Full Text Journal Articles by
Author Pierre I Karakiewicz

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External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients.

Christoph Würnschimmel, Mike Wenzel, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Fred Saad, Alberto Briganti, Shahrokh F Shariat, Nazareno Suardi, Carlo Terrone, Michele Gallucci, Felix Kh Chun, Derya Tilki, Markus Graefen, Pierre I Karakiewicz,

<h4>Objectives</h4>To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients.<h4>Methods</h4>In the Surveillance, Epidemiology and End Results database 2004-2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Clinical Outcomes and Adverse Events after First-Line Treatment in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis.

Luigi Nocera, Pierre I Karakiewicz, Mike Wenzel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Felix K H Chun, Alberto Briganti, Anil Kapoor, Aly-Khan Lalani,

<h4>Background</h4>Four recent first-line clinical trials leveraging immune-oncology agents demonstrated an overall survival (OS) benefit relative to sunitinib. We aimed to provide formal comparisons among immune-oncology combinations in term of OS, progression-free survival (PFS), objective response rates (ORR) and treatment-related adverse events (AEs).<h4>Methods</h4>Pubmed database was searched for studies indexed from January ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002252]

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Increased risk of postoperative in-hospital complications after radical prostatectomy in patients with prior organ transplant.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Severiné Banek, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>To analyze postoperative, in-hospital, complication rates in patients with organ transplantation before radical prostatectomy (RP).<h4>Methods</h4>From National Inpatient Sample (NIS) database (2000-2015) prostate cancer patients treated with RP were abstracted and stratified according to prior organ transplant versus nontransplant. Multivariable logistic regression models predicted in-hospital complications.<h4>Results</h4>Of all eligible 202,419 RP patients, ... Read more >>

Prostate (The Prostate)
[2021, :]

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Improvement in overall and cancer-specific survival in contemporary, metastatic prostate cancer chemotherapy exposed patients.

Benedikt Hoeh, Christoph Würnschimmel, Rocco S Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F Shariat, Derya Tilki, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Introduction</h4>Over the last decade, multiple clinical trials demonstrated improved survival after chemotherapy for metastatic prostate cancer (mPCa). However, real-world data validating this effect within large-scale epidemiological data sets are scarce. We addressed this void.<h4>Materials and methods</h4>Men with de novo mPCa were identified and systemic chemotherapy status was ascertained within the ... Read more >>

Prostate (The Prostate)
[2021, :]

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Stage and cancer-specific mortality differ within specific Asian ethnic groups for upper tract urothelial carcinoma: North American population-based study.

Claudia Collà Ruvolo, Christoph Würnschimmel, Luigi Nocera, Mike Wenzel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Paolo Verze, Ciro Imbimbo, Alberto Briganti, Vincenzo Mirone, Pierre I Karakiewicz,

<h4>Objectives</h4>To examine the effect of specific Asian ethnic subgroups on stage at presentation and cancer-specific mortality in non-metastatic upper tract urothelial carcinoma among North American upper tract urothelial carcinoma Asian patients treated with radical nephroureterectomy.<h4>Methods</h4>We relied on the Surveillance, Epidemiology and End Results database, from 2004 to 2016. Kaplan-Meier plots ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

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Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma.

Mike Wenzel, Nicolas Siron, Claudia Collà Ruvolo, Luigi Nocera, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Severine Banek, Luis A Kluth, Frederik C Roos, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>To compare Cancer-specific mortality (CSM) in patients with Squamous cell carcinoma (SCC) vs. non-SCC penile cancer, since survival outcomes may differ between histological subtypes.<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results database (2004-2016), penile cancer patients of all stages were identified. Temporal trend analyses, cumulative incidence and Kaplan-Meier plots, multivariable Cox ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2021, :]

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Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis.

Reza Sari Motlagh, Mohammad Abufaraj, Pierre I Karakiewicz, Pawel Rajwa, Keiichiro Mori, Dong-Ho Mun, Shahrokh F Shariat,

<h4>Purpose</h4>Androgen-regulated enzymes such as the angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are involved in the SARS-CoV-2 infection process. The expression of TMPRSS2 and its fusion gene, which are increased in the epithelium of the human prostate gland during prostate carcinogenesis, are regulated by androgens. Our ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Correction: Clinical impact of whole-body 68Ga-PSMA I&T PET/CT: lesion frequency and added benefit in lower extremities.

Lara Franziska Stolzenbach, Florian Löcherbach, Katharina Wargenau, Randi Pose, Thomas Steuber, Zhe Tian, Lars Budäus, Derya Tilki, Markus Graefen, Daniel Köhler, Pierre I Karakiewicz, Markus Sauer, Ivayla Ilieva Apostolova, Tobias Maurer, Christoph Berliner,

Nuklearmedizin (Nuklearmedizin. Nuclear medicine)
[2021, :]

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Feasibility and outcome of radical prostatectomy following inductive neoadjuvant therapy in patients with suspicion of rectal infiltration.

Benedikt Hoeh, Felix Preisser, Mike Wenzel, Clara Humke, Clarissa Wittler, Jens Köllermann, Boris Bodelle, Simon Bernatz, Thomas Steuber, Derya Tilki, Markus Graefen, Pierre I Karakiewicz, Andreas Becker, Luis A Kluth, Felix K H Chun, Philipp Mandel,

<h4>Objective</h4>To determine the feasibility and outcome of radical prostatectomy (RP) following neoadjuvant therapy (NAT) in patients with initial inoperable, rectum-infiltrating cT4 prostate cancer (PCa).<h4>Methods</h4>From 01/2018 to 12/2020, 26 patients with clinical (DRE) or radiographical (mpMRI) suspicion of rectum infiltrating PCa at diagnosis and NAT prior to RP were retrospectively identified ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Clinical impact of whole-body 68Ga-PSMA I&T PET/CT: lesion frequency and added benefit in lower extremities.

Lara Franziska Stolzenbach, Florian Löcherbach, Katharina Wargenau, Randi Pose, Thomas Steuber, Zhe Tian, Lars Budäus, Derya Tilki, Markus Graefen, Daniel Köhler, Pierre I Karakiewicz, Markus Sauer, Ivayla Ilieva Apostolova, Tobias Maurer, Christoph Berliner,

<h4>Aim</h4>Few small-scaled studies performed systematic analysis of the benefits of extending prostate specific membrane antigen positron-emission tomography/ computed tomography (68Ga-PSMA I&T PET/CT) to the lower extremities in prostate cancer (PCa) patients. We hypothesized that 68Ga-PSMA I&T PET/CT positive lesions are rare in lower extremities of prostate cancer (PCa) patients, the ... Read more >>

Nuklearmedizin (Nuklearmedizin. Nuclear medicine)
[2021, :]

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The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Fred Saad, Shahrokh F Shariat, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to less favorable prostate cancer characteristics in intermediate risk prostate cancer (IR PCa) patients. We tested this hypothesis in a subgroup of IR PCa patients treated with radical prostatectomy (RP).<h4>Methods</h4>We relied on the Surveillance, Epidemiology and End Results 2004-2016. The effect of race/ethnicity was tested in univariable ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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The Value of Preoperative Plasma VEGF Levels in Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy.

Keiichiro Mori, Victor M Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Pawel Rajwa, Frederik König, Abdulmajeed Aydh, Francesco Soria, Marco Moschini, Pierre I Karakiewicz, Yair Lotan, Douglas Scherr, Martin Haydter, Peter Nyirady, Jeremy Y C Teoh, Shin Egawa, Eva Compérat, Shahrokh F Shariat,

<h4>Background</h4>Elevated preoperative plasma levels of the angiogenesis-related marker VEGF have been associated with worse oncological outcomes in various malignancies.<h4>Objective</h4>To investigate the predictive/prognostic role of VEGF in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Design, setting, and participants</h4>VEGF plasma levels were measured preoperatively in 1036 patients ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Median time to progression with TKI-based therapy after failure of immuno-oncology therapy in metastatic kidney cancer: A systematic review and meta-analysis.

Mike Wenzel, Marina Deuker, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Andreas Becker, Frederik C Roos, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The efficacy of tyrosine kinase inhibitor (TKI)-based therapy after previous immuno-oncology therapy (IO) failure has been addressed before. However, summary efficacy estimates have never been generated in these reports. We addressed this void.<h4>Material and methods</h4>We systematically examined TKI efficacy after IO-failure and generated weighted median progression-free survival (PFS) estimates for ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 155:245-255]

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Catheterization Does Not Improve Course of Disease in Female Patients with Acute Cystitis or Pyelonephritis: Retrospective Analysis of >300 In-Hospital Treated Patients.

Mike Wenzel, Benedikt Hoeh, Konstatin Goeldner, Felix Preisser, Christoph Würnschimmel, Andreas Becker, Philipp Mandel, Pierre I Karakiewicz, Felix K-H Chun, Luis A Kluth,

<h4>Purpose</h4>Females with in-hospital treatment for acute cystitis (AC) or pyelonephritis may benefit from catheterization at admission.<h4>Methods</h4>All female patients with AC or pyelonephritis requiring in-hospital treatment at University Hospital Frankfurt (2004-2019) were retrospectively analyzed. Logistic regression models were used to predict the catheter value.<h4>Results</h4>Of 310 female patients, 40% harbored AC versus ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-9]

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The effect of primary urological cancers on survival in men with secondary prostate cancer.

Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Frederik C Roos, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>To test the effect of urological primary cancers (bladder, kidney, testis, upper tract, penile, urethral) on overall mortality (OM) after secondary prostate cancer (PCa).<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results (SEER) database, patients with urological primary cancers and concomitant secondary PCa (diagnosed 2004-2016) were identified and were matched in 1:4 ... Read more >>

Prostate (The Prostate)
[2021, 81(15):1149-1158]

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Adjuvant therapy with tyrosine kinase inhibitors for localized and locally advanced renal cell carcinoma: an updated systematic review and meta-analysis.

Ekaterina Laukhtina, Fahad Quhal, Keiichiro Mori, Reza Sari Motlagh, Benjamin Pradere, Victor M Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico С Grossmann, Pawel Rajwa, Irene Resch, Dmitry Enikeev, Pierre I Karakiewicz, Shahrokh F Shariat, Manuela Schmidinger,

<h4>Purpose</h4>Tyrosine kinase inhibitors (TKIs) have been widely used in the management of patients with metastatic renal cell carcinoma (RCC). However, the use of systemic therapies in the adjuvant setting of localized and locally advanced RCC has shown conflicting results across the literature. Therefore, we aimed to conduct an updated systematic ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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PSMA PET predicts metastasis-free survival in the setting of salvage radiotherapy after radical prostatectomy.

Mike Wenzel, Rada Hussein, Tobias Maurer, Pierre I Karakiewicz, Derya Tilki, Markus Graefen, Christoph Würnschimmel,

<h4>Introduction</h4>To evaluate the impact of PSMA PET (prostate specific membrane antigen positron emission tomography) findings prior to salvage radiotherapy (SRT) in recurrent prostate cancer (PCa) after radical prostatectomy (RP) on metastasis-free survival (MFS).<h4>Patients and methods</h4>Between 01/2012 and 12/2018, 1,599 patients received SRT for biochemical recurrence after RP at our institution. ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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The impact of time to prostate specific antigen nadir on biochemical recurrence and mortality rates after radiation therapy for localized prostate cancer.

Mike Wenzel, Charles Dariane, Fred Saad, Pierre I Karakiewicz, Philipp Mandel, Felix K H Chun, Derya Tilki, Markus Graefen, Guila Delouya, Daniel Taussky, Christoph Würnschimmel,

<h4>Purpose</h4>To investigate the effect of time to prostate-specific antigen (PSA) nadir (TTN) after radiation therapy (RTx) for prostate cancer (PCa) on biochemical recurrence (BCR) and overall survival (OS) rates.<h4>Patients and methods</h4>We analyzed 2,506 patients treated with RTx (external beam radiotherapy, brachytherapy or combinations) between years 2000 and 2021. Kaplan Meier ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Regional differences in patient age and prostate cancer characteristics and rates of treatment modalities in favorable and unfavorable intermediate risk prostate cancer across United States SEER registries.

Mike Wenzel, Claudia Collà Ruvolo, Luigi Nocera, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Markus Graefen, Andreas Becker, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Intermediate risk (IR) prostate cancer (PCa) is a highly heterogeneous entity and can be distinguished into favorable and unfavorable IR PCa according to biopsy, PSA and cT-stage characteristics. These differences may translate into differences in treatment type.<h4>Methods</h4>We tested for differences in PCa tumor characteristics and differences in active treatment rates ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2021, 74:101994]

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Assessment of the optimal number of positive biopsy cores to discriminate between cancer-specific mortality in high-risk versus very high-risk prostate cancer patients.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Frederik C Roos, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Number of positive prostate biopsy cores represents a key determinant between high versus very high-risk prostate cancer (PCa). We performed a critical appraisal of the association between the number of positive prostate biopsy cores and CSM in high versus very high-risk PCa.<h4>Methods</h4>Within Surveillance, Epidemiology, and End Results database (2010-2016), 13,836 ... Read more >>

Prostate (The Prostate)
[2021, 81(14):1055-1063]

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The Efficacy and Safety of Relugolix Compared with Degarelix in Advanced Prostate Cancer Patients: A Network Meta-analysis of Randomized Trials.

Reza Sari Motlagh, Mohammad Abufaraj, Keiichiro Mori, Abdulmajeed Aydh, Pawel Rajwa, Satoshi Katayama, Nico C Grossmann, Ekaterina Laukhtina, Hadi Mostafai, Benjamin Pradere, Fahad Quhal, Pierre I Karakiewicz, Dmitry V Enikeev, Shahrokh F Shariat,

<h4>Context</h4>Degarelix is associated with high rates of injection site reaction. The US Food and Drug Administration approved relugolix, an oral gonadotropin-releasing hormone (GnRH) antagonist, for the treatment of advanced prostate cancer patients.<h4>Objective</h4>This systematic review and network meta-analysis aimed to compare the efficacy and safety of relugolix versus degarelix.<h4>Evidence acquisition</h4>A systematic ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Nomogram Predicting Downgrading in National Comprehensive Cancer Network High-risk Prostate Cancer Patients Treated with Radical Prostatectomy.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Rocco Simone Flammia, Zhe Tian, Shahrokh F Shariat, Michele Gallucci, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Andreas Becker, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Some high-risk prostate cancer (PCa) patients may show more favorable Gleason pattern at radical prostatectomy (RP) than at biopsy.<h4>Objective</h4>To test whether downgrading could be predicted accurately.<h4>Design, setting, and participants</h4>Within the Surveillance, Epidemiology and End Results database (2010-2016), 6690 National Comprehensive Cancer Network (NCCN) high-risk PCa patients were identified.<h4>Outcome measurements and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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The effect of race on stage at presentation and survival in upper tract urothelial carcinoma.

Claudia Collà Ruvolo, Mike Wenzel, Luigi Nocera, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Nicola Longo, Ciro Imbimbo, Alberto Briganti, Vincenzo Mirone, Pierre I Karakiewicz,

Background The effect of racial/ethnic group on survival in upper tract urothelial carcinoma (UTUC) is unknown. We tested this concept in non-metastatic UTUC patients treated with radical nephroureterectomy (RNU) and hypothesized that important differences may exist according to racial/ethnic groups. Material and Methods We relied on the Surveillance Epidemiology and ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Prognostic value of the preoperative albumin-globulin ratio in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy: results from a large multicenter international collaboration.

Noriyoshi Miura, Keiichiro Mori, Ekaterina Laukhtina, Victor M Schuettfort, Mohammad Abufaraj, Jeremy Y C Teoh, Stefano Luzzago, Franziska Stolzenbach, Marina Deuker, Pierre I Karakiewicz, Alberto Briganti, Dmitry V Enikeev, Morgan Rouprêt, Vitaly Margulis, Piotr Chlosta, Peter Nyirady, Marek Babjuk, Shin Egawa, Takashi Saika, Shahrokh F Shariat,

<h4>Objective</h4>To assess the value of preoperative albumin to globulin ratio for predicting pathologic and oncological outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy in a large multi-institutional cohort.<h4>Materials and methods</h4>Preoperative albumin to globulin ratio was assessed in a multi-institutional cohort of 2492 patients. Logistic regression analyses ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(7):1149-1157]

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Increasing rates of NCCN high and very high-risk prostate cancer versus number of prostate biopsy cores.

Mike Wenzel, Christoph Würnschimmel, Claudia C Ruvolo, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Recently, an increase in the rates of high-risk prostate cancer (PCa) was reported. We tested whether the rates of and low, intermediate, high and very high-risk PCa changed over time. We also tested whether the number of prostate biopsy cores contributed to changes rates over time.<h4>Methods</h4>Within the Surveillance, Epidemiology and ... Read more >>

Prostate (The Prostate)
[2021, 81(12):874-881]

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