Full Text Journal Articles by
Author Ping Lu

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Magnetic signatures of 120 K superconductivity at interfaces in La2CuO4+δ.

Eun-Mi Choi, Bonan Zhu, Ping Lu, John Feighan, Xing Sun, Haiyan Wang, Judith L MacManus-Driscoll,

In self-assembled vertically aligned nanocomposite (VAN) thin films of La2CuO4+δ + LaCuO3, we find from DC magnetic susceptibility measurements, weak signatures of superconductivity at ∼120 K. This compares to a maximum TC of 40 K in bulk La2CuO4+δ. The 120 K signature occurs only when both c-axis and a-axis oriented ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(5):3157-3165]

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Delivery of TRAIL-expressing plasmid DNA to cancer cells in vitro and in vivo using aminoglycoside-derived polymers.

Sheba Goklany, Ping Lu, Sudhakar Godeshala, Andrea Hall, Elizabeth Garrett-Mayer, Christina Voelkel-Johnson, Kaushal Rege,

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand that can preferentially induce apoptosis in cancer cells over normal cells. The transmembrane form of TRAIL has been shown to elicit much stronger activity than its soluble counterpart but delivery is a potential challenge. Here, we investigated the potential of ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2019, 7(44):7014-7025]

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Identification and fine mapping of spot blotch (Bipolaris sorokiniana) resistance gene Sb4 in wheat.

Panpan Zhang, Guanghao Guo, Qiuhong Wu, Yongxing Chen, Jingzhong Xie, Ping Lu, Beibei Li, Lingli Dong, Miaomiao Li, Rongge Wang, Chengguo Yuan, Huaizhi Zhang, Keyu Zhu, Wenling Li, Zhiyong Liu,

KEY MESSAGE:A new spot blotch (Bipolaris sorokiniana) resistance gene Sb4 was mapped in a genomic interval of 1.34 Mb on wheat chromosome 4BL. Spot blotch, caused by Bipolaris sorokiniana, has emerged as a serious concern for cultivation of wheat in warmer and humid regions of the world, which results in substantial ... Read more >>

Theor. Appl. Genet. (TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik)
[2020, :]

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Metabolite Identification of Therapeutic Peptides and Proteins by Top-down Differential Mass Spectrometry and Metabolite Database Matching.

Xiang Yu, Arthur Fridman, Ansuman Bagchi, Shiyao Xu, Kristen A Kwasnjuk, Ping Lu, Mark T Cancilla,

As metabolism impacts the efficacy and safety of therapeutic peptides and proteins (TPPs), understanding of the metabolic fate of TPPs is critical for their preclinical and clinical development. Despite the continued increase of new TPPs entering clinical trials, the metabolite identification (MetID) of these emerging modalities remains challenging. In the ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, :]

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A review of the influences of microplastics on toxicity and transgenerational effects of pharmaceutical and personal care products in aquatic environment.

Ranran Zhou, Guanghua Lu, Zhenhua Yan, Runren Jiang, Xuhui Bao, Ping Lu,

PPCPs (pharmaceutical and personal care products) and microplastics (MPs) are two types of emerging pollutants that are ubiquitous and widely concerned in the environment. Both of them can accumulate in fish or aquatic invertebrates and transfer to offspring, thereby producing toxic effects on both parents and offspring, in which the ... Read more >>

Sci. Total Environ. (The Science of the Total Environment)
[2020, 732:139222]

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Polymorphism analysis and supertype definition of swine leukocyte antigen class I molecules in three-way crossbred (Landrace, Duroc, and Yorkshire) pigs: implications for the vaccine development of African swine fever virus.

Limin Ba, Zhenbao Wang, William J Liu, Dongxun Wu, Wangzhen Xiang, Peng Qi, Chunna Dong, Yanxin Hu, Ping Lu, Jin Xiao, Changyuan Yu,

Sci China Life Sci (Science China. Life sciences)
[2020, :]

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Introduction on collective quarantine of close contacts of patients with COVID-19 for medical observation in China: from the perspective of frontline staff.

Chenjie Dong, Yuan Tian, Wenzhong Xu, Jiangjiang He, Duo Chen, Jie Zhu, Ping Lu,

The World Health Organization (WHO) has deemed coronavirus disease 2019 (COVID-19) to be a pandemic. The strict prevention and control measures taken by China have proven to be effective, creating a window of opportunity for other countries. The tracking and management of contacts of patients with COVID-19 are important components ... Read more >>

Biosci Trends (Bioscience trends)
[2020, :]

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A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis.

Chengui Lu, Changjiang Guo, Han Chen, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Zhiyuan Niu, Ping Lu, Wuling Zhu,

Chimeric antigen receptor (CAR)-modified adoptive natural killer (NK) cells represent a promising immunotherapeutic modality for cancer treatment but face many challenges in solid tumors. One major obstacle is the immune-suppressive effects induced by inhibitory receptors (IR) including PD1. To interfere with PD1 signaling to augment CAR-NK cells' activity against solid ... Read more >>

Mol. Immunol. (Molecular immunology)
[2020, 122:200-206]

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Nanoengineering room temperature ferroelectricity into orthorhombic SmMnO3 films.

Eun-Mi Choi, Tuhin Maity, Ahmed Kursumovic, Ping Lu, Zenxhing Bi, Shukai Yu, Yoonsang Park, Bonan Zhu, Rui Wu, Venkatraman Gopalan, Haiyan Wang, Judith L MacManus-Driscoll,

Orthorhombic RMnO3 (R = rare-earth cation) compounds are type-II multiferroics induced by inversion-symmetry-breaking of spin order. They hold promise for magneto-electric devices. However, no spontaneous room-temperature ferroic property has been observed to date in orthorhombic RMnO3. Here, using 3D straining in nanocomposite films of (SmMnO3)0.5((Bi,Sm)2O3)0.5, we demonstrate room temperature ferroelectricity and ferromagnetism ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):2207]

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Room-Temperature Ferroelectric LiNb6Ba5Ti4O30 Spinel Phase in a Nanocomposite Thin Film Form for Nonlinear Photonics.

Jijie Huang, Han Wang, Dongfang Li, Zhimin Qi, Di Zhang, Ping Lu, Hou-Tong Chen, Dmitry A Yarotski, Pao-Tai Lin, Xinghang Zhang, Haiyan Wang,

Tetragonal tungsten bronze (TTB) materials are one of the most promising classes of materials for ferroelectric and nonlinear optical devices, owing to their very unique noncentrosymmetric crystal structure. In this work, a new TTB phase of LiNb6Ba5Ti4O30 (LNBTO) has been discovered and studied. A small amount of a secondary phase, ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(20):23076-23083]

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A Comparative Ocular Pharmacokinetics Study of Preservative-Free Latanoprost Unit-Dose Eye Drops and a Benzalkonium Chloride-Preserved Branded Product Following Topical Application to Rabbits.

Tianyan Zhou, Yan Miao, Zhengyan Li, Ping Lu, Zhen Liang, Jingjing Yang, Jijun He, Huiyun Xia, Zhen Zhang, Junjie Zhang,

Purpose: To evaluate the aqueous humor pharmacokinetics of a preservative-free 0.005% latanoprost unit-dose eye drop (test drug) compared with that of a benzalkonium chloride (BAK)-preserved 0.005% latanoprost branded product (control drug) following topical application to rabbits. Methods: A total of 120 healthy New Zealand albino rabbits were administrated test eye ... Read more >>

J Ocul Pharmacol Ther (Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics)
[2020, :]

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Comparative effects of unilateral and bilateral bone conduction hearing devices on functional hearing and sound localization abilities in patients with bilateral microtia-atresia.

Xinmiao Fan, Lu Ping, Tengyu Yang, Xiaomin Niu, Yushan Chen, Xin Xia, Ruzhen Gao, Yue Fan, Xiaowei Chen,

Background: Various amplification options are available for patients with congenital bilateral conductive hearing loss. Unilateral bone conduction hearing device (BCHD) is widely used for these patients, whereas benefits of bilateral BCHDs in certain subgroups of patients require further exploration.Objectives: To evaluate functional and directional hearing in patients with unilateral Bonebridge ... Read more >>

Acta Otolaryngol. (Acta oto-laryngologica)
[2020, :1-8]

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Anatomical and Histological Study of the Conjoint Fascial Sheath of the Levator and Superior Rectus for Ptosis Surgery.

Bei Li, Jianwei Yang, Wencan Wu, Chang Chai, Zhuo Gu, Zaiqing He, Zhiwei Tan, Shuanghua Cheng, Ping Lu, Liuzhi Zeng,

An anatomical and histological study of the conjoint fascial sheath of the levator and superior rectus (CFS) was carried out by using the cadavers for teaching. Three adult Asian cadaver heads fixed in formalin were used. The CFS was exposed by the same surgeon in each case. Then the CFS ... Read more >>

Ophthalmic Plast Reconstr Surg (Ophthalmic plastic and reconstructive surgery)
[2020, :]

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Highly efficient luminescent benzoylimino derivative and fluorescent probe from a photochemical reaction of imidazole as an oxygen sensor.

Yue Yu, Ruiyang Zhao, Changjiang Zhou, Xiaoyi Sun, Shizhao Wang, Yu Gao, Weijun Li, Ping Lu, Bing Yang, Cheng Zhang,

A photochemical reaction in which the imidazole ring is opened under UV irradiation to generate highly luminescent benzoylimino group by O2 has been discovered. This photochemical reaction displays great potential for applications that use a fluorescent probe as a oxygen sensor; it has a lowest detectable volume ratio of ∼0.2% ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(7):977-980]

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Synthesis of 8-Alkoxy-5H-isochromeno[3,4-c]isoquinolines and 1-Alkoxy-4-arylisoquinolin-3-ols through Rh(III)-Catalyzed C-H Functionalization of Benzimidates with 4-Diazoisochroman-3-imines and 4-Diazoisoquinolin-3-ones.

Zhenmin Li, Jianwei Xie, Ping Lu, Yanguang Wang,

Rh(III)-catalyzed C-H activation/annulation of benzimidates with 4-diazoisochroman-3-imines furnished 8-alkoxy-5H-isochromeno[3,4-c]isoquinolines in moderate to excellent yields with a broad range of substrate scope. The reaction was carried out under mild reaction conditions and could be scaled up with practical usage. Similar reaction between benzimidates and 4-diazoisoquinolin-3-ones provided 1-alkoxy-4-arylisoquinolin-3-ols in excellent yields. Moreover, ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2020, 85(8):5525-5535]

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Pyrene[4,5-d]imidazole-Based Derivatives with Hybridized Local and Charge-Transfer State for Highly Efficient Blue and White Organic Light-Emitting Diodes with Low Efficiency Roll-Off.

Yulong Liu, Hui Liu, Qing Bai, Chunya Du, Anqi Shang, Dongyan Jiang, Xiangyang Tang, Ping Lu,

A family of pyrene[4,5-d]imidazole derivatives, PyPA, PyPPA, PyPPAC, and PyPAC, with different excited states are successfully developed. Among them, PyPPA and PyPPAC possess hybridized local and charge-transfer (HLCT) state, endowing them with pure blue fluorescence as well as high quantum yields. The nondoped organic light-emitting diode (OLED) based on PyPPA ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(14):16715-16725]

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Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration.

Yinchen Shen, Mo Li, Kun Liu, Xiaoyin Xu, Shaopin Zhu, Ning Wang, Wenke Guo, Qianqian Zhao, Ping Lu, Fudong Yu, Xun Xu,

BACKGROUND:Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (MDEGs) in AMD and explore the involved pathways via integrated bioinformatics analysis. METHODS:Data from expression profile GSE29801 and methylation profile GSE102952 were obtained from ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):119]

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Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration

Yinchen Shen, Mo Li, Kun Liu, Xiaoyin Xu, Shaopin Zhu, Ning Wang, Wenke Guo, Qianqian Zhao, Ping Lu, Fudong Yu, Xun Xu,

Abstract Background: Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (MDEGs) in AMD and explore the involved pathways via integrated bioinformatics analysis. Methods: Data from expression profile GSE29801 and methylation profile GSE102952 ... Read more >>

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Misdiagnosis of primary intimal sarcoma of the pulmonary artery as chronic pulmonary embolism: A case report.

Ping Lu, Bei-Bei Yin,

BACKGROUND:Primary intimal sarcoma of the pulmonary artery is a rare malignant tumor originating from the pulmonary artery, which has a low incidence rate and is easily misdiagnosed as pulmonary embolism. There is no standard protocol for the treatment of primary intimal sarcoma of the pulmonary artery. CASE SUMMARY:This study reports ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(5):986-994]

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Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis.

Shai White-Gilbertson, Ping Lu, Christian M Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R Delaney, James S Norris, Christina Voelkel-Johnson,

Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the potential to generate progeny through primitive or cleavage-like division, which allows them to evade antimitotic insults. We ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(9):3142-3152]

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New nanoscale toughening mechanisms mitigate embrittlement in binary nanocrystalline alloys.

Nathan M Heckman, Stephen M Foiles, Christopher J O'Brien, Michael Chandross, Christopher M Barr, Nicolas Argibay, Khalid Hattar, Ping Lu, David P Adams, Brad L Boyce,

Nanocrystalline metals offer significant improvements in structural performance over conventional alloys. However, their performance is limited by grain boundary instability and limited ductility. Solute segregation has been proposed as a stabilization mechanism, however the solute atoms can embrittle grain boundaries and further degrade the toughness. In the present study, we ... Read more >>

Nanoscale (Nanoscale)
[2018, 10(45):21231-21243]

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Fosaprepitant versus aprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based chemotherapy: a multicenter, randomized, double-blind, double-simulated, positive-controlled phase III trial.

Zhonghan Zhang, Yunpeng Yang, Ping Lu, Xiaoqin Li, Jianhua Chang, Rongsheng Zheng, Lei Zhou, Shaoshui Chen, Xiaopin Chen, Biyong Ren, Wei Gu, Xiaodong Jiang, Jiyong Peng, Miaolong Huang, Guosheng Feng, Peng Shen, Qingyuan Zhang, Baihong Zhang, Yan Huang, Jingdong He, Yinglan Chen, Jingxu Cao, Hong Wang, Wei Li, Huiping Wan, Kejun Nan, Zijun Liao, Cuiying Zhang, Zhong Lin, Diansheng Zhong, Qing Xu, Hailong Liu, Tao Sun, Yanming Deng, Li Zhang,

Background:To establish the role of antiemetic therapy with neurokinin-1 (NK-1) receptor antagonists (RAs) in Chinese patients associated with cisplatin-base chemotherapy regimens, this study evaluated the efficacy and safety of single-dose intravenous fosaprepitant-based triple antiemetic regimen to a 3-day orally aprepitant-based antiemetic triplet schedule for the prevention of chemotherapy-induced nausea and ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(5):234]

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Large-Scale Plasmonic Hybrid Framework with Built-In Nanohole Array as Multifunctional Optical Sensing Platforms.

Xuejing Wang, Xuedan Ma, Enzheng Shi, Ping Lu, Letian Dou, Xinghang Zhang, Haiyan Wang,

Light coupling with patterned subwavelength hole arrays induces enhanced transmission supported by the strong surface plasmon mode. In this work, a nanostructured plasmonic framework with vertically built-in nanohole arrays at deep-subwavelength scale (6 nm) is demonstrated using a two-step fabrication method. The nanohole arrays are formed first by the growth ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(11):e1906459]

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Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma.

Min-Wei Yang, Ling-Ye Tao, Yong-Sheng Jiang, Jian-Yu Yang, Yan-Miao Huo, De-Jun Liu, Jiao Li, Xue-Liang Fu, Ruizhe He, Chaoyi Lin, Wei Liu, Jun-Feng Zhang, Rong Hua, Qing Li, Shu-Heng Jiang, Li-Peng Hu, Guang-Ang Tian, Xiao-Xin Zhang, Ningning Niu, Ping Lu, Juanjuan Shi, Gary G Xiao, Li-Wei Wang, Jing Xue, Zhi-Gang Zhang, Yong-Wei Sun,

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the microenvironment and how this affects PDAC progression. Transcriptome expression profiles of PDAC tissues with different perineural invasion status were compared, and the intratumoral T-cell density and levels of neurotransmitters ... Read more >>

Cancer Res. (Cancer research)
[2020, 80(10):1991-2003]

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The SR-protein FgSrp2 regulates vegetative growth, sexual reproduction and pre-mRNA processing by interacting with FgSrp1 in Fusarium graminearum.

Yimei Zhang, Yafeng Dai, Yi Huang, Kai Wang, Ping Lu, Hanfang Xu, Jin-Rong Xu, Huiquan Liu,

Serine/arginine (SR) proteins play significant roles in pre-mRNA splicing in eukaryotes. To investigate how gene expression influences fungal development and pathogenicity in Fusarium graminearum, a causal agent of Fusarium head blight (FHB) of wheat and barley, our previous study identified a SR protein FgSrp1 in F. graminearum, and showed that ... Read more >>

Curr. Genet. (Current genetics)
[2020, 66(3):607-619]

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