Full Text Journal Articles by
Author Pierre Tiberghien

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Trends in platelet distributions from 2008 to 2017: a survey of twelve national and regional blood collectors.

Mark H Yazer, Beth Shaz, Jansen N Seheult, Torunn O Apelseth, Dirk de Korte, Gerry Devin, Dana Devine, Cheryl Doncaster, Stephen Field, Peter Flanagan, Julie Huet, Alfredo Mendrone, Cath O'Brien, Joanne Pink, Mark Rashleigh, Eilat Shinar, Minoko Takanashi, Eka Tian, Pierre Tiberghien, Karin van den Berg, Colby Schmitt,

This multi-national study evaluated changes in platelet (PLT) unit distributions at 12 national or regional blood collectors over a 10-year period. Data on the total number of PLT distributions, the collection method, that is apheresis vs whole blood-derived (WBD), the PLT unit characteristics and post-collection modifications were obtained from 12 ... Read more >>

Vox Sang. (Vox sanguinis)
[2020, :]

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Collecting and evaluating convalescent plasma for COVID-19 treatment: why and how?

Pierre Tiberghien, Xavier de Lamballerie, Pascal Morel, Pierre Gallian, Karine Lacombe, Yazdan Yazdanpanah,

Plasma provided by COVID-19 convalescent patients may provide therapeutic relief as the number of COVID-19 cases escalates steeply worldwide. Prior findings in various viral respiratory diseases including SARS-CoV-related pneumonia suggest that convalescent plasma can reduce mortality, although formal proof of efficacy is still lacking. By reducing viral spread early on, ... Read more >>

Vox Sang. (Vox sanguinis)
[2020, :]

Cited: 2 times

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Donor-targeted serotherapy as a rescue therapy for steroid-resistant acute GVHD after HLA-mismatched kidney transplantation.

Julien Zuber, Olivia Boyer, Bénédicte Neven, Isabelle Jollet, Virginie Renac, Romain Berthaud, Romain Levy, Baptiste Lamarthée, Jonathan Visentin, Armance Marchal, Nathalie Gouge-Biebuyck, Astrid Godron-Dubrasquet, Nathalie Aladjidi, Melissa O Rabah, Sarah Winter, Juliette Léon, Michael Dussiot, Marion Rabant, Saoussen Krid, Pauline Krug, Marina Charbit, Florence Lacaille, Isabelle André, Marina Cavazzana, Brigitte Llanas, Lise Allard, France Pirenne, Sylvie Gross, Rachid Djoudi, Pierre Tiberghien, Jean-Luc Taupin, Stéphane Blanche, Rémi Salomon,

Acute graft-versus-host disease (GVHD) is a rare but frequently lethal complication after solid organ transplantation. GVHD occurs in unduly immunocompromised hosts but requires the escalation of immunosuppression, which does not discriminate between host and donor cells. In contrast, donor-targeted therapy would ideally mitigate graft-versus-host reactivity while sparing recipient immune functions. ... Read more >>

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(8):2243-2253]

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Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study.

Saurabh Zalpuri, Bas Romeijn, Elias Allara, Mindy Goldman, Hany Kamel, Jed Gorlin, Ralph Vassallo, Yves Grégoire, Naoko Goto, Peter Flanagan, Joanna Speedy, Andreas Buser, Jose Mauro Kutner, Karin Magnussen, Johanna Castrén, Liz Culler, Harry Sussmann, Femmeke J Prinsze, Kevin Belanger, Veerle Compernolle, Pierre Tiberghien, Jose Manuel Cardenas, Manish J Gandhi, Kamille A West, Cheuk-Kwong Lee, Sian James, Deanne Wells, Laurie J Sutor, Silvano Wendel, Matthew Coleman, Axel Seltsam, Kimberly Roden, Whitney R Steele, Milos Bohonek, Ramir Alcantara, Emanuele Di Angelantonio, Katja van den Hurk, ,

BACKGROUND:Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS:An online survey was performed among Biomedical Excellence for Safer Transfusion ... Read more >>

Transfusion (Transfusion)
[2020, 60(3):544-552]

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Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.

Mark H Yazer, Philip C Spinella, Leilani Doyle, Richard M Kaufman, Robyn Dunn, John R Hess, Luiz Amorim Filho, Magali Fontaine, Birgit Gathof, Bryon Jackson, Michael F Murphy, Jeremiah Pasion, Jay S Raval, Kristin Rosinski, Jansen Seheult, Andrew W Shih, Jason Sperry, Julie Staves, Erin E Tuott, Alyssa Ziman, Darrell J Triulzi, ,

BACKGROUND:Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This study investigated the impact of transfusing increasing numbers of uncrossmatched type O products on the recipient's first in-hospital ABO type. METHODS:This was a retrospective cohort study. Results of the first ABO type ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(3):525-534]

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The evolving blood donor deferral policy for men who have sex with men: impact on the risk of HIV transmission by transfusion in France.

Josiane Pillonel, Camille Pelat, Pierre Tiberghien, Claire Sauvage, Bruno Danic, Christophe Martinaud, Francis Barin, Isabelle Sainte-Marie, Bruno Coignard, Sylvie Gross, Syria Laperche, Florence Lot,

BACKGROUND:Blood donation deferral for men who have sex with men (MSM) in France was reduced from permanent to 12 months in July 2016. To inform a further reduction of the deferral period, an HIV risk assessment was conducted with two scenarios: S1, 4-month deferral; S2, 4-month deferral only in the case ... Read more >>

Transfusion (Transfusion)
[2020, 60(3):525-534]

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Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

Philip C Spinella, Marisa Tucci, Dean A Fergusson, Jacques Lacroix, Paul C Hébert, Stéphane Leteurtre, Kenneth B Schechtman, Allan Doctor, Robert A Berg, Tina Bockelmann, J Jaime Caro, Fabrizio Chiusolo, Lucy Clayton, Jill M Cholette, Gonzalo Garcia Guerra, Cassandra D Josephson, Kusum Menon, Jennifer A Muszynski, Marianne E Nellis, Amrita Sarpal, Stephanie Schafer, Marie E Steiner, Alexis F Turgeon, ,

Importance:The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized clinical trial. Objective:To determine if the transfusion of fresh red blood cells (stored ≤7 days) reduced new or progressive multiple organ dysfunction syndrome compared with the use of ... Read more >>

JAMA (JAMA)
[2019, 322(22):2179-2190]

Cited: 2 times

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The systematic use of evidence-based methodologies and technologies enhances shared decision-making in the 2018 International Consensus Conference on Patient Blood Management.

Hans Van Remoortel, Kari Aranko, Markus M Mueller, Emmy De Buck, Dana Devine, Gilles Folléa, Patrick Meybohm, Pierre Tiberghien, Erica M Wood, Philippe Vandekerckhove, Erhard Seifried,

BACKGROUND AND OBJECTIVES:Patient Blood Management (PBM) aims to optimize the care of patients who might need a blood transfusion. The International Consensus Conference on PBM (ICC-PBM) aimed to develop evidence-based recommendations on three topics: preoperative anaemia, red blood cell transfusion thresholds and implementation of PBM programmes. This paper reports how ... Read more >>

Vox Sang. (Vox sanguinis)
[2020, 115(1):60-71]

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Persisting higher prevalence of hepatitis A virus RNA in blood donors, France, 2018.

Pierre Gallian, Valérie Barlet, Lina Mouna, Sylvie Gross, Pascal Morel, Sophie Le Cam, Céline Ricard, Claude Maugard, Elodie Pouchol, Benoit Flan, Catherine Visse, Rachid Djoudi, Julie Figoni, Henriette De Valk, Pierre Tiberghien, Anne-Marie Roque-Afonso,

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2019, 24(47):]

Cited: 0 times

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Not all red cell concentrate units are equivalent: international survey of processing and in vitro quality data.

Andrew W Shih, Torunn Oveland Apelseth, Rebecca Cardigan, Denese C Marks, Stéphane Bégué, Andreas Greinacher, Dirk de Korte, Axel Seltsam, Beth H Shaz, Agneta Wikman, Rebecca L Barty, Nancy M Heddle, Jason P Acker, ,

INTRODUCTION:In vitro qualitative differences exist in red cell concentrates (RCCs) units processed from whole blood (WB) depending on the method of processing. Minimal literature exists on differences in processing and variability in quality data. Therefore, we collected information from blood manufacturers worldwide regarding (1) details of WB collection and processing ... Read more >>

Vox Sang. (Vox sanguinis)
[2019, 114(8):783-794]

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Transfusion-Transmitted Hepatitis E Virus Infection in France.

Pierre Gallian, Elodie Pouchol, Rachid Djoudi, Sébastien Lhomme, Lina Mouna, Sylvie Gross, Philippe Bierling, Azzedine Assal, Nassim Kamar, Vincent Mallet, Anne-Marie Roque-Afonso, Jacques Izopet, Pierre Tiberghien,

There is growing concern regarding the risk of transfusion- transmitted (TT) hepatitis E. Since the first described case in 2006, several TT hepatitis E have been reported to the French hemovigilance network. We performed a retrospective analysis of all cases of TT hepatitis E reported between 2006 and 2016. Transfusion-transmitted ... Read more >>

Transfus Med Rev (Transfusion Medicine Reviews)
[2019, 33(3):146-153]

Cited: 1 time

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The best blood product and its best use for each patient: An evolving role for hemovigilance?

Pierre Tiberghien,

Transfusion efficacy is an important clinical outcome strongly contributing to transfusion safety. Optimal transfusion care will soon require taking into account novel criteria's in relation with donor, blood product and/or recipient characteristics. Hemovigilance may prepare for these evolutions. ... Read more >>

Transfus Clin Biol (Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine)
[2019, 26(3):188-191]

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Viral load and clinical manifestations of hepatitis E virus genotype 3 infections.

Sebastien Lhomme, Pierre Gallian, Chloé Dimeglio, Azzedine Assal, Florence Abravanel, Pierre Tiberghien, Jacques Izopet,

A fraction of plasma donations undergoes hepatitis E virus (HEV) RNA screening since late 2014 in France. The aim of this study was to determine the frequency of HEV RNA as well as the viral load and the evolution of genotype distribution over a 3-year period (2015-2017) in asymptomatic blood ... Read more >>

J. Viral Hepat. (Journal of viral hepatitis)
[2019, 26(9):1139-1142]

Cited: 1 time

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Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference.

Markus M Mueller, Hans Van Remoortel, Patrick Meybohm, Kari Aranko, Cécile Aubron, Reinhard Burger, Jeffrey L Carson, Klaus Cichutek, Emmy De Buck, Dana Devine, Dean Fergusson, Gilles Folléa, Craig French, Kathrine P Frey, Richard Gammon, Jerrold H Levy, Michael F Murphy, Yves Ozier, Katerina Pavenski, Cynthia So-Osman, Pierre Tiberghien, Jimmy Volmink, Jonathan H Waters, Erica M Wood, Erhard Seifried, ,

Importance:Blood transfusion is one of the most frequently used therapies worldwide and is associated with benefits, risks, and costs. Objective:To develop a set of evidence-based recommendations for patient blood management (PBM) and for research. Evidence Review:The scientific committee developed 17 Population/Intervention/Comparison/Outcome (PICO) questions for red blood cell (RBC) transfusion in ... Read more >>

JAMA (JAMA)
[2019, 321(10):983-997]

Cited: 12 times

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Transfusion of HIV-infected blood products despite highly sensitive nucleic acid testing.

Pierre Cappy, Valérie Barlet, Quentin Lucas, Xavier Tinard, Josiane Pillonel, Sylvie Gross, Pierre Tiberghien, Syria Laperche,

BACKGROUND:In France, the risk of HIV transmission by transfusion was reduced by implementing pooled nucleic acid testing (NAT) in 2001 and individual NAT in 2010. We report here the first case in France of transfusion of human immunodeficiency virus (HIV)-infected blood donated during HIV pre-ramp-up phase that tested individual NAT ... Read more >>

Transfusion (Transfusion)
[2019, 59(6):2046-2053]

Cited: 1 time

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Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women.

Mohamed Slimane, Christophe Picard, Jacques Chiaroni, Anderson Loundou, Julien Paganini, Pierre Tiberghien, Jean-Michel Rebibou, Julie Di Cristofaro,

Factors determining anti-HLA immunization are poorly understood, although anti-HLA immunization following pregnancy is well described. The HLA-G molecule has been extensively described for its implication in immunological tolerance, especially during pregnancy. Transplant studies show an association between HLA-G haplotypes and alloimmunization. Our aim was to investigate the association of HLA-G ... Read more >>

Hum. Immunol. (Human immunology)
[2019, 80(2):120-125]

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Hepatitis A: an epidemiological survey in blood donors, France 2015 to 2017.

Pierre Gallian, Valérie Barlet, Lina Mouna, Sylvie Gross, Sophie Lecam, Céline Ricard, Françoise Wind, Elodie Pouchol, Cécile Fabra, Benoit Flan, Catherine Visse, Rachid Djoudi, Elisabeth Couturier, Henriette de Valk, Pierre Tiberghien, Anne-Marie Roque-Afonso,

Since mid-2016, hepatitis A virus (HAV) outbreaks, involving predominantly men who have sex with men (MSM), have affected countries in Europe and overseas. In France, HAV screening of blood donations in 2017 revealed a HAV-RNA prevalence ca fivefold higher than during 2015-16 (4.42/106 vs 0.86/106; p = 0.0005). In 2017, despite a higher ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2018, 23(21):]

Cited: 2 times

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Comparison of the Hemostatic Efficacy of Pathogen-Reduced Platelets vs Untreated Platelets in Patients With Thrombocytopenia and Malignant Hematologic Diseases: A Randomized Clinical Trial.

Frédéric Garban, Audrey Guyard, Helene Labussière, Claude-Eric Bulabois, Tony Marchand, Christiane Mounier, Denis Caillot, Jacques-Olivier Bay, Valérie Coiteux, Aline Schmidt-Tanguy, Catherine Le Niger, Christine Robin, Patrick Ladaique, Simona Lapusan, Eric Deconinck, Carole Rolland, Alison M Foote, Anne François, Chantal Jacquot, René Tardivel, Pierre Tiberghien, Jean-Luc Bosson, ,

Importance:Pathogen reduction of platelet concentrates may reduce transfusion-transmitted infections but is associated with qualitative impairment, which could have clinical significance with regard to platelet hemostatic capacity. Objective:To compare the effectiveness of platelets in additive solution treated with amotosalen-UV-A vs untreated platelets in plasma or in additive solution in patients with ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, 4(4):468-475]

Cited: 17 times

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More on Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma.

Pierre Tiberghien, Eric Deconinck, Oliver Adotevi,

N. Engl. J. Med. (The New England journal of medicine)
[2017, 377(21):2101-2102]

Cited: 1 time

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Context and social perceptions of blood donation in donors found positive for human immunodeficiency virus in France.

Alice Duquesnoy, Bruno Danic, Aurélie Santos, Christophe Martinaud, Geneviève Woimant, Syria Laperche, Pierre Tiberghien, Marie Jauffret-Roustide, Josiane Pillonel, ,

In France, information collected during postdonation interviews showed that a majority of human immunodeficiency virus (HIV)-infected donors were not eligible to donate as per donor selection criteria. In the interest of blood safety, this study aimed to explore the mechanisms of noncompliance with blood donor selection criteria, notably the permanent ... Read more >>

Transfusion (Transfusion)
[2017, 57(9):2240-2247]

Cited: 3 times

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An assessment of differences in costs and health benefits of serology and NAT screening of donations for blood transfusion in different Western countries.

M P Janssen, M van Hulst, B Custer, ,

The cost-utility of safety interventions is becoming increasingly important as a driver of implementation decisions. The aim of this study was to compare the cost-utility of different blood screening strategies in various settings, and to analyse the extent and cause of differences in health economic results.For eight Western countries (Australia, ... Read more >>

Vox Sang. (Vox sanguinis)
[2017, 112(6):518-525]

Cited: 3 times

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Changes in France's Deferral of Blood Donation by Men Who Have Sex with Men.

Pierre Tiberghien, Josiane Pillonel, François Toujas, Benoit Vallet,

N. Engl. J. Med. (The New England journal of medicine)
[2017, 376(15):1485-1486]

Cited: 3 times

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How to quantify microparticles in RBCs? A validated flow cytometry method allows the detection of an increase in microparticles during storage.

Clémentine Gamonet, Guillaume Mourey, Sophie Aupet, Sabéha Biichle, Régis Petitjean, Chrystelle Vidal, Aurore Pugin, Christian Naegelen, Pierre Tiberghien, Pascal Morel, Fanny Angelot-Delettre, Estelle Seilles, Philippe Saas, Laurent Bardiaux, Francine Garnache-Ottou,

The procoagulant and proinflammatory microparticles (MPs) released during storage of packed red blood cells (pRBCs) can potentially modify transfusion benefits. A robust method to quantify MPs in pRBCs is needed to evaluate their impact in clinical trials.The objective was to validate the preanalytic conditions required to prepare pRBC supernatant as ... Read more >>

Transfusion (Transfusion)
[2017, 57(3):504-516]

Cited: 2 times

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Epidemiology of Chikungunya Virus Outbreaks in Guadeloupe and Martinique, 2014: An Observational Study in Volunteer Blood Donors.

Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie,

During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases.Individual testing for CHIKV RNA of ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2017, 11(1):e0005254]

Cited: 19 times

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Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease.

Daisy Bougard, Jean-Philippe Brandel, Maxime Bélondrade, Vincent Béringue, Christiane Segarra, Hervé Fleury, Jean-Louis Laplanche, Charly Mayran, Simon Nicot, Alison Green, Arlette Welaratne, David Narbey, Chantal Fournier-Wirth, Richard Knight, Robert Will, Pierre Tiberghien, Stéphane Haïk, Joliette Coste,

Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from the consumption of meat products contaminated by the agent causing bovine spongiform encephalopathy. Evidence supporting the presence of a population of silent carriers that can potentially transmit the disease through blood transfusion is increasing. The development of a blood-screening ... Read more >>

Sci Transl Med (Science translational medicine)
[2016, 8(370):370ra182]

Cited: 30 times

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