Full Text Journal Articles by
Author Pierre Jean Lamy

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Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.

Pierre-Jean Lamy, Paul van der Leest, Nicolas Lozano, Catherine Becht, Frédérique Duboeuf, Harry J M Groen, Werner Hilgers, Nicolas Pourel, Naomi Rifaela, Ed Schuuring, Catherine Alix-Panabières,

Plasma-based tumor mutational profiling is arising as a reliable approach to detect primary and therapy-induced resistance mutations required for accurate treatment decision making. Here, we compared the FDA-approved Cobas® EGFR Mutation Test v2 with the UltraSEEK™ Lung Panel on the MassARRAY® System on detection of EGFR mutations, accompanied with preanalytical ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Body mass index trajectories and prostate cancer risk: Results from the EPICAP study.

Céline Lavalette, Emilie Cordina Duverger, Fanny Artaud, Xavier Rébillard, Pierre-Jean Lamy, Brigitte Trétarre, Sylvie Cénée, Florence Menegaux,

Elevated body mass index (BMI) has been inconsistently associated with prostate cancer occurrence but it has been suggested that life course adulthood obesity may be associated with an increased risk of prostate cancer. However, few studies have investigated lifetime BMI and prostate cancer risk. We analyzed life course BMI trajectories ... Read more >>

Cancer Med (Cancer medicine)
[2020, :]

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Circadian genes polymorphisms, night work and prostate cancer risk: Findings from the EPICAP study.

Méyomo G Wendeu-Foyet, Sylvie Cénée, Yves Koudou, Brigitte Trétarre, Xavier Rébillard, Géraldine Cancel-Tassin, Olivier Cussenot, Anne Boland, Robert Olaso, Jean-François Deleuze, Hélène Blanché, Pierre-Jean Lamy, Claire Mulot, Pierre Laurent-Puig, Thérèse Truong, Florence Menegaux,

Over the past two decades, several studies have attempted to understand the hypothesis that disrupting the circadian rhythm may promote the development of cancer. Some have suggested that night work and some circadian genes polymorphisms are associated with cancer, including prostate cancer. Our study aims to test the hypothesis that ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 147(11):3119-3129]

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Androgenic hormones and the excess male mortality observed in COVID-19 patients: new convergent data.

Pierre-Jean Lamy, Xavier Rébillard, Francis Vacherot, Alexandre de la Taille,

World J Urol (World journal of urology)
[2020, :]

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BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer.

William Jacot, Evelyne Lopez-Crapez, Caroline Mollevi, Florence Boissière-Michot, Joelle Simony-Lafontaine, Alexandre Ho-Pun-Cheung, Elodie Chartron, Charles Theillet, Antoinette Lemoine, Raphael Saffroy, Pierre-Jean Lamy, Séverine Guiu,

The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylation status (by methylation-specific polymerase chain reaction (MS-PCR) and MassARRAY® assays), ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(4):]

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Development of molecular analysis by digital PCR for clinical practice: positioning, current applications and perspectives.

Jérôme Alexandre Denis, Alexandre Perrier, Juliette Nectoux, Pierre-Jean Lamy, Anne-Sophie Alary, Nasrin Sarafan-Vasseur, Daniel Henaff, Benoit Busser, Romain Appay, Pascal Pedini, Pauline Romanet, Valerie Taly, Frederic Fina,

This review is the second part of the workshop on digital PCR (dPCR) proposed by the working group of the French society of clinical biology. The first part of the paper discusses the advantages and limitations of dPCR for the search of different molecular abnormalities such as point mutations, copy ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2019, 77(6):619-637]

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PIK3CA mutations early persistence in cell-free tumor DNA as a negative prognostic factor in metastatic breast cancer patients treated with hormonal therapy.

William Jacot, Florence Dalenc, Evelyne Lopez-Crapez, Leonor Chaltiel, Anna Durigova, Nathalie Gros, Nicolas Lozano, Jean-Louis Lacaze, Stéphane Pouderoux, Laurence Gladieff, Gilles Romieu, Henri Roché, Thomas Filleron, Pierre-Jean Lamy,

PURPOSE:The identification of biomarkers of hormonal therapy (HT) failure would allow tailored monitoring in metastatic breast cancer (mBC) patients. PIK3CA gene mutation is one of the most frequent events in mBC and is associated with HT resistance. We evaluated the early prognostic value of cell-free DNA (cfDNA) PIK3CA detection in ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2019, 177(3):659-667]

Cited: 2 times

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Circadian genes and risk of prostate cancer: Findings from the EPICAP study.

Méyomo G Wendeu-Foyet, Yves Koudou, Sylvie Cénée, Brigitte Trétarre, Xavier Rébillard, Géraldine Cancel-Tassin, Olivier Cussenot, Anne Boland, Delphine Bacq, Jean-François Deleuze, Pierre-Jean Lamy, Claire Mulot, Pierre Laurent-Puig, Thérèse Truong, Florence Menegaux,

Circadian rhythms regulate several physiological functions and genes controlling the circadian rhythm were found to regulate cell proliferation, cell cycle and apoptosis. Few studies have investigated the role of those circadian genes in prostate cancer occurrence. We aim to investigate the relationship between circadian genes polymorphisms and prostate cancer risk ... Read more >>

Int. J. Cancer (International journal of cancer)
[2019, 145(7):1745-1753]

Cited: 2 times

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Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes.

Alexandra Soler, Laure Cayrefourcq, Thibault Mazard, Anna Babayan, Pierre-Jean Lamy, Said Assou, Eric Assenat, Klaus Pantel, Catherine Alix-Panabières,

Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment efficacy. However, CTC investigation is hampered by their low number, making the establishment of permanent CTC lines very challenging. We derived and characterized nine CTC lines using blood samples from a patient with metastatic colorectal cancer collected before ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):15931]

Cited: 6 times

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Relevance of total PSA and free PSA prescriptions.

Pierre-Jean Lamy, Jean-Paul Brouillet, Laurent Bermont, Guy Fouillet, Sylvain Loric,

The total PSA testing has been frequently criticized for its effectiveness in the early detection of prostate cancer. These widely resumed in and out of the medical community have led to a decrease in prescriptions. Recommendations against the use of PSA for screening have been issued in France and in ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2018, 76(6):659-663]

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Abdominal obesity and prostate cancer risk: epidemiological evidence from the EPICAP study.

Céline Lavalette, Brigitte Trétarre, Xavier Rebillard, Pierre-Jean Lamy, Sylvie Cénée, Florence Menegaux,

Obesity is associated with an increased risk of several cancers, but inconsistent results have been observed between body mass index (BMI) and prostate cancer (PCa) risk. However, some associations have been reported with other indicators such as waist circumference (WC) and waist-hip ratio (WHR). We investigated the role of anthropometric ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(77):34485-34494]

Cited: 2 times

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Development of digital PCR molecular tests for clinical practice: principles, practical implementation and recommendations.

Jérôme Alexandre Denis, Juliette Nectoux, Pierre-Jean Lamy, Christelle Rouillac Le Sciellour, Hélène Guermouche, Anne-Sophie Alary, Olivier Kosmider, Nasrin Sarafan-Vasseur, Cécile Jovelet, Benoit Busser, Philippe Nizard, Valérie Taly, Frédéric Fina,

Digital PCR (dPCR) is a 3rd generation technology that complements traditional end-point PCR and real-time PCR. It was developed to overcome certain limitations of conventional amplification techniques, in particular for the detection of small amounts of nucleic acids and/or rare variants. This technology is in a full swing because of ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2018, 76(5):505-523]

Cited: 1 time

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Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study.

Marie Viala, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L Mott, Mary C Schroeder, Alexandra Thomas, William Jacot,

BACKGROUND:There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associated with not attaining a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for operable breast cancer. We report the impact ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):770]

Cited: 1 time

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Night work and prostate cancer risk: results from the EPICAP Study.

Méyomo Gaelle Wendeu-Foyet, Virginie Bayon, Sylvie Cénée, Brigitte Trétarre, Xavier Rébillard, Géraldine Cancel-Tassin, Olivier Cussenot, Pierre-Jean Lamy, Brice Faraut, Soumaya Ben Khedher, Damien Léger, Florence Menegaux,

OBJECTIVE:To investigate the role of night work in prostate cancer based on data from the EPICAP Study. METHODS:EPICAP is a French population-based case-control study including 818 incident prostate cancer cases and 875 frequency-matched controls that have been interviewed face to face on several potential risk factors including lifetime occupational history. ... Read more >>

Occup Environ Med (Occupational and environmental medicine)
[2018, 75(8):573-581]

Cited: 6 times

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First French Pilot Quality Assessment of the EndoPredict Test for Early Luminal Breast Carcinoma.

Jacqueline Lehmann-Che, Catherine Miquel, Jennifer Wong, Celine Callens, Etienne Rouleau, Veronique Quillien, Nicolas Lozano, Anne Cayre, Ludovic Lacroix, Ivan Bieche, Philippe Bertheau, Luis Teixeira, Frederique Penault Llorca, Pierre Jean Lamy, Patricia DE Cremoux, ,

Genomic signatures are needed for the determination of prognosis in patients with early stage, estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers. EndoPredict test is a RNA-based multigene assay that assesses the risk of 10-year relapse in this context. Quality assessment is a mandatory requirement for ... Read more >>

Anticancer Res. (Anticancer research)
[2018, 38(5):2909-2914]

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Prostatitis, other genitourinary infections and prostate cancer risk: Influence of non-steroidal anti-inflammatory drugs? Results from the EPICAP study.

Solène Doat, Miguelle Marous, Xavier Rebillard, Brigitte Trétarre, Pierre-Jean Lamy, Paolo Soares, Olivier Delbos, Rodolphe Thuret, Bruno Segui, Sylvie Cénée, Florence Menegaux,

Epidemiological studies have suggested that prostatitis may increase the risk of prostate cancer due to chronic inflammation. We studied the association between several genitourinary infections and the risk of prostate cancer based on data from the EPICAP study. EPICAP is a population-based case-control study conducted in the département of Hérault, ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 143(7):1644-1651]

Cited: 1 time

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Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers.

Séverine Guiu, Caroline Mollevi, Céline Charon-Barra, Florence Boissière, Evelyne Crapez, Elodie Chartron, Pierre-Jean Lamy, Marian Gutowski, Céline Bourgier, Gilles Romieu, Joelle Simony-Lafontaine, William Jacot,

BACKGROUND:In luminal androgen receptor (AR) tumours, FOXA1 may direct AR to sites occupied by ER in luminal tumours, thus stimulating proliferation. METHODS:AR and FOXA1 expression were evaluated by immunohistochemistry in 333 non-metastatic triple-negative breast cancers (TNBC). Positivity threshold was set at ≥ 1% staining. Lymphocytic infiltration, PD-L1expression, PIK3CA mutations, PTEN defects and ... Read more >>

Br. J. Cancer (British journal of cancer)
[2018, 119(1):76-79]

Cited: 10 times

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Family history of breast cancer increases the risk of prostate cancer: results from the EPICAP study.

Pierre-Jean Lamy, Brigitte Trétarre, Xavier Rebillard, Marie Sanchez, Sylvie Cénée, Florence Ménégaux,

Familial aggregation is now well established with an increased risk of prostate cancer in patients with a family history of prostate cancer in first degree relatives. The aim of this paper was to investigate the role of family history of cancer in first degree relatives in prostate cancer risk.As expected, ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(34):23661-23669]

Cited: 1 time

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Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

Akiko Chiba, Rachna Raman, Alexandra Thomas, Pierre-Jean Lamy, Marie Viala, Stephane Pouderoux, Sarah L Mott, Mary C Schroeder, Simon Thezenas, William Jacot,

INTRODUCTION:There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D levels during neoadjuvant chemotherapy (NAC) on the rates of achieving pathologic complete response (pCR) after ... Read more >>

Clin. Breast Cancer (Clinical breast cancer)
[2018, 18(2):144-149]

Cited: 3 times

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[Rates of total and free PSA prescriptions in France (2012-2014)].

Philippe Tuppin, Claire Leboucher, Gabrielle Peyre-Lanquar, Pierre-Jean Lamy, Pierre Gabach, Xavier Rébillard,

In 2010, the French Haute Autorité de santé (National Health Authority) confirmed the limited value of prostate cancer (PCa) screening by total prostate-specific antigen (PSA) assay.This study was designed to determine the modalities of ordering total PSA or free PSA assays (in the absence of PCa) according to various parameters ... Read more >>

Presse Med (Presse medicale (Paris, France : 1983))
[2017, 46(10):e237-e247]

Cited: 1 time

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Nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk: results from the EPICAP study.

Solene Doat, Sylvie Cénée, Brigitte Trétarre, Xavier Rebillard, Pierre-Jean Lamy, Jean-Pierre Bringer, François Iborra, Thibaut Murez, Marie Sanchez, Florence Menegaux,

Chronic inflammation may play a role in prostate cancer carcinogenesis. In that context, our objective was to investigate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in prostate cancer risk based on the EPICAP data. EPICAP is a population-based case-control study carried out in 2012-2013 (département of Hérault, France) that enrolled ... Read more >>

Cancer Med (Cancer medicine)
[2017, 6(10):2461-2470]

Cited: 8 times

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Prognostic impact of the inclusion of uPA/PAI-1 for adjuvant treatment decision-making in ER+/Her2- pN0 early breast cancers.

Marie Viala, Marie Alexandre, Simon Thezenas, Pierre-Jean Lamy, Aurélie Maran-Gonzalez, Marian Gutowski, Pierre-Emmanuel Colombo, Gilles Romieu, William Jacot, Severine Guiu,

Intermediate-risk early breast cancer (EBC) is a heterogeneous group in which adjuvant chemotherapy decision proves to be difficult. Clinical and pathological criteria are sometimes insufficient to determine the best therapeutic options, and validated biomarkers such as uPA/PAI-1, are needed to contribute to the decision-making. The objective of this study was ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2017, 165(3):611-621]

Cited: 4 times

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Prognostic Biomarkers Used for Localised Prostate Cancer Management: A Systematic Review.

Pierre-Jean Lamy, Yves Allory, Anne-Sophie Gauchez, Bernard Asselain, Philippe Beuzeboc, Patricia de Cremoux, Jacqueline Fontugne, Agnès Georges, Christophe Hennequin, Jacqueline Lehmann-Che, Christophe Massard, Ingrid Millet, Thibaut Murez, Marie-Hélène Schlageter, Olivier Rouvière, Diana Kassab-Chahmi, François Rozet, Jean-Luc Descotes, Xavier Rébillard,

CONTEXT:Prostate cancer stratification is based on tumour size, pretreatment PSA level, and Gleason score, but it remains imperfect. Current research focuses on the discovery and validation of novel prognostic biomarkers to improve the identification of patients at risk of aggressive cancer or of tumour relapse. OBJECTIVE:This systematic review by the ... Read more >>

Eur Urol Focus (European urology focus)
[2018, 4(6):790-803]

Cited: 10 times

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Radioactive iodine therapy, molecular imaging and serum biomarkers for differentiated thyroid cancer: 2017 guidelines of the French Societies of Nuclear Medicine, Endocrinology, Pathology, Biology, Endocrine Surgery and Head and Neck Surgery.

Slimane Zerdoud, Anne-Laure Giraudet, Sophie Leboulleux, Laurence Leenhardt, Stéphane Bardet, Jérôme Clerc, Marie-Elisabeth Toubert, Abir Al Ghuzlan, Pierre-Jean Lamy, Claire Bournaud, Isabelle Keller, Frédéric Sebag, Renaud Garrel, Eric Mirallié, Lionel Groussin, Elif Hindié, David Taïeb,

Ann. Endocrinol. (Paris) (Annales d'endocrinologie)
[2017, 78(3):162-175]

Cited: 4 times

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Added value of hepcidin quantification for the diagnosis and follow-up of anemia-related diseases.

Thibaud Lefebvre, Sigismond Lasocki, Martine Fénéant-Thibault, Pierre-Jean Lamy, Séverine Cunat, Madeleine Ropert-Bouchet, Patricia Aguilar-Martinez, Sylvain Lehmann, Constance Delaby,

Iron homeostasis is based on a strict control of both intestinal iron absorption and iron recycling through reticulo-endothelial system. Hepcidin controls the iron fluxes in order to maintain sufficient iron levels for erythropoietic activities, hemoproteins synthesis or enzymes function, but also to limit its toxic accumulation throughout the body. Hepcidin ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2017, 75(1):9-18]

Cited: 2 times

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