Full Text Journal Articles by
Author Pierre R Bourque

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Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Josée Masson-Roy, Ari Breiner, Jodi Warman-Chardon, Catherine E Pringle, David Allan, Christopher Bredeson, Lothar Huebsch, Natasha Kekre, Michael Lee Kennah, Lisa Martin, Sheryl McDiarmid, Sultan Altouri, Harold Atkins, Pierre R Bourque,

<h4>Background</h4>Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) refractory to conventional therapy can lead to marked disability and represents a therapeutic challenge.<h4>Objective</h4>To report five cases of treatment-refractory disabling CIDP treated with autologous hematopoietic stem cell transplantation (AHSCT).<h4>Methods</h4>This was a retrospective cohort study from a tertiary care referral center for both neuromuscular disease and ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2021, :1-7]

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Vertebral Ischemic Necrosis in Diabetic Lumbosacral Radiculoplexus Neuropathy.

Ari Breiner, Thanh B Nguyen, Bibianna Purgina, Pierre R Bourque,

Diabetes Care (Diabetes care)
[2021, 44(3):e53-e54]

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Temporal evolution of nerve conduction study abnormalities in anti-myelin-associated glycoprotein neuropathy.

Pierre R Bourque, Josée Masson-Roy, Jodi Warman-Chardon, Rami Massie, Michel Melanson, John Brooks, Ari Breiner,

<h4>Background</h4>A distal-predominant demyelinating symmetric pattern is most frequent in patients with neuropathy associated with anti-myelin-associated glycoprotein (MAG) antibodies. The literature however lacks longitudinal data to describe whether this is consistent over time.<h4>Methods</h4>From the Ottawa Neuromuscular Center database, we identified 23 patients with both immunoglobulin M gammopathy and anti-MAG antibodies. For ... Read more >>

Muscle Nerve (Muscle & nerve)
[2021, 63(3):401-404]

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Correction: Systematic prospective electrophysiological studies of the median nerve after simple distal radius fracture.

Pierre R Bourque, John Brooks, Theo Mobach, Braden Gammon, Steven Papp, Jodi Warman-Chardon,

[This corrects the article DOI: 10.1371/journal.pone.0231502.]. ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243490]

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Trigeminal-Abducens Pseudosynkinesis: Distinguishing Unconscious Motor Habits From True Synkinesis.

Pierre R Bourque, David A Grimes, Daniel A Lelli,

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2020, :]

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Advances in the diagnosis of inherited neuromuscular diseases and implications for therapy development.

Rachel Thompson, Sally Spendiff, Andreas Roos, Pierre R Bourque, Jodi Warman Chardon, Janbernd Kirschner, Rita Horvath, Hanns Lochmüller,

Advances in DNA sequencing technologies have resulted in a near doubling, in under 10 years, of the number of causal genes identified for inherited neuromuscular disorders. However, around half of patients, whether children or adults, do not receive a molecular diagnosis after initial diagnostic workup. Massively parallel technologies targeting RNA, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(6):522-532]

Cited: 5 times

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Systematic prospective electrophysiological studies of the median nerve after simple distal radius fracture.

Pierre R Bourque, John Brooks, Theo Mobach, Braden Gammon, Steven Papp, Jodi Warman-Chardon,

<b>Purpose: </b>To assess whether there is a measurable impairment of median nerve conduction study parameters with uncomplicated distal radius fracture.<br><br><b>Methods: </b>Patients were assessed prospectively at the time of cast removal (visit 1) after a standard 6-8 week immobilization for uncomplicated distal radius fracture. Patients with prior entrapment neuropathy or polyneuropathy ... Read more >>

PLoS One (PloS one)
[2020, 15(4):e0231502]

Cited: 0 times

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Edaravone for amyotrophic lateral sclerosis: barriers to access and lifeboat ethics.

Ari Breiner, Lorne Zinman, Pierre R Bourque,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(12):E319-E320]

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Spinal Capillary Hemangioma: A Rare Benign Extradural Tumor.

Naomi Niznick, Thanh Binh Nguyen, Pierre R Bourque,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(4):549-550]

Cited: 0 times

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Distal Cervical Spondylotic Amyotrophy: Case Reports Demonstrating Clinical/Imaging Segmental Discrepancy.

Pierre R Bourque, Theo Mobach, Jodi Warman-Chardon, Ari Breiner,

Monomelic pure motor amyotrophy may seem to be an ominous syndrome as it leads to consideration of motor neuron disease. We present a series of 3 very similar cases where unilateral pure distal lower motor neuron paresis and atrophy was limited to the C8-T1 myotomes, without long-tract signs. Electrodiagnostic studies ... Read more >>

J Clin Neuromuscul Dis (Journal of clinical neuromuscular disease)
[2019, 21(2):107-111]

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Myofibrillar Myopathy Mimicking Polyneuropathy.

Pierre R Bourque, Ari Breiner, Jodi Warman-Chardon,

A 76-year-old man with a 5-year history of gait difficulties was suspected to have length-dependent sensorimotor polyneuropathy. Electrodiagnostic results pointed to a foot drop of neurogenic etiology, except for the prominence of myotonic discharges on needle EMG. Tests for acquired and genetic causes of polyneuropathy were unrevealing. The patient's first-degree ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2020, 12(1):97-102]

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Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review.

Pierre R Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan, Carlos Torres,

BACKGROUND:Neurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is the presenting focal manifestation of occult lymphoma. CASE PRESENTATION:We present 3 examples of invasion of the lumbosacral plexus ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):1149]

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Cerebrospinal fluid total protein in Guillain-Barré syndrome variants: correlations with clinical category, severity, and electrophysiology.

Pierre R Bourque, J Brooks, J Warman-Chardon, A Breiner,

The discriminative value of CSF total protein (CSF-TP) in subtypes of Guillain-Barré syndrome has not been well documented in North-American patients. We reviewed 173 cases from a single institution, comprising the following clinical categories of neuropathy: 134 Sensorimotor (SM) GBS, 13 Motor (M) GBS, 8 Localized (L) GBS, and 18 ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(3):746-751]

Cited: 2 times

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Impact of disuse muscular atrophy on the compound muscle action potential.

Theo Mobach, John Brooks, Ari Breiner, Jodi Warman-Chardon, Steven Papp, Braden Gammon, Sanjeev D Nandedkar, Pierre R Bourque,

<h4>Background</h4>Disuse atrophy from immobilization is the result of decreased neural activity and muscle unloading.<h4>Methods</h4>We studied the impact of disuse on hand intrinsic compound muscle action potentials (CMAPs) in a cohort of 39 patients with unilateral 6-week immobilization of the hand in a cast, after distal radius fracture. We excluded patients ... Read more >>

Muscle Nerve (Muscle & nerve)
[2020, 61(1):58-62]

Cited: 0 times

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Intermittent undulating tongue as an involuntary movement in early amyotrophic lateral sclerosis.

Ari Breiner, Ahmed Basndwah, Jodi Warman-Chardon, Pierre R Bourque, Tiago A Mestre,

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2019, 67:1-2]

Cited: 0 times

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Cerebrospinal Fluid in Posterior Reversible Encephalopathy Syndrome.

Pierre R Bourque, Ari Breiner,

Neurohospitalist (The Neurohospitalist)
[2019, 9(3):125]

Cited: 0 times

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Age matters: Impact of data-driven CSF protein upper reference limits in Guillain-Barré syndrome.

Pierre R Bourque, John Brooks, Christopher R McCudden, Jodi Warman-Chardon, Ari Breiner,

<h4>Objective</h4>We conducted a retrospective review of patients with a diagnosis of Guillain-Barré syndrome (GBS) to assess the diagnostic impact of applying age-adjusted upper limits for CSF total protein (CSF-TP) supported by a systematic literature review.<h4>Methods</h4>Cases coded as GBS or inflammatory neuropathy for the period 2001-2016 at The Ottawa Hospital were ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(4):e576]

Cited: 2 times

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Updated cerebrospinal fluid total protein reference values improve chronic inflammatory demyelinating polyneuropathy diagnosis.

Ari Breiner, Pierre R Bourque, Jeffrey A Allen,

<h4>Introduction</h4>Recent literature has concluded that cerebrospinal fluid total protein (CSF-TP) upper reference limits (URL) should be higher than 45 mg/dl and stratified by age.<h4>Methods</h4>Data-driven URLs were applied to the analysis of a cohort of patients with correctly and incorrectly diagnosed chronic inflammatory demyelinating polyneuropathy (CIDP). Descriptive statistics were calculated, and ... Read more >>

Muscle Nerve (Muscle & nerve)
[2019, 60(2):180-183]

Cited: 3 times

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A Survey of Cerebrospinal Fluid Total Protein Upper Limits in Canada: Time for an Update?

Pierre R Bourque, Christopher R McCudden, Jodi Warman-Chardon, John Brooks, Harald Hegen, Florian Deisenhammer, Ari Breiner,

BACKGROUND:The antiquated standard reference range of 0.15-0.45 g/L for cerebrospinal fluid total protein (CSF-TP) is well entrenched in medical literature and laboratory operating procedures across the world. METHODS:We conducted a web-based survey with a response rate of 34.9% through the listserv of the Canadian Neurological Sciences Federation. Additional laboratory reference ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2019, 46(3):283-286]

Cited: 0 times

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Causes of albuminocytological dissociation and the impact of age-adjusted cerebrospinal fluid protein reference intervals: a retrospective chart review of 2627 samples collected at tertiary care centre.

John Alexander Brooks, Christopher McCudden, Ari Breiner, Pierre R Bourque,

<h4>Objective</h4>We set out to test the discriminative power of an age-adjusted upper reference limit for cerebrospinal fluid total protein (CSF-TP) in identifying clinically relevant causes of albuminocytological dissociation (ACD).<h4>Methods</h4>We reviewed the charts of 2627 patients who underwent a lumbar puncture at a tertiary care centre over a 20-year period. Samples ... Read more >>

BMJ Open (BMJ open)
[2019, 9(2):e025348]

Cited: 1 time

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Dataset for worldwide survey of cerebrospinal total protein upper reference values.

Pierre R Bourque, John Brooks, Jodi Warman-Chardon, Harald Hegen, Florian Deisenhammer, Chris R McCudden, Ari Breiner,

This article reports data pertaining to a worldwide web-based survey referenced in the publication "Adult CSF Total Protein: Higher upper reference limits should be considered worldwide " (P.R. Bourque, et al., 2019). This survey was distributed to corresponding authors of the journal Neurology and the Journal of neurological sciences for ... Read more >>

Data Brief (Data in brief)
[2019, 23:103760]

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Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45 g/L: a systematic review.

Ari Breiner, David Moher, John Brooks, Wei Cheng, Harald Hegen, Florian Deisenhammer, Christopher R McCudden, Pierre R Bourque,

<h4>Background</h4>Cerebrospinal fluid total protein (CSF-TP) is measured in the diagnosis of a range of immune or infectious disorders of the nervous system. Most laboratories and the medical literature use an antiquated, age-independent upper limit of 0.45 g/L. Therefore, we performed a systematic review of reference studies in the medical literature, with ... Read more >>

J Neurol (Journal of neurology)
[2019, 266(3):616-624]

Cited: 6 times

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Paraneoplastic recurrent tumefactive demyelination in a 62-year-old man with metastatic seminoma.

Simon Thebault, Ilana Hanes, John Woulfe, Pierre R Bourque,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(1):e527]

Cited: 1 time

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Pulmonary Function Testing in Elderly Patients Treated for a Myasthenia Gravis Exacerbation.

Stephen C van Gaal, Shane W English, Pierre R J Bourque, Jocelyn C Zwicker,

Background and Purpose:Pulmonary function testing is a standard part of care for patients admitted to hospital with a myasthenia gravis exacerbation. It may inform clinicians' decisions to intubate patients. It is known that pulmonary function declines with age in healthy adults. We studied the effect of age on pulmonary function ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2019, 9(2):79-84]

Cited: 0 times

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Adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey.

Pierre R Bourque, Ari Breiner, David Moher, John Brooks, Harald Hegen, Florian Deisenhammer, Christopher R McCudden,

<h4>Background</h4>The cerebrospinal fluid total protein level (CSF-TP) is commonly used as a potential marker of infectious or immune disease of the CNS and PNS. Recent laboratory reference studies indicate that the antiquated single upper reference limit of 0.45 g/L commonly used by hospital laboratories and widely quoted in medical literature is ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2019, 396:48-51]

Cited: 7 times

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