whole chloroplast genome of the T. mongolicus was sequenced, assembled and annotated, which contains 134 unique genes, including 89 protein-coding genes, 37 tRNA genes ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[0, 5(3):2597-2598]

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Self-templated formation of hierarchically yolk-shell-structured ZnS/NC dodecahedra with superior lithium storage properties.

Ping Wang, Aihua Yuan, Zhitao Wang, Xiaoping Shen, Hantao Chen, Hu Zhou,

Hierarchical ZnS/NC dodecahedra are successfully constructed via a two-step synthetic method combining a sulfidation process and subsequent carbonization treatment, benefiting from the inherent merits of zeolitic imidazolate frameworks as ideal precursors/self-sacrificing templates. Studies reveal that the sulfidation time plays a vital role in the morphological evolution and lithium storage performances ... Read more >>

Nanoscale (Nanoscale)
[2021, :]

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Sex Difference in The Association Between Plasma Selenium and First Stroke: A Community-Based Nested Case-Control Study

Huan Hu, Chonglei Bi, Tengfei Lin, Lishun Liu, Yun Song, Binyan Wang, Ping Wang, Ziyi Zhou, Chongqian Fang, Hai Ma, Xiao Huang, Lihua Hu, Xiping Xu, Hao Zhang, Yong Huo, Xiaobin Wang, Huihui Bao, Xiaoshu Cheng, Ping Li,

<h4>Background: </h4> To date, there is no clearly defined association between plasma selenium levels and first stroke. We aimed to investigate the association between baseline plasma selenium and first stroke risk in a community-based, Chinese population. <h4>Methods: </h4> Using a nested case-control study design, a total of 1255 first stroke ... Read more >>

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Iron Sucrose: A Double-Edged Sword in High Phosphate Media-Induced Vascular Calcification.

Ping Wang, Chengkun Guo, Hui Pan, Wangshan Chen, Dan Peng,

The high incidence of vascular calcification (VC) in patients with chronic kidney disease (CKD) has become an important clinical subject. Hyperphosphatemia is a primary cause of CKD-related VC. Intravenous iron sucrose (IS) is commonly used to treat anemia in CKD patients, and is effective and well tolerated worldwide. However, the interaction ... Read more >>

Calcif Tissue Int (Calcified tissue international)
[2021, :]

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Predication of the Underlying Protective Effect of Saffron on Parkinson's Disease via Network Pharmacology and Molecular Docking

Junjie Gong, Zijin Xu, Shushu Hao, Boqian Chen, Shengcheng Zhuang, guojun Jiang, SZ Bathaie, ping wang,

<h4>Background: </h4> Reports indicate that saffron originated from Iran then introduced into mainland China through the earlier established trans-Tibet trade routes in ancient China. Based to the theory of traditional Chinese medicine, saffron functions by promoting blood circulation and removing blood stasis, cooling blood and detoxification, as well as relieving ... Read more >>

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Antibacterial calcium phosphate cement with human periodontal ligament stem cell-microbeads to enhance bone regeneration and combat infection.

Gengtao Qiu, Mingguang Huang, Liu Jin, Ping Wang, Abraham Schneider, Ke Ren, Thomas W Oates, Michael D Weir, Hockin H K Xu, Liang Zhao,

<h4>Objectives</h4>(1) Develop a novel antibacterial scaffold of chitosan-reinforced calcium phosphate cement delivering doxycycline hyclate (CPCC+DOX) to combat infections; (2) Investigate proliferation and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) encapsulated in alginate beads and cocultured with CPCC+DOX scaffold.<h4>Methods</h4>CPCC+DOX scaffolds were fabricated to contain different concentrations of doxycycline hyclate ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2021, :]

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Fine mapping QTL and mining genes for protein content in soybean by the combination of linkage and association analysis.

Xiyu Li, Ping Wang, Kaixin Zhang, Shulin Liu, Zhongying Qi, Yanlong Fang, Yue Wang, Xiaocui Tian, Jie Song, Jiajing Wang, Chang Yang, Xu Sun, Zhixi Tian, Wen-Xia Li, Hailong Ning,

Soybean is one main source of dietary protein; therefore, improving protein content is an important objective in breeding programs. There is a significant negative correlation between protein and oil content, which influenced mapping quantitative trait locus (QTL) and quantitative trait nucleotides for these two traits. In this study, a linkage ... Read more >>

Theor Appl Genet (TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik)
[2021, :]

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Preparation of PEG-modified wool keratin/sodium alginate porous scaffolds with elasticity recovery and good biocompatibility.

Ji Ji, Guang Chen, Zitong Liu, Lili Li, Jiugang Yuan, Ping Wang, Bo Xu, Xuerong Fan,

To improve mechanical properties of keratin (KR) porous scaffolds, we prepared a PEGylated keratin through thiol-ene click reaction. Several porous scaffolds were prepared by blending PEGylated keratin with sodium alginate (SA). The surface morphology, mechanical properties, and porosity of scaffolds were detailed studied at different KR/SA proportions. The results showed ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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A novel gammapartitivirus from the entomopathogenic fungus Metarhizium brunneum.

Ping Wang, Guogen Yang, Najie Shi, Bo Huang,

Here, we report a novel partitivirus infecting Metarhizium brunneum, which was designated "Metarhizium brunneum partitivirus 2" (MbPV2). The complete genome of MbPV2 consists of two segments, dsRNA1 and dsRNA2, with each dsRNA possessing a single open reading frame (ORF). dsRNA1 (1,775 bp) encodes a conserved RNA-dependent RNA polymerase (RdRp) with ... Read more >>

Arch Virol (Archives of virology)
[2021, :]

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Balancing of the mitotic exit network and cell wall integrity signaling governs the development and pathogenicity in Magnaporthe oryzae.

Wanzhen Feng, Ziyi Yin, Haowen Wu, Peng Liu, Xinyu Liu, Muxing Liu, Rui Yu, Chuyun Gao, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang,

The fungal cell wall plays an essential role in maintaining cell morphology, transmitting external signals, controlling cell growth, and even virulence. Relaxation and irreversible stretching of the cell wall are the prerequisites of cell division and development, but they also inevitably cause cell wall stress. Both Mitotic Exit Network (MEN) ... Read more >>

PLoS Pathog (PLoS pathogens)
[2021, 17(1):e1009080]

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Chromoblastomycosis by Exophiala jeanselmei associated with squamous cell carcinoma.

Jiaqi Wang, Mengyan Zhu, Ping Wang,

Chromoblastomycosis is a subcutaneous, chronic, granulomatous mycosis that occurs more frequently in tropical and subtropical countries. Herein, we describe a case of a 90-year-old female patient with diagnosis of chromoblastomycosis by Exophiala jeanselmei with a 22-year evolution who developed a squamous cell carcinoma. In the meantime, She underwent two misdiagnoses ... Read more >>

J Mycol Med (Journal de mycologie medicale)
[2021, 31(1):101105]

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Long read sequencing of Toona sinensis (A. Juss) Roem: a chromosome-level reference genome for the Meliaceae family.

Yun-Tao Ji, Zhihui Xiu, Chun-Hai Chen, Youru Wang, Jing-Xia Yang, Juan-Juan Sui, San-Jie Jiang, Ping Wang, Shao-Yun Yue, Qian-Qian Zhang, Ji-Liang Jin, Guo-Shu Wang, Qian-Qian Wei, Bing Wei, Juan Wang, Hai-Lin Zhang, Qiu-Yan Zhang, Jun Liu, Chang-Jin Liu, Jian-Bo Jian, Chang-Qing Qu,

Chinese mahogany (Toona sinensis) is a woody plant that is widely cultivated in China and Malaysia. T. sinensis provides important economic attributes, including as a nutritious food source, as material for traditional Chinese medicine and as a high-quality hardwood. However, the absence of a reference genome has hindered in-depth molecular ... Read more >>

Mol Ecol Resour (Molecular ecology resources)
[2021, :]

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Analysis of binding modes of biopanning heptapeptides with specific affinity to chitosan wrapped MSN.

Yibing Wang, Yong Yu, Wenji Yao, Min Li, Ping Wang,

In this work, we demonstrated for the first time that six short heptapeptides screened out by biopanning strategy show affinity binding to chitosan wrapped mesoporous silica nanoparticle (CS/MSN). The interaction between peptide and chitosan-wrapped MSN (CS/MSN) was carefully analyzed with the aid of DLS and ELISA characterization. The results show ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 539:64-69]

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A Novel Machine Learning Framework for Comparison of Viral COVID-19-Related Sina Weibo and Twitter Posts: Workflow Development and Content Analysis.

Shi Chen, Lina Zhou, Yunya Song, Qian Xu, Ping Wang, Kanlun Wang, Yaorong Ge, Daniel Janies,

<h4>Background</h4>Social media plays a critical role in health communications, especially during global health emergencies such as the current COVID-19 pandemic. However, there is a lack of a universal analytical framework to extract, quantify, and compare content features in public discourse of emerging health issues on different social media platforms across ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2021, 23(1):e24889]

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Association of novel rare coding variants with juvenile idiopathic arthritis.

Xinyi Meng, Xiaoyuan Hou, Ping Wang, Joseph T Glessner, Hui-Qi Qu, Michael E March, Sipeng Zhang, Xiaohui Qi, Chonggui Zhu, Kenny Nguyen, Xinyi Gao, Xiaoge Li, Yichuan Liu, Wentao Zhou, Shuyue Zhang, Junyi Li, Yan Sun, Jie Yang, Patrick M A Sleiman, Qianghua Xia, Hakon Hakonarson, Jin Li,

<h4>Objective</h4>Juvenile idiopathic arthritis (JIA) is the most common type of arthritis among children, but a few studies have investigated the contribution of rare variants to JIA. In this study, we aimed to identify rare coding variants associated with JIA for the genome-wide landscape.<h4>Methods</h4>We established a rare variant calling and filtering ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2021, :]

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The efficacy of sphenopalatine ganglion block for pain management after endoscopic sinus surgery: a meta-analysis of randomized controlled studies.

Ping Wang,

<h4>Introduction</h4>The efficacy of sphenopalatine ganglion (SPG) block for pain control after endoscopic sinus surgery remains controversial. We conduct a systematic review and meta-analysis to explore the influence of SPG block on pain intensity after endoscopic sinus surgery.<h4>Methods</h4>We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through June ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2021, :]

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Decreased grain size1, a C3HC4-type RING protein, influences grain size in rice (Oryza sativa L.).

Xingjie Zhu, Shengzhong Zhang, Yaping Chen, Changlin Mou, Yunshuai Huang, Xi Liu, Jingli Ji, Jiangfeng Yu, Qixian Hao, Chunyan Yang, Mengying Cai, Thanhliem Nguyen, Weihan Song, Ping Wang, Hui Dong, Shijia Liu, Ling Jiang, Jianmin Wan,

<h4>Key message</h4>We reported that DGS1 plays a positive role in regulating grain size in rice and was regulated by OsBZR1. Grain size is an important agronomic trait that contributes to grain yield. However, the underlying molecular mechanisms that determine final grain size are still largely unknown. We isolated a rice ... Read more >>

Plant Mol Biol (Plant molecular biology)
[2021, :]

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