Full Text Journal Articles by
Author Phillip M Pierorazio

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Neoadjuvant Nivolumab in Patients with High-risk Nonmetastatic Renal Cell Carcinoma.

Michael A Gorin, Hiten D Patel, Steven P Rowe, Noah M Hahn, Hans J Hammers, Alice Pons, Bruce J Trock, Phillip M Pierorazio, Thomas R Nirschl, Daniela C Salles, Julie E Stein, Tamara L Lotan, Janis M Taube, Charles G Drake, Mohamad E Allaf,

Neoadjuvant immune checkpoint blockade represents a novel approach for potentially decreasing the risk of recurrence in patients with nonmetastatic renal cell carcinoma (RCC). In this early phase clincal tiral, we evaluated the safety and tolerability of neoadjuvant treatment with the programmed cell death protein 1 (PD-1) inhibitor nivolumab in patients ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Contemporary Prognostic Model for Renal Cell Carcinoma: Is it Time for Biomarkers?

Sunil H Patel, Nirmish Singla, Phillip M Pierorazio,

Eur Urol (European urology)
[2021, 80(1):32-33]

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Local and Regional Recurrences of Clinically Localized Renal Cell Carcinoma after Nephrectomy: A 15 Year Institutional Experience with Prognostic Features and Oncologic Outcomes.

Shagnik Ray, Joseph G Cheaib, Michael J Biles, Kevin G Pineault, Michael H Johnson, Yasser M A Ged, Mark C Markowski, Nirmish Singla, Mohamad E Allaf, Phillip M Pierorazio,

<h4>Objective</h4>To evaluate outcomes for patients with local recurrence (LR) of clinically localized renal cell carcinoma (RCC) without concurrent systemic metastasis from our institution, an event that occurs rarely (1%-3%) after surgery. LR may be a harbinger of poor outcomes, and the best management of these patients is unclear.<h4>Materials/methods</h4>We retrospectively reviewed ... Read more >>

Urology (Urology)
[2021, :]

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Testicular ultrasound underestimates the size of small testicular masses: a radiologic-pathologic correlation study.

Zeyad R Schwen, James L Liu, Andrew T Gabrielson, Hiten D Patel, Mohit Gupta, Steven P Rowe, Amin S Herati, Phillip M Pierorazio,

<h4>Purpose</h4>Increasing use and resolution of testicular ultrasound imaging has resulted in a greater diagnosis of non-palpable small testicular masses and subsequent over-treatment with orchiectomy. Our aim was to determine the diagnostic accuracy of testicular ultrasound to accurately determine the pathologic size of small testicular masses (SMTMs) and to evaluate the ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma.

Regina Kwon, Pedram Argani, Jonathan I Epstein, Kara A Lombardo, Xiaoming Wang, Phillip M Pierorazio, Rohit Mehra, Andres Matoso,

Our recent study of early-onset unclassified eosinophilic renal cell carcinoma (RCC) demonstrated that two third of cases could be reclassified by performing a limited number of immunohistochemistry stains. Following the same approach, we aimed to investigate what proportion of adult unclassified RCC could be reclassified. We identified 79 cases. The ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(4):450-462]

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Reply by Authors.

Meredith R Metcalf, Joseph G Cheaib, Michael J Biles, Hiten D Patel, Vanessa N Peña, Peter Chang, Andrew A Wagner, James M McKiernan, Phillip M Pierorazio,

J Urol (The Journal of urology)
[2021, 205(5):1293]

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Associations of preorchiectomy hormone levels to testicular germ cell tumor pathology, clinical stage, and size.

Kevin G Pineault, Joseph G Cheaib, Amin S Herati, Phillip M Pierorazio,

Asian J Androl (Asian journal of andrology)
[2021, 23(2):224-226]

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Assessing quality of care in the diagnosis and treatment of early-stage testicular cancer: A critical review and summary.

Mitchell M Huang, Joseph G Cheaib, Zhuo T Su, Michael J Biles, Ritu Sharma, Allen Zhang, Nirmish Singla, Eric B Bass, Phillip M Pierorazio,

<h4>Objective</h4>To review the current literature on quality of care in the diagnosis and management of early-stage testicular cancer.<h4>Methods</h4>PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for studies on quality of care in testicular cancer diagnosis and management from January 1980 to August 2018. Major overlapping themes ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(7):400-408]

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Outcomes of Active Surveillance for Young Patients with Small Renal Masses: Prospective Data from the DISSRM Registry.

Meredith R Metcalf, Joseph G Cheaib, Michael J Biles, Hiten D Patel, Vanessa N Peña, Peter Chang, Andrew A Wagner, James M McKiernan, Phillip M Pierorazio,

<h4>Purpose</h4>A paradigm shift in the management of small renal masses has increased utilization of active surveillance. However, questions remain regarding safety and durability in younger patients.<h4>Materials and methods</h4>Patients aged 60 or younger at diagnosis were identified from the Delayed Intervention and Surveillance for Small Renal Masses registry. The active surveillance, ... Read more >>

J Urol (The Journal of urology)
[2021, 205(5):1286-1293]

Cited: 2 times

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Clinical utility of the AJCC 8th edition pT1 subclassification and impact on practice patterns in stage I seminoma.

Rohit R Badia, Solomon Woldu, Hiten D Patel, Nirmish Singla, Arnav Srivastava, Joseph G Cheaib, Phillip M Pierorazio, Aditya Bagrodia,

<h4>Background</h4>The American Joint Committee on Cancer 8<sup>th</sup> edition staging guidelines for testicular cancer established a 3 cm cutoff to subclassify stage T1 seminomas (<3 cm = pT1a and ≥3 cm = pT1b). The efficacy of this cutoff in predicting metastatic disease and impact on treatment patterns have not been studied.<h4>Methods</h4>We retrospectively reviewed patients with ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(2):136.e19-136.e25]

Cited: 1 time

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Surgical ergonomics for urologists: a practical guide.

Andrew T Gabrielson, Marisa M Clifton, Christian P Pavlovich, Michael J Biles, Mitchell Huang, Jacqueline Agnew, Phillip M Pierorazio, Brian R Matlaga, Petar Bajic, Zeyad R Schwen,

Poor ergonomics in the operating room can have detrimental effects on a surgeon's physical, psychological and economic well-being. This problem is of particular importance to urologists who are trained in nearly all operative approaches (open, laparoscopic, robotic-assisted, microscopic and endoscopic surgery), each with their own ergonomic considerations. The vast majority ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2021, 18(3):160-169]

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Site of metastatic recurrence impacts prognosis in patients with high-grade upper tract urothelial carcinoma.

Joseph G Cheaib, Lauren E Claus, Hiten D Patel, Max R Kates, Andres Matoso, Noah M Hahn, Trinity J Bivalacqua, Jean H Hoffman-Censits, Phillip M Pierorazio,

<h4>Purpose</h4>Metastatic recurrence occurs in over 25% of upper tract urothelial carcinoma patients treated with radical nephroureterectomy. While metastatic recurrence suggests poor prognosis, the impact of the specific site of recurrence on prognosis is not well documented.<h4>Materials and methods</h4>We retrospectively analyzed 188 patients who underwent radical nephroureterectomy for high-grade, node-negative upper ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(1):74.e9-74.e16]

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Gender Differences in the Clinical Management of clinical T1a Renal Cell Carcinoma.

Meredith R Metcalf, Joseph G Cheaib, Julia Wainger, Vanessa N Peña, Hiten D Patel, Nirmish Singla, Phillip M Pierorazio,

<h4>Objective</h4>To evaluate gender differences in the management of clinical T1a (cT1a) renal cell carcinoma (RCC) before and after release of the AUA guidelines for management in 2009, which prioritized nephron-sparing approaches.<h4>Methods</h4>Patients aged ≥66 years diagnosed with cT1a RCC from 2004 to 2013 in Surveillance, Epidemiology, and End Results-Medicare were analyzed. ... Read more >>

Urology (Urology)
[2021, 151:129-137]

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Comparative Effectiveness of Surveillance, Primary Chemotherapy, Radiotherapy and Retroperitoneal Lymph Node Dissection for the Management of Early Stage Testicular Germ Cell Tumors: A Systematic Review.

Phillip M Pierorazio, Joseph G Cheaib, Hiten D Patel, Mohit Gupta, Ritu Sharma, Allen Zhang, Giorgia Tema, Eric B Bass,

<h4>Purpose</h4>Cancer specific survival for men with early stage (I to IIB) testicular germ cell tumors is greater than 90% with any management strategy. The data regarding the comparative effectiveness of surveillance, primary chemotherapy, radiotherapy and retroperitoneal lymph node dissection were synthesized with a focus on oncologic outcomes, patient reported outcomes, ... Read more >>

J Urol (The Journal of urology)
[2021, 205(2):370-382]

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A prospective comparative study of routine versus deferred pelvic drain placement after radical prostatectomy: impact on complications and opioid use.

Mitchell M Huang, Hiten D Patel, Zhuo T Su, Christian P Pavlovich, Alan W Partin, Phillip M Pierorazio, Mohamad E Allaf,

<h4>Purpose</h4>To evaluate the association of post-RP drain placement with post-operative complications and opioid use at a high-volume institution.<h4>Methods</h4>A prospective, comparative cohort study of patients undergoing robot-assisted or open RP was conducted. Patients for two surgeons did not routinely receive pelvic drains ("No Drain" arm), while the remainder routinely placed drains ... Read more >>

World J Urol (World journal of urology)
[2021, 39(6):1845-1851]

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Comparison of Perioperative and Pathologic Outcomes Between Single-port and Standard Robot-assisted Radical Prostatectomy: An Analysis of a High-volume Center and the Pooled World Experience.

Mitchell M Huang, Hiten D Patel, Julia J Wainger, Zhuo T Su, Russell E N Becker, Misop Han, Phillip M Pierorazio, Mohamad E Allaf,

<h4>Objective</h4>To perform an early comparative study of outcomes between single-port and robot-assisted laparoscopic radical prostatectomy (SP-RALRP) and standard RALRP at our institution and pooled analysis of series to date.<h4>Patients and methods</h4>Patients with organ-confined prostate cancer undergoing SP-RALRP at a high-volume institution were identified retrospectively along with reported SP-RALRP series to ... Read more >>

Urology (Urology)
[2021, 147:223-229]

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Active surveillance for small renal masses in elderly patients does not increase overall mortality rates compared to primary intervention: a propensity score weighted analysis.

Michele Marchioni, Joseph G Cheaib, Toshio Takagi, Nicola Pavan, Alessandro Antonelli, Wouter Everaerts, Matthias Heck, Koon H Rha, Alexandre Mottrie, Jihad Kaouk, Umberto Capitanio, Estevão Lima, Alessandro Veccia, Simone Crivellaro, Estefania Linares, Antonio Celia, Francesco Porpiglia, Riccardo Autorino, Marta Di Nicola, Luigi Schips, Phillip M Pierorazio, Maria Carmen Mir,

<h4>Background</h4>To test the effect of active surveillance (AS) versus primary intervention (PI) on overall mortality (OM) in elderly patients diagnosed with SRM.<h4>Methods</h4>Elderly patients (75 years or older) diagnosed with SRMs (< 4cm) and treated with either PI [i.e. partial nephrectomy or kidney ablation] or AS between 2009 and 2018 were ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, :]

Cited: 2 times

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Understanding Psychosocial and Sexual Health Concerns Among Women With Bladder Cancer Undergoing Radical Cystectomy.

Natasha Gupta, Sarah E Van Pilsum Rasmussen, Nora Haney, Armine Smith, Phillip M Pierorazio, Michael H Johnson, Jean Hoffman-Censits, Trinity J Bivalacqua,

<h4>Objective</h4>To better understand the physical and psychosocial components of female sexual dysfunction (FSD) among women undergoing radical cystectomy (RC) for bladder cancer (BCa).<h4>Methods</h4>We conducted semistructured individual interviews and a focus group with pre- and post-RC female patients and their partners regarding the impact of RC on sexual health and psychosocial ... Read more >>

Urology (Urology)
[2021, 151:145-153]

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A Comparative Analysis of Surgical Scar Cosmesis Based on Operative Approach for Radical Prostatectomy.

Mitchell M Huang, Zeyad R Schwen, Michael J Biles, Ridwan Alam, Andrew T Gabrielson, Hiten D Patel, Jeff Day, Phillip M Pierorazio, Christian P Pavlovich,

<b><i>Objective:</i></b> Recent developments in minimally invasive approaches to radical prostatectomy (RP) for localized prostate cancer have improved oncological outcomes, but may also affect surgical scar cosmesis, an important component of survivorship and patient quality of life. Our aim was to evaluate surgical scar appearance based on operative approach to RP ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(2):138-143]

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Advanced renal cell carcinoma and COVID-19 - a personal perspective.

Yasser Ged, Mark C Markowski, Phillip M Pierorazio,

Nat Rev Urol (Nature reviews. Urology)
[2020, 17(8):425-427]

Cited: 1 time

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Clinical Restaging and Tumor Sequencing are Inaccurate Indicators of Response to Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer.

Russell E N Becker, Alexa R Meyer, Aaron Brant, Adam C Reese, Michael J Biles, Kelly T Harris, George Netto, Andres Matoso, Jean Hoffman-Censits, Noah M Hahn, Woonyoung Choi, David McConkey, Phillip M Pierorazio, Michael H Johnson, Mark P Schoenberg, Max R Kates, Alex Baras, Trinity J Bivalacqua,

<h4>Background</h4>Standard of care for patients with muscle-invasive bladder cancer (MIBC) includes neoadjuvant cisplatin-based chemotherapy (NAC) followed by consolidative therapy with either chemoradiation or radical cystectomy (RC). Some patients experience robust pathologic responses to NAC, and these have been reported to associate with somatic mutations in specific gene pathways including DNA ... Read more >>

Eur Urol (European urology)
[2021, 79(3):364-371]

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NCCN Guidelines Insights: Kidney Cancer, Version 1.2021.

Robert J Motzer, Eric Jonasch, Shawna Boyle, Maria I Carlo, Brandon Manley, Neeraj Agarwal, Ajjai Alva, Katy Beckermann, Toni K Choueiri, Brian A Costello, Ithaar H Derweesh, Arpita Desai, Saby George, John L Gore, Naomi Haas, Steven L Hancock, Christos Kyriakopoulos, Elaine T Lam, Clayton Lau, Bryan Lewis, David C Madoff, Brittany McCreery, M Dror Michaelson, Amir Mortazavi, Lakshminarayanan Nandagopal, Phillip M Pierorazio, Elizabeth R Plimack, Lee Ponsky, Sundhar Ramalingam, Brian Shuch, Zachary L Smith, Bradley Somer, Jeffrey Sosman, Mary A Dwyer, Angela D Motter,

The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for diagnostic workup, staging, and treatment of patients with renal cell carcinoma (RCC). These NCCN Guidelines Insights focus on recent updates to the guidelines, including changes to certain systemic therapy recommendations for patients with relapsed or stage IV RCC. They also ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2020, 18(9):1160-1170]

Cited: 4 times

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Future strategies to enhance kidney preservation in upper urinary tract urothelial carcinoma.

Meredith Metcalf, Phillip M Pierorazio,

Though radical nephroureterectomy remains the gold standard treatment for high grade or invasive disease in upper tract urothelial cancer (UTUC), kidney-sparing surgery has become preferred for low risk disease, in order to minimize morbidity and preserve renal function. Many methods exist for endoscopic management, whether via an antegrade percutaneous or ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1831-1840]

Cited: 1 time

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